A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patientsCOVID-19 양성 증상 및 무증상 환자의 혈청학적 프로파일링을 위한 다중 화학발광 면역분석Article Published on 2021-02-022022-09-10 Journal: Nature Communications [Category] MERS, 바이오마커, 진단, 치료기술, [키워드] Affect antibodies antibody profiling Antibody Response Antibody responses Antimicrobial responses Asymptomatic individuals binding domain Biomarker chemiluminescent immunoassay children Cohort COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 PCR test Critical deaths detect Detection limit develop Diagnostic markers disease severity greater IgA IgA response IgA responses IgG IgG response IgG responses IgM IgM response IgM responses immune response initial large cohort Mild-to-moderate multiplex Multiplex assay multiplex serology participant Participants Patient PCR test risk robust SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2-specific antibodies serological serology significantly increased Symptom symptom onset symptomatic and asymptomatic symptomatic participant symptomatic participants the antibody response Viral viral infection Viral transmission with COVID-19 [DOI] 10.1038/s41467-021-21040-7 PMC 바로가기 [Article Type] Article
Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19COVID-19에 대한 혁신적인 백신 및 치료 전략을 위해 강글리오사이드에 대한 코로나바이러스 결합 활용Article Published on 2021-01-292022-09-12 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 진단, [키워드] ACE-2 receptor analyzed antibody Antibody binding Azithromycin bind binding binding domain binding site blocked cellular convalescent coronavirus COVID-19 Critical epitope explain flat ganglioside Hydroxychloroquine identity Infection Interaction isolate Lipid Lipid raft N-terminal domain neutralizing antibody NTD offer overlap patients plasma membrane RBD Receptor binding domain Respiratory disease S protein S trimer SARS-CoV-2 SARS-CoV-2 neutralization supported the S protein therapeutic therapeutic strategy These data unique Vaccine virus Virus spike [DOI] 10.1016/j.bbrc.2020.10.015 PMC 바로가기 [Article Type] Article
Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 PolymorphismArticle Published on 2021-01-282022-10-30 Journal: Molecules [Category] COVID-19, [키워드] absence ACE ACE2 ACE2 allelic variants ACE2 binding acute respiratory syndrome allele approach bind binding domain Chloroquine coding variant coronavirus coronavirus disease coronavirus spike protein country COVID-19 death domain drugs enzyme exhibited Frequency HCQ help Hydroxychloroquine in silico Infection Interaction intermolecular interaction malaria management mediation metabolite molecular docking molecular interactions Pathogenesis polymorphism Prevent reported Rheumatic diseases SARS-CoV-2 SARS-COV-2 infection spike the disease the WHO treat Vaccine variant [DOI] 10.3390/molecules26030673 PMC 바로가기 [Article Type] Article
Stereotypic neutralizing V H antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individualsCOVID-19 환자 및 건강한 개인에서 SARS-CoV-2 스파이크 단백질 수용체 결합 도메인에 대한 고정형 중화 V H 항체Research Article Published on 2021-01-272022-09-10 Journal: Science Translational Medicine [Category] 변종, 진단, [키워드] antibody binding binding domain composed de novo develop Evidence evidence of exposure to Genes healthy individual healthy individuals heavy chain host cells Human IgA2 IgG1 IgG2 IgG3 IGHJ6 IGHV IGHV3-53 IGHV3-66 IgM IgM isotype IgM isotypes Immunoglobulin in healthy individual in vitro infected with SARS-CoV-2 inhibit inhibiting light chains memory B cell memory B cells NAb NAbs naïve B cell naïve B cells neutralization neutralize Neutralizing Neutralizing antibodies neutralizing antibody no evidence of occurred Patient patients with COVID-19 produced protective immunity RBD Receptor binding domain Replication resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein SARS-CoV-2 spike protein receptor binding domain somatic mutations Spike protein subtype suggested switching the RBD Viral viral infection viral infections viral replication viruses [DOI] 10.1126/scitranslmed.abd6990 PMC 바로가기 [Article Type] Research Article
Allergen fragrance molecules: a potential relief for COVID-19알레르겐 향기 분자: COVID-19에 대한 잠재적 완화Research Article Published on 2021-01-212022-09-10 Journal: BMC Complementary Medicine and Therapies [Category] 신약개발, 치료법, [키워드] affected allergen analyzed Anti-viral fragrance molecules AutoDock AutoDock vina benzyl Benzyl Benzoate Benzyl Cinnamate Benzyl Salicylate best binding binding affinities binding affinity binding domain BRD2 bromodomain calculated carried China comparable coronavirus coronavirus SARS-CoV-2 COVID-19 cut-off default settings docking docking result dose drug expected FIVE flexible Fragrance allergen molecules function functional Galaxolide Health Host lowest macromolecules molecules MPro MVD nucleocapsid Prevent Protein protocol RBD Receptor binding domain reported Result Safe Salicylate SARS-CoV-2 Sclareol selected shown Spike protein Spread supplementary material target target proteins tested today treat Vaccine Virtual screening were used while [DOI] 10.1186/s12906-021-03214-4 PMC 바로가기 [Article Type] Research Article
Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patientsCOVID-19 환자의 다양한 검체 유형 및 혈청 항체 수준의 바이러스 부하 분석Research Published on 2021-01-072022-09-10 Journal: Journal of Translational Medicine [Category] 진단, 치료기술, 치료법, [키워드] affected anal swab anal swabs anti-S Anti-spike antibody antibody levels be positive best binding domain Blood caused collected correlation Course COVID-19 COVID-19 patient death detection rate digital PCR disease domain droplet digital PCR ELISA Factors False negative false negative results followed by global pandemic had no highest IgG antibodies IgG antibody IgM and IgG information Nasopharyngeal swab nasopharyngeal swabs no correlation Other Patient positive Protein Result Saliva SARS-CoV-2 detection serum antibody serum sample specimen swabs symptoms onset tested Urine urine specimens Viral Viral load was measured [DOI] 10.1186/s12967-020-02693-2 PMC 바로가기 [Article Type] Research
Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2SARS-CoV-2의 N 단백질 코딩 유전자의 RNA 결합 도메인에서 침묵 돌연변이의 식별 및 특성화Comparative Study Published on 2021-01-062022-09-10 Journal: BMC Research Notes [Category] 변종, 유전자 메커니즘, 치료기술, 치료법, [키워드] acute respiratory syndrome addition affinity Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence DNA sequences human body human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid nucleotide objective Occurrence pathogenicity proline repair mechanism respiratory Result resulting risk RNA RNA binding domain RNA sequence RNA sequences SARS-CoV-2 Severe acute respiratory syndrome silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral Viral RNA Zinc [DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study
Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2Comparative Study Published on 2021-01-062022-10-27 Journal: BMC Research Notes [Category] COVID-19, [키워드] acute respiratory syndrome addition Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid objective Occurrence pathogenicity proline repair mechanism Result resulting risk RNA RNA binding domain RNA sequence SARS-CoV-2 silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral RNA Zinc [DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study
Identification and characterization of a silent mutation in RNA binding domain of N protein coding gene from SARS-CoV-2Comparative Study Published on 2021-01-062022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, [키워드] acute respiratory syndrome addition Base excision repair binding domain changed China Chinese coding gene coding sequence COVID-19 cytosine DNA DNA sequence human immunity human-to-human transmission identification IMPROVE Iran leucine Missense mutation mutated Mutation N protein nucleocapsid objective Occurrence pathogenicity proline repair mechanism Result resulting risk RNA RNA binding domain RNA sequence SARS-CoV-2 silent single nucleotide TDG thymine Thymine DNA glycosylase (TDG) Transcription uracil Viral RNA Zinc [DOI] 10.1186/s13104-020-05439-x PMC 바로가기 [Article Type] Comparative Study
Cross-species recognition of SARS-CoV-2 to bat ACE2ACE2에 대한 SARS-CoV-2의 종간 인식530 Published on 2021-01-052022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] 변종, [키워드] Rhinolophus macrotis ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 attenuate bACE2 bat bat ACE2 bats benefit bind binding binding domain caused complex conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Evidence expressing global health hACE2 Health host cell host cells human ACE2 human ACE2 receptor infect Infection Interaction less molecular basis mutant pandemic pseudotyped pseudotyped SARS-CoV-2 virus RBD RBD binding receptor Receptor binding domain residue residues respiratory SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 receptor SARS-CoV-2 spike protein receptor binding domain SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Significance Spike protein the SARS-CoV-2 Variation variations virus virus infection was determined Y41H [DOI] 10.1073/pnas.2020216118 PMC 바로가기 [Article Type] 530