SperoPredictor: An Integrated Machine Learning and Molecular Docking-Based Drug Repurposing Framework With Use Case of COVID-19SPEROPDICTOR : COVID-19의 사용 사례와 함께 통합 된 기계 학습 및 분자 도킹 기반 약물 재검사 프레임 워크Article Published on 2022-06-162022-08-31 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 신약개발, [키워드] Accuracy association candidate clinically collected contagious contagious disease coronavirus costly COVID-19 data analytics database databases dataset de novo death disease drug drug candidate Drug discovery Drug repurposing effective effort Extensive FDA approval FDA-approved drug FDA-approved drugs feature Features followed by forest framework generic drug Gradient Host host proteomes human host indicated inefficient machine learning molecular docking molecular docking. pandemic Pandemics platform predicted proteome Random forest rapid response reduce repurposing Research resulting SARS Coronavirus SARS coronavirus 2 SARS-CoV-2 Spread spread of COVID-19 systematic review Threats Traditional tree trees variant [DOI] 10.3389/fpubh.2022.902123 PMC 바로가기 [Article Type] Article
Conserved Pattern and Potential Role of Recurrent Deletions in SARS-CoV-2 EvolutionSARS-CoV-2 진화에서 보존된 패턴 및 반복 삭제의 잠재적 역할Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] adaptive adaptive evolution addition association binding site Combination coronavirus COVID-19 deleted Deletion deletions described disease distribution Epidemic Evidence Evolution functions genome structure greater Host human host indicated insertion insertions integration means Mutation N-terminal domain Neutralizing antibodies NSP6 nucleotide nucleotide change occurred pattern Potential Prevention and control Previous studies proliferation Protein RDRs Receptor binding domain Recurrent recurrent deletion Region regions reported role SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-related coronavirus SARS-related coronaviruses single nucleotide Spike protein Strains Structural variation structural variation. structural variations the spike protein the WHO unique Vaccine development variant variants variants of concern variants of interest Variation Viral viral genome virus Virus evolution viruses VoC whole genome worldwide pandemic Δ144 Δ69-70 [DOI] 10.1128/spectrum.02191-21 PMC 바로가기 [Article Type] Article
Comparative Analysis of SARS-CoV-2 Variants of Concern, Including Omicron, Highlights Their Common and Distinctive Amino Acid Substitution Patterns, Especially at the Spike ORF오미크론을 포함한 우려되는 SARS-CoV-2 변이체의 비교 분석은 특히 스파이크 ORF에서 공통적이고 독특한 아미노산 치환 패턴을 강조합니다Comparative Study Published on 2022-03-292022-09-11 Journal: Viruses [Category] SARS, 변종, [키워드] acid Alpha Amino acid amino acid substitution amino acid substitutions analysis Beta common Comparative concern COVID-19 Delta dN/dS Evolution Gamma highest homologous hotspot human host Hypothesis Including introduced investigated Lambda Lineage lineages mutated mutations omicron ORF phylogenetic distribution Point mutation Positive selection RBD Receptor binding domain Recombination recurrent mutations residue Sarbecoviruses SARS-CoV-2 significantly higher spike Substitution the Spike vaccination variant variants variants of concern variants of concern. was performed [DOI] 10.3390/v14040707 PMC 바로가기 [Article Type] Comparative Study
Cardiorenal Disease in COVID-19 PatientsCOVID-19 환자의 심혈관 질환Review Published on 2022-03-182022-09-11 Journal: Journal of the Renin-Angiotensin-Aldosterone Syste [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association Atherosclerosis Cardiorenal Disease caused coding Comorbidities Comorbidity Complication component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical diabetes disease Endothelial dysfunction enzyme fusion Genetic heart failure high mortality rate human host hypertension Increased indicate management mechanism metabolic syndrome morbidity Novel coronavirus progression recent receptor renal renal disease Research SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity Spike proteins syndrome the disease the spike protein Variation variations virus with COVID-19 [DOI] 10.1155/2022/4640788 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Spike Protein 1 Activates Microvascular Endothelial Cells and Complement System Leading to Platelet AggregationSARS-CoV-2 스파이크 단백질 1은 미세혈관 내피 세포 및 보체 시스템을 활성화하여 혈소판 응집을 유도합니다Article Published on 2022-03-072022-09-11 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] ACE2 Activation addition adhesive molecule aggregate aggregation AMPK amplified Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antibody blockade blocking antibody Blot C3a C5a circulating complement Complement activation complement inhibitors complement system complexity conditions coronavirus disease Coronavirus disease 2019 COVID-19 detection element ELISA endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction enzyme evaluated Exocytosis experiment expression human host immunofluorescence incubated induce infect Inflammation Inflammatory inhibitors investigated leading leukocyte lung Microvascular thrombosis microvasculature Mortality multiorgan failure P-selectin performed phenotype Platelet platelet aggregation pro-inflammatory recruitment replicate robust S1 protein SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike protein 1 selectin sera severe COVID-19 patient severe COVID-19 patients significant level spike Spike protein System thromboembolic thromboembolic complication thromboembolic complications thrombomodulin thrombosis thrombosis. thrombotic thrombotic complication Thrombotic complications viral infection von Willebrand factor were assessed western blot Western blot analysis [DOI] 10.3389/fimmu.2022.827146 PMC 바로가기 [Article Type] Article
Evolution of the SARS-CoV-2 spike protein in the human hostArticle Published on 2022-03-042022-10-04 Journal: Nature Communications [Category] MERS, SARS, 변종, [키워드] ACE2 binding ACE2 receptor acquisition Alpha Alpha variant B.1.1.7 B.1.351 Beta binding changes in cleavage Combination Cryoelectron microscopy D614G Delta dependent on Evolution examined furin site greater transmissibility human host humans K417N Mutation N501Y Neutralising Antibodies observation omicron receptor receptor ACE2 Receptor binding receptor-binding domains required SARS-CoV-2 SARS-CoV-2 spike spike spike glycoprotein Spike protein spike trimer stability Substitution the SARS-CoV-2 Transmission variant variant spike variants of concern variants of SARS-CoV-2 viral evolution virus virus virus pathogenesis [DOI] 10.1038/s41467-022-28768-w PMC 바로가기 [Article Type] Article
The Slowing Rate of CpG Depletion in SARS-CoV-2 Genomes Is Consistent with Adaptations to the Human HostSARS-CoV-2 게놈에서 CpG 고갈의 둔화 속도는 인간 숙주에 대한 적응과 일치합니다Discoveries Published on 2022-03-032022-09-10 Journal: Molecular Biology and Evolution [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adaptation alpha- analyzed Antiviral antiviral protein Beta coding regions codon positions Coronavirus-2 CpG CpG depletion Depletion dinucleotide driven by equilibrium Evidence Evolution full-length SARS-CoV-2 genome Genome genomes help highest highlight Host Human human host immune immune responses Infection innate immune responses Loss majority motif motifs occur pandemic Rate reduced representing respiratory SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes selection pressure sequence sequences severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Temporal temporal variation TLR7 variants of concern Variation variations virus Virus evolution virus genome virus genomes virus replication ZAP ZAP-binding motif Zinc [DOI] 10.1093/molbev/msac029 PMC 바로가기 [Article Type] Discoveries
Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemicCOVID-19 전염병 전반에 걸친 SARS-CoV-2 동의어 코돈 사용 진화 분석Article Published on 2022-03-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] accompanied analysis antagonistic Betacoronavirus bioinformatic analysis codon codon adaptation index codon usage Codon usage bias Codons collected Complete coronavirus COVID-19 COVID-19 pandemic decrease effective Evolution Evolution of SARS-CoV-2 Genome human host humans infect less life-threatening pathogenic Perspective respiratory pathologies SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2. synonymous [DOI] 10.1016/j.virol.2022.01.011 PMC 바로가기 [Article Type] Article
Iron dysregulation in COVID-19 and reciprocal evolution of SARS-CoV-2: Natura nihil frustra facitCOVID-19의 철 조절 장애와 SARS-CoV-2의 상호 진화: 자연적 현실Meta-Analysis Published on 2022-03-012022-09-11 Journal: Journal of cellular biochemistry [Category] SARS, 변종, [키워드] accompanied acquired immunity Analysis binding booster component conserved COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patients Defense Deterioration docking dysregulated dysregulation Evolution evolved variants Extensive ferritin ferritin-transferrin paradox Ferroportin followed by functional greater transmissibility Healthcare system hepcidin hospitalized patients Host host defense host proteases host range human host hypoxia immune evasion Immunity immunopathology in-silico Infection internalization involved iron iron homeostasis iron homeostasis. Iron metabolism iron overload lung MD simulation MD simulations mechanism Meta-analysis metabolism molecular molecular mimicry Mutation New omicron Omicron variant Pathogenesis pathway Patient peptide positive Prognosis protease Proteases provide responsible SARS-COV-2 infection selective Septic shock sequence serum severe COVID-19 severe disease Severe infection Severe patient severe patients shown Spike protein Spike protein sequence strain Structural analysis the spike protein tissue Transferrin vaccination variant variants variants of SARS-CoV-2 Viral load viral spike protein [DOI] 10.1002/jcb.30207 PMC 바로가기 [Article Type] Meta-Analysis
SARS-CoV-2 competes with host mRNAs for efficient translation by maintaining the mutations favorable for translation initiationSARS-CoV-2는 번역 개시에 유리한 돌연변이를 유지함으로써 효율적인 번역을 위해 숙주 mRNA와 경쟁합니다Article Published on 2022-02-012022-09-11 Journal: Journal of applied genetics [Category] COVID19(2023년), SARS, 변종, [키워드] Algorithm amplifying analysis applied binding CDS coding sequence coding sequences energy Evolution of SARS-CoV-2 fixed GC content host mRNA Human human gene human genes Human genome Human genomes human host less molecular Mutation pandemic proliferation retrieved RNA RNA structure RNAs SARS-CoV-2 SARS-CoV-2 genes the SARS-CoV-2 translation translation initiation translation. understanding Viral RNA viral RNAs [DOI] 10.1007/s13353-021-00665-w PMC 바로가기 [Article Type] Article