innate immune response – Page 21 – Communicable Diseases Research

Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity

Article

Published on 2021-07-142022-10-04
Journal: Nature Communications [Category] SARS, 유전자 메커니즘,

Host factors facilitating SARS‐CoV‐2 virus infection and replication in the lungs

Review

Published on 2021-07-052022-10-31
Journal: Cellular and Molecular Life Sciences [Category] COVID-19, MERS, SARS,

Targeting TLR4 Signaling to Blunt Viral-Mediated Acute Lung Injury

둔기 바이러스 매개 급성 폐 손상에 대한 TLR4 신호 표적화

Review

Published on 2021-07-022022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료제,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome addition ALI antiviral agent Antiviral agents antiviral treatments approach ARDS caused circulating Consequences Critical cytokine Cytokine storm DAMPs danger-associated molecular pattern death effective Efficacy HMGB1 Hospitalization Infection Inflammatory response Influenza influenza infection influenza infections initiated innate immune response Interaction lead lethal infection life life threatening Local Lung injury PAMPs Pandemics pathogen pathogen-associated molecular pattern pathogen-associated molecular patterns Pathogens Pattern recognition pattern recognition receptor Pattern recognition receptors predicted PRRs respiratory respiratory distress Respiratory distress syndrome respiratory viral infections SARS-CoV-2 pandemic Signaling strain Symptom syndrome targeting TLR4 Treatment triggered uncontrolled Vaccine Viral viral infection viral infections Viral resistance virus viruses while
[DOI] 10.3389/fimmu.2021.705080 PMC 바로가기 [Article Type] Review

SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation

RIG-I 및 MDA5에 의한 SARS-CoV-2 감지는 상피 감염을 대식세포 염증과 연결합니다

Article

Published on 2021-07-022022-09-10
Journal: The EMBO Journal [Category] MERS, SARS, 유전자 메커니즘,

[키워드] Activation airway airway epithelial cell airway epithelial cells cause Cell cellular activation COVID‐19 cytokine cytokine production cytoplasmic develop disease downstream effective ENhance epithelial epithelial cell epithelial cells exacerbate exacerbated human macrophage immunology immunopathological induce Infection Inflammation Inflammatory inflammatory mediator Inflammatory mediators inflammatory state inflammatory stimuli inhibiting innate immune pathway innate immune pathways innate immune response Local lung epithelial cell Lung epithelial cells lung epithelium Macrophage macrophage activation macrophages MDA5 mechanism mediators Microbiology, Virology & Host Pathogen Interaction mitigate Pathways produced replicate required RNA RNA sensing robust SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 stimulate triggering
[DOI] 10.15252/embj.2021107826 PMC 바로가기 [Article Type] Article

Perspectives on anti-IL-1 inhibitors as potential therapeutic interventions for severe COVID-19

심각한 COVID-19에 대한 잠재적인 치료 개입으로서의 항IL-1 억제제에 대한 전망

Review

Published on 2021-07-012022-09-12
Journal: Cytokine [Category] MERS, SARS, 유전자 메커니즘, 임상, 진단,

Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age

이중 가닥 RNA는 dsRNA 길이, IFNAR1 발현 및 연령에 따라 항바이러스성 선천성 면역 반응, 질병 행동 및 인지 기능 장애를 유발합니다.

Article

Published on 2021-07-012022-09-11
Journal: Brain, behavior, and immunity [Category] SARS, 치료법,

[키워드] age age-dependent effect age-dependent effects Alzheimer's disease Analysis Anti-viral autism base binding Brain circulating CNS cognitive Cognitive function COVID19 cytokine Cytokines dependent on disease dose dsRNA dysfunction expression Gene Expression IFN-I IFNAR1 Ifnb IFNβ IL-1β IL-6 immune activation immune responses Impact implication Inflammation innate immune response innate immune responses Innate immunity integrity IRF7 memory mice molecular weight neurodegenerative disorder neurodegenerative disorders Neuroinflammation overcome parkinson s disease Parkinson's Disease plasma Poly I:C produced Psychiatric question response responses RNA robust SARS-CoV-2 Schizophrenia Sickness Sickness behaviour significantly Symptom systemic systemic inflammation TNF-α Transcription triggered type I interferon viral infection viral replication Working memory
[DOI] 10.1016/j.bbi.2021.04.016 PMC 바로가기 [Article Type] Article

Human Rhinovirus Infection Blocks Severe Acute Respiratory Syndrome Coronavirus 2 Replication Within the Respiratory Epithelium: Implications for COVID-19 Epidemiology

Major Articles and Brief Reports

Published on 2021-07-012022-10-29
Journal: The Journal of Infectious Diseases [Category] COVID-19, SARS,

An Impaired Inflammatory and Innate Immune Response in COVID-19

Review

Published on 2021-06-302023-06-16
Journal: Molecules and cells [Category] MERS, SARS,

[키워드] COVID-19 Cytokine storm immunoparalysis Inflammatory cytokines innate immune response
[DOI] 10.14348/molcells.2021.0068 PMC 바로가기 [Article Type] Review

Innate Immune Response to SARS-CoV-2 Infection: From Cells to Soluble Mediators

Review

Published on 2021-06-292022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS,

C9orf72 Intermediate Repeats Confer Genetic Risk for Severe COVID-19 Pneumonia Independently of Age

C9orf72 중간 반복은 연령과 관계없이 심각한 COVID-19 폐렴에 대한 유전적 위험을 부여합니다

Article

Published on 2021-06-292022-09-12
Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단,

[키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted age allele ALS Amyotrophic lateral sclerosis association Autoimmune Autoimmune disorders autophagy C9orf72 caused characterized Clinical outcome Cohort contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pneumonia Critical Cytokine storm Cytokines Degradation determinants driving dysfunction expressed feature frontotemporal dementia functions Gene Expression genetic background genetic cause genetic risk haploinsufficiency Host immune functions impair independent Infection innate immune response Innate immunity intermediate intermediate alleles involved Lateral Sclerosis lysosomal magnitude mechanical ventilation modulate Mutation myeloid cell myeloid cells Neuroinflammation Non-invasive non-invasive or mechanical ventilation Odds ratio pathogenic Patient phenotype Phenotypes proinflammatory cytokines Regulation Repeat responsible risk risk factor SARS-CoV-2 SARS-CoV-2 infected patients severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 Severe COVID-19 pneumonia significantly systemic level These data
[DOI] 10.3390/ijms22136991 PMC 바로가기 [Article Type] Article