From rare disorders of immunity to common determinants of infection: Following the mechanistic thread희귀 면역 장애부터 일반적인 감염 결정 요인까지: 기계론적 실마리를 따라Review Published on 2022-08-182022-09-11 Journal: Cell [Category] 유전자 메커니즘, [키워드] approach autoantibodies autoantibody Autoimmune clinical variability COVID-19 COVID-19 cases Critical determinant disorder Genetic Genotype IFN-α/β IFN-γ Immunity impairing Inborn error Inborn errors Infection infections Infectious disease Infectious diseases Influenza Influenza virus mechanism Neutralizing Seasonal influenza Tuberculosis TYK2 virulent virus [DOI] 10.1016/j.cell.2022.07.004 PMC 바로가기 [Article Type] Review
Heterologous immunity induced by 1st generation COVID-19 vaccines and its role in developing a pan-coronavirus vaccineArticle Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] acute respiratory syndrome adaptive addition COVID-19 COVID-19 pandemic COVID-19 vaccine cross-reactive develop Evolution Heterologous heterologous immunity highlight Hospitalization illnesses Immunity immunization individual Infection mechanism Mortality MOST mutated mutated variant other coronaviruses pan-coronavirus vaccine pandemic Prevent PROTECT protective role Protein SARS-CoV-2 SARS-CoV-2 antigens T cell the Spike understanding universal vaccine development. Vaccine Vaccine development variant viral strains virulent virus strain [DOI] 10.3389/fimmu.2022.952229 PMC 바로가기
Determining SARS-CoV-2 non-infectivity state-A brief overviewArticle Published on 2022-08-122022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] accumulated addition addressed applied claimed clinical experience Combination Consequences contagiousness coronavirus 2 COVID-19 COVID-19 pandemic determine Determining detrimental Iceland Immunity infected individual non-infectious non-infectious state pandemic patients with COVID-19 physician question reached respiratory SARS-CoV-2 Transmission transmission of SARS-CoV-2 transmitted variants viral testing virulent [DOI] 10.3389/fpubh.2022.934242 PMC 바로가기
A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection포괄적인 SARS-CoV-2 및 COVID-19 검토, 1부: SARS-CoV-2 감염에 대한 세포내 과잉Review Published on 2022-08-012022-09-11 Journal: European Journal of Human Genetics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료제, [키워드] affected caused cellular claimed clinical observation contributed COVID-19 COVID-19 patients disease explain help highlight in viral Infection Intracellular knowledge mechanism Part pathogen Prevent reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus Scientific community significantly Support the disease the SARS-CoV-2 virus viral replication virulent virus [DOI] 10.1038/s41431-022-01108-8 PMC 바로가기 [Article Type] Review
An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design다중 에피토프 기반 펩타이드(MEBP) 백신 설계에서 에피토프 순서의 역할을 연구하기 위한 in silico 접근법Article Published on 2022-07-222022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] Accessibility approaches bioinformatics candidate Candidates cellular response country COVID-19 pandemic death rates develop epitope Epitopes experimental protocols experimental validation faster highest humoral immunization immunoinformatics in silico in silico Approach introduced less likelihood limitation methodology MOST MVP overcome pandemic peptide positive predicted predictors Quantitative ranking reported SARS-CoV-2 SARS-CoV-2 variant shown Vaccine vaccine candidate vaccine candidates Vaccine design Vaccine development variant virulent [DOI] 10.1038/s41598-022-16445-3 PMC 바로가기 [Article Type] Article
Exercise-induced myokines downregulates the ACE2 level in bronchial epithelial cells: Implications for SARS-CoV-2 prevention운동 유도 미오카인은 기관지 상피 세포에서 ACE2 수준을 하향 조절합니다: SARS-CoV-2 예방에 대한 의미Article Published on 2022-07-202022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] A549 ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal models applied approach approaches Bronchial epithelium cancer cell line Cell Cell culture cell culture study cell line centrifugation condition conditioned media controls COVID-19 pandemic culture system cytokine Cytokines death rate decrease demonstrated downregulate downregulation Effect ELISA ELISAs enzyme enzyme-linked immunosorbent assay epidemiological studies epithelial exercise exposure to expression form generate highlighting human lung immortalized lung cancer marker mass spectroscopy media mitigate modulating mRNA myokine pandemic Part PCR physical activity potential therapeutic target potential therapeutic targets priming protective effect protein level proteomic Proteomic analysis public health pulse Quantitative quantitative real-time PCR Quantitative RT-PCR receptor reduction remained replicated respiratory viruses rigor risk of infection RT-PCR SARS-CoV-2 sensitivity Serine shown Skeletal muscle skeletal muscles stimulated the SARS-CoV-2 TMPRSS2 TMPRSS2 protein transmembrane serine protease transmembrane serine protease 2 treated Treatment vaccination Vaccinations virulent virus was performed while [DOI] 10.1371/journal.pone.0271303 PMC 바로가기 [Article Type] Article
RNA enigma: “From origin of life to novel Coronavirus-COVID-19”Review article Published on 2022-07-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 변종, [키워드] coronavirus COVID-19 disease event Evolution forms Genome imperative measure Modification natural selection nCoV-19 and mutation recent RNA RNA virus RNA viruses shown Spread Strains viral outbreak virulence virulent [DOI] 10.1016/j.sjbs.2022.103331 [Article Type] Review article
COVID-19: Omicron – the latest, the least virulent, but probably not the last variant of concern of SARS-CoV-2COVID-19: 오미크론 - 최신, 가장 덜 독성이지만 SARS-CoV-2의 우려의 마지막 변종은 아닐 것입니다.Review Published on 2022-07-012022-09-11 Journal: Microbial Biotechnology [Category] COVID19(2023년), SARS, 변종, [키워드] affected Antibody Response Antiviral booster breadth cell entry Cellular immune response convalescent patient Convalescent patients COVID-19 pandemic Delta demonstrated dominant Endocytic pathway experiment explain fusion hamsters Immune escape immunization Infection intrinsic less Lineage Lung function mainstream mice monoclonal antibodies mutated Mutation neutralization omicron Omicron variant plasma membrane population immunity preserved question raising Replication respiratory tract SARS-CoV-2 SARS-CoV-2 strain serum antibodies serum antibody Severe infection severe infections South Africa Spike protein the spike protein therapeutic titre trajectory Transmission vaccinee vaccinees variant virulence virulent VoC widespread [DOI] 10.1111/1751-7915.14064 PMC 바로가기 [Article Type] Review
Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of ConcernSARS-CoV-2 및 우려 변종에 대한 파마피모드 및 피오글리타존의 상승적 항바이러스 활성Article Published on 2022-06-202022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acting activity agonist Alpha Anti-inflammatory antiviral activity antiviral potency approved Arthritis assumption Beta cell type cellular cellular pathway cellular targets clinical study clinically evaluated Combination components concern coronavirus COVID-19 COVID-19 patients Delta described diabetes drug effective evaluated Gamma in vitro inhibit SARS-CoV-2 inhibitor kinase mitogen mitogen-activated protein kinase molnupiravir omicron p38-inhibitor pamapimod pathway Paxlovid pioglitazone polymerase potential therapy PPRy-agonist Protease inhibitor protein kinase public health threat reduce Replication replication of SARS-CoV-2 rheumatoid arthritis SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication selective Severity of disease small molecule Small molecules Support synergistic These data transmitted treat Treatment type 2 diabetes Vaccine-induced immunity variant variants variants of concern viral replication virulent virus variants VOCs Wuhan [DOI] 10.3390/ijms23126830 PMC 바로가기 [Article Type] Article
Comprehensive fitness landscape of SARS-CoV-2 M pro reveals insights into viral resistance mechanismsSARS-CoV-2 M pro의 종합적인 피트니스 환경은 바이러스 저항 메커니즘에 대한 통찰력을 보여줍니다Article Published on 2022-06-202022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] active site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Amino acid amino acid changes amino acids analyzed Anti-viral drugs can be used cleave Complete Comprehensive conserved contribute Coronavirus-2 correlated Critical deep mutational scanning deep sequencing defined drug drug design drug resistance Effect effective elicit evade Evolution Evolutionary biology expression functional human population Infectious disease inhibitor inhibitors life cycle M pro main protease mechanism Microbiology MPro Mutation network new strain performed physically protease Protein reduced reveal S. cerevisiae SARS-CoV-2 SARS-CoV-2 main protease selection pressure Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Toxicity Vaccines variant viral life cycle Viral resistance virulent yeast [DOI] 10.7554/eLife.77433 PMC 바로가기 [Article Type] Article