Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19SARS-COV-2 유도 된 작은 RNA의 검출 및 COVID-19와 관련된 순환 소형 RNA의 변화Brief Report Published on 2021-08-112022-09-10 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] Ageusia Analysis candidate gene change circulating circulating-miRNA cleavage conserved convalescent COVID-19 patient COVID COVID-19 cytokine Cytokine storm Defense defense mechanism described detectable detection double-stranded RNA events homologous Host host defense human miRNA human miRNAs immune response immune responses Jak-STAT Long COVID mechanism Mild miRNA miRNAs NSP2 nsp4 plasma plasma sample plasma samples product reduced RNA sequence RNAs SARS-CoV-2 sequence Sequencing severe cases severe COVID-19 siRNA small RNA Small RNAs STAT Symptoms the disease transcriptional gene silencing Trigger triggers Viral viral infection virus with COVID-19 [DOI] 10.3390/v13081593 PMC 바로가기 [Article Type] Brief Report
A Single-Center (Sibiu, Romania), Retrospective Study (March–November 2020) of COVID-19 Clinical and Epidemiological Features in ChildrenArticle Published on 2021-08-102022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] abdominal pain Asymptomatic Central nervous system children clinical clinical feature Clinical features coronavirus coronavirus disease cough COVID-19 Critical disease Critically ill Diagnosis diagnosis of COVID-19 diarrhea disease severity effective enzyme epidemiological Epidemiology fatigue Fever gastrointestinal system headache increase in Infant IQR laboratory characteristics less Leukocytosis liver lymphopenia management median age Mild moderate myalgia Myocardial nasal congestion nose and throat ocular pandemic Patient pediatric Pediatric patient Pneumonia proportion rhinorrhea Romania SARS-CoV-2 screened severe cases sore throat Symptom the disease the patient understanding vomiting [DOI] 10.3390/jcm10163517 PMC 바로가기 [Article Type] Article
Characteristics of immune and inflammatory responses among different age groups of pediatric patients with COVID-19 in China중국에서 COVID-19를 가진 소아 환자의 다른 연령 그룹 사이에서 면역 및 염증 반응의 특성Original Article Published on 2021-08-022022-09-10 Journal: World Journal of Pediatrics [Category] MERS, SARS, 바이오마커, [키워드] age Age difference antibody B cell B cells C3c CD19 CD19+ Cell cell count children Children's Hospital China Clinical characteristics complement condition coronavirus disease Coronavirus disease 2019 Course COVID-19 demographic disease elevated evaluated group IgA IgM IL-6 immune immune cells Immunity Immunoglobulin Inflammation Inflammatory response information laboratory result Laboratory results Lactate lactate dehydrogenase less lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes marker Moderate COVID-19 Necrosis neutrophil Neutrophils Patient patients with moderate pediatric Pediatric patient Pediatric patients procalcitonin Recovery time recruited Result serum Severe case severe cases significantly significantly shorter supplementary material Symptoms Tumor tumor necrosis tumor necrosis factor while with COVID-19 Wuhan [DOI] 10.1007/s12519-021-00440-1 PMC 바로가기 [Article Type] Original Article
Clinical relevance of serum α-l-fucosidase activity in the SARS-CoV-2 infectionSARS-CoV-2 감염에서 혈청 α-l-fucosidase 활성의 임상적 관련성Article Published on 2021-08-012022-09-12 Journal: Clinica chimica acta; international journal of cli [Category] MERS, SARS, 진단, [키워드] antibodies C-reactive protein clinical Clinical relevance Comorbidities Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 patient COVID-19 patients CRP Disease progression disorder disorders enzyme highest IgG IgG antibody IgM IgM/IgG immune response Infection Invasion material Mortality mRNA Non-severe case nucleic acid nucleic acid test Odds ratio Patient reduced SAA SARS-CoV-2 Serological antibodies serum serum amyloid severe cases spike glycoprotein the SARS-CoV-2 virus α-l-fucosidase. [DOI] 10.1016/j.cca.2021.03.031 PMC 바로가기 [Article Type] Article
Half-year follow-up of patients recovering from severe COVID-19: Analysis of symptoms and their risk factors중증 COVID-19에서 회복 중인 환자의 반년 추적: 증상 및 위험 요인 분석Article Published on 2021-08-012022-09-12 Journal: Journal of internal medicine [Category] MERS, 진단, [키워드] Analysis antibody cough COVID-19 Critical demonstrated discharge discharged fatigue Follow-up had more IgG independent risk factor multivariate logistic regression participant Patient populations risk factor SARS-CoV-2 severe cases severe coronavirus disease Shortness of breath sleep disorder Symptom women [DOI] 10.1111/joim.13284 PMC 바로가기 [Article Type] Article
Hydroxychloroquine in COVID-19: therapeutic promises, current status, and environmental implicationsCOVID-19의 하이드록시클로로퀸: 치료적 약속, 현황 및 환경적 영향Review Published on 2021-08-012022-09-11 Journal: Environmental science and pollution research inter [Category] Coronavirus, SARS, 치료제, [키워드] absence acute respiratory distress acute respiratory distress syndrome Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected antimalarial antimalarial drug characterized clinical clinical evidence clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients drug Environmental implications HCQ Hydroxychloroquine hypoxia implication in vitro management mortality rate outbreak pandemic reduce Registered respiratory distress Respiratory failure SARS-CoV-2 Severe case severe cases severity specific treatment Spread supportive care syndrome the disease therapeutic therapeutic option therapeutic options therapeutic potential Treatment Viral load [DOI] 10.1007/s11356-020-12200-1 PMC 바로가기 [Article Type] Review
Immunity against seasonal human coronavirus OC43 mitigates fatal deterioration of COVID-19계절 인간 코로나바이러스 OC43에 대한 면역은 COVID-19의 치명적인 악화를 완화합니다Article Published on 2021-08-012022-09-11 Journal: International Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 analysed antibody Antibody titre antibody titres cleavage cleavage site Clinical course Clinical data conserved coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 correlation COVID-19 cross-reactive antibodies cross-reactive antibody cross-reactivity detect Deterioration develop disease Effect enzyme enzyme-linked immunosorbent assay epitope Epitopes fusion fusion peptide help human coronavirus human coronavirus OC43 Immunity immunogenic Immunosuppression Inpatient Inpatients investigated Mild mitigate not differ OC43 Outpatient outpatients patients with COVID-19 peptide peptides Pneumonia predict produced Prognosis respiratory S2ʹ cleavage site SARS-CoV-2 searched sera Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe cases Standard therapy titre with COVID-19 [DOI] 10.1016/j.ijid.2021.07.015 PMC 바로가기 [Article Type] Article
Single-Cell Transcriptomic Profiling of MAIT Cells in Patients With COVID-19COVID-19 환자에서 MAIT 세포의 단일 세포 전사체 프로파일링Immunology Published on 2021-07-302022-09-11 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory syndrome adaptive addition Analysis analyzed Apoptosis apoptotic cause Cell cell cytotoxicity cell death cells cellular chemotaxis coronavirus COVID-19 cytometry analysis DEGs differentially expressed gene Differentially expressed genes disease severity Flow Flow cytometry analysis frequencies Frequency healthy donors highest Host immune response humoral immune response immune immune responses indicated involved killing leukocyte lymphocyte MAIT moderate myeloid leukocyte Pathogenesis Patient patients with COVID-19 performed Profiling provide pyroptosis respiratory Result SARS-CoV-2 SARS-COV-2 infection Severe case severe cases severe disease significantly single-cell Single-cell RNA sequencing T-cell receptor the disease transcriptional profile transcriptomic transcriptomic data [DOI] 10.3389/fimmu.2021.700152 PMC 바로가기 [Article Type] Immunology
What Is the Role of Therapeutic Plasma Exchange as an Adjunctive Treatment in Severe COVID-19: A Systematic ReviewSystematic Review Published on 2021-07-282022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] Adverse albumin appear ARDS biomarkers of inflammation C-reactive protein Cochrane Library Concentration convalescent plasma COVID-19 COVID-19 pandemic COVID-19 patient CRP Cytokine storm D-dimer Effect effective exchange ferritin FIVE IL-6 IMPROVE interleukin-6 Laboratory lactate dehydrogenase LDH Lymphocyte count majority Mortality outbreak PaO patients plasma ranged Respiratory function review role Safe SARS-CoV-2 screened severe cases severe COVID-19 Side effects Supportive treatment tested Therapeutic plasma exchange TPE Treatment Web of Science [DOI] 10.3390/v13081484 PMC 바로가기 [Article Type] Systematic Review
A Review on the Development of Gold and Silver Nanoparticles-Based Biosensor as a Detection Strategy of Emerging and Pathogenic RNA Virus신흥 및 병원성 RNA 바이러스의 탐지 전략으로 금 및은 나노 입자 기반 바이오 센서의 개발에 대한 검토Review Published on 2021-07-282022-09-10 Journal: Sensors (Basel, Switzerland) [Category] SARS, 치료기술, 치료제, [키워드] Accuracy addition analytical methods antibody Antigen biological activity biosensor Characteristics clinical samples Containment contribute death detection detection system development disease Diseases DNA early diagnosis effective electrochemical biosensing enhancer gold higher risk highly pathogenic human coronaviruses immunological involved knowledge MERS-CoV Nanoparticles nanotechnologies Nanotechnology nucleic acid optical pathogenic plasmonic POC point-of-care probe Protein provide required review RNA RNA viruses robust SARS-CoV SARS-CoV-2 Sensitivity and specificity severe cases silver single-stranded DNA ssDNA Strategy Treatment unique Viral viral disease Viral diseases viral infection viral nucleic acid virtue viruses [DOI] 10.3390/s21155114 PMC 바로가기 [Article Type] Review