Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis유전자 공동 발현 네트워크 분석에 기초한 코로나 바이러스 (SARS-COV-2)에 대한 약물 재생Article Published on 2021-11-082022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 신약개발, 유전자 메커니즘, 치료기술, 치료제, [키워드] acute respiratory syndrome analyses Analysis applied approach Asia candidate drug candidate drugs cisplatin co-expression Computational models contagious coronavirus Cyclophosphamide database disease drug Drug repurposing Drug screening drugs drugs targeting effective drug effective drugs FIVE FLUOROURACIL gene co-expression network Gene ontology Genes Genome Interaction list METHYLDOPA Microarrays miRNA miRNAs reconstructed respiratory Respiratory illness retrieved SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 disease Severe acute respiratory syndrome Sirolimus Systems biology target gene the SARS-CoV-2 transcription factor transcription factors treat Treatment Viral viral respiratory virus [DOI] 10.1038/s41598-021-01410-3 PMC 바로가기 [Article Type] Article
Medicines for Malaria Venture COVID Box: a source for repurposing drugs with antifungal activity against human pathogenic fungi말라리아 벤처 코비드 박스를위한 의약품 : 인간 병원성 곰팡이에 대한 항진균 활동을 가진 약물을 용도의 소스Research Article Published on 2021-11-082022-08-31 Journal: Memórias do Instituto Oswaldo Cruz [Category] MERS, SARS, 말라리아, 신약개발, 치료제, [키워드] affected Antibiotics antifungal activity antimalarial antitumor agent antitumor agents Antiviral Box caused cells Concentration COVID COVID Box Cryptococcus neoforman Cryptococcus neoformans cycloheximide cyclosporine drug Drug repurposing effective therapy evaluated fungal fungal infections fungi fungicidal fungicidal activity fungistatic Fusarium genetic disorder growth highlight Histoplasma Histoplasma capsulatum Immunosuppressant immunosuppressants impair inhibited malaria Medicine Medicines morphological change morphological changes morphology MOST Mycoses nervous system niclosamide not affected Paracoccidioides brasiliensis pathogenic pathogenic fungi Side effects tested treat [DOI] 10.1590/0074-02760210207 PMC 바로가기 [Article Type] Research Article
A transferable deep learning approach to fast screen potential antiviral drugs against SARS-CoV-2SARS-COV-2에 대한 빠른 스크린 잠재적 항 바이러스 약물에 대한 양도 가능한 딥 러닝 접근Article Published on 2021-11-052022-08-31 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 신약개발, 치료제, [키워드] accelerate anti-SARS-CoV-2 antiviral drug applied approach binding build can be used cause Compound coronavirus COVID-19 COVID-19 pandemic database deep learning demonstrated disease Docking studies docking study drug candidate drug candidates Drug discovery Drug repurposing effective enzyme FDA-approved drug FDA-approved drugs fine-tune inhibit list proof protease reported SARS-CoV-2 Seven tested transfer Treatment Virtual screening [DOI] 10.1093/bib/bbab211 PMC 바로가기 [Article Type] Article
AI-based language models powering drug discovery and developmentAI 기반 언어 모델에는 약물 발견 및 개발에 힘을 발휘합니다Review Published on 2021-11-012022-08-31 Journal: Drug discovery today [Category] SARS, 신약개발, [키워드] artificial artificial intelligence changed coronavirus COVID-19 drug Drug development Drug discovery Drug repurposing highlight inefficient Infectious disease Infectious diseases landscape language Language models Medicine natural language natural language processing other infectious diseases Pandemics pharmacovigilance Regulatory time-consuming Treatment [DOI] 10.1016/j.drudis.2021.06.009 PMC 바로가기 [Article Type] Review
Molecular docking and simulation studies on SARS-CoV-2 M pro reveals Mitoxantrone, Leucovorin, Birinapant, and Dynasore as potent drugs against COVID-19Article Published on 2021-11-012023-06-19 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, [키워드] Drug repurposing molecular docking molecular dynamic simulation SARS-CoV-2 main protease (Mpro) [DOI] 10.1080/07391102.2020.1805019 PMC 바로가기
In silico validation of coumarin derivatives as potential inhibitors against Main Protease, NSP10/NSP16-Methyltransferase, Phosphatase and Endoribonuclease of SARS CoV-2Article Published on 2021-11-012022-10-04 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] ADME ADME/T ADP Analysis approach binding binding free energy caused combination therapy Compound coronavirus 2 coumarin COVID-19 COVID-19 infection derivative develop docked docking docking result docking score drug Drug repurposing drug-likeness endoribonuclease enzyme FIVE help identification IMPROVE in silico information inhibitor inhibitory activity Ligand LLC MD simulation molecular pandemic performed protease Protein provide radius of gyration receptor receptor protein respiratory RMSD SARS CoV-2 SARS-CoV-2 Seven stability therapy Treatment USA Virtual screening virus was performed were used WHO [DOI] 10.1080/07391102.2020.1808075 PMC 바로가기 [Article Type] Article
Drug repurposing for COVID-19: a potential threat of self-medication and controlling measuresCOVID-19에 대한 약물 용도 : 자기 치료 및 조치 통제의 잠재적 위협Comment Published on 2021-11-012022-08-31 Journal: Postgraduate medical journal [Category] MERS, SARS, 신약개발, 치료제, [키워드] Abstract Drug repurposing immunology Infectious diseases measure Medical journalism Virology [DOI] 10.1136/postgradmedj-2020-138447 PMC 바로가기 [Article Type] Comment
Untapping host-targeting cross-protective efficacy of anticoagulants against SARS-CoV-2Review Published on 2021-10-282023-07-01 Journal: Pharmacology & therapeutics [Category] COVID19(2023년), SARS, [키워드] ACE2, angiotensin-converting enzyme 2 Ang II, Angiotensin II Anti-inflammatory Anticoagulant Antiviral AT1, angiotensin II type 1 receptor COPD, Chronic obstructive pulmonary disease coronavirus CoV, coronaviruses COVID-19, Coronavirus disease 2019 Drug repurposing FasL, Fas ligand HIV, Human immunodeficiency virus Host-targeting therapies IL1B, interleukin 1B IL6, Interleukin 6 Mpro, virally encoded main protease of SARS-CoV-2 MERS-CoV, Middle East respiratory syndrome coronavirus MSC, mesenchymal stem cell Nafamostat mesylate Nrf2, nuclear factor erythroid 2 p45-related factor 2 PD-L1, Programmed death-ligand 1 RdRp, RNA dependent RNA polymerase SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus TTSP, type II transmembrane serine protease VSV, Vesicular stomatitis virus [DOI] 10.1016/j.pharmthera.2021.108027 PMC 바로가기 [Article Type] Review
Genome‐scale metabolic modeling reveals SARS‐CoV‐2‐induced metabolic changes and antiviral targets게놈 규모의 대사 모델링은 SARS-CoV-2 유도 대사 변화 및 항바이러스 표적을 보여줍니다Meta-Analysis Published on 2021-10-282022-09-10 Journal: Molecular Systems Biology [Category] MERS, SARS, 신약개발, 치료제, [키워드] acting Algorithm Analysis Antiviral antiviral target applied approach approved caused Cell cells change changes Combination Coronaviruses COVID‐19 dataset Drug repurposing effective facilitate GEM gene expression dataset Genetic genetic screen genome‐scale metabolic modeling Host identify medical need metabolic metabolism Microbiology, Virology & Host Pathogen Interaction pandemic Patient Pharmacology & Drug Discovery predict predicted provide Remdesivir reveal RNAi screen SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 virus SARS‐CoV‐2 siRNA target therapeutic option Vero E6 Viral viral proliferation [DOI] 10.15252/msb.202110260 PMC 바로가기 [Article Type] Meta-Analysis
Deep Learning Driven Drug Discovery: Tackling Severe Acute Respiratory Syndrome Coronavirus 2Microbiology Published on 2021-10-282022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] accelerate Antibiotics antimalarial drug Atazanavir Azithromycin Compound contribute coronavirus 2 daclatasvir database deep deep learning Diseases drug drug candidate Drug discovery Drug repurposing Efficiency enalaprilat global effort identify indomethacin Kaletra learning niclosamide ombitasvir Pathogens Perspective Posaconazole Pralatrexate respiratory SARS-CoV-2 SARS-CoV-2 drug significantly Spread toremifene [DOI] 10.3389/fmicb.2021.739684 PMC 바로가기 [Article Type] Microbiology