Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesisSARS-CoV-2의 뉴클레오캡시드 돌연변이는 복제 및 병인을 증가시킵니다Article Published on 2022-06-212022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] Ablation Alanine alanine substitution Alpha component ENhance fitness Genetic variation GSK-3 human infection in vitro in vivo increase Infection molecular basis motif mutant Mutation nucleocapsid nucleocapsid protein Omicron variant Omicron variants pandemic Pathogenesis pathogenesis of SARS-CoV-2 Phosphorylation Protein Replication residue residues SARS-CoV-2 SARS-CoV-2 replication spike gene the SARS-CoV-2 Transmission variable region variant Viral Viral RNA virus replication while [DOI] 10.1371/journal.ppat.1010627 PMC 바로가기 [Article Type] Article
Liver Injury in COVID-19 Patients with Drugs as Causatives: A Systematic Review of 996 DILI Cases Published 2020/2021 Based on RUCAM as Causality Assessment Method약물을 원인으로 하는 COVID-19 환자의 간 손상: 인과 평가 방법으로 RUCAM을 기반으로 2020/2021 게시된 996개의 DILI 사례에 대한 체계적인 검토Review Published on 2022-04-272022-09-11 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] Abnormalities abnormality Alanine alanine aminotransferase Algorithm ALT ALT/AST antiviral drug antiviral drugs aspartate Aspartate aminotransferase assessment AST Causality caused Characteristics China Clinical characteristics clinical feature Clinical features confounders confounding variable coronavirus disease country COVID-19 COVID-19 case COVID-19 patient COVID-19 patients defined Diagnosis diagnostic DILI drug drug treatment Drug-induced liver injury drug-induced liver injury. Established diagnosis feature female hepatocellular injury India Japan Liver disease liver diseases Liver injury liver test Liver tests male median age Montenegro Most patients outcome patients patients treated provided ranged reported review robust Roussel Uclaf Causality Assessment Method RUCAM searched Spain systematic review the mean therapeutic efficacy Treatment Undetermined virus [DOI] 10.3390/ijms23094828 PMC 바로가기 [Article Type] Review
Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domain스파이크 수용체 결합 도메인의 특정 에피토프를 표적으로 하는 단일클론항체에 의한 SARS-CoV-2 감염의 중화 또는 증강Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] abrogated ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Alpha angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody-dependent enhancement binding binding epitope caused cellular contrary coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity Delta demonstrated dose-dependent manner ELISA epitope Epitopes Epsilon exhibited exhibiting experiment Gamma HEK293T cells Infection lentivirus MERS-CoV monoclonal antibodies monoclonal antibody mouse monoclonal antibody NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody Prophylactic Protein pseudotyped RBD receptor Receptor binding domain Receptor-binding domain reduction Region reported residue residues respiratory S protein S proteins SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike Spike receptor binding domain Spike receptor binding domain. spike receptor-binding domain the RBD the receptor-binding domain the S protein Therapeutic treatment variant variants of SARS-CoV-2 wild-type [DOI] 10.1016/j.antiviral.2022.105290 PMC 바로가기 [Article Type] Article
Longitudinal relationship of liver injury with inflammation biomarkers in COVID-19 hospitalized patients using a joint modeling approach공동 모델링 접근법을 사용하는 COVID-19 입원 환자의 염증 바이오마커와 간 손상의 종단 관계Article Published on 2022-04-012022-09-11 Journal: Scientific Reports [Category] 바이오마커, 치료법, 치료제, [키워드] age Alanine Alanine transaminase alkaline phosphatase ALT approach aspartate Aspartate transaminase AST Biomarker blood lymphocyte count C-reactive protein change consecutive patient correlated correlation COVID-19 COVID-19 infection CRP D-dimer decrease died evaluate Generalized hospital Hospitalization hospitalized patient Inflammation inflammation marker inflammation markers interleukin interleukin-6 joint Liver damage Liver disease Liver injury longitudinal lymphocyte Lymphocyte count marker mechanism negative correlation Patient patients with COVID-19 phosphatase plasma positive serum serum C-reactive protein Sex Spain statistical survival Survivors systemic inflammation the patient therapy was used were used [DOI] 10.1038/s41598-022-09290-x PMC 바로가기 [Article Type] Article
Organ function biomarker abnormalities, associated factors and disease outcome among hospitalized patients with COVID-19COVID-19를 가진 입원 환자의 장기 기능 바이오 마커 이상, 관련 요인 및 질병 결과Research Article Published on 2022-03-022022-09-10 Journal: Biomarkers in Medicine [Category] COVID19(2023년), Fulltext, SARS, 바이오마커, [키워드] 95% CI Abnormalities Addis Ababa adjusted odds ratio Alanine Alanine transaminase alkaline phosphatase AOR aspartate Aspartate transaminase association Biomarker Biomarkers cardiac marker center co-morbidity conducted COVID-19 COVID-19 patient Critical critical patients determine disease disease severity elevated Ethiopia Factor hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hospitalized patients liver function tests magnitude male marker median age morbidity Mortality Organ failure organ function outcome P-value Patient phosphatase prospective cohort study renal function tests significantly study participant to define with COVID-19 [DOI] 10.2217/bmm-2021-0681 PMC 바로가기 [Article Type] Research Article
An integrated framework for identifying clinical-laboratory indicators for novel pandemics: COVID-19 and MIS-CArticle Published on 2022-01-202022-10-30 Journal: NPJ Digital Medicine [Category] COVID-19, [키워드] Alanine analyses associations C-reactive protein can be used Combination complementary COVID-19 Critical D-dimer early stage Epidemiology ferritin fibrinogen FIVE identify IL10 IL4 inhibit Laboratory test MIS-C offer pandemic Pandemics pathogen-specific public health recorded risk SARS-COV-2 infection SARS-CoV-2 PCR test Standard Surveillance Translational research viral infection [DOI] 10.1038/s41746-021-00547-9 PMC 바로가기 [Article Type] Article
Liposome-Mediated Delivery of MERS Antigen Induces Potent Humoral and Cell-Mediated Immune Response in MiceArticle Published on 2022-01-092022-10-30 Journal: Molecules [Category] COVID-19, [키워드] adjuvant Alanine ALT Antigen antigen-specific antibody Antiviral antiviral immunity Aspartate transaminase AST Blood Blood urea nitrogen Cell-mediated immune responses delivery DPPC effective exhibited Freund’ greater humoral IFN-γ IgG1 IgG2a immunization immunized immunized mice Incomplete induce lactate dehydrogenase LDH Liposome MERS MERS-CoV MERS-CoV infection mice Middle East notable Papain-like protease platform PLPro potent Prevent proliferation Prophylactic provided respiratory syndrome coronavirus response secreted serum shown significantly higher splenocyte switching the vaccine Toxicity vaccine delivery Vaccines Vesicle was used [DOI] 10.3390/molecules27020403 PMC 바로가기 [Article Type] Article
Laboratory biomarker predictors for disease progression and outcome among Egyptian COVID-19 patients이집트 COVID-19 환자의 질병 진행 및 결과에 대한 실험실 바이오마커 예측자Article Published on 2022-01-012022-09-11 Journal: International journal of immunopathology and pharm [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Admission Alanine alanine aminotransferase ALT Biomarker Biomarkers blood cell C-reactive protein changes in Chest computed tomography Clinical characteristics Clinical deterioration Clinical outcome clinical outcomes Computed tomography Consequences coronavirus coronavirus disease correlation COVID-19 COVID-19 patient creatinine D-dimer death diabete diabetes Disease progression disease severity examined FIVE help high-risk patient High-risk patients highly sensitive C-reactive protein hs-CRP hypertension identify Increased increased respiratory rate infected case Laboratory laboratory biomarkers laboratory findings laboratory-confirmed Lactate lactate dehydrogenase LDH lymphocyte lymphopenia Mild moderate Mortality neutrophil neutrophil lymphocyte ratio neutrophil lymphocyte ratio and lactate dehydrogenase. neutrophilia NLR outcome pandemic Patient physician Platelet Platelet count predict predictor prognostic indicator respiratory respiratory rate risk factor SARS-CoV-2 SARS-COV-2 infection secondary to severe acute respiratory syndrome Coronavirus severe cases severity the disease White blood cell white blood cell count [DOI] 10.1177/03946320221096207 PMC 바로가기 [Article Type] Article
Serological Biomarkers at Hospital Admission Are Not Related to Long-Term Post-COVID Fatigue and Dyspnea in COVID-19 Survivors병원 입원 시 혈청학적 바이오마커는 COVID-19 생존자의 장기간의 COVID 이후 피로 및 호흡곤란과 관련이 없습니다Article Published on 2022-01-012022-09-11 Journal: Respiration [Category] SARS, 바이오마커, [키워드] acute phase Alanine Alanine transaminase aspartate Aspartate transaminase association Biomarker Biomarkers Clinical data Coagulopathy cohort study collected collecting data conducted COVID-19 discharge Dyspnea exhibited exhibiting explain fatigue First wave hemoglobin hospital Hospital admission hospital discharge Hospitalization data Infection Lactate lactate dehydrogenase LDH long-COVID lymphocyte Lymphocyte count neutrophil outbreak Patient patients patients hospitalized Platelet Platelet count Platelets platelets count platelets counts Post-COVID post-COVID fatigue Prevalence problem regression analysis serological Spain Standard deviation variance were assessed women [DOI] 10.1159/000524042 PMC 바로가기 [Article Type] Article
Identification of raloxifene as a novel α-glucosidase inhibitor using a systematic drug repurposing approach in combination with cross molecular docking-based virtual screening and experimental verificationResearch article Published on 2022-01-012022-10-05 Journal: Carbohydrate Research [Category] 신약개발, [키워드] Alanine amino acid residue analyses approach binding binding affinity binding free energy Combination Contact Critical cross Cross molecular docking database demonstrated diabetes drug Drug repurposing Efficacy FDA identification identify in silico in vitro activity inhibitor interactions molecular Molecular docking study Molecular dynamics simulation molecular dynamics simulations molecular mechanism Mutagenesis performed physiological condition Protein Proteins raloxifene screened stability Toxicity Treatment Virtual screening α-Glucosidase inhibitor [DOI] 10.1016/j.carres.2021.108478 [Article Type] Research article