innate and adaptive immunity – Page 2 – Communicable Diseases Research

What we know and still ignore on COVID‐19 immune pathogenesis and a proposal based on the experience of allergic disorders

Review

Published on 2021-10-122023-06-15
Journal: Allergy [Category] COVID19(2023년), MERS, SARS,

Critical COVID-19 is associated with distinct leukocyte phenotypes and transcriptome patterns

중요한 COVID-19는 뚜렷한 백혈구 표현형 및 전사체 패턴과 관련이 있습니다

Article

Published on 2021-09-012022-09-11
Journal: Journal of internal medicine [Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] (PD-1 activated adaptive Admission affecting Alpha analysed B cells B-cell Bacterial sepsis Blood calprotectin CD25 CD4 CD8 T cells characterized classical monocytes cohort study collected comparable controls COVID-19 COVID-19 patient COVID-19 severity Critical disease disease severity Exhaustion exhibited expression flow cytometry groups healthy control healthy controls HLA-DR Hospitalization immune function immune functions Immune phenotype Immune profile immune response Immunity innate and adaptive immunity leukocyte marker monocyte Monocytes mononuclear cell mononuclear cells naïve Non-classical monocytes pathway Patient PBMCs PD-1 PD-L1 peripheral Peripheral blood Peripheral blood mononuclear cells phenotype plasma Prognostic markers Protein receptor reduced RNA sequencing SARS-CoV-2 Sepsis severity T cell T cells T-cell therapeutic target therapeutic targets these cell These cells transcript Transcriptome transcriptomic transcriptomics WHO guideline with COVID-19
[DOI] 10.1111/joim.13310 PMC 바로가기 [Article Type] Article

Immune cartography of macrophage activation syndrome in the COVID-19 era

코로나19 시대 대식세포 활성화 증후군의 면역 지도 촬영

Review

Published on 2021-03-012022-09-11
Journal: Nature reviews. Rheumatology [Category] SARS, 변종, 유전자 메커니즘,

[키워드] adaptive alveolitis antigen receptor Arthritis Cancer Cancer immunotherapy cancers CAR Cell therapy chimeric antigen receptor complex interplay Connective tissue diseases continuum COVID-19 COVID-19 pneumonia Cytokine storm develop disease disparate dominant feature Gain Gain of function genetics Hyperinflammatory hypersensitivity immune immune function Immunity immunodeficiency immunological immunological disease immunothrombosis Implications in some Infection infectious innate and adaptive immunity innate immune juvenile idiopathic arthritis limit limits Macrophage macrophage activation syndrome MHC class MHC class II occur offer patients with COVID-19 Pneumonia provide responses second wave Sepsis severe inflammation Still T cell therapeutic therapy Trigger triggers type I interferon variant
[DOI] 10.1038/s41584-020-00571-1 PMC 바로가기 [Article Type] Review

Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset

SARS-CoV-2 항원에 대한 IgG 항체에 대한 직교 면역분석은 면역 반응이 발병 후 4개월 이상 지속된다는 것을 보여줍니다

408

Published on 2021-02-022022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 진단, 치료법,

[키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Analysis Anti-spike Antibody testing Antibody titers antigens approach Asymptomatic clinical feature Clinical features Community community setting conducted coronavirus correlation COVID-19 COVID-19 illness COVID-19 infection COVID-19 pandemic Health help humoral immune response IgG IgG antibodies IgG antibody IgG titer IgG titers illness onset immune protection immune response Immunity immunoassay Infection innate and adaptive immunity intensity long-lasting Longevity Middle East Middle East respiratory syndrome morbidity and mortality Neutralizing activity Neutralizing antibody titer nucleocapsid orthogonal other coronavirus other coronaviruses pandemic Patient pattern platform Protein public health measure public health measures Receptor binding domain Research respiratory S1 subunit SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody testing SARS-CoV-2 antigen SARS-CoV-2 antigens severe acute respiratory syndrome Coronavirus severity severity of COVID-19 Significance Spread symptom onset symptomatic patient syndrome the disease understanding vaccination Viral viral antigens virus with COVID-19
[DOI] 10.1073/pnas.2021615118 PMC 바로가기 [Article Type] 408

Can Zn Be a Critical Element in COVID-19 Treatment?

Zn이 COVID-19 치료에서 중요한 요소가 될 수 있습니까?

Review

Published on 2021-02-012022-09-11
Journal: Biological trace element research [Category] 치료제,

Obesity and COVID-19: what makes obese host so vulnerable?

Review

Published on 2021-01-042022-10-30
Journal: Immunity & Ageing : I & A [Category] COVID-19,

Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases

무증상, 경증 및 중증 사례의 SARS-CoV-2 감염에 대한 다양한 선천성 및 적응성 면역 반응

Clinical Trial

Published on 2020-12-162022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단,

[키워드] adaptive Adaptive immune response antibodies Antibody Response Asymptomatic asymptomatic individual Asymptomatic individuals B cells Clinical course clinical expression Clinical presentations Course COVID-19 COVID-19 cases COVID-19 disease eight excessive inflammation Follow-up Frequency healthy humans IgA IgG IgM immune responses Immunity Immunological studies Immunological study individual immune response infected cases Infection Innate innate and adaptive immunity innate and adaptiveimmune response kinetics of antibody memory Mild Mild COVID-19 disease Mild disease moderate to severe monocyte Monocytes NK cell NK cells Novel coronavirus organ damage Patient patients with moderate performed produced Protective protective immune response response SARS-CoV-2 SARS-CoV-2 illness SARS-COV-2 infection SARS-CoV-2-negative contact serological analysis severe COVID-19 severe COVID-19 disease severe disease short-lived Spectrum tissue tissues with mild disease
[DOI] 10.3389/fimmu.2020.610300 PMC 바로가기 [Article Type] Clinical Trial

Genetic ancestry and population differences in levels of inflammatory cytokines in women: Role for evolutionary selection and environmental factors

여성의 염증성 사이토카인 수치의 유전적 조상과 집단 차이: 진화적 선택과 환경적 요인의 역할

Research Article

Published on 2018-06-072022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accumulated adaptive African age alcohol allele Analysis ancestry Antigen antigen receptor Blood cells CCL11 CCL2 chemokine chemokines chronic inflammation circulating circulating cytokines cytokine Cytokines Diseases Endemic environmental factor eosinophils European examined explain exposure to Factor Factors finding gene encoding Genetic genetic difference genetic differences Genetic variant Genetic variation Health Human human immunity IFNα2 IL10 IL1RA IL4 immune immune response immune response genes immune system Immunity implicated implication individual Infection Inflammation Inflammatory Inflammatory cytokine innate and adaptive immunity involved Level living environment living environments Local malaria Migration molecular monocyte Monocytes obesity occur Part pathogen Pathogens phenotypic variance plasma Plasma levels populations pro-inflammatory Protein receptor protein red blood cells Regulation role Selection selection pressure signal significant difference significant differences smoking susceptibility systemic level thought variant Variation White blood cells women
[DOI] 10.1371/journal.pgen.1007368 PMC 바로가기 [Article Type] Research Article