Activation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cellsResearch Published on 2022-01-182022-11-01 Journal: Cell & Bioscience [Category] COVID-19, [키워드] activate Activation acute respiratory syndrome caused Cell cellular coronavirus coronavirus disease COVID-19 Efficacy endogenous Fatty acid fatty acids Glutamine Glycolysis Host Infection inhibitor Intervention introduced investigated metabolism metabolite MHV Mitochondria mitochondrial metabolism mouse hepatitis mouse hepatitis virus NAD+ nicotinamide riboside NR pandemic pyruvate Replication reported Result SARS-CoV-2 significantly supplementary material suppress suppresse suppressed survival TCA cycle therapeutic Therapeutic molecule therapy for COVID-19 Transport viral replication virus virus-infected cell [DOI] 10.1186/s13578-021-00740-z PMC 바로가기 [Article Type] Research
Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis중증 COVID-19 환자의 입원 시 아미노산 대사가 크게 변경됨: 종단 표적 대사체학 분석 결과Observation Published on 2021-12-082022-09-10 Journal: Microbiology Spectrum [Category] SARS, 바이오마커, [키워드] acid acute phase addition Altered approach arginine biomarker signature Care citrulline clinical manifestation clinical manifestations Clinical severity complement complementary Course COVID-19 COVID-19 case COVID-19 cases COVID-19 patient COVID-19 patients Defense defense mechanisms Deprivation described disease Disease progression disease stage effective evaluate Evidence evidence of finding fluctuation fluctuations followed by functional Glutamine heterogeneity highlight hospitalized patient Host host defense immune response immune responses Infection inhibited knowledge Kynurenine list longitudinal longitudinal study M2 macrophage polarization Macrophage marker mechanism metabolic pathway metabolic pathways metabolism metabolite metabolites metabolomic metabolomic profiling metabolomic signature metabolomics molecular molecular mechanism molecular mechanisms ornithine outcome Pathogenesis pathogenesis of COVID-19 pathway Pathways Patient Phenylalanine profile SARS-CoV-2 SARS-COV-2 infection serum serum sample serum samples severity the disease time Tryptophan tyrosine Virus-host interactions [DOI] 10.1128/spectrum.00338-21 PMC 바로가기 [Article Type] Observation
The effect of glutamine supplementation on serum levels of some inflammatory factors, oxidative stress, and appetite in COVID-19 patients: a case-control studyClinical Trial Published on 2021-12-012022-10-05 Journal: Inflammopharmacology [Category] 임상, [키워드] age analyzed Appetite blood sample case-control study clinical status control group COVID-19 COVID-19 patient COVID-19 patients FIVE Gender Glutamine Health hospital IL1β IMPROVE increase inflammatory factors L-Glutamine Malnutrition oxidative stress Patient per day receive reduce reduced reducing respiratory infection Serum level significant increase significantly Stress therapy total antioxidant capacity Treatment tumor necrosis factor-α [DOI] 10.1007/s10787-021-00881-0 PMC 바로가기 [Article Type] Clinical Trial
Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage항체 생산으로의 이동 - 영양소, 신호 전달, 성숙한 B 계통의 세포 대사 프로그래밍 제공Review Published on 2021-11-152022-09-11 Journal: Cellular and Molecular Immunology [Category] Fulltext, MERS, 유전자 메커니즘, 진단, [키워드] antibody B lymphocyte Cell cell surface receptor cell surface receptors cell type cell types cellular cellular metabolism COVID cytokine Cytokines elicit enzyme exhibiting Fatty acid focus gene transcription Germinal centres Glucose Glutamine Glycoproteins immune defense Infection Intermediary metabolism interstitium lead Lineage Lymphocytes mechanism metabolism microbe microbes microenvironment molecular nutrient pandemic Plasma cell Plasma cells plasmablast plasmablasts programming proliferate receive Recognition regulate secrete secreted secreting secretion Signal transduction Signaling Somatic hypermutation Stage sustained the cells Transcription translation turn Vaccine [DOI] 10.1038/s41423-021-00782-w PMC 바로가기 [Article Type] Review
Effects of dietary supplementation with glutamine on the lymphocyte proliferation and intestinal immune gene expression in broiler chickens infected with Salmonella Enteritidisarticle Published on 2021-10-312024-09-01 Journal: Research in Veterinary Science [Category] 살모넬라증, [키워드] Broiler cytokine Glutamine Lymphocyte proliferation Salmonella Enteritidis [Article Type] article
Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19 Reviews Published on 2021-10-182022-10-05 Journal: Cell Death and Differentiation [Category] 바이오마커, 신약개발, 임상, 치료제, [키워드] Activation age Cancer cardiovascular diseases cascade cells characteristic complications COVID-19 COVID-19 cases deficiency described develop diabetes drug dysregulated Effect exacerbate Glutamine group groups High-risk patients human immunity hyperinflammation hypertension immune response include Infection lung metabolism metabolomics NAD+ NET Neutrophil extracellular traps obesity overproduced Pathologies pathophysiology pathway Patient predisposition Prevent profile Proinflammatory cytokine promote reduced regulatory T cells risk SARS-COV-2 infection SARS-CoV-2 vaccination severe COVID-19 severe COVID-19 patient Severe COVID-19 pneumonia STAT3 suggested suppressed the disease Treg while [DOI] 10.1038/s41418-021-00892-y [Article Type] Reviews
Improved Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents Targeting 3C and 3CL Proteases Including SARS-CoV-2 M proSARS-CoV-2 M pro를 포함한 3C 및 3CL 프로테아제를 표적으로 하는 항바이러스제에 사용되는 고리형 글루타민 유사체의 향상된 합성Article Published on 2021-09-172022-09-11 Journal: The Journal of organic chemistry [Category] SARS, 치료제, [키워드] 3CL agent Alanine Amino acid analogue Antiviral Compound conditions cyclic form Glutamine Improved Including lack M pro methodology oxime preparation Protease inhibitor purification reagent SARS-CoV-2 synthesis targeting yielding [DOI] 10.1021/acs.joc.1c01299 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variant evolution in the United States: High accumulation of viral mutations over time likely through serial Founder Events and mutational burstsSARS-COV-2 변이체 진화 미국에서 : 연쇄 창립자 사건 및 돌연변이 버스트를 통해 시간이 지남에 따라 바이러스 돌연변이의 높은 축적Research Article Published on 2021-07-232022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 변종, 치료기술, [키워드] accumulating additional Spike mutations Amino acid amino acid change amino acid changes B.1.1.7 burst caused Cohort Combination concerning COVID-19 death enzyme Evolution Evolution of SARS-CoV-2 Frequency furin furin cleavage site Genome Glutamine Infection Lineage low frequencies low frequency Mutation mutations nucleotide pandemic pattern predominant Prevalence prominence Protein quartile residue RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 variant sequence sequences single nucleotide variation single nucleotide variations SNVs spike Spike protein Spread summer super-spreader events the SARS-CoV-2 genome the Spike The United States United States vaccine platform variant variants of concern Variation Viral viral genome viral genomes viral isolates viral mutation Wuhan Wuhan, China [DOI] 10.1371/journal.pone.0255169 PMC 바로가기 [Article Type] Research Article
Incomplete Systemic Recovery and Metabolic Phenoreversion in Post-Acute-Phase Nonhospitalized COVID-19 Patients: Implications for Assessment of Post-Acute COVID-19 Syndrome급성기 비입원 COVID-19 환자의 불완전한 전신 회복 및 대사성 표현 전환: Post-Acute COVID-19 증후군 평가에 대한 시사점Article Published on 2021-06-042022-09-11 Journal: Journal of Proteome Research [Category] SARS, 치료기술, [키워드] acute COVID-19 acute respiratory syndrome adaptive amino acids Analysis analyzed Anosmia approach assessment Asymptomatic biochemical Biomarker Biomarkers blood sample Blood samples Chronic fatigue Control controls Correlation analysis cough COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients discriminant analysis Dyspnea elevated exhibiting Follow-up functional Functional assessment Glutamate Glutamine Glycoproteins greater healthy control healthy controls Hospitalized immune immune function in some Incomplete Infection joint joint pain Kynurenine Lipoproteins liver long-COVID long-COVID syndrome mass spectrometry metabolic Metabolic data metabolites Multiorgan multiorgan disease multiple parameter multiple parameters myalgia NMR nuclear magnetic resonance Other Pain parameter pathophysiology pathway Patient patients PCA phenoconversion phenoreversion phenotype plasma plasma samples Post-acute COVID-19 syndrome Principal component principal component analysis reduced reduction in remained resonance respiratory-related symptom respiratory-related symptoms rhinorrhea SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patient Severe acute respiratory syndrome Significant significantly significantly lower Spectrum Symptom symptomatic symptomatic patient Symptomatic patients syndrome systemic systemic inflammatory Taurine the healthy the patient tissue repair Tryptophan was normalized [DOI] 10.1021/acs.jproteome.1c00224 PMC 바로가기 [Article Type] Article
Importance of glutamine 189 flexibility in SARS-CoV-2 main protease: Lesson learned from in silico virtual screening of ChEMBL database and molecular dynamicsSARS-CoV-2 주요 프로테아제에서 글루타민 189 유연성의 중요성: ChEMBL 데이터베이스 및 분자 역학의 인실리코 가상 스크리닝에서 얻은 교훈Article Published on 2021-05-012022-09-11 Journal: European journal of pharmaceutical sciences : offi [Category] SARS, 치료제, [키워드] approved caused ChEMBL ChEMBL database Clinical management complexes Compound COVID-19 database evaluated filtered finger GLN189 global pandemic Glutamine Importance in silico include infected patient infected patients infection control inhibitor inhibitory activity lesson MD simulation mechanical ventilator molecular molecular docking molecular dynamics Molecular dynamics (MD) outbreak oxygen performed pharmacological pharmacophore Pharmacophore elucidation pharmacophores plasticity protease Protein target Repurposed drug Repurposed drugs S-protein SARS-CoV-2 SARS-CoV-2 main protease social distancing supplemental oxygen Support supportive care targets the SARS-CoV-2 therapeutic efficacy training set treating COVID-19 US-FDA Virtual screening were used WHO guideline [DOI] 10.1016/j.ejps.2021.105744 PMC 바로가기 [Article Type] Article