COVID-19 and neurological sequelae: Vitamin D as a possible neuroprotective and/or neuroreparative agentReview article Published on 2022-05-012022-10-05 Journal: Life sciences [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Affect association Atypical Brain canonical cell damage cellular Central nervous system consequence coronavirus COVID-19 COVID-19 pandemic Cytokines decrease deficiency Effect Effects enzyme etiological agent Evidence form function humans impairment Inflammation Invasion neurodegeneration Neuroinflammation neurological Neuropsychiatric Neuroreparation neutralize organ oxidative stress Pneumonia predisposition receptor regulate Respiratory function Respiratory system SARS-CoV-2 SARS-COV-2 infection Sequelae Vitamin D [DOI] 10.1016/j.lfs.2022.120464 [Article Type] Review article
Recent Advances in Understanding Nrf2 Agonism and Its Potential Clinical Application to Metabolic and Inflammatory DiseasesReview Published on 2022-03-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] advance Agonism agonist antioxidant application Autoimmune diseases Cell cell damage cellular clinical Clinical practice clinical trials complications Coordinate diabete Diabetic disease disorders dysfunction Enzymes Evidence expression of gene fat homeostasis implication Inflammation Inflammatory bowel disease inflammatory disease metabolic metabolic disease molecular Nrf2 obesity organism oxidative stress Pathogenesis pathway Potential Protein recent regulated Regulation Stress therapeutic use tissue transcription factor understanding [DOI] 10.3390/ijms23052846 PMC 바로가기 [Article Type] Review
Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection공기-액체-인터페이스 분화된 인간 코 상피: SARS-CoV-2 감염의 강력한 1차 조직 배양 모델Article Published on 2022-01-132022-09-10 Journal: International Journal of Molecular Sciences [Category] 변종, [키워드] air–liquid-interface apical surface basal cells caused Cell cell damage ciliated cells communicable communicable disease condition confocal microscopy COVID-19 COVID-19 pandemic Culture culture system delta variant determined by Differentiated cell disease dominant Donor donors Effectiveness feature Human human nasal epithelium human SARS-CoV-2 human tissue human tissues immunofluorescence infected cell infected cells Infection initial inoculated invasive medical countermeasure Medical countermeasures Model nasal nasal epithelium nasal turbinate nose occurred offer organoids portal Prevent progenitor progenitor cells replicate respiratory respiratory tissue robust SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-COV-2 infection Severe acute respiratory syndrome TCID tissue tissue culture unmet need urgency Viral viral entry virus was determined [DOI] 10.3390/ijms23020835 PMC 바로가기 [Article Type] Article
Strong relationship between cholesterol, low-density lipoprotein receptor, Na + /H + exchanger, and SARS-COV-2: this association may be the cause of death in the patient with COVID-19Editorial Published on 2021-12-132022-10-29 Journal: Lipids in Health and Disease [Category] COVID-19, SARS, [키워드] accelerated ACE2 activated Activation Ang II angiotensin-converting enzyme-2 association Atherosclerosis cause Cell cell damage cell membrane cholesterol COVID-19 death decrease dysfunction energy metabolism Exchanger Extracellular fat-soluble vitamins fatty functions genetic material high-density increase Increases infect inhibiting interact Ion LDL LDLR limits Lipid lipids low-density Na+/H+ exchanger novel novel coronavirus disease Patient PCSK9 pH value physiological previous study Prolonged receptor replicate RNA SARS-CoV-2 SARS-COV-2 infection severity of COVID-19 shown stimulate Strong susceptibility the patient Transport Treatment treatment regimen variety with COVID-19 [DOI] 10.1186/s12944-021-01607-5 PMC 바로가기 [Article Type] Editorial
FDA approved L-type channel blocker Nifedipine reduces cell death in hypoxic A549 cells through modulation of mitochondrial calcium and superoxide generationArticle Published on 2021-12-012022-10-04 Journal: Free radical biology & medicine [Category] SARS, 신약개발, [키워드] A549 cell A549 cells alveolar Analysis approved blocker calcium channel Calcium channel blocker can be used CCB CCBs Cell cell damage cell death cellular cellular and molecular confocal microscopy COVID-19 cytosolic evaluated examined FDA hypoxia hypoxic ImageJ individual cell inducer L-type lung epithelial cell mitochondrial Mitochondrial calcium modulation molecular morphology Nifedipine nuclear oxygen pathophysiology platform Protective protective effect Quantitative analysis reactive oxygen species (ROS) reduce reduction required ROS ROS production SARS-CoV-2 significant increase suggested targets therapeutic trials viability was used [DOI] 10.1016/j.freeradbiomed.2021.08.245 PMC 바로가기 [Article Type] Article
Elevated fecal and serum calprotectin in COVID-19 are not consistent with gastrointestinal symptomsArticle Published on 2021-11-092022-10-04 Journal: Scientific Reports [Category] 바이오마커, 치료기술, [키워드] acute phase association Biochemistry Biomarkers calprotectin caused cell damage controls COVID-19 COVID-19 case COVID-19 disease COVID-19 patient diarrhea disease severity elevated epithelial fecal Gastrointestinal symptom GI symptom Health care healthy control healthy individuals immune system immunology inflammation marker Inflammatory marker Inflammatory response investigated manifestation median Medical research not correlated not significantly different performed progressed progression SARS-COV-2 infection serum subgroup thought triggered uninfected were measured [DOI] 10.1038/s41598-021-01231-4 PMC 바로가기 [Article Type] Article
Dehydrozingerone ameliorates Lipopolysaccharide induced acute respiratory distress syndrome by inhibiting cytokine storm, oxidative stress via modulating the MAPK/NF-κB pathwayDehydrozingerone은 MAPK/NF-κB 경로를 조절하여 사이토카인 폭풍, 산화 스트레스를 억제함으로써 지질다당류 유도 급성 호흡 곤란 증후군을 개선합니다Article Published on 2021-11-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome alveolar alveolar inflammation analysed Analysis Apoptosis ARDS Bacterial BALF Cell cell damage cell injury cell lines chemokine chemokines country COVID-19 pandemic CRS cytokine Cytokine release syndrome Cytokine storm Cytokines Dehydrozingerone develop distress dose-dependent manner Elastase ELISA Endothelial cell endothelial cells evaluated event events Gene Expression Health Hyperactivation immune cells In-vitro increase in Infection Inflammation Inflammatory inflammatory cascade inflammatory cell inflammatory cells Inflammatory cytokine Inflammatory cytokines inhibiting Injury intensive care units lipopolysaccharide LPS lung cell lung epithelial Lung injury lung tissues macrophages majority MAPK MAPKinase marker modulating modulation molecular mechanism molecular mechanisms morbidity neutrophil NF-κB NF-κB pathways oxidative oxidative stress pathogen pathogen-mediated pathophysiology pathway performed Pneumonia problem Prophylactic protective effect Protective effects Protein provide RATs reduced respiratory distress resulting ROS significantly Standard therapy stimulate stimulated Support syndrome the patient therapeutic therapeutic activity therapeutic agent therapeutic effect therapeutic effects Treatment turn was determined western blot Western blot analysis [DOI] 10.1016/j.phymed.2021.153729 PMC 바로가기 [Article Type] Article
Association of serum KL-6 levels on COVID-19 severity: A cross-sectional study design with purposive samplingResearch article Published on 2021-09-012022-10-05 Journal: Annals of Medicine and Surgery [Category] 바이오마커, [키워드] Alveolar Type II analyzed association AT2 Biomarker cause Cell cell damage COVID-19 COVID-19 patient cross-sectional evade greater decrease group IL-1β IL-6 independent t-test Indonesia innate immune system KL-6 lung non-severe group normally distributed objective produced Proinflammatory cytokine prospective design Purposive sampling Result resulting SARS-CoV2 serum severe group severity severity of COVID-19 Study design subject t-test the mean TNF-α treated were measured Wilcoxon test [DOI] 10.1016/j.amsu.2021.102673 [Article Type] Research article
A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19Public Health Published on 2021-07-282022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] accelerate ACE2 ACE2 receptor Affect aggravate airways alveolar cells article ASL blood glucose carbohydrates Cell cell damage cell death cells Combination Complication computational modeling Concentration condition COVID-19 Critical care Cytokine storm database diagnostic disease disease severity dysregulated dysregulation Effect elevated Elevation evade Evidence explain facilitate feasibility Glucose glycemia glycemic control Glycolysis glycosylation hyper-inflammation hyperglycemia Hypothesis immune defense inactivation induce Infection infection process infections Inflammation information innate immune system involved Ketogenic diet knowledge Level lung Lungs machine learning model MOST multi-organ failure multiple mechanism pandemic potential treatments progression proportion provide pulmonary inflammatory response Quantitative reached replicate Replication Research risk role SARS-CoV-2 Severe case severe COVID-19 severity subsequent Symptoms tested the cytokine storm the disease the patient the SARS-CoV-2 Thrombotic events treatment strategy View viral infection Viral load virus weakened [DOI] 10.3389/fpubh.2021.695139 PMC 바로가기 [Article Type] Public Health
Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal HemoglobinuriaCase Report Published on 2021-07-132022-10-31 Journal: Case Reports in Hematology [Category] COVID-19, [키워드] activate acute respiratory syndrome cause cell damage complement coronavirus coronavirus disease COVID-19 deficiency demonstrated facial fatigue hemoglobinuria Hemolysis Laboratory test paroxysmal nocturnal hemoglobinuria Patient Regulation SARS-CoV-2 Symptom upper respiratory infection virus [DOI] 10.1155/2021/6619177 PMC 바로가기 [Article Type] Case Report