Rarely Recognized Antibody Diversification in Covid-19 Evolution to Counteract Advanced SARS-CoV-2 Evasion Strategies, and Implications for Prophylactic TreatmentPhysiology Published on 2021-08-032022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] adaptive Amino acid amino-acid sequence dependency antibody antibody diversification B-cell candidate component consequence COVID-19 Critical defined determinant disease effective elicited epitope vaccines Evidence Evolution example explain gene sequence Genome glycosylation help highlight human cell humoral immune response hypothese immune response immune system Immunity immunogenic peptides immunomodulatory effects Implications Interpretation mechanism natural infection neutralizing antibody pandemic patient groups platform post-translational modification prophylactic treatment rarely recognized immune responses Safe SARS-CoV-2 SARS-COV-2 infection sequence somatic mutations Structural variation the vaccine translational Trial unique Vaccine design virus [DOI] 10.3389/fphys.2021.624675 PMC 바로가기 [Article Type] Physiology
White button mushroom interrupts tissue AR-mediated TMPRSS2 expression and attenuates pro-inflammatory cytokines in C57BL/6 miceArticle Published on 2021-08-022022-10-29 Journal: NPJ Science of Food [Category] COVID-19, [키워드] Activation animal model antagonistic antagonized Asia-Pacific attenuate C57BL/6 Cell chemokines coronavirus Dihydrotestosterone disease European functional host cell Host immune response immune dysregulation implicated Influenza interrupt kidney Lungs mice Nuclear receptors patients pro-inflammatory cytokine Prostate Prostate cancer protease receptor reduce reduced reported serine 2 serum small intestine the United State tissue TMPRSS2 TMPRSS2 expression translational triggering unique white [DOI] 10.1038/s41538-021-00102-6 PMC 바로가기 [Article Type] Article
Long-term shedding of viable SARS-CoV-2 in kidney transplant recipients with COVID-19COVID-19가 있는 신장 이식 환자에서 생존 가능한 SARS-CoV-2의 장기 배출Article Published on 2021-08-012022-09-11 Journal: American journal of transplantation : official jou [Category] SARS, 변종, [키워드] Cell culture cell cultures clinical research/practice Complication complication: infectious COVID-19 favor Infection infection and infectious agents - viral infectious infectious agent infectious agents Infectious disease investigated Isolation kidney kidney transplant recipient kidney transplant recipients kidney transplantation/nephrology nasopharyngeal sample Nasopharyngeal samples onset of symptom PCR testing proportion RT-PCR testing SARS-CoV-2 SARS-CoV-2 RT-PCR symptom onset symptomatic symptomatic COVID-19 These data translational translational research/science variants with COVID-19 [DOI] 10.1111/ajt.16636 PMC 바로가기 [Article Type] Article
Systematizing the genomic order and relatedness in the open reading frames (ORFs) of the coronaviruses코로나바이러스의 오픈 리딩 프레임(ORF)에서 게놈 순서와 관련성을 체계화Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 유전자 메커니즘, 치료법, [키워드] Accessory Accessory genes accessory protein accessory proteins agent analyzed Cluster complex conserved Coronaviridae coronavirus coronavirus disease coronavirus disease-2019 CoV CoVs effort ENCODE envelope focus Frame gene clusters Genes Genome genomes genomic genus greater mechanisms membrane naming nucleocapsid Open reading frame ORF ORF gene ORF3a ORF3b ORF3c ORF3d ORF5 ORFs pandemic Phylogeny polypeptide Protein Proteins Referral RNA genome RNA genome. RNA virus RNA viruses SARS-CoV-2 structural proteins the Spike transcriptional translational viral genome [DOI] 10.1016/j.meegid.2021.104858 PMC 바로가기 [Article Type] Article
Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain423 Published on 2021-07-272022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] AAVP Administered aerosolization Antibody Response Antigen approach attributes Bacteria circulation CMV promoter coronavirus disease COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine COVID-19 vaccine development development displaying effective vaccine elicit Emergency use authorization epitope experiments expression gene delivery Genetic highly pathogenic humans humoral immune response immunization imperative infect inherent initial injected Ligand lung lung epithelium mice Particle Particles peptide performed phage phage display plasticity platform Protein Rapid Research robust S protein S protein-specific antibody safety profile SARS-CoV-2 SARS-CoV-2 S protein Significance stability subcutaneous vaccination sustained temperature the SARS-CoV-2 transgene translational Transport unique vaccination Vaccine Vaccine development virus widespread [DOI] 10.1073/pnas.2105739118 PMC 바로가기 [Article Type] 423
Catalyzing pathways for translational research beyond COVID-19 Comments & Opinion Published on 2021-07-212022-10-05 Journal: Communications Physics [Category] 진단, [키워드] COVID-19 pathway Research translational [DOI] 10.1038/s42005-021-00672-7 [Article Type] Comments & Opinion
COVID-19 lockdown has altered the dynamics between affective symptoms and social isolation among older adults: results from a longitudinal network analysisObservational Study Published on 2021-07-192022-10-04 Journal: Scientific Reports [Category] 임상, [키워드] affective Alter analyses Anxiety anxiety symptoms change changes in cohort study Community COVID-19 COVID-19 pandemic Depression disorders examined greater Human behaviour implication individual individuals lockdown mental health network analysis Older partial correlation Perspective Psychology questionnaire Significant significantly increased social interaction social isolation Symptom timepoints total score translational [DOI] 10.1038/s41598-021-94301-6 PMC 바로가기 [Article Type] Observational Study
Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome dataArticle Published on 2021-07-192022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] Analysis blood transcriptome Cohort Data mining development fixed functional immunological Interpretation knowledge molecular patient cohorts physiological state profile profiles Research resources subject supported Systems biology transcriptional transcriptional profiles Transcriptome translational Translational immunology [DOI] 10.1038/s41467-021-24584-w PMC 바로가기 [Article Type] Article
Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging PathogensReview Published on 2021-07-142022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] adhere adhesin adhesins adhesion Antibiotic resistance Antibiotics approach Bacterial basic Basis binding binding site complexes Compound conserved COVID-19 develop diagnostic diagnostics disease eukaryotic Factor Health Host host cell identify in vitro Infectious disease Infectious diseases Interaction IVD knowledge Ligand maintain mechanisms microbial molecular molecular analysis pathogen pathogen detection Pathogens Precision Protein receptor Receptor binding domain receptors Research SARS-CoV-2 selective sensitivity specificity stimulate Structure supported targets tissues translational Treatment virus [DOI] 10.3390/diagnostics11071259 PMC 바로가기 [Article Type] Review
Circulating immune biomarkers in peripheral blood correlate with clinical outcomes in advanced breast cancerArticle Published on 2021-07-132022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] ABC activated analyzed Biomarker Biomarkers Breast cancer Cancer Cell cells clinical benefit clinical evolution Clinical outcome Cohort correlated Critical decrease diagnosed Disease progression element explain expressing group healthy identification immune immune inhibitory immunology increase in inhibited lymphocyte oncology opposite OX40 Patient Peripheral blood progression of disease reflected Regulatory T cell regulatory T cells Research Result T lymphocyte therapy translational Treatment Tregs tumor microenvironment women [DOI] 10.1038/s41598-021-93838-w PMC 바로가기 [Article Type] Article