Safety and Efficacy of Combined Intramuscular/Intranasal RAZI-COV PARS Vaccine Candidate Against SARS-CoV-2: A Preclinical Study in Several Animal ModelsSARS-CoV-2에 대한 결합된 근육내/비강내 RAZI-COV PARS 백신 후보의 안전성 및 효능: 여러 동물 모델에서의 전임상 연구Article Published on 2022-05-262022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence adjuvant administration Against Amino acid animal approval BALB/c mice blood chemistry candidate candidate vaccine Cellular immune response changes in clearance Combined control group COVID-19 different dose dose Efficacy Efficacy and safety evaluated hamster hamsters heterologous prime-boost High dose humoral IgA antibody immune immune response Immunity induce interval intramuscular intranasal intranasally Iran lung Lung pathology Lungs mice middle Model Modification monomeric mucosal N-terminal domain Neutralizing antibodies New NTD organs parameters Pathological examination pfu Placebo Preclinical Protective RAZI-COV PARS RBD regimens repeated robust Safety SARS-CoV-2 SARS-CoV-2 preclinical study SARS-CoV-2 spike protein significantly specific IgG antibody Spike protein Spread stimulated subunits tested the vaccine trimer vaccination Vaccine vaccine candidate viral infection virus virus load was performed [DOI] 10.3389/fimmu.2022.836745 PMC 바로가기 [Article Type] Article
Characterization of Immune Response Diversity in Rodents Vaccinated with a Vesicular Stomatitis Virus Vectored COVID-19 Vaccine수포성 구내염 바이러스 벡터가 적용된 COVID-19 백신을 접종한 설치류의 면역 반응 다양성 특성화Article Published on 2022-05-242022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome Administered animal model animal models applied BALB/c mice candidate Cellular immune response cellular immunity challenge characterization coronavirus coronavirus disease COVID-19 COVID-19 vaccine Diversity effective Efficacy evaluated hamsters humoral immune response immune response immunization immunization routes intramuscular intranasal Neutralizing neutralizing antibody Protective protective immunity provide public health recombinant COVID-19 vaccine recombinant vesicular stomatitis virus reflect response robust rodent SARS-CoV-2 significantly higher stomatitis susceptible Syrian Golden hamsters T cell Th1 Th2 triggered Vaccine vaccine candidate vesicular vesicular stomatitis virus VSV [DOI] 10.3390/v14061127 PMC 바로가기 [Article Type] Article
Role of antibodies, inflammatory markers, and echocardiographic findings in postacute cardiopulmonary symptoms after SARS-CoV-2 infectionSARS-CoV-2 감염 후 급성 심폐 증상에서 항체, 염증 표지자 및 심장초음파 소견의 역할Article Published on 2022-05-232022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] Abnormalities age antibodies association baseline characteristics binding domain Biomarker Biomarkers breath C-reactive protein Cardiology Cardiopulmonary cardiovascular cardiovascular disease Cellular immune response chest pain COVID-19 cross-sectional analysis Dyspnea echocardiograms echocardiographic echocardiographic finding echocardiographic findings enrolled Evidence functional Hospitalization IgG antibody immune response individual Inflammation inflammatory markers investigation Logistic regression marker mechanism median median age occur palpitation palpitations parameter participant performed Receptor binding domain reported role SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 receptor Sex Shortness of breath Symptom Symptoms systemic inflammation women [DOI] 10.1172/jci.insight.157053 PMC 바로가기 [Article Type] Article
Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine CandidatesSARS-CoV-2 mRNA와 재조합 단백질 백신 후보에 의해 유발된 면역 반응의 비교Article Published on 2022-05-192022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Arm BALB/c mice binding candidate cellular Cellular immune response COVID-19 demonstrated elicit Head-to-head comparison humoral IgG IgG subclass antibodies immune immune response induce mRNA mRNA vaccine mRNA vaccines Neutralizing antibody titer outbreak PROTECT Protein protein vaccine recombinant recombinant protein vaccine recombinant vaccines reported response Result SARS-CoV-2 SARS-CoV-2 vaccine Subtypes Vaccine vaccine candidate viral infection [DOI] 10.3389/fimmu.2022.906457 PMC 바로가기 [Article Type] Article
Humoral, Cellular and Cytokine Immune Responses Against SARS-CoV-2 Variants in COVID-19 Convalescent and Confirmed Patients With Different Disease Severities다양한 질병 중증도를 가진 COVID-19 회복기 및 확인된 환자의 SARS-CoV-2 변이체에 대한 체액, 세포 및 사이토카인 면역 반응Article Published on 2022-05-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ADE Against Alpha alpha and delta variants Alpha variant Anti-RBD IgG cellular Cellular immune response cellular immunity chemokine chemokines Confirmed convalescent convalescent sera correlation COVID-19 Cytokines delta variant Delta variants disease disease severity ELISA ELISPOT evaluate exhibited fold greater humoral Humoral and cellular immune responses humoral immune response Humoral immunity IgG IL-6 immune immune response immune responses Immunity immunoassays individual Inflammatory mediators IP-10 MCP-1 mediators multiplex neutralization potency Neutralizing activity Omicron variant Omicron variants Patient patients performed pseudovirus pseudovirus infection quantified Raji cells RBD-specific IgG response risk SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant SARS-CoV-2 variants serum severe disease Significant significantly specific antibodies spike-specific antibodies Spike-specific antibody T cell T cells variant virus was measured [DOI] 10.3389/fcimb.2022.862656 PMC 바로가기 [Article Type] Article
Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant비활성화 백신을 사용한 이종 면역화 후 mRNA-부스터는 SARS-CoV-2 오미크론 변이체에 대한 강력한 면역을 유도합니다Article Published on 2022-05-132022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] boost booster Cell Cellular immune response dose ectodomain Efficacy elicit Heterologous heterologous immunization homologous humoral Humoral and cellular immune responses IgG antibodies IgG antibody immune responses Immunity Inactivated vaccine Inactivated Vaccines increase individual Infection memory B memory B cell mRNA vaccine omicron Omicron variant Omicron variants plasma raised RBD receiving Receptor-binding domain SARS-CoV-2 significantly significantly increased specific antibodies specific antibody T cell T cell response the receptor-binding domain vaccination Vaccination strategies Vaccine vaccine efficacy variant variants variants of concern virus Virus neutralization [DOI] 10.1038/s41467-022-30340-5 PMC 바로가기 [Article Type] Article
Augmentation of humoral and cellular immune responses after third-dose SARS-CoV-2 vaccination and viral neutralization in myeloma patients골수종 환자에서 SARS-CoV-2 3차 접종 및 바이러스 중화 후 체액 및 세포 면역 반응의 증대Article Published on 2022-05-092022-09-12 Journal: Cancer cell [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] augmentation Cellular immune response humoral Patient SARS-CoV-2 vaccination viral neutralization [DOI] 10.1016/j.ccell.2022.03.013 PMC 바로가기 [Article Type] Article
Broad humoral and cellular immunity elicited by one-dose mRNA vaccination 18 months after SARS-CoV-2 infectionSARS-CoV-2 감염 18개월 후 1회 투여 mRNA 백신 접종으로 유발된 광범위한 체액 및 세포 면역Article Published on 2022-05-042022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] analyzed cell-mediated immune response Cell-mediated immune responses Cellular immune response cellular immunity comparable convalescent individual convalescent individuals coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis Diagnosis dose elicit elicited Guidance humoral Humoral and cellular immune responses immune response immune responses include Infection mRNA mRNA vaccination mRNA vaccine Neutralizing activity omicron Omicron variant pandemic Patient recruited respiratory SARS-CoV-2 SARS-COV-2 infection second dose second dose of vaccine Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 significantly vaccination Vaccine vaccine dose vaccine doses variant variants variants of concern were assessed wild-type [DOI] 10.1186/s12916-022-02383-4 PMC 바로가기 [Article Type] Article
Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2레플리콘 기반 mRNA 백신 후보의 박테리아 지원 경구 전달은 조상 및 델타 변이형 SARS-CoV-2로부터 보호Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphaviruses antibody antigenic diversity B.1.617.2 Bacteria Cellular immune response cellular immune responses clade contributed contributing to Coronavirus-2 COVID-19 cross-protective domain Efficacy epitope Epitopes Evolution feasible forest gene delivery hamster hamsters heptad repeat immune responses immunization immunized immunized mice Immunoglobulin lung Lungs mass vaccination membrane protein mRNA mRNA vaccine mucosal mucosal vaccine NAbs nasal Nasal cavity Neutralizing antibodies neutralizing antibody non-structural protein nsp13 offer oral Oral Immunization oral route Pneumonia principle PROTECT provide RBD Receptor binding domain recorded replicon-based respiratory Salmonella Salmonella-mediated SARS-CoV-2 secretory IgA SIgA the vaccine vaccination Vaccine vaccine efficacy variant variants Viral viral replication virus [DOI] 10.1016/j.ymthe.2022.01.042 PMC 바로가기 [Article Type] Article
Adaptive Immune Responses and Immunity to SARS-CoV-2SARS-CoV-2에 대한 적응 면역 반응 및 면역Review Published on 2022-05-042022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] activated Activation adaptive Adaptive immune response adaptive immune responses Adaptive immunity Antigen antigen-presenting cell antigen-presenting cells B cell B cell receptors B.1.1.529 B.1.617.2 backbone biological interaction Blood Blood donors Breakthrough infection breakthrough infections cellular Cellular immune response cellular immunity cellular response Clonality competence COVID-19 COVID-19 pandemic defend Defense defense mechanism Delta demonstrated heparinized blood Host humoral Humoral response humoral responses IgA immune immune reaction immune responses Immunity Immunocompromised Immunocompromised patient Immunocompromised patients Immunological memory immunology induce Infection interferon gamma interferon gamma. Interferon-gamma knowledge long-lasting maturation mechanism memory mucosal nasal omicron pandemic peptides Research response SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 T cell memory shown stimulated T cell T cell memory T cells the SARS-CoV-2 translate undetectable Vaccine Vaccines variants variants of concern Viral antigen viral particle virus [DOI] 10.3389/fimmu.2022.848582 PMC 바로가기 [Article Type] Review