Identification of B-cell dominant epitopes in the recombinant protein P29 from Echinococcus granulosusArticle Published on 2022-05-012023-06-22 Journal: Immunity, Inflammation and Disease [Category] 조류인플루엔자, [키워드] B-cell epitope Echinococcus granulosus rEg.P29. [DOI] 10.1002/iid3.611 PMC 바로가기
Rapid Detection of Anti-SARS-CoV-2 Antibodies with a Screen-Printed Electrode Modified with a Spike Glycoprotein Epitope스파이크 당단백질 에피토프로 변형된 스크린 인쇄 전극을 사용한 항 SARS-CoV-2 항체의 신속한 검출Article Published on 2022-04-262022-09-11 Journal: Biosensors [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] 2019 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody B-cell epitope capture caused Chagas disease Chikungunya Consequences coronavirus coronavirus disease COVID-19 cross-reaction Dengue detection diagnose diagnoses diagnosing Diagnostic method differentiation dilution factor electrochemical biosensor electrode epitope Final flexibility Health hydroquinone IgG immunocomplex Immunoglobulin Immunoglobulin G immunological immunological diagnostic individual Infection linear material Molecular biology non-infected other disease other diseases pandemic Pathogens patient sera point of care Rapid reaction required respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike glycoprotein SARS-CoV-2-specific IgG SARS-CoV-2-specific IgGs selectivity sera serological serum samples severe acute respiratory syndrome Coronavirus specificity spike spike glycoprotein Spike protein Spread synthesis the SARS-CoV-2 the spike protein variants of SARS-CoV-2 Volume was measured was selected [DOI] 10.3390/bios12050272 PMC 바로가기 [Article Type] Article
Identification of B-Cell Epitopes for Eliciting Neutralizing Antibodies against the SARS-CoV-2 Spike Protein through Bioinformatics and Monoclonal Antibody Targeting생물정보학 및 단일클론 항체 표적화를 통한 SARS-CoV-2 스파이크 단백질에 대한 중화 항체 유도를 위한 B-세포 에피토프 식별Review Published on 2022-04-142022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity Analysis antibody approach Astra Zeneca B cell B cells B-cell B-cell epitope B-cell epitopes caused cells complex coronavirus COVID-19 COVID-19 vaccine Critical effective Eliciting epitope Epitopes global public health Health crisis Hospitalization identification Immunity Impact in silico in vivo less linear B-cell epitope mapping membrane Moderna monoclonal antibodies monoclonal antibody multi-epitope peptide vaccine Neutralizing Neutralizing antibodies neutralizing antibody new SARS-CoV-2 nucleocapsid protein offer peptide Pfizer-BioNTech potent produced Protective provide reducing respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein targeting the SARS-CoV-2 three-dimensional structure transmission of SARS-CoV-2 Vaccine Vaccines variants virus viruses Wuhan strain [DOI] 10.3390/ijms23084341 PMC 바로가기 [Article Type] Review
The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMINARTY vaccine (Pfizer/BioNTech)SARS-CoV-2 스파이크 잔기 616/644 및 1138/1169는 COVID-19 mRNA COMINARTY 백신에서 2개의 항체 에피토프를 나타냅니다(화이자/바이오엔텍)Article Published on 2022-04-092022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody epitope Antibody Response Antigen B-cell epitope BALB/c mice conjugate contribute coronavirus SARS-CoV-2 COVID-19 COVID-19 mRNA vaccines COVID-19 recovered patients COVID-19 vaccine COVID-19 vaccines effective Efficacy effort ELISA assay full-length identify immune immunogenic individuals linear B-cell epitope mRNA peptide peptide-based performed Pfizer-BioNTech Pfizer/BioNTech Protective question raise recipient residue responsible SARS-CoV-2 spike SARS-CoV-2 spike protein sera the SARS-CoV-2 the spike protein Vaccine worldwide pandemic [DOI] 10.1038/s41598-022-10057-7 PMC 바로가기 [Article Type] Article
Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant VirusesArticle Published on 2022-02-072022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis anti-viral antibody approach B-cell epitope B.1.1.7 B.1.351 Beta collected contribute COVID-19 COVID-19 vaccine cross-protective diagnostic Efficacy epitope epitope mapping examined Frequency Genetic variant host cell humoral Identified immune immunodominant immunogenic immunological Immunotherapy implication in vitro experiment Infection K18-hACE2 linear epitope linear epitopes mice neutralization tests SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 strain SARS-CoV-2 variants serum sample serum samples spike Spike protein targets the SARS-CoV-2 the spike protein transgenic viral entry virus variant [DOI] 10.3390/vaccines10020251 PMC 바로가기 [Article Type] Article
Screening and identification of B cell epitope of the nucleocapsid protein in SARS-CoV-2 using the monoclonal antibodies단일클론항체를 이용한 SARS-CoV-2의 뉴클레오캡시드 단백질 B 세포 에피토프의 스크리닝 및 동정Article Published on 2022-02-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibody antibody affinity Antibody titer Antibody titers Antigen B cell B-cell B-cell epitope cause cells Characteristics codon coronavirus coronavirus disease COVID-19 ELISA epitope expressed expression Guidance high affinity Host immune response insect cell insect cells linear mAb mAbs modulation monoclonal antibodies monoclonal antibody N gene N protein nucleocapsid nucleocapsid protein overlapped peptide peptides Protein reactivity Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 N protein Screening sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown strain targets the N protein the SARS-CoV-2 Transcription variants variants of concern variants of interest Viral viral pathogenesis virus virus detection VOCs VOIs were used [DOI] 10.1007/s00253-022-11769-6 PMC 바로가기 [Article Type] Article
Immunodominant and Neutralizing Linear B-Cell Epitopes Spanning the Spike and Membrane Proteins of Porcine Epidemic Diarrhea VirusImmunology Published on 2022-01-192022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] amino acid sequence B-cell epitope cause Complete consensus sequence contribute demonstrated disease ELISA testing epidemic diarrhea epitope Epitope prediction genetic diversity greater group high mortality rate identify immune stimulation immunodominant epitope immunoinformatics insight linear linear B-cell epitope M protein membrane membrane protein NCBI database neutralization Neutralizing neutralizing epitope nine offer PEDV peptide peptide-based immunoassays Porcine epidemic diarrhea virus predicted profile Protein Proteins provided retrieved S2 subunit sera Seven Spike protein strain Strains the S protein the Spike Vaccine virus Virus neutralization [DOI] 10.3389/fimmu.2021.785293 PMC 바로가기 [Article Type] Immunology
Emerging genetic diversity of SARS-CoV-2 RNA dependent RNA polymerase (RdRp) alters its B-cell epitopesSARS-CoV-2 RNA 의존성 RNA 중합효소(RdRp)의 유전적 다양성이 B 세포 에피토프를 변경Article Published on 2022-01-012022-09-11 Journal: Biologicals : journal of the International Associa [Category] SARS, 변종, [키워드] Alter B cell B cell epitope B cell epitopes B-cell epitope carried contributed COVID-19 Epitopes flexibility genetic diversity highlight identify India isolates life cycle linear mutant mutants Mutation mutations predicted Protein RdRP RdRp sequence RdRp sequences reported RNA RNA dependent RNA polymerase RNA dependent RNA polymerase (RdRp) RNA polymerase RNA virus SARS-CoV-2 SARS-CoV-2 RNA sequence Spread stability the SARS-CoV-2 Variation variations viral genome Virus life cycle Wuhan Wuhan, China [DOI] 10.1016/j.biologicals.2021.11.002 PMC 바로가기 [Article Type] Article
Phylodynamic analysis and spike protein mutations in porcine deltacoronavirus with a new variant introduction in TaiwanResearch Article Published on 2021-11-242022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] Alter amino acid change amino acid insertion Analysis anorexia B-cell epitope binding cause cellular membrane Clinical symptoms Concentration Critical demonstrated diarrhea ENhance Epidemic evolutionary rates fusion peptide Genetic greater intestinal Lineage Mild Mutation N-terminal domain pathogen Pathogenesis penetration phylodynamics phylogenetics Point mutation Porcine deltacoronavirus receptor regions responsible sequence spike glycoprotein Spike protein strain Strains Structural analysis Taiwan Transmission variant Viral protein virus virus infectivity vomiting watery [DOI] 10.1093/ve/veab096 PMC 바로가기 [Article Type] Research Article
Epitope Profiling Reveals the Critical Antigenic Determinants in SARS-CoV-2 RBD-Based AntigenImmunology Published on 2021-09-212022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] analyzed antibodies Antibody Response Antigen B-cell epitope binding caused characterized conserved COVID-19 COVID-19 pandemic cross-reactive antibody determinant diagnostic domain effort epitope facilitate globe humoral IFA immunization immunized immunodominant immunodominant epitope immunogenic in viral Infection information linear mapped mice monoclonal antibody neutralization activity Neutralizing antibodies peptide peptides Profiling Protein public health crisis RBD RBM receptor binding motif Result SARS-CoV SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 S trimer SARS-CoV-2 spike SARS-CoV-2 strains SARS-CoV-2 vaccine sera Spike protein Structural analysis the antibody response the RBD [DOI] 10.3389/fimmu.2021.707977 PMC 바로가기 [Article Type] Immunology