mononuclear cell – Page 11 – Communicable Diseases Research

Identifying Risk Factors for Secondary Infection Post-SARS-CoV-2 Infection in Patients With Severe and Critical COVID-19

Immunology

Published on 2021-09-302022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

Specific CD8 + TCR Repertoire Recognizing Conserved Antigens of SARS-CoV-2 in Unexposed Population: A Prerequisite for Broad-Spectrum CD8 + T Cell Immunity

Article

Published on 2021-09-282022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] acute respiratory syndrome adaptive analyzed antibody immunity Antigen Blood broad-spectrum adaptive immunity CD8 CD8⁺ T cell CDR3 clone Clustering Cohort complementary conserved coronavirus coronavirus disease COVID-19 cross-reactive effort epitope Epitopes Evidence healthy healthy donor help Immunity implementation implicated IMPROVE in vitro individuals membrane memory T cell MHC-I mononuclear cell Mutation naïve neutralization nucleocapsid PBMCs peptide peptides peripheral populations proportion Protein Proteins provide recognizing recovered patient repertoire SARS-CoV-2 selected Sequencing Specific stimulated T cell T cell receptor T cells TCR TCR repertoire TCR sequencing the healthy therapy translational Vaccine variant virus
[DOI] 10.3390/vaccines9101093 PMC 바로가기 [Article Type] Article

The host immune response of a discharged COVID-19 patient with twice reemergence of SARS-CoV-2: a case report

SARS-COV-2의 두 번 재발을 갖는 퇴원 된 COVID-19 환자의 숙주 면역 반응 : 사례 보고서

Case Reports

Published on 2021-09-232022-09-01
Journal: BMC Infectious Diseases [Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Case report caused Cell cell count coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 patient Diagnosis discharged during treatment global pandemic help hospital Host immune response host immune system IgG Immunoglobulin Immunoglobulin G Infection initial mechanism mononuclear cell Patient PBMC Peripheral blood positive proportion Protective Re-infection Reemergence reported respiratory RNA test SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA serum severe acute respiratory syndrome Coronavirus suggested T cell T cells tested the cell the patient Treatment treatment of COVID-19 virus
[DOI] 10.1186/s12879-021-06679-3 PMC 바로가기 [Article Type] Case Reports

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

I형 인터페론 자가항체는 COVID-19 환자의 전신 면역 변화와 관련이 있습니다

Research Article

Published on 2021-09-222022-09-10
Journal: Science Translational Medicine [Category] MERS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibodies autoantibodies autoantibody caused change circulating leukocyte circulating leukocytes Control coronavirus coronavirus disease Coronavirus disease 2019 correlated Course COVID-19 Critical Critical disease dendritic cell description diagnosed disease course disease pathogenesis Effect elevated epitope evaluated Evidence evidence of expressed expression functional healthy controls help IFNs immune immune system Immunoglobulin in some increased expression individual individuals with COVID-19 inhibitory receptor interferon interferon response interferons ISG lack LAIR1 leukocyte leukocytes longitudinal mechanisms moderate disease monocyte Monocytes mononuclear cell mononuclear cells myeloid cell myeloid cells Patient patients with COVID-19 Peripheral blood Peripheral blood mononuclear cells peripheral blood samples Population Prevalence producing receptor reduced respiratory response SARS-CoV-2 severe acute respiratory syndrome Coronavirus Severe case severe cases severe disease severity single-cell Single-cell transcriptomics subset Support systemic impact systemic impacts the disease Transcriptome transcriptome sequencing transcriptomics turn Type type I Type I IFN type I interferon type I interferons
[DOI] 10.1126/scitranslmed.abh2624 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 Coronavirus Spike Protein-Induced Apoptosis, Inflammatory, and Oxidative Stress Responses in THP-1-Like-Macrophages: Potential Role of Angiotensin-Converting Enzyme Inhibitor (Perindopril)

Immunology

Published on 2021-09-202022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

[키워드] ACE ACE2 activated Activation Analysis analyzed angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor Apoptosis binding Blood Cell cells changed circulation component conditioned media coronavirus CoV cytokine expression Effect Effects Endothelial cell entry of SARS-CoV-2 expression glycoprotein HUVEC cells increase in Inflammation Inflammatory marker inhibitor intracellular calcium intracellular cytokine involved Local Macrophage macrophage polarization macrophages MCP-1 MHC-II modulation monocyte/macrophages mononuclear cell oxidative stress pathway PBMC PBMCs Perindopril Peripheral blood phenotype Potential proinflammatory Proteins Proteomic analysis purified receptors reduced regulated response role ROS S protein SARS-CoV-2 sensitivity significantly increased spike Spike protein stimulated Stimulation systemically the S protein THP-1 TNFα treating Treatment upregulation Vascular viability was used
[DOI] 10.3389/fimmu.2021.728896 PMC 바로가기 [Article Type] Immunology

Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients

단일 세포 면역 프로파일링은 무증상 COVID-19 환자에서 뚜렷한 면역 반응을 나타냅니다

Clinical Trial

Published on 2021-09-162022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 임상,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Asymptomatic Asymptomatic COVID-19 asymptomatic infections asymptomatic patient asymptomatic patients BCR CD16 CD4 CD56 CD8 Cell cell population clonal expansion collected coronavirus disease Evidence evidence of expression healthy controls identify immune profiling immune response immune signature individual infected individuals Infection Infectious diseases interferon Interferon-gamma interferon-stimulated gene interferon-stimulated genes ISG ISGs lack magnitude moderate mononuclear cell natural killer NK cells Patient patients performed Peripheral blood receptor respiratory reveal robust SARS-CoV-2 SARS-CoV-2-infected individual Sequencing severe acute respiratory syndrome Coronavirus severe disease Severe patient single-cell T cell T cells TCR temporal dynamics Transcriptome upregulation Variability while
[DOI] 10.1038/s41392-021-00753-7 PMC 바로가기 [Article Type] Clinical Trial

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)

Articles

Published on 2021-09-112022-10-30
Journal: Lancet (London, England) [Category] COVID-19,

[키워드] 95% CI Academy analyses antibodies antibody Antibody titre antibody titres AstraZeneca AZD1222 baseline boost booster ChAdOx1 nCoV-19 Chinese Clinical research Coalition Cohort Controlled trial Council country COVID-19 vaccine dose Efficacy ELISA Engineering enrolled extended interval finding first dose funding geometric mean titre IgG Immunity immunogenicity data induce Innovation IQR ISRCTN median Medical Science mononuclear cell network NIHR Oxford participant PBMC Peripheral blood persistence phase 2/3 prime-boost interval randomised controlled trial reactogenicity Registered remained Science second dose SFU significantly higher single dose South supply shortage T-cell Response T-cell responses T-cells responses the vaccine titre vaccination Vaccine Valley viral particle Volunteer
[DOI] 10.1016/S0140-6736(21)01699-8 PMC 바로가기 [Article Type] Articles

Acute HIV-1 and SARS-CoV-2 Infections Share Slan+ Monocyte Depletion—Evidence from an Hyperacute HIV-1 Case Report

Communication

Published on 2021-09-102022-10-28
Journal: Viruses [Category] COVID-19,

TIM‐3 as a potential exhaustion marker in CD4 + T cells of COVID‐19 patients

COVID-19 환자의 CD4 + T 세포에서 잠재적인 피로 마커로서의 TIM-3

Original Article

Published on 2021-09-092022-09-10
Journal: Immunity, Inflammation and Disease [Category] SARS, 치료기술,

[키워드] Blood Blood urea nitrogen C‐reactive protein calculated cause CD39 CD4 clinical information clinical symptom Clinical symptoms collected COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 creatinine Critical critical patients deaths disease erythrocyte sedimentation erythrocyte sedimentation rate evaluate evaluated Exhausted cell flow cytometry group groups healthy individuals in healthy individual laboratory data lymphocyte Lymphocytes lymphopenia marker Mild mononuclear cell mononuclear cells neutrophil neutrophil count nitrogen occur overexpression Patient patient groups PBMCs PD‐1 PD‐1 peripheral Peripheral blood Peripheral blood mononuclear cells Result sedimentation rate significant difference significantly higher subjects subpopulation T cell T cells TIM‐3 urea
[DOI] 10.1002/iid3.526 PMC 바로가기 [Article Type] Original Article

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응

Research Article

Published on 2021-09-022022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, SARS, 유전자 메커니즘,

[키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article