Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials코로나19에서의 토실리주맙: 무작위 대조 시험의 메타 분석, 시험 순차 분석 및 메타 회귀Meta-Analysis Published on 2021-06-012022-09-11 Journal: Intensive care medicine [Category] Fulltext, SARS, 임상, 진단, [키워드] adjusted Admission benefit Beta Composite conducted control group COVID-19 defined did not reduce disease Evidence excluded hospitalized COVID-19 patients ICU ICU admission IL-6 IL-6 blockade IL-6 inhibition Immunologic Immunologic factors interleukin interleukin-6 mechanical ventilation Meta-analysis meta-regression Mild Mortality mortality risk outcome Patient patients with COVID-19 pharmacological intervention pharmacological interventions Placebo Primary outcome randomized-controlled RCT RCTs reduce reducing Regression reported required risk secondary secondary outcome Secondary outcomes sequential analysis severe COVID-19 severe disease standard care suggested systematic review therapeutic strategy Tocilizumab Treatment Trial trial sequential analysis TSA [DOI] 10.1007/s00134-021-06416-z PMC 바로가기 [Article Type] Meta-Analysis
Evaluation of Cellular and Serological Responses to Acute SARS-CoV-2 Infection Demonstrates the Functional Importance of the Receptor-Binding Domain급성 SARS-CoV-2 감염에 대한 세포 및 혈청학적 반응 평가는 수용체 결합 도메인의 기능적 중요성을 보여줍니다Article Published on 2021-06-012022-09-11 Journal: Journal of immunology (Baltimore, Md. : 1950) [Category] SARS, 치료법, [키워드] activated B cell response B cell responses B cell subset B cell subsets Cell changes in Course cross-sectional analysis Depletion domain Donor effective elevated Epitopes Factor full-length hospitalized COVID-19 patients humoral immune response immune response Importance individuals Infection mAb memory B memory B cell neutralization activity Neutralizing activity nucleoprotein observé plasmablast plasmablasts populations RBD-specific IgG response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 virus serum Serum Neutralization spike subset Vaccine design [DOI] 10.4049/jimmunol.2001420 PMC 바로가기 [Article Type] Article
Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trialRandomized Controlled Trial Published on 2021-06-012022-10-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] 유전자 메커니즘, 임상, 치료법, [키워드] 95% CI 95% confidence interval ACE2 ACE2angiotensin-converting enzyme 2 activities Acute kidney injury acute respiratory syndrome Admission adult COVID-19 patient adverse events Affect angiotensin-converting enzyme 2 Anti-inflammatory anti-inflammatory agents assigned caffeic acid phenethyl ester CAPEcaffeic acid phenethyl ester Care clinical benefit Clinical improvement Control control group Controlled clinical trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19coronavirus disease 2019 defined dose Effect enrolled Evidence evidenced group High dose Hospital stay Hospitalized hospitalized COVID-19 hospitalized COVID-19 patients human transmembrane protease 2 immune immunoregulation Inflammatory intensive care lower dose median need for oxygen NF-kBnuclear factor-kappa B nuclear factor-kappa B Odds ratio Open-label outcome Oxygen therapy p21-activated kinase 1 PAK1 PAK1 blocker PAK1p21-activated kinase 1 Patient post-intervention primary end point promote Propolis Randomized receive reduce reduction in SARS-CoV-2 SARS-CoV-2severe acute respiratory syndrome coronavirus 2 secondary Seven severe acute respiratory syndrome coronavirus 2 significantly single-center Standard standard care targets tested therapeutic therapy TLR4toll like receptor 4 TMPRSS2 TMPRSS2human transmembrane protease 2 toll like receptor 4 treated Treatment Trial vasoactive drugs [DOI] 10.1016/j.biopha.2021.111526 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical features and outcomes of hospitalized COVID-19 patients in a low burden region저부담 지역 입원한 코로나19 환자의 임상 양상 및 결과Observational Study Published on 2021-06-012022-09-11 Journal: Pathogens and global health [Category] SARS, 임상, 치료제, [키워드] Admission age Analysis Chest chest X-ray clinical Clinical data clinical feature Clinical features Comorbidity country COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients Critical disease death died disease European country Factor feature Greece hospital hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hypertension ICU ICU admission ICU care Immunosuppression In-hospital death independent predictor independent predictors independent risk factor independent risk factors intensive care unit invasive ventilation lower mortality lung field male median medical record medical records Mortality multivariable logistic regression outbreak outcome pandemic Patient patients hospitalized Pneumonia Region reported required Respiratory failure Retrospective study SARS-CoV2 Solid solid tumor the disease thrombocytopenia Tumor univariable [DOI] 10.1080/20477724.2021.1893485 PMC 바로가기 [Article Type] Observational Study
Shedding of infectious SARS-CoV-2 by hospitalized COVID-19 patients in relation to serum antibody responses혈청 항체 반응과 관련하여 입원한 COVID-19 환자에 의한 감염성 SARS-CoV-2의 배출Research Published on 2021-05-272022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway airways antibodies Antibody Response Antibody titers caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-sectional cross-sectional study Culture detectable global pandemic Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients IgG immunofluorescence assay immunofluorescence assay (IFA Immunoglobulin Immunoglobulin G in vitro Karolinska University Hospital lower risk median microneutralization Microneutralization assay Neutralizing antibodies neutralizing antibodies titer neutralizing antibodies titers Neutralizing antibody titer neutralizing antibody titers objective Patient patients PCR analysis performed positively correlated potential risk replicating virus respiratory Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 RNA SARS-CoV-2 specific antibodies SARS-CoV-2 transmission SARS-CoV-2-specific IgG serum serum antibody response severe acute respiratory syndrome Coronavirus shedding specific antibody symptom duration symptom onset Total Transmission two patients Viral viral shedding virus were assessed [DOI] 10.1186/s12879-021-06202-8 PMC 바로가기 [Article Type] Research
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes환기된 COVID-19 환자의 심각한 T 세포 과민반응은 장기간의 바이러스 지속성 및 나쁜 결과와 상관관계가 있습니다Article Published on 2021-05-212022-09-12 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] basophils benefit blood sample caused Cell clinical recovery components coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine secretion dendritic cells downstream Effect extrinsic Factor female hospitalized COVID-19 patient hospitalized COVID-19 patients hyperinflammation identify IL-2 Immunosuppressive medication independent independent of male marker monocyte Monocytes neutrophil Neutrophils outcome overcome Patient patients plasma plasmacytoid dendritic cells Pneumonia polyclonal poor prognosis predict prolonged virus persistence reduced Respiratory distress syndrome respond SARS-CoV-2 SARS-CoV2 infection shown T cell T cell activation T cell response Ventilated ventilated patients viral infection viral persistence Whole blood [DOI] 10.1038/s41467-021-23334-2 PMC 바로가기 [Article Type] Article
COVID-19 and the liver: an adverse outcome pathway perspectiveCOVID-19와 간: 불리한 결과 경로 관점Review Published on 2021-05-152022-09-11 Journal: Toxicology [Category] SARS, 치료제, [키워드] adverse outcome anticipated AOP binding caused COVID-19 COVID-19 patients hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia knowledge liver Liver damage Liver injury Local mechanism pathway Pathways Perspective pharmacological treatment Research SARS-CoV-2 systemic inflammation Therapies Vaccine virus [DOI] 10.1016/j.tox.2021.152765 PMC 바로가기 [Article Type] Review
Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance심혈관 자기 공명으로 평가한 회복된 트로포닌 양성 COVID-19 환자의 심근 손상 패턴Article Published on 2021-05-142022-09-11 Journal: European heart journal [Category] Fulltext, SARS, 치료기술, [키워드] adenosine cardiovascular Cardiovascular Magnetic Resonance change clinically Control convalescence convalescent coronary disease COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients de novo diffuse discharged disease Ejection fraction Evidence evidence of fibrosis functional gadolinium had no heart disease hospital Hospital admission hospitalized COVID-19 patients indicated Infarction Inflammation Injury Ischaemic heart disease left less LV dysfunction male median Myocardial Myocardial infarction myocardial injury Myocardial oedema myocarditis Myocardium no evidence of oedema past history pathology Patient patients pattern proportion quarter Recovered COVID-19 patients SARS-CoV-2 scar Severe COVID-19 Infection silent Stress troponin underlying aetiology Undetermined ventilatory ventilatory support ventricular [DOI] 10.1093/eurheartj/ehab075 PMC 바로가기 [Article Type] Article
Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease중증 COVID-19 질환 환자의 표준 요법에 대한 회복기 혈장 요법의 무작위 대조 시험Randomized Controlled Trial Published on 2021-05-112022-08-13 Journal: Scientific Reports [Category] SARS, 임상, 치료기술, 치료법, [키워드] 95% CI appear biochemical parameter Biochemical parameters clinical Clinical outcome confirmation Control Controlled trial convalescent patient Convalescent plasma therapy COVID-19 disease COVID-19 patient CP group died feasibility ferritin ferritin level higher risk hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia IMPROVE measure mechanical ventilation Mortality NIV no difference no differences no significant difference no significant differences Non-invasive not differ one patient open open label Patient pilot study plasma Primary outcome primary outcome measure Randomized Randomized controlled trials required respiratory indice respiratory indices risk risk ratio Safe secondary outcome secondary outcome measure Secondary outcomes severe COVID-19 severe COVID-19 disease severe disease Standard of care Standard therapy therapy Trial Two patient two patients Ventilation Virology [DOI] 10.1038/s41598-021-89444-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Circulating calprotectin as a supporting inflammatory marker in discriminating SARS-CoV-2 infection: an observational studySARS-CoV-2 감염을 식별하는 데 도움이 되는 염증 표지자로서의 순환 칼프로텍틴: 관찰 연구Observational Study Published on 2021-05-062022-09-10 Journal: Inflammation research : official journal of the Eu [Category] MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] addition Analysis analyzed calprotectin circulating Circulating calprotectin controls COVID-19 current cutoff value Granulocytes greater hospitalized COVID-19 patient hospitalized COVID-19 patients increase in indication Infection Inflammatory Inflammatory bowel disease inflammatory bowel diseases Inflammatory marker inflammatory status intestinal Laboratory medicine marker Molecular tests objective Patient Perspective plasma positive Predictive Prevent Protein Quantitative Research Result ROC Curve ROC curves RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic SARS-CoV-2 patient serum serum and plasma Stool stools subject suspected patient suspected patients systemic inflammatory [DOI] 10.1007/s00011-021-01465-y PMC 바로가기 [Article Type] Observational Study