Evaluation of circulating leucocyte populations both in subjects with previous SARS-COV-2 infection and in healthy subjects after vaccinationObservational Study Published on 2022-03-012022-10-05 Journal: Journal of Immunological Methods [Category] SARS, 임상, [키워드] addition binding CD4 CD8 Cell circulating COVID-19 COVID-19 infection COVID-19 mRNA BNT162b2 COVID-19 mRNA BNT162b2 (Pfizer-BioNTech) vaccine Cytometry decrease develop effector effector cell Flow Flow cytometry characterization groups healthy healthy subject healthy subjects immune mechanism immune response immune system increased expression Infection initial Innate innate immune response leucocyte leukocyte pathogen Pfizer-BioNTech Population promote receptor reduction subject subjects T cell T cell immune response T cell response T cells TEMRA terminal vaccination Vaccine viral clearance viral replication [DOI] 10.1016/j.jim.2022.113230 PMC 바로가기 [Article Type] Observational Study
DExD/H-box helicase 9 intrinsically controls CD8 + T cell-mediated antiviral response through noncanonical mechanismsDExD/H-box 헬리카제 9는 비정규 메커니즘을 통해 본질적으로 CD8 + T 세포 매개 항바이러스 반응을 제어합니다Article Published on 2022-02-112022-09-11 Journal: Science Advances [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activated Activation antiviral immunity antiviral response Apoptosis binding CD8 Control Coordinate COVID-19 patients DHX9 domain effector effector cell ERK event expression Helicase independent independent of intrinsically LCK mechanism nuclear Phosphorylation proliferation proliferative promote PROTECT regulate Regulatory required survival T cell T cells TCR Transcription viral clearance virus infection ZAP70 [DOI] 10.1126/sciadv.abk2691 PMC 바로가기 [Article Type] Article
Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection차등 인터페론-α 아형 유도 면역 시그니처는 SARS-CoV-2 감염 억제와 관련이 있습니다420 Published on 2022-02-072022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundance activate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 additive effects Analysis analyzed Antiviral antiviral activity antiviral drug antiviral host response antiviral host responses antiviral response antiviral responses autoantibody Cell culture cellular Clinical treatment coronavirus Course defined disease downstream early administration Effect effector effector molecule epithelial cell epithelial cells Express functional hAEC help Host Human identify IFN-alpha IFN-I IFN-I signaling IFNs IFNα immune immune response immune responses immune signature Immune-mediated Immunity Immunotherapy Inborn error Inborn errors interferon Interferon-α interferons involved knowledge life-threatening negative regulation Pathologies Pathways pleiotropic primary human airway Primary human airway epithelial cells Prophylaxis Protective proteomic Remdesivir respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–infected mice severe acute respiratory syndrome Coronavirus signaling cascade Significance subtype Subtypes Support Therapeutic approach therapeutic potential transcriptional transcriptomic analysis Treatment Type type I IFNs type I interferons Viral Viral diseases viral infections virus viruses [DOI] 10.1073/pnas.2111600119 PMC 바로가기 [Article Type] 420
Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, including Platelet Factor 4, High-Mobility Group Box 1 Protein and HistonesArticle Published on 2022-02-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] activated Adsorbent Adsorption binding Box Complication coronavirus disease COVID-19 deplete deregulated disease severity disorders driven by effector event Evidence expressing extracellular vesicle Extracellular vesicles Factor group heparin histone Histones HMGB1 immunothrombosis increased mortality marker multiorgan failure NETs Neutrophil extracellular trap Neutrophil extracellular traps Pathogens PF4 Platelet platelet factor 4 Platelets Protein Sepsis thrombosis thrombotic complication [DOI] 10.3390/ijms23031823 PMC 바로가기 [Article Type] Article
Advanced CRISPR-Cas Effector Enzyme-Based Diagnostics for Infectious Diseases, Including COVID-19Review Published on 2021-12-072022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] Accuracy amplification Cas12 Cas13 COVID-19 CRISPR-Ca CRISPR-Cas current Diagnosis diagnostic Diagnostic method diagnostic test Diseases effective effector enzymatic activity feature identify immunoassay immunoassays include Including Infectious diseases limitations molecular Molecular diagnosis Nucleic acid detection Pandemics pathogen detection platform Prevent provide Rapid reduced SARS-CoV-2 SARS-COV-2 infection sensitivity Spread time-consuming unique [DOI] 10.3390/life11121356 PMC 바로가기 [Article Type] Review
MicroRNAs are minor constituents of extracellular vesicles that are rarely delivered to target cellsmicroRNA는 표적 세포로 거의 전달되지 않는 세포 외 소포의 작은 성분입니다.Research Article Published on 2021-12-062022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect Alter analyzed applied approach Biological functions Blood cells carried Cell cell line cell lines cell types cell-to-cell communication cellular cellular membrane cellular membranes contribute defined document effector effectors Evidence EVs Exosome Exosomes experiments extracellular vesicle Extracellular vesicles fraction functional FUSE had no majority mammalian cells messenger RNAs microRNA MicroRNAs Microvesicles miRNA miRNAs mRNA mRNAs packaged purified Quantitative recipient regulate RNAs Sensitivity and specificity stability target target cell target cells target mRNA Transcriptome Vesicle vesicles Viral viral miRNAs [DOI] 10.1371/journal.pgen.1009951 PMC 바로가기 [Article Type] Research Article
Potential Use of CRISPR/Cas13 Machinery in Understanding Virus–Host InteractionMicrobiology Published on 2021-11-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acquisition approaches Cas13 Cas9 class component CRISPR-Cas Degradation degrade diagnostics DNA effector elements Features Genetic identify immune system Interaction modulate Nuclease nucleases nucleic acid offer Palindromic phage plasmids Potential Prokaryote Protein Proteins recognizing Repeat Research RNA RNA interference RNA-labeling sequence spacer subsequent understanding variant Viral RNA Virological virus diagnosis virus interference virus resistance [DOI] 10.3389/fmicb.2021.743580 PMC 바로가기 [Article Type] Microbiology
Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute InfectionArticle Published on 2021-11-222022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 바이오마커, [키워드] CD4+ T-cell cells Coronavirus disease 2019 COVID-19 cytokine level cytokine response Cytokines death demonstrated deregulation effector events excessive inflammation exhausted/senescent T cells expression Frequency hallmark Ill immune system immunodeficiency immunopathology infected patient mechanism phenotype Reinfection Respiratory failure response SARS-CoV-2 severe pneumonia significantly increased susceptibility T cell T-cell T-cell exhaustion the cytokine storm [DOI] 10.1093/infdis/jiab425 PMC 바로가기
TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionTMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다Research Article Published on 2021-11-222022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘, [키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus entry virus infection virus infections viruses [DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVSImmunology Published on 2021-11-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activating Activation attenuate Calu-3 caused cells clinical study COVID-19 cytokine cytokine expression cytokine production effector ENhance expression IL-1β IL-2 IL-6 increase induce infected with SARS-CoV-2 Infectious disease inhibitor investigated knockdown MAVS molecular mechanism NF-κB NF-κB NF-κB activation NF-κB signaling nsp5 overexpression pathway Patient pro-inflammatory cytokine promote Protein protein level Research SARS-CoV-2 SARS-COV-2 infection stability SUMOylation the disease TNF-α Treatment triggering upstream [DOI] 10.3389/fimmu.2021.750969 PMC 바로가기 [Article Type] Immunology