Treating COVID-19: are we missing out the window of opportunity?COVID-19 치료: 기회의 창을 놓치고 있습니까?Article Published on 2021-01-192022-09-11 Journal: Journal of Antimicrobial Chemotherapy [Category] Coronavirus, 치료제, [키워드] administer Antiviral approach benefit cascade Course COVID-19 disease Efficacy events followed by Immunomodulatory agent Immunomodulatory agents immunomodulatory therapy Inflammatory inflammatory cascade initial offer severe COVID-19 severe disease the disease time interval time intervals translated treating Treatment Viral viral replication [DOI] 10.1093/jac/dkaa442 PMC 바로가기 [Article Type] Article
COVID-19 Amplifiers on Health Inequity Among the Older PopulationsPublic Health Published on 2021-01-152022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] affecting aging alleviate amplifier cascade consequence coronavirus disease COVID-19 Health health equity help highlight knowledge Older older population Population populations public health policy reduction response social determinants Trigger triggers while [DOI] 10.3389/fpubh.2020.609695 PMC 바로가기 [Article Type] Public Health
Alu retrotransposons and COVID-19 susceptibility and morbidityAlu 레트로트랜스포존과 COVID-19 감수성 및 이환율Review Published on 2021-01-042022-09-10 Journal: Human Genomics [Category] MERS, 변종, 유전자 메커니즘, [키워드] F13B ACE ACE gene Alu Biomarker cascade Clinical outcome clinical outcomes COVID-19 COVID-19 patient COVID-19 patients COVID-19 susceptibility Diseases Epigenetic Evolution Gene Expression Genetic host response Human evolution human population immune response Infectious diseases insertion Intronic mechanisms morbidity pathway Pathways PGR PLAT polymorphism regulate Research retrotransposon SARS-CoV-2 SARS-COV-2 infection Spread supplementary material susceptibility Symptom treatment strategy variant variety Viral viral infection with COVID-19 [DOI] 10.1186/s40246-020-00299-9 PMC 바로가기 [Article Type] Review
Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ Analogues바이러스 감염 중 MAPK 캐스케이드에 대한 분자적 통찰력: HCQ와 HCQ 유사체 간의 잠재적인 누화Review Published on 2020-12-312022-09-10 Journal: BioMed Research International [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome coronavirus analogue analogues antimalarial approach approved attacks cascade cause claimed Combination coronavirus country COVID-19 COVID-19 pandemic Critical Crosstalk deaths Defense disease Diseases drugs Efficacy Extracellular HCQ highlight Host host defense Hydroxychloroquine in viral indicated Infection inhibitor insight MAPK mechanism mitogen mitogen-activated protein kinase molecular mechanisms molecular pattern molecular patterns Pandemics pathway Potential Protein quinoline receptor respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specific treatment Transcription transducing Treatment variety Viral viral infection viral infections Virus Disease [DOI] 10.1155/2020/8827752 PMC 바로가기 [Article Type] Review
Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ AnaloguesReview Published on 2020-12-312022-10-27 Journal: BioMed Research International [Category] [키워드] analogue analogues antimalarial approach approved attacks cascade cause claimed Combination country COVID-19 COVID-19 pandemic Critical Crosstalk deaths Defense disease Diseases drugs Efficacy Extracellular HCQ highlight Host Hydroxychloroquine in viral indicated Infection inhibitor insight MAPK mechanism molecular mechanisms molecular pattern Pandemics pathway Potential Protein receptor respiratory SARS-CoV-2 specific treatment Transcription transducing Treatment variety viral infection viral infections [DOI] 10.1155/2020/8827752 PMC 바로가기 [Article Type] Review
Molecular Insights into the MAPK Cascade during Viral Infection: Potential Crosstalk between HCQ and HCQ AnaloguesReview Published on 2020-12-312022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] analogue analogues antimalarial approach approved attacks cascade cause claimed Combination country COVID-19 COVID-19 pandemic Critical Crosstalk deaths Defense disease Diseases drugs Efficacy Extracellular HCQ highlight Host Hydroxychloroquine in viral indicated Infection inhibitor insight MAPK mechanism molecular mechanisms molecular pattern Pandemics pathway Potential Protein receptor respiratory SARS-CoV-2 specific treatment Transcription transducing Treatment variety viral infection viral infections [DOI] 10.1155/2020/8827752 PMC 바로가기 [Article Type] Review
Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19포스파티딜세린 인사이드 아웃: COVID-19의 염증 및 응고 이상에서 가능한 기본 메커니즘Review Published on 2020-12-272022-09-10 Journal: Cell Communication and Signaling : CCS [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Abnormalities abnormality ACE2 Activation Acute inflammation ADAM17 ADAMTS13 addition aggregation association biochemical C reactive protein cascade cause cell membrane clinical complication clinical complications Coagulation coagulation cascade coronavirus coronavirus disease COVID-19 COVID-19 pathophysiology Cytokines damage death DIC-COVID-19 EGFR Endothelial cell endothelial cells Endothelium explained expression extrinsic pathway factor VII Health humans IFN-γ IL-1β IL-6 IL-6R IL-8 immune induce infected cell Inflammation Inflammatory response inhibitory action involved management mechanism membrane monocyte pathophysiological pathophysiology Phosphatidylserine plasma Platelet Platelets pro-inflammatory cytokines pro-inflammatory molecule pro-inflammatory molecules SARS-CoV-2 Spread Support the cell the SARS-CoV-2 thrombi tissue Tissue Factor TNF-α Vascular Viral viral infection [DOI] 10.1186/s12964-020-00687-7 PMC 바로가기 [Article Type] Review
Platforms Exploited for SARS-CoV-2 Vaccine DevelopmentReview Published on 2020-12-252022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome affected approved candidate cascade clinical trials Community coronavirus coronavirus disease CoV COVID-19 development disadvantage effort event glycoprotein group highlight host cell humans Infection infections limit mounted pandemic platform Prevent public health reached receive SARS-CoV-2 SARS-CoV-2 vaccine subsequent treat Vaccine Vaccine development vaccine platforms Vaccines viral spread virus [DOI] 10.3390/vaccines9010011 PMC 바로가기 [Article Type] Review
Physiology of Midkine and Its Potential Pathophysiological Role in COVID-19Physiology Published on 2020-12-222022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] angiotensin autoimmune condition autophagy cascade cause cellular clinical complication coagulative coronary syndrome COVID-19 cytokine dependent on Disseminated intravascular coagulation distress dysregulation Effect effector cells elicited facilitate fibrinolytic growth factor highlight Hyperactivation hypoxia immune immune responses include increases in induce Inflammatory literature mechanism mechanisms mediators of inflammation Midkine myocarditis NETs, autophagy neutrophil infiltration Neutrophils New coronavirus Occurrence organs pathogen clearance pathological condition pathophysiological physiological Physiology Potential pro-inflammatory cytokines pulmonary fibrosis receptor Renin replicate response role SARS-CoV2 SARS-CoV2 infection severe cases severe pneumonia similarity System target tissues Thromboembolism tissue tissue damage virus entry [DOI] 10.3389/fphys.2020.616552 PMC 바로가기 [Article Type] Physiology
Can Coronaviruses Steal Genes from the Host as Evidenced in Western European Hedgehogs by EriCoV Genetic Characterization?Article Published on 2020-12-202022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] Erinaceus coronavirus Eulipotyphla adaptive ancestor Asia bat Betacoronavirus Betacoronavirus infection betacoronaviruses Can cascade CD200 CD200 glycoprotein CD200 ortholog circulating collected Complete coronavirus correlation CoV eight EriCoV Erinaceus Erinaceus europaeus Eurasia Europe European Evolution Fecal sample genes encoding genetics genomes global pandemic hedgehog hedgehogs Host host gene Human involved Italy living cells MERS-CoV Middle East NGS ORF ORF3a ortholog pandemic Pathogens Phylogenetic Protein Proteins reported reservoir RT-PCR Sanger sequencing SARS-CoV SARS-CoV-2 sequence Sequence analysis Sequencing Steal strain the Spike viral strain virus viruses were used zoonotic [DOI] 10.3390/v12121471 PMC 바로가기 [Article Type] Article