epithelial cell – Page 16 – Communicable Diseases Research

SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition

SARS-CoV-2 감염은 숙주 세포 대사를 다시 연결하고 잠재적으로 mTORC1 억제에 취약합니다

Article

Published on 2021-03-252022-09-12
Journal: Nature Communications [Category] SARS, 진단,

Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epithelium

Article

Published on 2021-03-232022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients

폐동맥 고혈압 환자에서 복잡성을 만드는 SARS-CoV-2 감염에 대한 바이오마커 및 경로 식별

Article

Published on 2021-03-222022-09-11
Journal: Briefings in Bioinformatics [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Arterial hypertension Biomarker carried caused Compound conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic diagnosed differentially expressed gene EDN1 effective drugs epithelial cell epithelial cells Evidence evidence of expression level expression profiling Extensive gene expression profile Gene expression profiling Gene ontology genomic Genomic analysis human lung human lung epithelial cells hypertension identification identify immune response Infection infections Inflammatory response Inflammatory responses integration lung observation Ontology PAH pathway Patient performed Phylogenetic tree promoter protein-protein interaction provided pulmonary arterial hypertension Regulatory Research respiratory response Ribonucleic acid RNA virus RNA viruses S100A12 S100A8 S100A9 Saa1 SAA2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe acute respiratory syndrome Coronavirus Signaling signaling pathway signaling pathways significant interaction the SARS-CoV-2 therapeutic these compound these compounds transcriptomic Transcriptomic analyses transcriptomic analysis Transcriptomic profiling Transferrin viruses
[DOI] 10.1093/bib/bbab026 PMC 바로가기 [Article Type] Article

Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells

비강 상피 세포의 SARS-CoV-2 감염 예방에 있어 스핑고지질을 표적으로 하는 약물의 효능을 평가하기 위한 생체 외 분석

Article

Published on 2021-03-192022-08-31
Journal: STAR protocols [Category] MERS, SARS, 신약개발, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 amitriptyline antidepressant approved assays Cell isolation Cell-based assays. Complete Coronavirus-2 COVID-19 drug drugs targeting Efficacy epithelial cell epithelial cells evaluate Ex vivo Infection infection level infection levels inhibitor nasal epithelial cell offer Particle presenting protocol quantified Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sphingolipid Spike protein stomatitis the SARS-CoV-2 vesicular stomatitis vesicular stomatitis virus Volunteer were infected
[DOI] 10.1016/j.xpro.2021.100356 PMC 바로가기 [Article Type] Article

Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication

항바이러스 약물 검사를 통해 DNA 손상 반응 억제제가 SARS-CoV-2 복제의 강력한 차단제임을 확인

Report

Published on 2021-03-182022-09-11
Journal: Cell Reports [Category] MERS, SARS, 신약개발, 진단, 치료기술, 치료제,

[키워드] Abstract Anti-SARS-CoV-2 Activity antiviral activity Antiviral agents ATR ATR kinase berzosertib block blocked cell type cell types cellular cellular signaling pathway cellular signaling pathways clinical trials Compound compounds coronavirus Coronavirus replication CoV infection COVID-19 Critical Cytopathic effect DDR DNA-damage response pathway drug drug candidate effective epithelial cell epithelial cells exhibited Health Health crisis high-throughput screen highlight host-pathogen interactions human epithelial cells identify inhibited inhibiting inhibitor inhibitors involved Kinase inhibitor kinase inhibitors library MAPK mechanism MERS MERS-CoV MERS-CoV infection Middle East Middle East respiratory syndrome Coronavirus modulate mTOR mTOR-PI3K-AKT pathway multiple coronaviruses nucleoside analogs Pathways PI3K precipitated Protein protein kinase protein kinase inhibitor protein kinase inhibitors provide Replication respiratory respiratory syndrome coronavirus SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication shown signaling cascades signaling pathway signaling pathways Stage the SARS-CoV-2 therapeutic therapy Treatment treatment of COVID-19
[DOI] 10.1016/j.celrep.2021.108940 PMC 바로가기 [Article Type] Report

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes

인간 기도 상피에서 SARS-CoV-2 감염에 대한 단일 세포 종단 분석은 표적 세포, 유전자 발현의 변경 및 세포 상태 변화를 식별합니다

Research Article

Published on 2021-03-172022-08-13
Journal: PLoS Biology [Category] SARS, 유전자 메커니즘, 진단,

[키워드] acute respiratory syndrome air–liquid interface alteration basal and club cells bronchial epithelial cell bystander cells Cell cell tropism cell types cell-intrinsic expression change ciliated cell ciliated cells Club cells coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 Critical Culture cultures drug Drug administration enhanced epithelial cell epithelial cell type epithelial cell types epithelial cells expand expression food Gene Expression Genes HBECs host–viral interaction human airway human airway epithelial human airway epithelial cells Human airway epithelium human bronchial epithelial cells identify IFNs IL-1 IL6 immunofluorescence microscopy induce infected with SARS-CoV-2 Infection interactions interferon interferon-stimulated gene interferon-stimulated genes interferons interleukin ISGs longitudinal analysis novel over Pathogenesis performed polyadenylated viral transcript polyadenylated viral transcripts provide respiratory resulting reveal RNA sequencing RNA-Seq SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 single-cell single-cell analysis target cells the cell Therapeutics Treatment type I type I and type III IFNs type I and type III interferons Type III IFN type III interferon Vaccine Viral viral replication viral transcripts
[DOI] 10.1371/journal.pbio.3001143 PMC 바로가기 [Article Type] Research Article

Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients

Article

Published on 2021-03-122022-10-31
Journal: Cancers [Category] COVID-19,

[키워드] ACE2 ACE2 expression acute respiratory syndrome adenocarcinoma alveolar alveolar epithelial cells Analysis AT2 Cancer CD36 Cell cells cellular distribution Clinical management co-expressed Cohort coronavirus coronavirus disease COVID-19 COVID-19 pandemic death rates Defense DMBT1 elevated enzyme epithelial cell examined Express expressed expression expression level expression profile Features Genes Health HHIP highest Host host protein identify implicated individual Inflammation landscape lung lung adenocarcinoma lung cancer patient lung cancer patients lung cell lung cells lung epithelial Lung epithelial cells Lung inflammation lung neoplasms malignant marker Mortality normal novel coronavirus SARS-CoV-2 offer pandemic pathway patients patients with comorbidity Pneumonia Population positively correlated Potential treatment presenting Proteases proteases Tmprss2 pulmonary raising receptor Respiratory complications Respiratory failure risk SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 receptor scRNA-seq significantly simple single-cell Single-cell RNA sequencing Single-cell RNA-sequencing Spread symptomatic target the United State therapeutic target tissue TMPRSS2 TMPRSS4
[DOI] 10.3390/cancers13061250 PMC 바로가기 [Article Type] Article

mRNA-lncRNA Co-Expression Network Analysis Reveals the Role of lncRNAs in Immune Dysfunction during Severe SARS-CoV-2 Infection

mRNA-lncRNA 공동 발현 네트워크 분석, 심각한 SARS-CoV-2 감염 시 면역 기능 장애에서 lncRNA의 역할 밝혀

Article

Published on 2021-03-032022-09-10
Journal: Viruses [Category] SARS, 유전자 메커니즘,

[키워드] Activation addition affected analyzed anti-viral response anti-viral responses BALF Bronchoalveolar lavage fluid Clinical features co-expression network co-expression network analysis correlated COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patients critical COVID-19 patients cytokine cytokine signaling Cytokine storm Cytokine storms Cytokines differentially expressed epithelial cell epithelial cell line expression Factor global public health Host human lung human lung epithelial cell lines hyper-inflammatory response Hyper-inflammatory responses immune response immune responses Infection involved lncRNA long non-coding RNA Lungs molecular interaction molecular mechanism network neutrophilia non-coding RNA pathway Patient patients plasma pro-inflammatory cytokine pro-inflammatory cytokines required respiratory respiratory disorder responsible role SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 virus Sepsis Sequencing severe SARS severe SARS-CoV-2 specimen the cytokine storm Transcriptome transcriptome sequencing with COVID-19
[DOI] 10.3390/v13030402 PMC 바로가기 [Article Type] Article

Epithelial response to IFN‐γ promotes SARS‐CoV‐2 infection

IFN-γ에 대한 상피 반응은 SARS-CoV-2 감염을 촉진합니다

Report

Published on 2021-03-032022-09-11
Journal: EMBO Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ACE2 ACE2 expression Affect agent angiotensin Antiviral cause cell differentiation cellular cellular differentiation characterized Colon colonic COVID‐19 Culture differentiation disease elevated Enterocyte enterocytes epithelial epithelial cell epithelial cells expressed expressing gastrointestinal mucosa IFN‐γ immune response immune responses immunology induce Inducing inefficient infected cells Infection Inflammation Inflammatory response interferon interferon signaling KRT20 maturation mechanism mediator Microbiology, Virology & Host Pathogen Interaction mouse Organoid organoids outcome patients promote promoted receptor Replication respiratory response robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 Severe case severe cases subset susceptibility susceptibility to infection Treatment virus clearance virus production virus replication virus transmission
[DOI] 10.15252/emmm.202013191 PMC 바로가기 [Article Type] Report

Stem cells and COVID-19: are the human amniotic cells a new hope for therapies against the SARS-CoV-2 virus?

줄기 세포와 COVID-19: 인간 양막 세포는 SARS-CoV-2 바이러스에 대한 치료법에 대한 새로운 희망입니까?

Review

Published on 2021-03-012022-09-10
Journal: Stem Cell Research & Therapy [Category] 임상,

[키워드] Amnion amniotic anti-inflammatory properties applied caused Cell Cell therapy clinical trial clinical trials coronavirus COVID-19 COVID-19 treatment cytokine Diseases effective epithelial cell epithelial cells hAEC Health Human amniotic epithelial cells Human amniotic mesenchymal stromal cells in some in vivo models Inflammatory response Lung disease Lung diseases Lung infection Lung injury membrane Mesenchymal stem cells MSC MSCs New coronavirus pandemic Patient patients with COVID-19 Placenta positioned preclinical studies preclinical study problems producing Proinflammatory cytokine reduced regenerative respiratory Respiratory disease respiratory diseases restored Safe SARS-CoV-2 SARS-CoV-2 virus severe patients stem cell Stem cell therapy stem cells stromal cell stromal cells suggested term tested the SARS-CoV-2 the SARS-CoV-2 virus therapy therapy for COVID-19 tissue Treatment Trigger triggers
[DOI] 10.1186/s13287-021-02216-w PMC 바로가기 [Article Type] Review