Emergence of B.1.524(G) SARS-CoV-2 in Malaysia during the third COVID-19 epidemic wave제 3의 COVID-19 전염병 파에서 말레이시아에서 B.1.524 (G) SARS-COV-2의 출현Article Published on 2021-11-112022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] A701V Analysis carried Cluster contributing to COVID-19 COVID-19 case COVID-19 epidemic COVID-19 pandemic descendant East emergence epidemic wave epidemic waves epidemiological link Epidemiology Genetic variation Genetic variations Genome Genome sequencing independent Lineage lineages Malaysia Mutation mutations occurred Peninsular Malaysia performed Phylogenetic Protein remained Result S-D614G mutation SARS-CoV-2 SARS-CoV-2 strain Selangor sequence sequenced specific mutation specific mutations spike Spike protein Spread spread to Strains suggested Support the SARS-CoV-2 variant virus [DOI] 10.1038/s41598-021-01223-4 PMC 바로가기 [Article Type] Article
Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE ResidentsUAE 거주자 사이의 비타민 D 대사 경로의 유전적 변이와 COVID-19의 심각성 간의 연관성Article Published on 2021-10-202022-09-10 Journal: Nutrients [Category] MERS, 바이오마커, 변종, 유전자 메커니즘, [키워드] 25-hydroxyvitamin D affected association Cell COVID-19 COVID-19 severity Critical CYP2R1 deficiency Effect Factor genetic determinant genetic determinants genetic variants Genetic variation Genetic variations genotype data genotypes hospital Human immune system implicated Infection investigated involved mechanism mechanism of action metabolism NADSYN1 outcomes Patient patients with SARS-CoV-2 polymorphism Population potential risk Research resident SARS-CoV-2 SARS-COV-2 infection serum serum 25-hydroxyvitamin D severe COVID-19 severity of COVID-19 single-nucleotide Single-nucleotide polymorphisms Spread two groups UAE United Arab Emirate United Arab Emirates vaccination variant VDR Viral viral infection Vitamin D vitamin D deficiency Vitamin D Metabolism Vitamin D status [DOI] 10.3390/nu13113680 PMC 바로가기 [Article Type] Article
Molecular epidemiology analysis of early variants of SARS-CoV-2 reveals the potential impact of mutations P504L and Y541C (NSP13) in the clinical COVID-19 outcomesSARS-CoV-2의 초기 변이체에 대한 분자 역학 분석은 임상 COVID-19 결과에서 돌연변이 P504L 및 Y541C(NSP13)의 잠재적 영향을 보여줍니다Article Published on 2021-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition aggregation Amino acid Amino acid variations Analysis analyzed Canada caused Characteristics clade contribute coronavirus country COVID-19 death demonstrated detect Effect Epidemiology Evolution Fatality rate feature functional Genetic variation Genetic variations Genome Genotype global pandemic identify Infection involved Mutation nonsynonymous nsp13 ORF1 ORF1ab outcome outcomes performed Phylogenetic analysis Phylogenetic tree Prevent proportion Report date Result reveal SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 strains. sequence Sequence alignment severe acute respiratory syndrome Coronavirus state strain Strains the United State The United States United States variant variants variants of SARS-CoV-2 Variation variations virus Washington [DOI] 10.1016/j.meegid.2021.104831 PMC 바로가기 [Article Type] Article
RT-PCR based SARS-CoV-2 variant screening assays require careful quality controlRT-PCR 기반 SARS-CoV-2 변이체 스크리닝 분석에는 신중한 품질 관리가 필요합니다.Article Published on 2021-08-012022-09-11 Journal: Journal of Clinical Virology [Category] SARS, 변종, 치료기술, 치료제, [키워드] Accuracy antibody asked bioinformatic analysis characteristic complex confidence copy number detect determine diagnostic external quality assessment FIVE genetic information Genetic variations genomic variant genomic variants Genotype highest identify initial Interpretation Laboratory less lineages loss of confidence melting melting curve analysis molecular nucleotide nucleotide mutation nucleotide mutations participant pathogenicity qPCR Quality control reliability reported RT-PCR RT-qPCR SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant Sequencing Spike protein target region target regions the SARS-CoV-2 time-consuming Transmission variant variant of concern variants of concern Variation virus VoC whole genome Whole genome sequencing [DOI] 10.1016/j.jcv.2021.104905 PMC 바로가기 [Article Type] Article
Pathogenic perspective of missense mutations of ORF3a protein of SARS-CoV-2SARS-CoV-2의 ORF3a 단백질의 미스센스 돌연변이의 병원성 관점Article Published on 2021-07-152022-09-11 Journal: Virus research [Category] SARS, 변종, 치료기술, [키워드] Amino acid among others Cluster coded Complete coronavirus COVID-19 COVID-19 pathogenesis Critical disease Effect function functions Genetic variations Genome include ion channel K-means clustering knowledge life-threatening Missense mutation Missense mutations morphogenesis Mutation mutations NCBI database Neutral Non-synonymous mutation ORF3 ORF3a ORF3a protein pathogenic pathogenicity Perspective Protein SARS-CoV-2 SARS-CoV-2 genome Shannon entropy stability the SARS-CoV-2 genome timeline virulence virus [DOI] 10.1016/j.virusres.2021.198441 PMC 바로가기 [Article Type] Article
The extent of molecular variation in novel SARS-CoV-2 after the six-month global spread6개월간의 글로벌 확산 이후 신종 SARS-CoV-2의 분자 변이 정도Article Published on 2021-07-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 America Amino acid amino acid change amino acid changes Analysis Asia cause changes in characterized clade clades collected Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical D614G Economy epidemiological Epidemiological trend Europe Evolution Genetic Genetic variation Genetic variations genome sequence genotyping global public health haplogroup Haplotype haplotypes highlight indicated L37F molecular mutations notable Nsp12 nsp13 NSP2 nucleocapsid nucleotide ORF3a ORF8 outbreak pandemic pandemic spread pathogen Phylogenetic tree prevalent Q57H reported SARS-CoV-2 SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences severe acute respiratory syndrome Coronavirus spike Spread spread of COVID-19 T85I threat unique United State United States Variation [DOI] 10.1016/j.meegid.2021.104800 PMC 바로가기 [Article Type] Article
From bedside to bench: regulation of host factors in SARS-CoV-2 infection침대 옆에서 벤치까지: SARS-CoV-2 감염의 숙주 요인 조절Review Published on 2021-04-072022-09-10 Journal: Experimental & Molecular Medicine [Category] MERS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 advance angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 assays Asymptomatic case Asymptomatic cases cause Cell chromatin Chromatin structure chromosomal coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 severity determinant disease severity Edinburgh Effect enzyme Enzymes explain exploration expression expression level facilitate Factor Factors focus Genetic variant genetic variants Genetic variation Genetic variations Genetics research Genome-wide association studies Genome-wide association study GWASs help heterogeneity high expression levels highlight Host Host immune response identify immune responses implicated Interaction knowledge mechanism methodology molecular multiple organ failure organ Organ failure pandemic pathway Pathways Patient patients physiological proinflammatory Regulation Replication Research researcher respiratory RNA SARS-CoV-2 SARS-COV-2 infection selected Sequencing Serine Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe COVID-19 severity severity of COVID-19 single-cell Symptom therapeutic therapeutic option therapeutic options TMPRSS2 Transcriptional regulatory elements transcriptomics transmembrane serine protease transmembrane serine protease 2 understanding university Variation variations Viral viral entry viral infection virus Virus-host interactions with COVID-19 Zoonotic coronavirus [DOI] 10.1038/s12276-021-00595-x PMC 바로가기 [Article Type] Review
A bioinformatic approach to investigating cytokine genes and their receptor variants in relation to COVID-19 progressionCOVID-19 진행과 관련하여 사이토카인 유전자 및 그 수용체 변이체를 조사하기 위한 생물정보학적 접근Article Published on 2021-04-012022-09-11 Journal: International journal of immunogenetics [Category] 변종, [키워드] acute respiratory syndrome Affect Analysis approach binding binding efficiency binding site Biotechnology center change conducted contribute coronavirus correlated COVID-19 COVID-19 pathogenesis COVID-19 progression CXCR2 cytokine cytokine receptor Cytokines database dbSNP decrease Deleterious detect determine Effect elevated endothelial evaluate Genes genes encoding Genetic variation Genetic variations growth factor IL10RB immune regulation in silico Infection lung damage Manifestations miRNA miRNAs Missense Mutation no symptom nucleotide Pathogenesis patients with COVID-19 polymorphism predicted progression protein sequence receptor receptors Severe acute respiratory syndrome silico studies Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs stability suggested Symptom TNFRSF1B variant Vascular vascular endothelial growth factor VEGFR2 Viral pneumonia was used website [DOI] 10.1111/iji.12522 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Entry Related Viral and Host Genetic Variations: Implications on COVID-19 Severity, Immune Escape, and InfectivitySARS-CoV-2 진입 관련 바이러스 및 숙주 유전자 변이: COVID-19 심각도, 면역 탈출 및 감염성에 미치는 영향Review Published on 2021-03-172022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Adhesion Molecule Affect angiotensin antiviral drugs binding Cell contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical determine driving drug enzyme escape Evolution genetic diversity genetic risk Genetic variation Genetic variations Genome geographical regions glycoprotein high risk Host host protein human population human populations immune Immune escape Impact in viral Infectivity integrin intercellular intercellular adhesion molecule Mutation Pathogenesis Pathogens Population Positive selection Precision protease Protein Receptor binding domain Research respiratory S glycoprotein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 S glycoprotein SARS-CoV-2 variant SARS-CoV-2 variants Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity spike glycoprotein susceptibility the cell the SARS-CoV-2 TMPRSS2 transmembrane transmembrane protease serine 2 Transmissibility Transmission variants Variation Viral viral evolution viral S virus virus transmissibility vital role vital roles [DOI] 10.3390/ijms22063060 PMC 바로가기 [Article Type] Review
Detecting SARS-CoV-2 variants with SNP genotypingSNP 유전자형으로 SARS-CoV-2 변이체 검출Research Article Published on 2021-02-242022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 변종, 치료기술, [키워드] 384-well plate 384-well plates Analysis circulating circulation clinical sample clinical samples collected costly detect evaluate Genetic variation Genetic variations Genotype genotypes genotyping identify information Laboratory marker MONITOR outbreak positive positive sample Probability qRT-PCR Randomly SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 variant SARS-CoV-2 variants screened sequenced Sequencing SNP SNP genotyping South tested Transmission variant variants Viral West [DOI] 10.1371/journal.pone.0243185 PMC 바로가기 [Article Type] Research Article