SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescenceSARS-COV-2- 특이 적 순환 T 여포 헬퍼 세포는 중화 항체와 관련이 있으며 조기 회복기 동안 증가합니다.Research Article Published on 2021-07-162022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 진단, 치료기술, 치료법, [키워드] addition Antibody neutralization Antigen approved assist Blood caused CD4 T cells CD4 T-cell Cell circulating contribute convalescence convalescent convalescent individuals coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 CXCR5 declined defined detectable examined follicular Frequency generate greater helper cells helping immune response immune responses individual Infection M protein magnitude majority median morbidity and mortality mounted N protein Neutralizing antibodies neutralizing antibody neutralizing antibody responses pandemic PD1 post-symptom onset PROTECT Protein response responses responses against robust S protein SARS-CoV-2 SARS-COV-2 infection specificity Spike protein structural protein structural proteins subset symptom onset T cells T cells) T follicular helper cells T-cell immunity T-cell Response T-cell responses Tfh the spike protein the strongest These cells These data Vaccine [DOI] 10.1371/journal.ppat.1009761 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney시리아 햄스터 모델의 SARS-COV-2 감염은 심장과 신장을 포함한 호흡기 및 비-자극 조직 모두에서 I 형 INTERFERON DYSREGUM뿐만 아니라 염증을 유발합니다.Research Article Published on 2021-07-152022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, SARS, [키워드] (coronavirus disease 2019 acute respiratory syndrome Affect affecting antiviral cytokine antiviral cytokines antiviral response captures cardiovascular system cause caused clinical symptom coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines damage disease dysregulation evaluate Evidence evidence of examination extrapulmonary tissue hamsters heart host response host responses IL-1beta IL-6 immune host response immune responses indicated Infection Inflammation Inflammatory cytokine Inflammatory cytokines inhibited interferon interferons investigated kidney kidneys liver microthrombi multiorgan disease myocarditis neurological system non-respiratory tissue occur organ system organ systems PASC people with COVID-19 prolonged disease regulated required respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity significant increases in Symptom Therapeutics TNF tubular inflammation type I interferon type I interferons type II interferon type II interferons upregulation Urinary tract Viral viral infection with infection [DOI] 10.1371/journal.ppat.1009705 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variantsSARS-COV-2 중화 항체 : 신흥 바이러스 변이체에 의한 장수, 폭 및 회피Research Article Published on 2021-07-062022-08-13 Journal: PLoS Medicine [Category] Biochemistry, COVID-19, SARS, [키워드] acute respiratory syndrome Antibody neutralization breadth Breakthrough infection Chain Reaction characterized convalescent plasma coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 severity Critical demographics donors high responders immunoreactivity individual Longevity membrane neutralization potency Neutralizing neutralizing response Nucleocapsid proteins polymerase chain polymerase chain reaction Proteins reduced Reinfection representing respiratory Responder reverse transcription reverse transcription polymerase chain reaction risk RT-PCR SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 neutralization SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity spike spike variants sustained vaccination Vaccine variant variants Viral viral neutralization viral variant Viral variants VoC with COVID-19 [DOI] 10.1371/journal.pmed.1003656 PMC 바로가기 [Article Type] Research Article
Characterization of antibody response in asymptomatic and symptomatic SARS-CoV-2 infection무증상 및 증상 SARS-COV-2 감염에서 항체 반응의 특성화Research Article Published on 2021-07-022022-08-13 Journal: PLoS ONE [Category] Biochemistry, SARS, 진단, [키워드] antibody Antibody Response Asymptomatic asymptomatic subject asymptomatic subjects characterization Course decrease detectable followed by Health care health care systems high correlation Hospital admission hospitalized COVID-19 patients IgA IgG IgM investigated morbidity and mortality Neutralizing antibodies no difference nucleoprotein outcome parameter Patient performed reached SARS-CoV-2 SARS-CoV-2 pandemic Spike protein subject symptomatic SARS-CoV-2 infection the antibody response Viral Viral antigen viral antigens [DOI] 10.1371/journal.pone.0253977 PMC 바로가기 [Article Type] Research Article
Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis심각하고 치명적인 코비드 -19 사례에 대한 적기로서의 사이토 카인 폭풍의 바이오 마커 : 살아있는 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-06-292022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 바이오마커, [키워드] abstracts Analysis aspartate Aspartate aminotransferase Biomarker Biomarkers C-reactive protein C-Reactive-Protein conducted Confidence intervals Controlled controlled trials COVID-19 creatinine cytokine Cytokine storm Cytokine storm syndrome D-dimer database elevated eligible fatal COVID-19 ferritin Final final analysis for inclusion Grey literature hematology Hyperferritinemia IBECS identify interleukin interleukin-6 Laboratory laboratory biomarker laboratory biomarkers laboratory data laboratory parameter Laboratory parameters Lactate lactate dehydrogenase leucocyte leucocytes leukocytes LILACS Lymphocytes lymphopenia mean difference mean differences meta-analyses Meta-analysis Mild moderate neutrophil Neutrophils Newcastle-Ottawa Scale objective parameters patients Platelets poor prognosis predictor procalcitonin retrieved risk of bia screened selected serum serum interleukin-6 levels severe and fatal COVID-19 cases severe COVID-19 syndrome synonym systematic review systemic inflammation the cytokine storm the MEDLINE the Newcastle-Ottawa Scale thrombocytopenia was performed [DOI] 10.1371/journal.pone.0253894 PMC 바로가기 [Article Type] Meta-Analysis
Restriction of SARS-CoV-2 replication by targeting programmed −1 ribosomal frameshifting프로그래밍 된 -1 리보솜 프레임 시프 팅을 목표로하여 SARS-COV-2 복제의 제한407 Published on 2021-06-292022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, SARS, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral betacoronaviruses changes in Compound coronavirus cultured cells effective Efficiency Frame frameshift Gene Expression impede in viral inhibitor merafloxacin Mutation Novel coronavirus novel coronavirus SARS-CoV-2 Open reading frame ORF1b other coronavirus other coronaviruses principle promote promoted regulate respiratory restriction ribosomal frameshift ribosomal frameshifting RNA RNA pseudoknot RNA structure RNA viruses robust SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus Significance translation variety Vero E6 VERO E6 cells Viral viral gene expression viral replication [DOI] 10.1073/pnas.2023051118 PMC 바로가기 [Article Type] 407
SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanismsSARS-COV-2 바이러스 단백질 NSP1 및 NSP13은 별개의 메커니즘을 통해 인터페론 활성화를 억제합니다.Research Article Published on 2021-06-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus bind bypasse caused coronavirus Disease progression downregulate global pandemic host mRNA identify IFIT1 immune evasion infecting inhibit innate immune activation interferon interferon signaling IRF3 Last mechanism mechanisms molecular mechanism molecular mechanisms multiple innate immune activation pathways NF-κB NF-κB activation NF-κB phosphorylation NF-κB promoter signaling nsp1 nsp13 nuclear translocation pathway phospho-IRF3 phospho-TBK1 Protein protein expression protein level reduce reduced respiratory SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 TBK1 the SARS-CoV-2 These data translation Viral protein Viral proteins virus infection [DOI] 10.1371/journal.pone.0253089 PMC 바로가기 [Article Type] Research Article
The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody초기 회복기 COVID-19 환자로부터 분리 된 강력한 SARS-COV-2 중화 항체, SC31의 FC- 매개 이펙터 기능은 항체의 최적의 치료 효능에 필수적이다.Research Article Published on 2021-06-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 addition Administered animal models Anti-SARS-CoV-2 Activity anti-viral immune responses antibody Antibody-dependent enhancement Antibody-mediated neutralization convalescent convalescent patient COVID-19 COVID-19 patient demonstrated dose-dependent efficacy effective Efficacy epitope evidenced exhibited Fc-mediated effector function Fc-mediated effector functions Fc-null LALA variant Histopathology IFNγ immune responses Inflammatory responses K18-human ACE2 transgenic mice LALA variant Lower respiratory tract lung Lungs mice neutralization ability Neutralizing antibodies neutralizing antibody occur preclinical studies preclinical study prevented pro-inflammatory response pro-inflammatory responses promote Protein Receptor-binding domain reduced viral load reduced viral loads reduction respiratory rhesus macaques SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein SARS-CoV-2-infected hamsters SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody SC31 SC31 treatment severity of COVID-19 significantly spike Spike protein sub-therapeutic doses the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic efficacy therapeutic potential Therapeutics transgenic mice treated treatment with SC31 undetectable Viral Viral load viral loads viral-induced viral-induced lung inflammatory responses weight loss [DOI] 10.1371/journal.pone.0253487 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19SARS-COV-2는 주요 내피 인테그린 αVβ3을 사용하여 COVID-19 동안 혈관 조절 조절을 유발합니다.Research Article Published on 2021-06-232022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, SARS, [키워드] accelerate Anti-viral binding site bloodstream Candidates cardiovascular complications Characteristics cilengitide COVID-19 COVID-19 infection COVID-19 infections COVID-19 pandemic dysregulation Effect effort ENCODE endothelial endothelial cells Endothelium epithelium etiological expressed Final Host host protein in viral in-silico In-vitro infection rate integrin Integrins Interaction International leakage microbial motif Mutagenesis pathogen pathogenicity reproductive SARS-CoV-2 Spike protein Transmissibility unique Vascular vascular endothelial cell vascular endothelial cells vasculature Viral viral propagation [DOI] 10.1371/journal.pone.0253347 PMC 바로가기 [Article Type] Research Article
Dysnatremia is a Predictor for Morbidity and Mortality in Hospitalized Patients with COVID-19dysnatremia는 Covid-19를 가진 입원 환자의 이환율 및 사망률에 대한 예측 인자입니다.Clinical Research Articles Published on 2021-06-232022-08-13 Journal: The Journal of Clinical Endocrinology and Metaboli [Category] Biochemistry, COVID-19, [키워드] 95% CI Acute kidney injury Admission advanced respiratory support AKI association Bacterial bacterial pneumonia clinical outcomes Context coronavirus disease Coronavirus disease 2019 COVID-19 death Dysnatremia evaluated except for exposure to greater hospital Hospital stay Hospitalization hypernatremia hypernatremic hyponatremia hyponatremic Hypovolemia hypovolemic hyponatremia in-hospital mortality incidence increase in increased risk independent Inflammatory response likelihood London longitudinal cohort study marker median age Mortality normonatremia objective Patient patients with COVID-19 paucity of data Pneumonia poor prognosis prognostic respiratory Respiratory failure Result retrospective risk risk factor Risk factors risk of death risk stratification SARS-CoV-2 serum serum sodium Serum sodium value Serum sodium values SIAD sodium sodium concentration sodium level Sodium value Sodium values subgroup of patient ventilatory support with COVID-19 [DOI] 10.1210/clinem/dgab107 PMC 바로가기 [Article Type] Clinical Research Articles