The effects of COVID-19 on the dispensing rates of antidepressants and benzodiazepines in CanadaCOVID-19가 캐나다의 항우울제 및 벤조디아제핀 조제 비율에 미치는 영향Article Published on 2022-02-012022-09-11 Journal: Depression and anxiety [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed antidepressant antidepressants Anxiety Benzodiazepine Canada caused changes in Community conducted COVID-19 COVID-19 pandemic cross-sectional Depression depressive detectable determine deviation disorders Effect Emergency Intervention medication medications MONITOR National pandemic pharmacological treatment Pharmacy population study Prevalence reduction in Research returned shown significant changes in state of emergency Symptom Tablet treat [DOI] 10.1002/da.23228 PMC 바로가기 [Article Type] Article
Antidepressant drug treatment protecting from COVID-19: one more piece in the repurposing puzzleEditorial Published on 2022-01-202022-10-28 Journal: BJPsych Open [Category] COVID-19, [키워드] antidepressant antidepressants Cohort coronavirus disease COVID-19 COVID-19 disease Deterioration drugs Efficacy Evidence First wave hospital incidence Infection infection risk medical records medication medications on COVID-19 New York observation period pandemic Patient positive prevention protective effect Psychiatric reduced repurposing Retrospective analysis risk significantly lower SSRI therapy Treatment were infected [DOI] 10.1192/bjo.2021.1075 PMC 바로가기 [Article Type] Editorial
Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitroPharmacology Published on 2022-01-192022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activity Against Alpha Alpha variant antidepressant antidepressants (AD) antipsychotic antipsychotic drug antiviral action B.1 B.1 lineage B.1.1.7 B.1.351 B.1.617.2 Beta variant Calu-1 Cell Cell culture Clinical practice clinical study clinically Compound consequence COVID-19 delta variant derivative doses drug E484K Effect effective embryonic kidney cell epithelial cell line expand First wave Fluoxetine human lung in vitro Infection information inhibited inhibitor investigated K417N Lineage mutations N501Y novel performed primary mechanism Pseudotyped virus pseudovirus pseudoviruses Receptor binding domain remained repurposing Rolipram SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike show tested these compound variants variants of concern variants of SARS-CoV-2 viability [DOI] 10.3389/fphar.2021.755600 PMC 바로가기 [Article Type] Pharmacology
Ongoing Use of SSRIs Does Not Alter Outcome in Hospitalized COVID-19 Patients: A Retrospective AnalysisArticle Published on 2021-12-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] age antidepressant clinical information clinical presentation consequence COVID-19 Critical database determine disease severity drug Efficacy evaluate Gender hospital Hospital admission identify imperative infectious agents laboratory-confirmed logistic regression model medical record Mortality new strain no significant difference outcome Pandemics Patient Prevent reduce reduced retrospective SARS-CoV-2 Severe COVID-19 Infection shown Spread SSRI symptom severity treating COVID-19 Treatment utility vaccination [DOI] 10.3390/jcm11010070 PMC 바로가기 [Article Type] Article
Low-Dose Fluvoxamine Modulates Endocytic Trafficking of SARS-CoV-2 Spike Protein: A Potential Mechanism for Anti-COVID-19 Protection by AntidepressantsPharmacology Published on 2021-12-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 antidepressant antidepressants Cell complex Concentration COVID-19 diversion Drug repurposing endocytosis endosomal trafficking Endosomes fluvoxamine HEK293T cells highlighting host receptor investigated mechanism membrane Potential Prophylactic protection protective effect provide resulting SARS-CoV-2 severe COVID-19 spike Spike protein the SARS-CoV-2 therapeutic upregulated [DOI] 10.3389/fphar.2021.787261 PMC 바로가기 [Article Type] Pharmacology
Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor AntidepressantsResearch Published on 2021-11-152022-10-29 Journal: JAMA Network Open [Category] COVID-19, MERS, SARS, [키워드] adjusted age antidepressant association Care cohort study Comorbidities control patient control patients COVID-19 database decreased mortality defined demographic characteristics diagnosed with COVID-19 duration of follow-up EHR Electronic health record Evidence exposure finding Frame Health Importance involved lower mortality risk measure medication Mortality multicenter cohort study objective outcome outcomes participant Patient patients with COVID-19 Point Proinflammatory cytokine propensity score matching randomized clinical trial receiving reduce mortality reduced reduction in reflected Relevance reported representing Research Result retrospective cohort study Reuptake risk risk of death RR of mortality selective serotonin reuptake inhibitor setting severe COVID-19 severity of COVID-19 statistically significant subject suggested Support treated was reduced women [DOI] 10.1001/jamanetworkopen.2021.33090 PMC 바로가기 [Article Type] Research
COVID-19 and the impact of arterial hypertension-An analysis of the international HOPE COVID-19 Registry (Italy-Spain-Germany)COVID-19와 동맥 고혈압의 영향-국제 HOPE COVID-19 레지스트리 분석(이탈리아-스페인-독일)Article Published on 2021-11-012022-09-11 Journal: European Journal of Clinical Investigation [Category] SARS, 치료제, [키워드] absence ACEi Acute kidney injury Admission all-cause mortality Analysis angiotensin angiotensin receptor blocker Angiotensin receptor blockers anticoagulation antidepressant antiviral drugs ARB ARBs Arterial hypertension Benzodiazepine bleeding bleeding event bleeding events Clinical outcome Cohort Complication conducted COVID COVID-19 COVID-19 patient COVID-19 patients Cox regression analysis creatinine Diagnosis discharge elevated Follow-up heart failure hypertension in-hospital complication in-hospital complications independent independent predictor inhibitor interferon interferon treatment International LDH material Mortality mortality rate multicentre multivariate Non-invasive respiratory support outcome Patient patients Pneumonia positive registry regression analysis required respiratory insufficiency Sepsis significantly more suffered systematic analysis treated Treatment [DOI] 10.1111/eci.13582 PMC 바로가기 [Article Type] Article
Fluoxetine hydrochloride loaded lipid polymer hybrid nanoparticles showed possible efficiency against SARS-CoV-2 infectionFluoxetine hydrochloride가 탑재된 지질 고분자 하이브리드 나노 입자는 SARS-CoV-2 감염에 대해 가능한 효율성을 보여주었습니다Article Published on 2021-09-252022-09-11 Journal: International journal of pharmaceutics [Category] SARS, 신약개발, [키워드] acute respiratory syndrome coronavirus Affect Anti-inflammatory anticoagulant effects antidepressant Antiviral approach approved drug binding energy cells cellular coronavirus COVID 19 COVID-19 COVID-19 pandemic disease drug Drug repurposing drugs Economy Efficiency encapsulation ENhance fibroblast Fluoxetine Fluoxetine hydrochloride global health Health Human hydrogen Hydrogen bond Interaction Lipid Lipid polymer hybrid lung management molecular docking molecular docking studies Molecular docking study optimization Paroxetine performed Polymer predict protease repurposing respiratory SARS-COV-2 infection SARS-CoV-2 main protease selective Serotonin serotonin reuptake inhibitor severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 SSRIs. suggested therapeutic activity Treatment zeta potential [DOI] 10.1016/j.ijpharm.2021.121023 PMC 바로가기 [Article Type] Article
Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?선택적 세로토닌 재흡수 억제제의 약물 용도 변경: 이 약물이 COVID-19와 싸우고 생명을 구하는 데 도움이 될 수 있습니까?Review Published on 2021-06-012022-08-31 Journal: Journal of clinical neuroscience : official journa [Category] MERS, 신약개발, 치료제, [키워드] 2019 novel coronavirus absence Affect Anti-inflammatory antidepressant Antidepressant drugs antiviral properties attenuate CCL-2 class clinical trials confirmed case coronavirus disease COVID-19 COVID-19 patients curative treatment Cytokines death disease drug Drug repurposing effective Emerging infectious disease Evidence Fluoxetine focus help identify IL-6 immune system immunomodulatory Infectious disease life management mental health morbidity Neurological complication Neurological complications Novel coronavirus novel coronavirus disease pandemic present pro-inflammatory Quality of life reduce reducing reported Safe SARS-CoV-2 selective Selective serotonin reuptake inhibitors (SSRIs). Serotonin serotonin reuptake inhibitor serotonin reuptake inhibitors tested therapeutic therapeutic agent therapeutic strategy TNF-α Tolerability Vaccine widespread [DOI] 10.1016/j.jocn.2021.03.010 PMC 바로가기 [Article Type] Review
Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells비강 상피 세포의 SARS-CoV-2 감염 예방에 있어 스핑고지질을 표적으로 하는 약물의 효능을 평가하기 위한 생체 외 분석Article Published on 2021-03-192022-08-31 Journal: STAR protocols [Category] MERS, SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 amitriptyline antidepressant approved assays Cell isolation Cell-based assays. Complete Coronavirus-2 COVID-19 drug drugs targeting Efficacy epithelial cell epithelial cells evaluate Ex vivo Infection infection level infection levels inhibitor nasal epithelial cell offer Particle presenting protocol quantified Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sphingolipid Spike protein stomatitis the SARS-CoV-2 vesicular stomatitis vesicular stomatitis virus Volunteer were infected [DOI] 10.1016/j.xpro.2021.100356 PMC 바로가기 [Article Type] Article