Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses알파 및 베타 코로나바이러스의 뉴클레오캡시드 단백질에 의한 숙주 유형 I 인터페론 반응 조절 메커니즘Review Published on 2022-10-012022-09-11 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha animals Antiviral antiviral responses betacoronavirus cause coronavirus Coronavirus infections COVID-19 pandemic Critical diarrhea epidemic diarrhea facilitate Fatality rate function genomic RNA Health Host Human humans initial innate immune response involved knowledge modulate modulation Neonatal nucleocapsid protein Nucleocapsid proteins PEDV Replication responses responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Signaling type I interferon viral genomic RNA Viral RNA virions virus Virus-host interactions [DOI] 10.1007/s00705-022-05513-8 PMC 바로가기 [Article Type] Review
Investigation of healthcare-associated COVID-19 in a large French hospital group by whole-genome sequencing전체 게놈 시퀀싱에 의한 대규모 프랑스 병원 그룹의 의료 관련 COVID-19 조사Article Published on 2022-10-012022-09-11 Journal: Microbiological research [Category] COVID19(2023년), SARS, 치료기술, [키워드] 30-day mortality rate acute respiratory syndrome acute respiratory syndrome coronavirus Analysis assigned Cluster coronavirus correlated COVID-19 epidemiological Epidemiology evaluate Evolution examined exclusion France French Frequency group HCWs healthcare healthcare worker Healthcare workers Healthcare-associated infection hospital Hospitalized hospitalized patient hospitalized patients implementation incidence Infection infection control Infection prevention investigation many case many cases Mortality nosocomial COVID-19 Nosocomial transmission Paris Patient Personal protective equipment Prevention and control PROTECT reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 study period Transmission transmission route Transmission routes university were infected WGS Whole genome sequencing whole genome sequencing. whole-genome sequencing with COVID-19 [DOI] 10.1016/j.micres.2022.127133 PMC 바로가기 [Article Type] Article
Transchromosomic bovines-derived broadly neutralizing antibodies as potent biotherapeutics to counter important emerging viral pathogens with a special focus on SARS-CoV-2, MERS-CoV, Ebola, Zika, HIV-1, and influenza A virusSARS-CoV-2, MERS-CoV, 에볼라, 지카, HIV-1 및 인플루엔자 A 바이러스에 특히 중점을 두고 중요한 신흥 바이러스 병원체에 대응하는 강력한 생물 치료제로서의 형질전환 소 유래 광범위 중화 항체Review Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adjuvant adjuvants Alpha animals antibody antibody-based therapies Antiviral approach approved assist Beta Biotherapeutics blocked bovine bovine-derived biotherapeutics Clinical studies colostrum convalescent coronavirus creating Delta disease Donor E484K Ebola effective Efficiency emerging viruses Epsilon Gamma highlight HIV-1 Human Human immunodeficiency virus human immunodeficiency virus type 1 human infection human infections hyperimmunization immune immunoreactivity Immunotherapy Influenza influenza A influenza A virus Iota K417N L452R Lambda MERS MERS-CoV Middle East Middle East respiratory syndrome Coronavirus mutations N501Y neutralization neutralized Neutralizing Neutralizing activity neutralizing antibody omicron Omicron variants outbreak P681R Pandemics platform polyclonal antibodies polyclonal antibody produced Protective respiratory respiratory syndrome coronavirus robust Safe SARS-CoV-2 serum severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown T478K therapeutic option transchromosomic bovines. Vaccine variant variants variants of concern variants of interest Viral viral infection viral infections viral pathogen VOCs VOIs Zika [DOI] 10.1002/jmv.27907 PMC 바로가기 [Article Type] Review
A paper-based optical sensor for the screening of viruses through the cysteine residues of their surface proteins: A proof of concept on the detection of coronavirus infection표면 단백질의 시스테인 잔기를 통한 바이러스 스크리닝을 위한 종이 기반 광학 센서: 코로나바이러스 감염 감지에 대한 개념 증명Article Published on 2022-10-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus BENZOTHIAZOLE Biothiol cause Chain Reaction clinical study Colorimetric assay complex Concentration coronavirus Coronavirus infection current cysteine cysteine residue Disulfide disulfide bond Filter Paper group Health Human immunodeficiency virus human Papilloma virus immunodeficiency intensity lab lack limit of detection linear relationship logarithm lowest naked eye nasopharyngeal swabs optical pandemic paper Paper based sensor papilloma pathology Patient pink color polymerase chain polymerase chain reaction proof proof of concept Protein Proteins qRT-PCR Rapid reduced required reverse transcription reverse transcription polymerase chain reaction S1 protein Saliva SARS-CoV-2 SARS-CoV-2. screening method severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimens Spike protein subunit sulfhydryl the S1 protein time-consuming virus virus viruses [DOI] 10.1016/j.talanta.2022.123630 PMC 바로가기 [Article Type] Article
Genomic surveillance of the Lambda SARS-CoV-2 variant in a global phylogenetic context글로벌 계통 발생학적 맥락에서 Lambda SARS-CoV-2 변이체의 게놈 감시Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis carried clade coronavirus country detect determine downloaded Endemic epidemiologically Europe genomic Genomic surveillance GISAID GISAID database identify isolate Lambda Lineage Local local outbreak local outbreaks local outbreaks.. North America occurred Pandemics past Phylogenetic Phylogenetic analysis Phylogenetic relationship prevalent SARS-CoV-2 SARS-CoV-2 variant sequence Sequencing severe acute respiratory syndrome Coronavirus South America spike spike mutation spike mutations Spread Surveillance variant variants of concern virus [DOI] 10.1002/jmv.27889 PMC 바로가기 [Article Type] Article
Automated, portable, and high-throughput fluorescence analyzer (APHF-analyzer) and lateral flow strip based on CRISPR/Cas13a for sensitive and visual detection of SARS-CoV-2SARS-CoV-2의 감도 및 시각적 검출을 위한 CRISPR/Cas13a 기반의 자동화된 휴대용 고처리량 형광 분석기(APHF 분석기) 및 측면 흐름 스트립Article Published on 2022-10-012022-09-11 Journal: Talanta [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed amplification automated biosensor Care Contamination coronavirus COVID-19 CRISPR CRISPR/Cas13a detect Detection limit develop globe Health Lateral lateral flow strip MOST On-site detection ORF1ab gene POCT Point point of care Point of care testing (POCT) polymerase provided recombinase polymerase amplification Recombinase polymerase amplification (RPA) RPA S gene SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2. severe acute respiratory syndrome Coronavirus specificity Visualization [DOI] 10.1016/j.talanta.2022.123594 PMC 바로가기 [Article Type] Article
An impedimetric biosensor for COVID-19 serology test and modification of sensor performance via dielectrophoresis force유전영동력을 통한 센서 성능 수정 및 COVID-19 혈청학 테스트를 위한 방해계 바이오센서Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-S antibody antibody Antibody detection Antibody test assistance AuNP binding buffer causative agent caused Concentration conjugate coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 antibody COVID-19 serology test described detect Dielectrophoresis force digit faster gold Gold interdigitated electrodes Gold nanoparticles human sera IDE immunization impedance Impedimetric biosensor. limit of detection Modification morbidity and mortality non-specific phenomenon point-of-care solution Protein purified reached responses SARS-CoV-2 secondary antibody sensitivity sensor sera serology serology test serology tests serum severe acute respiratory syndrome Coronavirus Spectroscopy spike the disease therapeutic time-consuming [DOI] 10.1016/j.bios.2022.114476 PMC 바로가기 [Article Type] Article
Genomic diversity of SARS-CoV-2 in Pakistan during the fourth wave of pandemic전염병의 네 번째 물결 동안 파키스탄에서 SARS-CoV-2의 게놈 다양성Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] A222V acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Alpha B.1.617.2 Beta variant characteristic circulating circulation conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D950N delta variant Delta variants exhibited followed by G142D genomic Genomic surveillance Germany globe highlight Illumina isolate isolates Karachi L452R lineages P681R Pakistan pandemic Patient Phylogenetic analysis SARS-CoV-2 SARS-CoV-2 strain severe acute respiratory syndrome Coronavirus Singapore spike mutation T19R T478K United Kingdom V483A variant variants variants of concern variants of concern. whole-genome sequencing [DOI] 10.1002/jmv.27957 PMC 바로가기 [Article Type] Article
Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessmentSARS-CoV-2 스파이크 감염성 및 병원성의 오미크론(BA.1) 및 하위 변이체(BA.1.1, BA.2 및 BA.3): 비교 시퀀스 및 구조 기반 계산 평가Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin BA.1 BA.2 BA.3 BA1.1 bind binding affinity bronchial cells computational tool computational tools contribute contributing to coronavirus COVID-19 Deleterious domain Effectiveness electrostatic expressed Factor hACE2 higher affinity human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonds indicate Interaction K417N less lineages Lower respiratory tract lung mutated Mutation mutations N-terminal domain N501Y negative NTD omicron Omicron variant pathogenicity positive predicted Q498 RBD RBM receptor receptors residue residues Salt Bridge SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2. sequence severe acute respiratory syndrome Coronavirus significantly Spike protein Spread surface potential T478K the RBD the spike protein thought Transmission transmission potential variant variants wild-type [DOI] 10.1002/jmv.27927 PMC 바로가기 [Article Type] Article
A highly powerful nonspecific strategy to reduce COVID-19 deathsCOVID-19 사망자를 줄이기 위한 매우 강력한 비특이적 전략Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral antiviral therapy Case fatality rate caused Co-infection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case death deaths disease Diseases Disinfection fatality Fatality rate feasible flexible function Good Health Health Behavior IMPROVE Infectious diseases Isolation less maintain maintenance Mild nonspecific pandemic Pandemics pathogenic reduce SARS-CoV-2 severe acute respiratory syndrome Coronavirus strategy. supported Symptom to some degree Treatment Vaccines [DOI] 10.1002/jmv.27949 PMC 바로가기 [Article Type] Article