Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 units페리틴은 폐 침범의 심각성과 관련이 있지만 COVID-19 환자의 더 나쁜 예후와는 관련이 없습니다: 2개의 이탈리아 COVID-19 유닛의 데이터Clinical Trial Published on 2021-03-012022-08-13 Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] 95% CI Abruzzo Admission age and gender Biomarker Care clinical clinical decision Clinical sign Clinical signs complex Computed tomography conducted coronavirus coronavirus 2019 disease Course covariate covariates COVID-19 CT scan death Deceased demonstrated discharged disease disease severity enrolled evaluated feature female ferritin ferritin level ferritin levels help heterogeneous hospital hospitalized patient hospitalized patients identify investigated Italian Italy Logistic regression analysis lung abnormalities lung abnormality lung involvement lymph node enlargement males median age mediastinal lymph node mediastinal lymph node enlargement no differences occurred outcome outcomes pathophysiology Patient patients patients with COVID-19 Prognosis prognosis of patient pulmonary involvement pulmonary lobe pulmonary lobes regression analysis retrospective SARS-CoV-2 SARS-COV-2 infection septal thickening serological severe pulmonary involvement severity Therapeutic approach therapeutic approaches unit worse prognosis [DOI] 10.1038/s41598-021-83831-8 PMC 바로가기 [Article Type] Clinical Trial
COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new IssueCOVID-19 관련 사이토카인 폭풍 증후군 및 진단 원칙: 오래된 문제와 새로운 문제Review Published on 2021-02-182022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Antigen Autoimmune disease Autoimmune diseases autologous benefit Bone marrow CAR-T Characteristics chimeric chimeric antigen receptor claimed clinical experience Clinical sign Clinical signs clinician coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRS CSS cytokine cytokine release Cytokine release syndrome Cytokine storm Cytokine storm syndrome Cytokines Deterioration diagnosed diagnoses diagnosing Diagnosis diagnostic Diagnostic Criteria disease early stage early stages Evolution familial/primary hemophagocytic lymphohistiocytosis hemophagocyte hemophagocytic lymphohistiocytosis hemophagocytic syndrome HLH include issue less limitation Macrophage macrophage activation macrophage activation syndrome malignancy mechanisms non-specific paper Pathogenesis Patient Research respiratory SARS-CoV-2 secondary hemophagocytic lymphohistiocytosis sensitivity severe acute respiratory syndrome Coronavirus sHLH Signs and symptoms Symptoms T-cell T-cell receptor therapy [DOI] 10.1080/22221751.2021.1884503 PMC 바로가기 [Article Type] Review
The rationale for a multi-step therapeutic approach based on antivirals, drugs and nutrients with immunomodulatory activity in patients with coronavirus-SARS2-induced disease of different severities다양한 중증도의 코로나바이러스-SARS2 유발 질환 환자에서 면역조절 활성을 갖는 항바이러스제, 약물 및 영양소를 기반으로 한 다단계 치료 접근법의 근거Full Papers Published on 2021-02-142022-09-10 Journal: The British Journal of Nutrition [Category] Fulltext, MERS, SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome antivirals assumption Cell Characteristics China Clinical sign Clinical signs Compound concerning Corona Corona virus coronavirus COVID-19 cytokine cytokine release Cytokine release syndrome disease drug element Epidemic Europe fat-soluble Genome homology Host immune response identify immune response immunomodulatory activity Immunopathogenesis Infection involved Italy modality Modification modulating outbreak pathogenic mechanism pathogenic mechanisms Patient patients with SARS Pneumonia public health Replication required respiratory SARS SARS infection SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome Severe Acute Respiratory Syndrome Corona Virus severity Signs and symptoms Spread stimulate Symptom the cell the SARS-CoV-2 Therapeutic approach therapeutic strategy therapy Transmission Treatment Vitamin vitamins was performed Wuhan [DOI] 10.1017/S0007114520002913 PMC 바로가기 [Article Type] Full Papers
Clinical presentation and outcomes of the first patients with COVID-19 in Argentina: Results of 207079 cases from a national databaseResearch Article Published on 2021-02-112022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] Admission adverse outcome age Analysis Asthma Care case report form clinical Clinical characteristics Clinical diagnosis Clinical sign co-morbidity Coma condition conducted Contact cough country COVID-19 database dataset defined diabete diagnosed disease severity Dyspnea Effects elevated Evidence Factor Fatality rate Fever Follow-up headache healthcare Healthcare provider hypertension ICU admission immunodeficiency information initial intensive care Latin Latin America Liver disease male Male sex males measure Mild morbidities MOST nasal National obesity Older age outcome pandemic patients with COVID-19 Pharyngeal swab polymerase chain positive positive result question renal Result risk factor RT-PCR RT-PCR testing SARS-COV-2 infection Seizures Sequencing sore throat specimens Symptom Symptoms System tachypnea was collected [DOI] 10.1371/journal.pone.0246793 PMC 바로가기 [Article Type] Research Article
Expanding spontaneous pneumothorax in COVID-19 pneumonia: Case report and review of literatureCase Report Published on 2021-02-072022-10-30 Journal: Journal of Cardiovascular and Thoracic Research [Category] COVID-19, [키워드] caused Chest Clinical sign complications Coronavirus disease 2019 COVID-19 CT Deterioration instance intubation management Patient patients Pneumothorax resulting Symptoms variety with COVID-19 [DOI] 10.34172/jcvtr.2021.16 PMC 바로가기 [Article Type] Case Report
Coinfection of porcine deltacoronavirus and porcine epidemic diarrhea virus increases disease severity, cell trophism and earlier upregulation of IFN-α and IL12Article Published on 2021-02-042022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] Antigen antigens Cell characterized Clinical sign clinically Co-infection Coinfection collected Combination conducted demonstrated diarrhea disease disease severity Enterocyte epidemic diarrhea evaluated exacerbate fecal group groups IFN-α IL12 immunology increase indicated Infection Inflammatory cytokine inoculated Interferon alpha intestinal mucosa intestinal tissues investigated lesion Microbiology Microscopic Pathogenesis PEDV Porcine deltacoronavirus post inoculation Regulatory reported severity significantly Swab the disease up-regulated upregulation virus viruses [DOI] 10.1038/s41598-021-82738-8 PMC 바로가기 [Article Type] Article
Acute Symptomatic Seizures in Critically Ill Patients with COVID-19: Is There an Association?COVID-19가 있는 중환자의 급성 증상성 발작: 연관성이 있습니까?Case Reports Published on 2021-02-012022-09-11 Journal: Neurocritical care [Category] 치료기술, [키워드] 2019 Affect benefit blood-brain barrier Brain Central nervous system clinical Clinical sign Clinical signs Contamination coronavirus coronavirus disease cortical COVID-19 COVID-19 disease cross-contamination cytokine disease Disseminated intravascular coagulopathy elevated Encephalopathy epilepsy global pandemic health system Hospitalization human coronavirus human coronaviruses Ill Infection Injury levetiracetam Lung disease male mechanism motor multifactorial neurological neurological manifestation neurological manifestations Neurological symptom Neurological symptoms neurotropic Organ failure Patient patients patients with COVID-19 positive precipitated pro-inflammatory cytokine Reactions reported Resolution resources respiratory risk SARS-CoV-2 secondary to Seizure Seizures severe COVID-19 disease status epilepticus symptomatic tested therapy thought Viral viral infection with COVID-19 [DOI] 10.1007/s12028-020-01006-1 PMC 바로가기 [Article Type] Case Reports
Clinical and epidemiological features discriminating confirmed COVID-19 patients from SARS-CoV-2 negative patients at screening centres in Madagascar마다가스카르 스크리닝 센터에서 코로나19 확진자와 SARS-CoV-2 음성 환자를 구별하는 임상 및 역학적 특징Article Published on 2021-02-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] age Ageusia Anosmia arthralgia chest pain clinical Clinical findings Clinical sign Clinical signs Cluster Community confirmed case confirmed cases Contact tracing cough COVID-19 COVID-19 in patients COVID-19 patient COVID-19 patients Critical epidemiological Evidence evidence of feature Fever help high risk identify incidence Infection Isolation limit Mortality multivariate logistic regression myalgia negative patients neighbourhood Patient patients prediction Probability reducing SARS-CoV-2 SARS-CoV-2 PCR testing score Screening Signs and symptoms sore throat Spread Symptom symptoms onset Transmission undergo virus [DOI] 10.1016/j.ijid.2020.11.151 PMC 바로가기 [Article Type] Article
Machine learning model for predicting severity prognosis in patients infected with COVID-19: Study protocol from COVID-AI BrasilRegistered Report Protocol Published on 2021-02-012022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Algorithm alternative hypothesis AUC beta coronavirus Chest computed tomography Chest CT China Clinical sign collected Course COVID-19 COVID-19 infection develop development discomfort dysfunction epidemiological epidemiological data epidemiological history evaluate exclusion criteria expected Factor hospital Hypotension identify include Inclusion individual infected with COVID-19 Length machine Metrics multicenter New coronavirus outcome outcomes Patient patients performed positive predict Prognosis prognosis of patient prognostic Prognostic factors protocol radiological respiratory retrospective RNA SARS-CoV-2 secondary secondary outcome severity single-stranded Symptom syndrome the disease time Vasopressor Wuhan [DOI] 10.1371/journal.pone.0245384 PMC 바로가기 [Article Type] Registered Report Protocol
An extensive study on the COVID-19 pandemic, an emerging global crisis: Risks, transmission, impacts and mitigationCOVID-19 대유행, 신흥 글로벌 위기에 대한 광범위한 연구: 위험, 전파, 영향 및 완화Review Published on 2021-02-012022-09-11 Journal: Journal of infection and public health [Category] 치료기술, 치료제, [키워드] 2019-nCoV acute respiratory syndrome Analysis Antiviral antiviral medication Antiviral medicinal drugs approved ARDS auxiliary Awareness bat bats boost Care caused changes Characteristics China clinical manifestations clinical recovery Clinical sign Clinical signs clinical trials Corona Corona virus cough COVID-19 COVID-19 pandemic death Diagnosis drug epidemiological Epidemiological characteristics extreme Fever Genomic analysis Health Organization Impact intermediate malaise over pathogenic pathogenicity pathological Pathological characteristics phylogenetically Pneumonia raise recorded reported respiratory resulting SARS-CoV-2 Severe acute respiratory syndrome Signs and symptoms Spread Symptom systematic analysis tested tiredness Transmission transmitted Vaccine Viral viral infection virus viruses WHO World Health Organization Wuhan Wuhan, China [DOI] 10.1016/j.jiph.2020.12.020 PMC 바로가기 [Article Type] Review