Applicability of MuLBSTA scoring system as diagnostic and prognostic role in early warning of severe COVID-19Research article Published on 2021-01-012022-10-05 Journal: Microbial pathogenesis [Category] SARS, 진단, [키워드] accompanied Accuracy age Analysis analyzed applicability Bacterial infection change city Clinical characteristics COVID-19 COVID-19 patient COVID-19 patients described diagnostic distribution Early warning effect Efficacy Factor greater hypertension indicated infiltration less lobes Lymphocyte count Mild MuLBSTA score Patient prognostic Retrospective analysis ROC Curve score scored scoring system sensitivity severe COVID-19 severe COVID-19 patients Severe patient severe symptom smoking specificity statistically significant was performed [DOI] 10.1016/j.micpath.2020.104706 [Article Type] Research article
Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease developmentCOVID-19와 관련된 신경계 질환의 뇌척수액 발견 및 질병 발병 메커니즘에 대한 통찰력Article Published on 2021-01-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] Acute disseminated encephalomyelitis age cell counts Central nervous system cerebrospinal fluid Cerebrovascular disease characterized clinical condition CNS Combination Concentration COVID-19 COVID-19 symptoms CSF defined disease Disseminated encephalomyelitis elevated Encephalitis Encephalomyelitis Encephalopathy evaluated Evidence evidence of Glucose Guillain-barrè syndrome headache IgG Immune cell immune cells Infection infiltration Inflammation Inflammatory Injury intracranial pressure light chain mechanism men Meningitis meningoencephalitis Myelitis neurofilament Neurofilament light protein neurological Neurological disease Neurological diseases neurological manifestation neurological manifestations Neuromyelitis Optica neuronal Older oligoclonal band Oligoclonal bands Patient patients with SARS-CoV-2 pleocytosis profile profiles Protein Proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA serum Sex subsequent syndrome systemic inflammation Total total protein Total Tau protein. triggering Viral viral replication with COVID-19 [DOI] 10.1016/j.ijid.2020.10.044 PMC 바로가기 [Article Type] Article
Current advances in the development of SARS-CoV-2 vaccinesReview Published on 2021-01-012022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, [키워드] acute respiratory syndrome Antibody-dependent enhancement caused China clinical trial clinically contribute coronavirus Coronavirus disease 2019 country COVID-19 COVID-19 vaccine current global pandemic group help Inactivated vaccine infiltration International phase protective effect public health risk SARS-CoV SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 vaccine SARS-CoV-2 vaccines Sinopharm Trial United Arab Emirate Vaccine development Vaccines [DOI] 10.7150/ijbs.52569 PMC 바로가기 [Article Type] Review
ACE2 Correlated With Immune Infiltration Serves As A Novel Prognostic Biomarker In Clear Cell Renal Cell Carcinoma: Implication For COVID-19Research Paper Published on 2021-01-012022-10-29 Journal: International Journal of Biological Sciences [Category] COVID-19, [키워드] ACE2 ACE2 expression acute respiratory syndrome advanced tumor stage Affect Analysis Cancer patients caused ccRCC CD4 Cell cell entry receptor cell lines Characteristics Cohort coronavirus correlated COVID-19 datasets determine down-regulated feature GEO histological Immune cell immune infiltration immunohistochemistry independent indicated Infection infiltration Lower memory Metastasis multivariate Cox regression novel patients poor prognosis Prognosis prognostic reduced renal SARS-CoV-2 significantly TIP tissue was related were used western blot [DOI] 10.7150/ijbs.51969 PMC 바로가기 [Article Type] Research Paper
Favipiravir Effects on the Control of Clinical Symptoms of Hospitalized COVID-19 Cases: An Experience with Iranian Formulated Dosage FormOriginal Article Published on 2021-01-012022-10-30 Journal: Iranian Journal of Pharmaceutical Research : IJPR [Category] COVID-19, [키워드] Adverse drug reaction adverse effect Antiviral caused clinical Clinical sign clinical trials Combination Control cough COVID-19 disease dose Dyspnea early administration Effect Efficacy and safety evaluate experience Favipiravir FIVE form Hospitalization ICU in both group in both groups infiltration Intervention introduced investigated Iran Laboratory liver enzyme Lopinavir-ritonavir median time Medical Sciences Medicine mortality rate no significant difference not significantly different occurred pandemic Patient patients with COVID-19 peripheral oxygen saturation Pharmacy public health randomized clinical trial recruited reduce Research SARS-CoV-2 SARS-COV-2 infection School Seven significantly Spread Symptom symptoms onset Tablet Tehran the patient time-consuming two groups university X-ray [DOI] 10.22037/ijpr.2021.115510.15401 PMC 바로가기 [Article Type] Original Article
Imaging Mass Cytometric Analysis of Postmortem Tissues Reveals Dysregulated Immune Cell and Cytokine Responses in Multiple Organs of COVID-19 PatientsMicrobiology Published on 2020-12-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] accompanied alteration Antigen B cell CD11b CD11c controls coronavirus COVID-19 COVID-19 patient COVID-19 patients cytokine Cytometry dendritic cell evaluated expression IL-10 imaging imaging mass cytometry (IMC) Immune cell immune dysregulation immunosuppressive immunosuppressive cytokine infiltration Inflammatory response intestine involved kidney kidneys leukocyte liver liver tissues lung Lungs Macrophage mass monocyte Multiple natural killer Necrosis not express organ organ specific response Pathogenesis patients with COVID-19 Postmortem postmortem tissues pro-inflammatory prognostic response spleen suggested T cell therapeutic target TNF-α [DOI] 10.3389/fmicb.2020.600989 PMC 바로가기 [Article Type] Microbiology
Effect of COVID-19 on Lungs: Focusing on Prospective Malignant PhenotypesReview Published on 2020-12-182022-10-31 Journal: Cancers [Category] COVID-19, [키워드] ACE2 acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome affected angiotensin-converting enzyme 2 ARDS biologic Cancer cancer patient cause characteristic clinical feature Computed tomography Concentration coronavirus Coronavirus infection COVID-19 COVID-19 patient death develop disease Effect epithelial cell Existence facilitated flu Focusing Follow-up GGO glass Ground glass opacity healthcare high-risk population host cell immune system Immunopathogenesis individual induce infiltration Inflammation Inflammatory cytokine Intracellular Invasive mechanical ventilation Johns Hopkin lung lung cancer Lung fibrosis Lungs malignant management Medicine membrane protein Mortality oncogenic opacity pandemic pathophysiological conditions Patient Pneumonia pro-inflammatory cytokines Prospective protease pulmonary fibrosis resource SARS-CoV2 severe symptom simple spike glycoprotein subject survivor Symptom syndrome the patient TMPRSS2 upregulation Viral load viral outbreak virus virus particle viruses [DOI] 10.3390/cancers12123822 PMC 바로가기 [Article Type] Review
A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters시리아 햄스터의 바이러스 부담과 질병 중증도를 감소시키는 강력한 SARS-CoV-2 중화 인간 단일클론 항체Immunology Published on 2020-12-182022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] antibody approach burden caused Clinical management clone contributed coronavirus COVID COVID-19 COVID-19 patients deaths demonstrated Dexamethasone disease disease severity Efficacy hamster Histopathology Human Human monoclonal antibody immunopathological in vitro infiltration Lungs monoclonal Ab monocyte morbidity neutralized pandemic potent Receptor binding domain reduced reducing reduction Remdesivir SARS-CoV-2 significantly specificity Spike protein the SARS-CoV-2 therapeutic antibodies therapy Treatment Viral load virus yeast [DOI] 10.3389/fimmu.2020.614256 PMC 바로가기 [Article Type] Immunology
COVID-19 experience of the major pandemic response center in the capital: results of the pandemic’s first month in Turkey수도에 있는 주요 팬데믹 대응 센터의 COVID-19 경험: 터키에서 팬데믹 첫 달의 결과Article Published on 2020-12-172022-08-31 Journal: Turkish Journal of Medical Sciences [Category] MERS, 바이오마커, 진단, [키워드] acute respiratory illness Admission age Anosmia Bilateral chronic obstructive chronic obstructive pulmonary disease city Clinical characteristics Clinical course cohort study Comorbidity Coronary artery Coronary artery disease COVID-19 COVID-19 case COVID-19 cases COVID-19 patient COVID-19 patients Critical disease disease elevated elevated liver enzymes Enzymes epidemiological Epidemiology evaluate ferritin Fever GFR ground-glass opacity Hospitalized IL-6 illness onset increased risk infiltration liver liver enzymes loss of taste lymphocyte material median time monocyte Mortality mortality rate neutrophil obstructive pulmonary disease Older Older age on admission pandemic parameter patchy patients Platelet Platelet count positive patient predictor Prognosis pulmonary disease respiratory Result reveal SARI SARS-CoV-2 PCR severe disease significantly higher Symptoms Taste Turkey [DOI] 10.3906/sag-2006-164 PMC 바로가기 [Article Type] Article
Prognostic Factors of COVID-19 Infection in Elderly Patients: A Multicenter StudyCommunication Published on 2020-12-042022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activity age C-reactive protein (CRP Chest clinical outcomes Comorbidity COVID-19 COVID-19 infection COVID-19 pandemic CRP daily living death defined died elderly Elderly patient elderly patients enrolled Factor Fatality rate Fever Health hospital Hospitalization impairment infiltration initial Logistic regression analysis multicenter multicenter study Novel coronavirus outbreak Oxygen treatment poor prognosis Population Prognosis Prognostic factor reduce Retrospective study risk factor robust SARS-CoV-2 severe pneumonia significantly South Korea the disease the patient understanding with COVID-19 [DOI] 10.3390/jcm9123932 PMC 바로가기 [Article Type] Communication