Investigation of possible preventable causes of COVID-19 deaths in the Kampala Metropolitan Area, Uganda, 2020–2021Research article Published on 2022-09-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제, [키워드] Admission advanced disease age Area cause coronavirus disease COVID-19 COVID-19 test Critical death Diagnosis died differential diagnosis Health health worker hospital hospitalized patient identifying Increased intensive care investigated investigation male mechanical ventilation Medical conditions MOST pandemic polymerase chain receive reducing mortality reported Result reverse transcription SARS-CoV-2 Symptoms the median Uganda with COVID-19 [DOI] 10.1016/j.ijid.2022.05.033 [Article Type] Research article
Serum stratifin and presepsin as candidate biomarkers for early detection of COVID-19 disease progressionCOVID-19 질병 진행의 조기 검출을위한 후보 바이오 마커로서 혈청 스트라 티핀 및 프리 셉신Article Published on 2022-09-012022-08-31 Journal: Journal of pharmacological sciences [Category] MERS, 바이오마커, 진단, 치료기술, 치료제, [키워드] Biomarker Biomarkers changes in Cohort collected condition COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 progression Critical elevated FIVE Hospitalization independent kallistatin Like lung oxygen oxygen support Patient patients Pneumonia Predictive predictive biomarker Presepsin Prognosis prognosis of patient prognostic biomarker Prognostic biomarkers progression remained reported Serum level serum levels serum sample serum samples Severe case severe cases severe COVID-19 significantly significantly higher Stage stratifin Stratifin. Symptom the patient [DOI] 10.1016/j.jphs.2022.06.002 PMC 바로가기 [Article Type] Article
FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronavirusesArticle Published on 2022-09-012022-11-15 Journal: Journal of Lipid Research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Cell click chemistry conserved coronavirus CoV CoV-229E Critical cysteine de novo enzyme epithelial cells examined expressed FASN fatty Fatty acid host cell Host cell entry human coronavirus in vitro incubated Infection inhibited inhibitor isoform Modification modify Multiple other coronavirus palmitate phylogenetically Prevent Protein reduction in reported residues S-acylation SARS-CoV-2 specificity spike coronavirus. Spike protein Spread the spike protein ZDHHC ZDHHC5 [DOI] 10.1016/j.jlr.2022.100256 PMC 바로가기
SARS-CoV-2 genomic epidemiology: data and sequencing infrastructureSARS-CoV-2 게놈 역학: 데이터 및 시퀀싱 인프라Article Published on 2022-09-012022-09-11 Journal: Future Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] available data computation country COVID-19 case Critical develop Epidemiology funds genomic Genomic surveillance identify implementation Influenza initiative lack Low- and middle-income countries mobilization molecular Molecular epidemiology Next-generation sequencing next-generation sequencing platforms Outbreaks Oxford Nanopore MinION platform SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 sequencing Sequencing significantly higher Support Surveillance viral lineages whole-genome whole-genome sequencing [DOI] 10.2217/fmb-2021-0207 PMC 바로가기 [Article Type] Article
The basis of mink susceptibility to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 밍크 감수성의 근거Review Published on 2022-09-012022-09-11 Journal: Journal of applied genetics [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals B.1.1.7 B.1.617.1 B.1.617.2 coronavirus coronavirus disease COVID-19 COVID-19 pandemic Critical Cross-species infection Cross-species transmission D614G death rate disease Evolution highest Host host range Human humans Infection interact issue Minks Mutation Occurrence over Pathogens phenomenon possession Protein raise RBD receptor Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sequence Sequence alignment spike Spike protein susceptibility the receptor-binding domain Transmission variants Viral diseases viral pathogenesis viral pathogens virus Y453F [DOI] 10.1007/s13353-022-00689-w PMC 바로가기 [Article Type] Review
A Randomized Double-Blinded Placebo Controlled Trial of Clazakizumab for the Treatment of COVID-19 Pneumonia With Hyperinflammation고염증을 동반한 COVID-19 폐렴의 치료를 위한 Clazakizumab의 무작위 이중 맹검 위약 대조 시험Clinical Trial Published on 2022-09-012022-09-12 Journal: Critical Care Medicine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 1:1 accompanied added Bayesian benefit board changes Clazakizumab Clinical outcome clinical status Controlled COVID-19 COVID-19 disease Critical cumulative double-blinded dropped enrolled Frequency greater High-dose hospitalized patient hyperinflammation ICU ICU admission inhibitor Inpatient interleukin-6 intubation Logistic low-dose measurement monitoring Odds ratio outcome Patient patients patients hospitalized Placebo placebo-controlled Poisson regression model Primary outcome Randomized receiving recommendations risk Safety seamless secondary secondary outcome severe COVID-19 disease significantly suggested survival Trial Ventilation ventilator-free survival were used with COVID-19 [DOI] 10.1097/CCM.0000000000005591 PMC 바로가기 [Article Type] Clinical Trial
HERPES-LIKE LESIONS IN PATIENTS WITH COVID-19: REPORT OF FOUR CASES AND TREATMENT APPROACHConference abstract Published on 2022-09-012022-10-05 Journal: Oral surgery, oral medicine, oral pathology and or [Category] 치료법, [키워드] age antimicrobial Comorbidity contribute Critical dentist diagnosed Diagnosis female Health highlight hospital Hospitalization IMPROVE intensive care intravenous lesion male mechanical ventilation Oral hygiene oral manifestation oral mucosa Patient patients with COVID-19 polymerase chain Rapid reduce severe COVID-19 severe disease therapy was performed [DOI] 10.1016/j.oooo.2022.01.393 [Article Type] Conference abstract
IGHG3 hinge length variation was associated with the risk of critical disease and death in a Spanish COVID-19 cohortArticle Published on 2022-09-012022-11-15 Journal: Genes and Immunity [Category] SARS, 진단, [키워드] 95% CI adverse effect Affect allele Amino acid carrier cohorts COVID-19 COVID-19 cohort Critical Critical disease death explained functions genotyped ICU IgG3 IGHG3 immune adaptive response impair increased risk induce less moderate-severe Mortality neutralization Patient phagocytosis plasma polymorphism reduce reduced risk risk of COVID-19 risk of death S allele SARS-CoV-2 sequence severity Spanish Variation viral neutralization [DOI] 10.1038/s41435-022-00179-3 PMC 바로가기
Susceptibility of SARS-CoV-2 Omicron Variants to Therapeutic Monoclonal Antibodies: Systematic Review and Meta-analysisArticle Published on 2022-08-312022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibody Antiviral antiviral therapy clinical development Combination combinations conserved COVID-19 Critical Determining disparate effective eight eligible in vitro in vitro activity inactive interquartile range loss of activity measure median monoclonal monoclonal antibody Multidrug resistance Mutation neutralization omicron Omicron variant receptor-binding domains reduced reduction in Region reported review SARS-CoV-2 Spike protein spike receptor-binding domain Standardization susceptibility the median the SARS-CoV-2 therapeutic treating COVID-19 variant variants wild-type [DOI] 10.1128/spectrum.00926-22 PMC 바로가기
Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseasesArticle Published on 2022-08-312022-11-15 Journal: Journal of Nanobiotechnology [Category] 치료제, [키워드] Affect anticipated Cancer chronic disease classical COVID-19 pandemic COVID-19 testing Critical Detection sensitivity diagnostic Disease diagnosis Diseases disrupt effective Health healthcare Magnetic nanoparticles management MNP nanomedicine Neurological disorders overcome Perspective point-of-care RNA therapeutics Si-RNA therapeutics specificity stability therapeutic therapy Vascular vascular diseases Vascular diseases. [DOI] 10.1186/s12951-022-01595-3 PMC 바로가기