pro-inflammatory cytokine – Page 2 – Communicable Diseases Research

Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host

Article

Published on 2022-10-012022-11-15
Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective

Article

Published on 2022-10-012022-11-15
Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 치료제,

[키워드] acute lung injury acute respiratory distress acute respiratory syndrome Anti-inflammatory anti-inflammatory cytokines antioxidant antioxidant effects Antiviral ARDS Complication complications coronavirus COVID-19 Cytokine storm disease-causing disorders dysregulation hyper inflammation immune response Immunity IMPROVE indirect effect inflammatory signaling inhibit lung manifestation mitigate neurological oxidative stress pandemic Pandemics Pathways Perspective pro-inflammatory cytokine pro-inflammatory cytokines progression RAS reactive oxygen specy reduce renin-angiotensin system ROS SARS-CoV-2 SARS-COV-2 infection severe cases syndrome ursolic acid Viral pneumonia
[DOI] 10.1007/s10787-022-01038-3 PMC 바로가기

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis

Article

Published on 2022-09-272022-11-16
Journal: Frontiers in Immunology [Category] SARS, 변종,

[키워드] accompanied acute respiratory distress addition Comorbidity coronavirus disease COVID-19 COVID-19 pathology cytokine production decrease dysregulated immune response effective Efficacy Evidence functions glycyrrhiza Glycyrrhiza glabra Hamster model hamsters hypercoagulable IL-17A IL-4 immunocompromised individuals immunomodulator immunomodulatory properties Inflammatory cytokine ingredient Lung pathology lung viral load mice mice and human neutrophil functions. mitigate Mortality mRNA expression murine NET NETosis neutrophil polymorphonuclear neutrophil pro-inflammatory cytokine Protective provide Pulmonary pathology reduced reducing robust ROS SARS-CoV-2 SARS-COV-2 infection skewed suppress syndrome Th17 Th2 Th2/Th17 differentiation Treatment vaccination Vaccine variant
[DOI] 10.3389/fimmu.2022.945583 PMC 바로가기

SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability

Article

Published on 2022-09-132022-11-16
Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘,

Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infection

Article

Published on 2022-09-122022-11-15
Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술,

[키워드] absence acute respiratory syndrome Administered administration animal model blocked bronchoalveolar C57BL/6 caused CD4 CD8 coronavirus Coronavirus disease-19 COVID-19 COVID-19 progression current demonstrated effective Efficacy elicited evaluated expressing full-length histopathological IgA antibody IgG immune responses Immunity immunogenic immunogenicity induce intramuscular intranasal intranasal delivery K18-hACE2 transgenic mice Local lung lung lesion lymph nodes mice modified vaccinia virus morbidity and mortality mucosal mucosal immune MVA nasal washe Nasal washes neutralizing antibody parental Prevent pro-inflammatory cytokine PROTECT Protective protective efficacy Protein responses Result S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2-specific immune response serum single dose spleen susceptible systemic immune response systemically T-cell immune response the SARS-CoV-2 Transmission undetectable upper respiratory tract vaccination Vaccine vaccine administration vaccine candidate vaccine candidates vaccine dose virus infection
[DOI] 10.3389/fimmu.2022.995235 PMC 바로가기

Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells

Article

Published on 2022-09-052022-11-15
Journal: Frontiers in Immunology [Category] SARS, 진단,

[키워드] Activation alteration antibodies autoantibodies autoantibody Autoimmune disease autoreactive autoreactive antibody B cell B cells BCR Cell changes in characterized CRP described DN1 DN2 DN3 DN3 cells DN4 double negative elevated elicited Frequency functional heterogenous IFNγ IL-1β IL-6 Immunoglobulin increase increase in Infection Inflammation interferon negative precursor pro-inflammatory cytokine reduction in reported SARS-COV-2 infection SARS–CoV–2 secreting cell serum Severe infection severe SARS-CoV-2 Signaling significantly subset systemic inflammation systemic level TNFα viral infection
[DOI] 10.3389/fimmu.2022.988125 PMC 바로가기

Infliximab in the treatment of patients with severe COVID-19 (INFLIXCOVID): protocol for a randomised, controlled, multicentre, open-label phase II clinical study

Article

Published on 2022-09-022022-10-04
Journal: Trials [Category] SARS, 임상, 진단,

[키워드] 28-day mortality addition Affect Alpha approved assessment Blood changes chronic inflammatory disease clinical study clinical trial collected Course COVID-19 current therapy dose driven by Effectiveness ethics committee EudraCT Friedrich Schiller high mortality hyperinflammation IL-6 IMPROVE infections Infectious diseases infliximab International Laboratory molecular molecular diagnostics monoclonal antibody morbidity multicentre Open-label Patient patients with COVID-19 primary endpoint pro-inflammatory cytokine protocol randomised randomised controlled trial receive Registered Research respiratory respiratory infections resulting severe COVID-19 Standard of care systemic inflammatory the disease therapy TNF-α Treatment Trial university Urine
[DOI] 10.1186/s13063-022-06566-5 PMC 바로가기 [Article Type] Article

Mesenchymal stem cell treatment for hyperactive immune response in patients with COVID-19

COVID-19 환자의 과민성 면역 반응을 위한 중간엽 줄기세포 치료

Review

Published on 2022-09-012022-09-11
Journal: Immunotherapy [Category] COVID19(2023년), SARS, 변종,

Immune modulation as a consequence of SARS-CoV-2 infection

Article

Published on 2022-08-302022-11-15
Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술,

SARS-CoV-2 Delta variant induces enhanced pathology and inflammatory responses in K18-hACE2 mice

Article

Published on 2022-08-292022-11-15
Journal: PLoS ONE [Category] SARS, 변종, 치료제,

[키워드] activated Analysis Beta Brain Cell challenge COVID-19 COVID-19 pandemic Delta delta variant Delta VOC Differential gene expression disease dose engage ENhance evaluate experiment Gene Expression highest histopathological host response IFN-γ in silico in vivo induce infiltration Inflammation Inflammatory response interferon response K18-hACE2 mice lung lung tissue magnitude mice nasal no significant difference observation Pathogenesis pathology Pneumonia pro-inflammatory cytokine qRT-PCR analysis Receptor binding RNA-sequencing SARS-CoV-2 strain Strains suggested T-cell TCR Total Transmissibility unique Vaccines variants of concern Viral RNA VoC was performed
[DOI] 10.1371/journal.pone.0273430 PMC 바로가기