Preliminary investigation of gene expression levels of PAPP-A, STC-2, and HIF-1α in SARS-Cov-2 infected patientsArticle Published on 2022-09-012022-11-16 Journal: Molecular biology reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alteration Analysis Clinical data condition COVID-19 COVID-19 infection COVID-19 patients cytokine Cytokine storm demonstrated determine evaluated expression extracted RNA Gene Expression gene expression level gene expression pattern healthy individual HIF-1α individuals induce infected patient Infection influence Laboratory material molecular mRNA expression Other pandemic PAPP-A Patient patients with COVID-19 Peripheral blood positive correlation pro-inflammatory molecules Prognosis Real-time PCR SARS-CoV-2 Severe patient STC-2. stimulate target was used [DOI] 10.1007/s11033-022-07710-9 PMC 바로가기
SARS-CoV-2 vaccine-induced antibody and T cell response in SARS-CoV-1 survivorsArticle Published on 2022-08-302022-11-15 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody boost comparable coronavirus disease Coronavirus-2 CP: Immunology cross-reactive elicit healthy individual Immunity immunized induce memory T cells neutralization Neutralizing neutralizing antibody omicron robust SARS-CoV-1 SARS-CoV-1 survivors SARS-CoV-2 SARS-CoV-2 variant serum sample single dose survivor Survivors T cell response T cells the antibody response vaccination Vaccine variants of concern variants of concern. [DOI] 10.1016/j.celrep.2022.111284 PMC 바로가기
Anti-SARS-COV-2 specific immunity in HIV immunological non-responders after mRNA-based COVID-19 vaccinationArticle Published on 2022-08-262022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] antibody booster vaccination CD4 cell Cellular immune response Cohort control group correlated COVID-19 COVID-19 vaccination disease FIVE Follow-up healthy individual HIV HIV-1 Human immunodeficiency virus immune immune response immune responses Immunity immunological immunological non-responder (INR) Immunosuppression immunosuppression. individual lack mRNA-based non-responder Patient receive receiving SARS-CoV-2 SARS-COV-2 infection vaccinated against COVID-19 Vaccine [DOI] 10.3389/fimmu.2022.994173 PMC 바로가기
Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19심각하거나 치명적인 COVID-19에 대한 숙주 유전자 변이 및 감수성의 임상적 의미Review Published on 2022-08-192022-09-11 Journal: Genome Medicine [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advanced age age allergy Asymptomatic disease clinical clinical implications Clinical management clinical picture Comorbidities convergence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical deficiency develop Effects expected Factor Genetic genetic finding genetic screening Genetic variant Genetic variation healthy individual heterogeneous Host host genetics human immune response IFN-I Immunity implication indicate Infectious disease interferon Male sex malignancies manifestation Mendelian disorder Mendelian disorders modulate pandemic pathogenic variant pathway Pathways Patient Pneumonia predisposition Prevalence rare variant Rare variants risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe manifestations of COVID-19 shown susceptibility susceptibility loci the interferon TLR7 virus X-linked [DOI] 10.1186/s13073-022-01100-3 PMC 바로가기 [Article Type] Review
Humoral immune response characterization of heterologous prime-boost vaccination with CoronaVac and BNT162b2CoronaVac 및 BNT162b2를 사용한 이종 프라임-부스트 백신 접종의 체액 면역 반응 특성화Article Published on 2022-08-192022-09-12 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome ADCC ADCP Analysis anti-RBD anti-RBD IgG antibody antibody Antibody binding assays baseline binding domain binding kinetics BNT162b2 booster Cohort CoronaVac coronavirus decrease dose elapsed enrolled evaluated Fc-mediated function Fc-mediated functions Follow-up General population healthy individual Heterologous heterologous prime-boost heterologous vaccination high correlation humoral immune response IgG antibody IgG level immune immune response increase in individual Interaction mechanisms Neutralization assay Participants Prevent Prospective Study RBD RBD-ACE2 remained reporter SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. Seroconversion serological seronegative serum severe infections significantly to define vaccination vaccination schedule Vaccine [DOI] 10.1016/j.vaccine.2022.07.023 PMC 바로가기 [Article Type] Article
Differential gene expression profiling reveals potential biomarkers and pharmacological compounds against SARS-CoV-2: Insights from machine learning and bioinformatics approachesArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, 치료제, [키워드] acid approach bioinformatics caused Comorbidities complex interplay Compound contribute coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 progression Critical cyclosporine DEGs detect develop differentially expressed gene disease disease pathogenesis dysregulated E2F1 effort EGR1 expressed Factor functional functional enrichment Gene expression profiling Gene regulatory networks Genetic Genomics healthy controls healthy individual humans identify indicated individual individuals insight inter-individual Interaction machine learning approach MAX Mental mental retardation miRNA expression miRNAs nasopharyngeal network analysis offer Ontology overexpressed pandemic pathophysiology pathway pharmacological Potential biomarker Regulatory respiratory responsible reveal RNA-Seq RNA-seq data SARS-CoV-2 SARS-COV-2 infection Spread SRF TFS the SARS-CoV-2 therapeutic option therapeutic target therapeutic targets therapeutic targets. Vaccine Variability with COVID-19 YY1 [DOI] 10.3389/fimmu.2022.918692 PMC 바로가기
Improving taste sensitivity in healthy adults using taste recall training: a randomized controlled trial Research Published on 2022-08-162022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] asked assigned bitterness Concentration control group develop disorder healthy healthy individual IMPROVE Improving participant Patient Randomized controlled trial Randomly recall repeated sensitivity Therapeutic approach threshold [DOI] 10.1038/s41598-022-18255-z [Article Type] Research
Rheumatoid arthritis patients treated with Janus kinase inhibitors show reduced humoral immune responses following BNT162b2 vaccinationJanus kinase inhibitor로 치료받은 류마티스 관절염 환자, BNT162b2 백신 접종 후 체액성 면역 반응 감소Article Published on 2022-08-032022-09-12 Journal: Rheumatology (Oxford, England) [Category] SARS, 진단, [키워드] Activation alteration analysed anti-spike antibodies anti-Spike IgG Anti-spike IgG antibody antibodies antibody antibody titres Arthritis B cell B cell responses B cells B-lymphocytes BNT162b2 BNT162b2 vaccine collected COVID-19 COVID-19 vaccine determine dose Efficacy elicited ELISA expression germinal centre healthy individual healthy individuals humoral humoral immune response Humoral immunity IgA antibody individuals JAK inhibitor Janus kinase Janus kinase inhibitor Janus kinase inhibitors less mRNA-based COVID-19 vaccine neutralization activity Neutralization assay neutralization capacity Patient patients patients treated plasma plasma sample quantitative PCR reduced Rheumatoid rheumatoid arthritis SARS-CoV-2 SARS-COV-2 infection shown Spike protein suppressed the SARS-CoV-2 the vaccine titre treated vaccination Vaccine Vaccines Vaccines. Virus neutralization was reduced was used [DOI] 10.1093/rheumatology/keab879 PMC 바로가기 [Article Type] Article
Robust humoral and cellular immune responses in long-term convalescent COVID-19 individuals following one-dose SARS-CoV-2 inactivated vaccinationSARS-CoV-2 비활성화 백신 접종 후 장기간 회복 중인 COVID-19 개인의 강력한 체액 및 세포 면역 반응Article Published on 2022-08-012022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] addition anti-S Antigen antigen-specific T cell Antigen-specific T cells B cell booster caused CD4 Cellular immune response characterized convalescent COVID-19 death demonstrated Efficacy exhibited frequencies Frequency healthy healthy individual healthy individuals Hospitalization humoral IFN-γ IgG IL-2 immune immune responses inactivated Inactivated vaccine individual infected patient Infection long-term convalescent. NAbs Neutralizing antibodies neutralizing antibody neutralizing capacity RBD IgG RBD-specific IgG recipients recovered patient recovered patients robust SARS-CoV-2 SARS-CoV-2 inactivated vaccine SARS-CoV-2 RBD SARS-CoV-2 vaccine severe disease significantly significantly higher significantly increased single dose subject T cell T cell response T cell responses T cells the vaccine TNF-α utility vaccination Vaccine vaccine-induced immune response variants variants of concern VoC VOCs wild type [DOI] 10.3389/fimmu.2022.966098 PMC 바로가기 [Article Type] Article
Label-free electrochemical aptasensor for rapid detection of SARS-CoV-2 spike glycoprotein based on the composite of Cu(OH) 2 nanorods arrays as a high-performance surface substrate고성능 표면 기판으로서 Cu(OH) 2 나노로드 어레이의 합성물을 기반으로 한 SARS-CoV-2 스파이크 당단백질의 신속한 검출을 위한 무표지 전기화학 앱타센서Article Published on 2022-08-012022-09-11 Journal: Bioelectrochemistry (Amsterdam, Netherlands) [Category] SARS, 치료기술, 치료제, [키워드] addition aptamer Aptamer-based sensors carbon Chain Reaction characterized Combination complexes copper Copper hydroxide nanorods COVID-19 cross-reactivity decrease Detection limit diffraction dynamic range Efficiency electrode electron microscopy electron transfer evaluated exhibited feasibility glycoprotein healthy individual high stability hydroxide immobilization lAbel Microscopy PCR polymerase chain polymerase chain reaction probe provided repeatability reproducibility Saliva SARS-CoV-2 SARS-CoV-2 spike glycoprotein Screen sensitivity sick spike spike glycoprotein spike glycoprotein. transport medium Viral transport medium VTM was used X-ray X-ray diffraction [DOI] 10.1016/j.bioelechem.2022.108106 PMC 바로가기 [Article Type] Article