HIV, Human immunodeficiency virus – Page 2 – Communicable Diseases Research

SARS-CoV-2: Current trends in emerging variants, pathogenesis, immune responses, potential therapeutic, and vaccine development strategies

Review

Published on 2021-10-162022-10-04
Journal: International immunopharmacology [Category] MERS, SARS, 변종, 신약개발, 유전자 메커니즘,

Current diagnostic approaches to detect two important betacoronaviruses: Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Review

Published on 2021-07-242023-07-01
Journal: Pathology, research and practice [Category] SARS,

[키워드] 5’-UTR, 5’-untranslated region acpcPNA, pyrrolidinyl peptide nucleic acid ALI, Acute Lung Injury ASO, Antisense oligonucleotides BSL, biosafety level CDC, Centers for Disease Control and Prevention clinical CoV, coronavirus COVID-19, Coronavirus disease of 2019 CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats CT, Computed tomography CXR, chest radiography ddNTPs, dideoxynucleotide triphosphates Diagnosis DNA, Deoxyribonucleic acid dPCR, digital polymerase chain reaction EIA, Enzyme immunoassay ELISA, enzyme-linked immunosorbent assay EUA, Emergency Use Authorization FDA, Food and Drug Administration FIPV, feline infectious peritonitis virus Hel, helicase HIV, Human immunodeficiency virus ICU, Intensive care unit IFA, Immunofluorescence assay Laboratory LAMP, Loop-mediated isothermal amplification LoD, limit of detection LOQ, Limit of quantification MALDI-TOF, MassARRAY matrix-assisted laser desorption ionization-time of flight MERS-CoV MERS, Middle East respiratory syndrome MN, Microneutralisation MS, mass spectrometry NP, nucleocapsid protein NSP, Non-structural Proteins ORF, open reading frame OSN-qRT-PCR, One-step single-tube nested (OSN)-qRT-PCR PCR, polymerase chain reaction PFU, Plaque forming units POCT, Point of care testing ppNT, Pseudoparticle neutralization test PRNT, Plaque reduction neutralization test qPCR, Quantitative or real-time polymerase chain reaction qRT-PCR, Real-time reverse transcription polymerase chain reaction RAD, Rapid antigen test radiological RBD, receptor binding domain RdRp, RNA-dependent RNA polymerase RFLP, restriction fragment length polymorphism RNA, Ribonucleic acid RSV, respiratory syncytial virus RT-iiPCR, Reverse transcription-insulated isothermal polymerase chain reaction RT-RPA, Reverse transcription recombinase polymerase amplification SARS-CoV-2 SARS, Severe acute respiratory syndrome SNP, single nucleotide polymorphism TCID, Tissue Culture Infectious Dose TRPMSS2, Type II transmembrane serine protease upE, Regions upstream of gene E VOC, variants of concern VOHC, Variant of High Consequence VOI, variant of interest VUM, variant under monitoring WGS, Whole-genome sequencing WHO, World Health Organization
[DOI] 10.1016/j.prp.2021.153565 PMC 바로가기 [Article Type] Review

Chemotherapy vs . Immunotherapy in combating nCOVID19: An update

Review

Published on 2021-05-182023-07-01
Journal: Human immunology [Category] SARS,

[키워드] AAK1, AP2-associated protein kinase 1 ACE2 ARDS, acute respiratory distress syndrome ARDS1, Acute respiratory distress syndrome1 ATP, adenosine triphosphate AZT, Azithromycin BCG, Bacillus Calmette-Guerin vaccine CM, Camostat mesylate COVID-19 COVID19, Coronavirus disease CSIR-IICT, Council of Scientific and Industrial Research’s Indian Institute of Chemical Technology CT, Computed tomography drugs ERGIC, ER-Golgi intermediate compartment FDA, Federal drug administration GERD, gastroesophageal reflux disease GERD1, Gastroesophageal reflux disease1 GM-CSF, granulocyte-macrophage colony-stimulating factor GOIMHRD, Government of India Ministry of Health & Family Welfare HIV, Human immunodeficiency virus IFN, interferon IL, interleukin immunomodulation IMPDH, Inosine monophosphate dehydrogenase IMPDH1, Inosine monophosphate dehydrogenase1 IMQ, Imiquimod JAK, Janus kinase LMWH, low molecular weight heparin MERS, Middle East respiratory syndrome PAMP, Pathogen associated molecular pattern molecules Plasma-therapy RA, Rheumatoid arthritis RBD, receptor-binding domain RCT, Randomized controlled trial RdRp, RNA-dependent RNA polymerase RSV, Severe respiratory syncytial virus RT-PCR, Real-time fluorescence reverse-transcription polymerase chain reaction SARS-CoV-2 SARS, Severe acute respiratory syndrome SIC, Sepsis-induced coagulopathy SLE, systemic lupus erythematosus Spike protein STAT, signal transducers and activators of transcription TLR TMPRSS2, transmembrane protease, serine 2 TNF, Tumor Necrosis Factor Vaccines WHO, World Health Organization
[DOI] 10.1016/j.humimm.2021.05.001 PMC 바로가기 [Article Type] Review

Lipid homeostasis and mevalonate pathway in COVID-19: Basic concepts and potential therapeutic targets

Review

Published on 2021-04-262023-06-15
Journal: Progress in lipid research [Category] MERS, SARS,

[키워드] ACE2, angiotensin converting enzyme 2 BPs, bisphosphonates cholesterol CMV, human cytomegalovirus CoV, coronavirus DENV, dengue virus EBOV, Ebola virus FDPS, farnesyl diphosphate synthase HCV, hepatitis C virus HDL, high-density lipoprotein HIV, Human immunodeficiency virus HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase IAV, influenza A virus IFN, interferon IL, interleukin KSHV, Kaposi's sarcoma-associated herpesvirus LDL, low-density lipoprotein lipid homeostasis LXR, liver X receptor MβCD, methyl-β-cyclodextrin MERS, middle-East respiratory syndrome Mevalonate pathway inhibitors Mpro, SARS-CoV-2 main protease MVA, mevalonate PI, phosphatidil-inositol RSV, respiratory syncytial virus SARS-CoV-2 SARS, Severe acute respiratory syndrome SREBP, sterol regulatory element binding protein statins T_reg, T regulatory cells TMPRSS2, Transmembrane Protease Serine 2 viral infections VZV, Varicella zoster virus WNV, West Nile virus ZIKV, Zika virus
[DOI] 10.1016/j.plipres.2021.101099 PMC 바로가기 [Article Type] Review

In pursuit of sensitivity: Lessons learned from viral nucleic acid detection and quantification on the Raindance ddPCR platform

Review

Published on 2021-04-092023-06-16
Journal: Methods (San Diego, Calif.) [Category] COVID19(2023년), MERS, SARS,

[키워드] cART, combination antiretroviral therapy COVID-19, Coronavirus disease 2019 CT, Computed tomography Ct, threshold cycle Cure research ddPCR, droplet digital polymerase chain reaction digital PCR dMIQE, Minimum Information for Publication of Quantitative digital PCR experiments DNA dPCR, digital PCR FFPE, formalin-fixed paraffin-embedded HIV HIV, Human immunodeficiency virus HO, high occupancy HPV, Human Papillomavirus HTLV, human T-cell leukaemia virus Infectious diseases LoD, limit of detection MGB, minor groove binder MiRNA, MicroRNA NGS, next generation sequencing NHP, Non-human primate PCR sensitivity PIV, parainfluenza virus qPCR, quantitative (real time) polymerase chain reaction RNA RSV, respiratory syncytial virus RT-dPCR, reverse transcription digital polymerase chain reaction RT-qPCR, quantitative reverse transcription (real time) polymerase chain reaction RT, reverse transcriptase SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS, Severe acute respiratory syndrome SIV, simian immunodeficiency virus SNP, single nucleotide polymorphism SNV, single nucleotide variant STLV-1, simian T cell lymphotropic viruses type 1 STLV-2, simian T cell lymphotropic viruses type 2 Tm, melting temperature virus
[DOI] 10.1016/j.ymeth.2021.04.008 PMC 바로가기 [Article Type] Review

Focused role of nanoparticles against COVID-19: Diagnosis and treatment

Review

Published on 2021-04-062023-06-15
Journal: Photodiagnosis and photodynamic therapy [Category] MERS, SARS,

[키워드] 2019-nCoV, severe acute respiratory syndrome coronavirus 2 Ag-MES, silver nanoparticle capped with mercaptoethane sulfonate AMT, 4′-aminomethyl-trioxsalene ARDS, acute respiratory distress syndrome AuNP-ab, gold-antibody nanoparticle BAL, bronchoalveolar lavage cDNA, complementary DNA COVID-19 COVID-19, coronavirus disease CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats CT, Computed tomography Diagnosis EHEC, enterohemorrhagic Escherichia coli ELISA, enzyme-linked immunosorbent assay ergic, endoplasmic reticulum-golgi intermediate compartment EUA, Emergency Use Authorization FDA, Food and Drug Administration FISH, fluorescent in situ hybridization G-CSF, (Granulocyte colony-stimulating facto) GQD, graphene quantum dot GSH, glutathione HBV, hepatitis B virus HCV, hepatitis C virus HIV, Human immunodeficiency virus HSV-1, herpes Simplex type-1 virus IC, inhibitory concentration ICU, Intensive Care Units IFN-γ, interferon gamma IGG, immunoglobulin g IGM, immunoglobulin m IP10, 10 Kda interferon gamma-induced protein LAMP, Loop-mediated isothermal amplification MagLev, magnetic levitation MB, methylene blue MCP1, monocyte chemoattractant protein-1 MERS-CoV, Middle East respiratory syndrome coronavirus MHV-A59, mouse coronavirus MWCNTs, multi-walled carbon nanotubes NagC, nano-silver colloids nanomedicine Nanoparticles PCR, polymerase chain reaction PDI, photodynamic inactivation PDT, photodynamic therapy PICALM, phosphatidylinositol binding clathrin assembly protein PS, photosensitizer PTAF, photocatalytic titanium apatite filter RCA, rolling circle amplification RdRp, RNA-dependent RNA polymerase RNA, Ribonucleic acid ROS, reactive oxygen species RPA, recombinase polymerase amplification RT-PCR, Reverse transcription polymerase chain reaction SARS-CoV, severe acute respiratory syndrome coronavirus SPION, superparamagnetic iron oxide nanoparticles Th2, T-helper-2 TNFα, Tumor necrosis factor alpha TPPS2a, tetraphenyl porphyrin disulphonate treatment protocols USFDA, United States Food And Drug Administration UV, ultraviolet WHO, World Health Organization
[DOI] 10.1016/j.pdpdt.2021.102287 PMC 바로가기 [Article Type] Review

Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning

Article

Published on 2021-03-302023-06-16
Journal: Computers in biology and medicine [Category] MERS, SARS,

[키워드] ACE2, angiotensin converting enzyme 2 artificial intelligence AUC, area under the curve Chemotherapy COVID-19 COVID-19, Coronavirus disease 2019 FDA, Food and Drug Administration HIV, Human immunodeficiency virus Infectious diseases LBE, lowest binding energy MERS, Middle East respiratory syndrome natural products ROC, Receiver Operating Characteristic SARS, Severe acute respiratory syndrome ssRNA, single-stranded RNA virus WHO, World Health Organization
[DOI] 10.1016/j.compbiomed.2021.104359 PMC 바로가기 [Article Type] Article

Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2

Original Article

Published on 2021-03-032023-06-15
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS,

[키워드] Nerium oleander ALP, alkaline phosphatase ALT, alanine transaminase antiviral activity ATP, adenosine triphosphate BDNF, brain-derived neurotrophic factor BSA, bovine serum albumin COVID-19 CPE, cytopathic effect DMSO, dimethyl sulfoxide DPBS, Dulbecco’s phosphate-buffered saline DPI, day post infection EC₅₀, half maximal effective concentration ELISA, enzyme-linked immunoassay FBS, fetal bovine serum H&E, hematoxylin and eosin HIV, Human immunodeficiency virus HTLV-1, human T-lymphotropic virus LDH, lactic dehydrogenase mAb, monoclonal antibody MERS, Middle East respiratory syndrome NP, nucleocapsid protein Nrf-2, nuclear factor erythroid 2-related factor 2 Oleandrin PFU, plaque-forming unit qRT-PCR, real-time quantitative polymerase chain reaction Reduced infectivity RNA, Ribonucleic acid SARS-CoV-2 SARS, Severe acute respiratory syndrome
[DOI] 10.1016/j.biopha.2021.111457 PMC 바로가기 [Article Type] Original Article

Underscoring the immense potential of chitosan in fighting a wide spectrum of viruses: A plausible molecule against SARS-CoV-2?

Review

Published on 2021-02-162023-06-15
Journal: International journal of biological macromolecules [Category] MERS, SARS,

An update review of emerging small-molecule therapeutic options for COVID-19

Review

Published on 2021-02-032023-06-15
Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, SARS,

[키워드] 3C-like protease (3CL^pro) 3CL^pro, 3C-Like protease 6MP, 6-Mercaptopurine 6TG, 6-Thioguanine ACE2, angiotensin-converting enzyme 2 AMPK, AMP-activated protein kinase BECN1, Beclin1 BSAs, Broad-spectrum antiviral drugs CMK, Decanoyl-RVKR-chloromethylketone Coronaviruses CoV, coronavirus COVID-19, 2019 coronavirus disease CPE, cytopathic effect CQ, Chloroquine DAAs, Direct-acting antiviral agents DHO, Dihydroorotate DHODH, dihydroorotate dehydrogenase E, Envelope protein EBOV, Ebola virus ELs, Endolysosomes EUA, Emergency Use Authorization FDA, US Food and Drug Administration GM1, Monosialotetrahexosylganglioside 1 GTP, Guanosine triphosphate HA, Haemagglutinin HC, QHydroxychloroquine HIV, Human immunodeficiency virus HTAs, Host-targeting antivirals HyCoSuL, Hybrid Combinatorial Substrate Library IFN, interferon IMPDH, Inosine monophosphate dehydrogenase IRF3, interferon regulatory factor 3 LPV/r, Lopinavir/ritonavir M, Membrane protein M^pro, main protease MERS-CoV, Middle East respiratory syndrome coronavirus N, nucleocapsid protein NIAID, National Institute of Allergy and Infectious Diseases nsps, Non-structural proteins papain-like protease (PL^pro) PC, Pro-protein Convertase PIP2, Phosphatidylinositol 4,5-bisphosphate PL^pro, Papain-like protease PP2A, Protein phosphatase 2A RBV, Ribavirin RDP, Ribavirin diphosphate RdRp, RNA-dependent RNA polymerase RMP, Ribavirin monophosphate RNA-dependent RNA polymerase (RdRp) RTP, Ribavirin triphosphate S, spike protein SAR, Structure-activity relationship SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus SKP2, S-Phase kinase-associated protein 2 TGN, Trans-Golgi Network Transmembrane serine protease (TMPRSS2) WHO, World Health Organization
[DOI] 10.1016/j.biopha.2021.111313 PMC 바로가기 [Article Type] Review