Evaluation of methylene blue based photodynamic inactivation (PDI) against intracellular B-CoV and SARS-CoV2 viruses under different light sources in vitro as a basis for new local treatment strategies in the early phase of a Covid19 infectionCovid19 감염 초기 단계의 새로운 국소 치료 전략의 기초로서 시험관 내 다양한 광원에서 세포 내 B-CoV 및 SARS-CoV2 바이러스에 대한 메틸렌 블루 기반 광역학 불활화(PDI) 평가Article Published on 2022-03-012022-09-11 Journal: Photodiagnosis and photodynamic therapy [Category] SARS, 치료기술, [키워드] Antiviral aPDT (antimicrobial photodynamic therapy). approach Cell Concentration Corona viruses dark dose early phase experiment Extracellular in vitro inactivation Incubation infected cell infected cells Infection intensity Laser Local logarithmic reduction low dose Methylene Methylene blue nose and throat PDI PDI (photodynamic inactivation) phenothiazine Phenothiazine dye in aPDT photodynamic inactivation photodynamic therapy photosensitizer Prognosis radiation intensity reducing reduction SARS-CoV-2 SARS-CoV-2 inactivation SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV2 sensitizer substitute therapy treated treatment strategy Vero E6 Viral load virus was reduced [DOI] 10.1016/j.pdpdt.2021.102642 PMC 바로가기 [Article Type] Article
Shorter Incubation Period among Unvaccinated Delta Variant Coronavirus Disease 2019 Patients in Japan일본의 2019년 델타 변종 코로나바이러스 백신 접종하지 않은 환자의 잠복기 단축Article Published on 2022-01-202022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 변종, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus Bayesian calculated coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 credible interval Delta delta variant distribution enrolled exposure to Incubation Incubation period Japan L452R Mann–Whitney U test mean incubation period Mutation P -value Patient Period respiratory SARS-CoV-2 Serial interval severe acute respiratory syndrome Coronavirus statistical framework Strains Transmission dynamics transmission time relative to symptom onset unvaccinated variant virus [DOI] 10.3390/ijerph19031127 PMC 바로가기 [Article Type] Article
Distinguishing Incubation and Acute Disease Stages of Mild-to-Moderate COVID-19경증에서 중등도의 COVID-19의 배양 및 급성 질환 단계의 구별Article Published on 2022-01-202022-09-01 Journal: Viruses [Category] 진단, [키워드] Activation acute disease acute infection admittance Anti-inflammatory Anti-viral antibodies baseline blood sample characterized clinician Concentration controls correlated COVID-19 COVID-19 patient COVID-19 patients cytokine Cytokines Cytometry Cytotoxic T cells Definition Diagnosis disease phases disease stage disease stages distinguishing Donor elevated Flow flow cytometry healthy donors help hospital ill patient immature neutrophil immune Immune cell immune response immune responses immunoglobulins increase in Incubation IP-10 Kinetics Monocytes Neutrophils outcomes parameter PD-1 Peripheral blood plasma Plasma levels plasmablast plasmablasts Prevent pro-inflammatory monocyte pro-inflammatory monocytes progressed refinement returned SARS-CoV-2 SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody Seven significantly specific antibodies Stage T cells terminally differentiated to define trajectory Treatment venipuncture virus was performed while [DOI] 10.3390/v14020203 PMC 바로가기 [Article Type] Article
Thiol-sensitive probe enables dynamic electrochemical assembly of serum protein for detecting SARS-Cov-2 marker protease in clinical samples티올에 민감한 프로브는 임상 샘플에서 SARS-Cov-2 마커 프로테아제를 검출하기 위한 혈청 단백질의 동적 전기화학적 조립을 가능하게 합니다.Article Published on 2021-12-152022-09-11 Journal: Biosensors & bioelectronics [Category] SARS, 치료기술, 치료제, [키워드] Clinical practice clinical sample Concentration COVID-19 fluorescent incorporation Incubation induce infected patient infected patients Interaction main protease marker mimicking molecule network nucleic acid Nucleic acid detection peptide Peptide nano-network probe protease Protein Region SARS-CoV-2 sensitivity serum Serum protein serum samples spreading target target protein thiol thiol group Thiol probe. virus virus assay while [DOI] 10.1016/j.bios.2021.113579 PMC 바로가기 [Article Type] Article
Effects of prolonged incubation period and centralized quarantine on the COVID-19 outbreak in Shijiazhuang, China: a modeling studyResearch Article Published on 2021-12-072022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] 95% CI age analyzed Asymptomatic available data Characteristics Contact tracing COVID-19 COVID-19 outbreak cumulative diagnosed Diagnosis Effect Epidemic epidemiological Epidemiology evaluated identify implementation Incubation Incubation period indicated information Intervention Isolation likelihood Local male measure Monte Carlo method Non-pharmaceutical intervention nucleic acid occur occurred outbreak Patient quarantine reduce reduced Result secondary transmission SEIR SEIR model Sex suggested supplementary material symptomatic symptoms onset virus transmission were used [DOI] 10.1186/s12916-021-02178-z PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 S1 Protein Induces Endolysosome Dysfunction and Neuritic DystrophyCellular Neuroscience Published on 2021-10-272022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] Brain Cell contribute cortical COVID-19 pandemic cross Dystrophy endocytosis endolysosomal acidification endolysosome Hypothesis incidence Incubation induce Injury lysosome membranes morphology neuritic dystrophy Neurological disorder Neuron neuronal neurons Pathogenesis released reported SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 S1 protein specimens tested the S1 protein undetectable with COVID-19 [DOI] 10.3389/fncel.2021.777738 PMC 바로가기 [Article Type] Cellular Neuroscience
The Effects of “Dry Swab” Incubation on SARS-CoV-2 Molecular TestingSARS-CoV-2 분자 테스트에 대한 "건조 면봉" 배양의 효과Article Published on 2021-09-012022-09-12 Journal: The journal of applied laboratory medicine [Category] SARS, 진단, [키워드] Accuracy average COVID-19 Ct value cycle threshold Effect evaluated incubated Incubation inoculated media medium mitigate molecular molecular testing. no statistical difference positive protocol provided repeated risk Roche SARS-CoV-2 specimen stability Swab swabs temperature tested Testing Transport Transport media UTM viral transport media VTM was performed was used [DOI] 10.1093/jalm/jfab010 PMC 바로가기 [Article Type] Article
Protective Effects of Astodrimer Sodium 1% Nasal Spray Formulation against SARS-CoV-2 Nasal Challenge in K18-hACE2 MiceK18-HACE2 마우스에서 SARS-COV-2 코 챌린지에 대한 아스 토드리머 나트륨 1% 코 스프레이 제제의 보호 효과Article Published on 2021-08-202022-08-31 Journal: Viruses [Category] MERS, SARS, 치료기술, 치료제, [키워드] administration animal animal model animals anti-SARS-CoV-2 Antiviral astodrimer blocked Brain challenge chemokine COVID-19 Cytokines Day dendrimer detectable Effect Efficacy Formulation hACE2 IL-1 IL-1α IL-1β IL-6 Incubation infected intranasally Infection Infectious virus intranasally K18-hACE2 K18-hACE2 mice lack liver lung MCP-1 nasal Nasal cavity Nasal spray neutralisation pathogen PBS Post-infection pro-inflammatory cytokine pro-inflammatory cytokines product PROTECT reduced reducing reduction reduction in SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication secretion serum severity of COVID-19 significantly sodium SPL7013 spray Strategy TGFβ These data TNFα Trachea treated Treatment undetectable Viraemia Viral viral genome viral replication viral shedding virus virus replication virus transmission was used were infected [DOI] 10.3390/v13081656 PMC 바로가기 [Article Type] Article
COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of CanakinumabCOVID19 관련 심근 세포 기능 장애, 부정맥 및 카나 키누맙의 효과Research Article Published on 2021-08-192022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 신약개발, 진단, [키워드] addition aims amplitude Anti-inflammatory therapy approach ARDS arrhythmia Arrhythmias baseline canakinumab cardiac function cardiac injury Cell cellular Co-incubation coronavirus coronavirus disease COVID19 COVID19 patient COVID19 patients cytokine cytokine release cytosolic decrease dysfunction Effect electrical evaluated event exposure to had no ICU IL-1β impaired cardiac function In-vitro Incubation Inflammatory response intensive care intensive care unit investigated Isolated LVEF membrane Microscopy mitigate Mortality no effect nuclear occur Patient patients pharmacological Precision RAT Result SARS-CoV-2 sensitivity serum severe ARDS Signaling significantly stem cell therapeutic potential veno-venous extracorporeal membrane oxygenation ventricular [DOI] 10.1371/journal.pone.0255976 PMC 바로가기 [Article Type] Research Article
Severe Acute Respiratory Syndrome Coronavirus-2 Inactivation Activity of the Polyphenol-Rich Tea Leaf Extract with Concentrated Theaflavins and Other Virucidal Catechins중증 급성 호흡기 증후군 코로나바이러스-2 농축 테아플라빈 및 기타 바이러스성 카테킨을 함유한 폴리페놀이 풍부한 찻잎 추출물의 불활성화 활성Article Published on 2021-08-082022-09-10 Journal: Molecules [Category] MERS, SARS, 치료제, [키워드] absence activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed auxiliary catechin Cell Cell culture cell culture medium cells coronavirus culture media culture medium death ENhance evaluate evaluated Extract Genome Impact in vitro incubated Incubation Infection inhibited inhibition activity leaf Measures media Other polyphenol producing provided real-time RT-PCR replaced respiratory RT-PCR S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus structural protein structural proteins suggested tea tea leaf extract the cell the cells the S protein theaflavin Treatment Ty-1 Viral viral genome Viral protein Viral proteins Viral RNA viral titer viral titers virucidal virucidal activity western blotting [DOI] 10.3390/molecules26164803 PMC 바로가기 [Article Type] Article