Respiratory distress syndrome – Page 22 – Communicable Diseases Research

Severe SARS-CoV-2 disease in the context of a NF-κB2 loss-of-function pathogenic variant

NF-κB2 기능 상실 병원성 변이체의 맥락에서 심각한 SARS-CoV-2 질병

Case Reports

Published on 2021-02-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] MERS, SARS, 변종, 진단, 치료제,

Review of Trials Currently Testing Stem Cells for Treatment of Respiratory Diseases: Facts Known to Date and Possible Applications to COVID-19

호흡기 질환 치료를 위해 현재 줄기 세포를 테스트하는 시험 검토: 현재까지 알려진 사실 및 COVID-19에 대한 가능한 적용

Review

Published on 2021-02-012022-09-11
Journal: Stem cell reviews and reports [Category] 임상,

[키워드] acute respiratory distress syndrome acute respiratory syndrome application ARDS Bone marrow carried clinical clinical study clinical trial clinical trials Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cultured cell cultured cells cytokine Cytokine storm Date Fact feasibility health emergency Health Organization help immunomodulatory Inflammation inhibit International MERS Mesenchymal stem cells Microvesicles Middle East Middle East respiratory syndrome mitigate MSC MSCs outcome pharmacological treatment pharmacological treatments Phase 1 Phase 2 preclinical studies preclinical study Prevent public health emergency respiratory respiratory distress Respiratory distress syndrome review Severe acute respiratory syndrome STEM stem cell stem cells Testing the cytokine storm the disease therapeutic therapy Tolerability Treatment umbilical Umbilical cord WHO World Health Organization
[DOI] 10.1007/s12015-020-10033-6 PMC 바로가기 [Article Type] Review

Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19

호중구 세포외 트랩의 순환 마커는 COVID-19 환자에서 예후 가치가 있습니다

Article

Published on 2021-02-012022-09-11
Journal: Arteriosclerosis, Thrombosis, and Vascular Biology [Category] MERS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome association Asymptomatic Blood cells C-reactive protein cell-free DNA characterized circulating Clinical outcome Coagulation convalescent plasma coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 disease COVID-19 disease severity Cytokines declined Disease progression disease severity elevated endothelial damage enrolled evaluate Evidence Extracellular extracellular traps fibrinolysis healthy controls healthy individual healthy individuals histone Hospital admission hyperinflammation immunothrombosis in healthy individual in vivo Infection Inflammation Inflammatory cytokines marker moderate moderate to severe Mortality NET NETs neutrophil Neutrophil elastase Neutrophil extracellular trap Neutrophils pathogenic mechanism pathogenic mechanisms patients with COVID-19 plasma plasma sample plasma samples Post-infection progression respiratory respiratory distress Respiratory distress syndrome Respiratory Support SARS-CoV2 severe disease syndrome target targets therapeutic intervention thrombosis thrombotic thrombotic microangiopathy TRAP value were assessed White blood cells with COVID-19
[DOI] 10.1161/ATVBAHA.120.315267 PMC 바로가기 [Article Type] Article

SARS-CoV-2 infection: molecular mechanisms of severe outcomes to suggest therapeutics

SARS-CoV-2 감염: 치료법을 제안하는 심각한 결과의 분자 메커니즘

Review

Published on 2021-02-012022-09-11
Journal: Expert review of proteomics [Category] MERS, 유전자 메커니즘, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory distress syndrome. ARDS Area base pair base pairs Biomarker Biomarkers Clinical course clinical risk factor Clinical risk factors Combination COVID-19 cytokine cytokine signaling dataset datasets defined door drug endotheliopathy expert genetics Google Scholar Human Impact infect Infection literature MODS molecular molecular mechanism multiple organ dysfunction multiple organ dysfunction syndrome NCBI NETosis opens organ dysfunction syndrome outcome pathology pathway Patient patients with COVID-19 Pneumonia positive feedback positive feedback loop Precision pyroptosis respiratory distress Respiratory distress syndrome Risk factors RNA SARS-CoV-2 SARS-CoV-2 genome secondary infections severe COVID-19 SRA Support syndrome tested the SARS-CoV-2 genome therapeutic Therapeutics thrombocytopathy treat Treatment Treatment strategies treatment strategy understanding unique
[DOI] 10.1080/14789450.2021.1908894 PMC 바로가기 [Article Type] Review

Successful treatment of two Japanese ESRD cases with severe COVID-19 pneumonia

중증 코로나19 폐렴을 동반한 일본 ESRD 사례 2건의 성공적인 치료

Case Reports

Published on 2021-02-012022-09-11
Journal: CEN case reports [Category] MERS, SARS, 진단, 치료제,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory distress syndrome (ARDS) Admission anti-cytokine anti-cytokine therapy ARDS Clinical course cohort study coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 pneumonia Diabetic diabetic nephropathy disease distress effective End-stage renal disease End-stage renal disease (ESRD) ESRD exhibited Hemodialysis high mortality rate ICU Immunoglobulin indicate infected with COVID-19 intensive care intensive care unit Intravenous immunoglobulin Intravenous immunoglobulin (IVIG) IVIG Japanese Maintenance hemodialysis mechanical ventilation nephropathy novel Novel coronavirus novel coronavirus disease Patient patients renal renal disease respiratory distress Respiratory distress syndrome Severe COVID-19 pneumonia syndrome Tocilizumab treated Treatment were infected with COVID-19
[DOI] 10.1007/s13730-020-00512-7 PMC 바로가기 [Article Type] Case Reports

Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series

COVID-19로 유발된 중증 ARDS 환자 치료를 위한 주산기 조직 유래 중간엽 줄기세포: 사례 시리즈

Clinical Trial

Published on 2021-01-292022-08-13
Journal: Stem Cell Research & Therapy [Category] 바이오마커, 임상, 진단,

[키워드] acute renal and hepatic failure acute respiratory distress syndrome age Allogeneic allogeneic prenatal Alpha ARDS ARDS patients C-reactive protein C-reactive protein (CRP candidate Cardiac arrest Cardiomyopathy case sery cell infusion cell infusions Cell therapy cells chronic lymphocytic leukemia clinical trial CLL CMP Comorbidities Comorbidity Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 Critically ill develop diabetes diagnosed died discharged distress Dyspnea eight enrolled fatal complication feasibility finding FIVE hepatic failure High dose hospital human umbilical cord MSCs hypertension Hypoxemia ICU ICUs IFN-γ IL-6 IL-6 level IL-6 levels IL-8 IMPROVE Inflammatory biomarker inflammatory biomarkers infusion intensive care unit intensive care units interferon gamma intravenous infusion Large randomized multicenter clinical trials leukemia Leukocytosis lung lymphocyte Lymphocytes mechanical ventilation men mesenchymal stem cell Mesenchymal stem cells Mesenchymal stromal cells MSC MSCs multi-organ failure multicenter one patient outcome Patient patients perinatal tissue Phase 1 PL-MSCs Placenta placental MSC placental MSCs Pneumonia Potential treatment Radiological parameter Radiological parameters Randomized reduce reduced renal reported required respiratory distress Respiratory distress syndrome Safe Sepsis Serious Adverse Event Serious Adverse Events Serum level serum levels Seven severe hypoxemia Significant reduction significant reductions SpO2 stem cell Stem cell therapy supplementary material survivor Survivors syndrome the cell therapeutic potential TNF-α Tolerability Treatment Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha UC-MSCs umbilical Umbilical cord women
[DOI] 10.1186/s13287-021-02165-4 PMC 바로가기 [Article Type] Clinical Trial

The Central Role of Fibrinolytic Response in COVID-19—A Hematologist’s Perspective

COVID-19에서 섬유소 용해 반응의 중심 역할 - 혈액 전문의의 관점

Review

Published on 2021-01-282022-09-12
Journal: International Journal of Molecular Sciences [Category] 진단,

[키워드] ACE acute respiratory diseases acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome aldosterone angiotensin angiotensin-converting enzyme 2 ARDS balance Characteristics contagious coronavirus coronavirus disease cough Course COVID-19 drug target Evidence fatigue Fever fibrinolysis fibrinolytic fibrinolytic system headache host cells hypercoagulable Hypercoagulable state Infection inhibitor involved kidney lesion lesions lung MERS Middle East Middle East respiratory syndrome Novel coronavirus novel coronavirus disease other organ other organs Pathogenesis pathway patients with COVID-19 plasminogen activator inhibitor 1 (PAI-1) pulmonary complications RAAS receptor Renin renin-aldosterone-angiotensin-system (RAAS) respiratory respiratory diseases respiratory distress Respiratory distress syndrome respiratory tract infection response role SARS-CoV-2 Severe acute respiratory syndrome severe pneumonia sore throat Spike protein spike protein of SARS-CoV-2 syndrome the spike protein tissue plasminogen activator Transmission uPA Urokinase-Type Plasminogen Activator Viral viral illnesses
[DOI] 10.3390/ijms22031283 PMC 바로가기 [Article Type] Review

Cytokine Signature Induced by SARS-CoV-2 Spike Protein in a Mouse Model

마우스 모델에서 SARS-CoV-2 스파이크 단백질에 의해 유도된 사이토카인 시그니처

Immunology

Published on 2021-01-282022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome Adenovirus alveolitis angiotensin Angiotensin-converting enzyme ARDS BALB/c mice BALF Bronchoalveolar lavage fluid change Clinical use colony-stimulating factor Combination contribute COVID-19 COVID-19 patient CSS cytokine Cytokine storm Cytokine storm syndrome Cytokines domain drugs effective enzyme Extracellular global health GM-CSF granulocyte granulocyte-macrophage colony-stimulating factor Health Human angiotensin-converting enzyme 2 IL-1α IL-6 IL-6 inhibitor immunostimulant indicated induced Inflammatory cytokines inhibitor inhibitors Injury interleukin interleukin 6 interleukin 6 (IL-6 investigated Jak lead lung Lung injury mAb mAbs magnetic resonance imaging mechanism Model monoclonal antibodies monoclonal antibody mortalities mouse murine model myeloperoxidase Neutralizing neutrophilic Occurrence opens phenotype polyinosinic-polycytidylic acid pro-inflammatory Protein reduced respiratory distress Respiratory distress syndrome resulting Safe SARS-CoV-2 signature spike syndrome the cytokine storm therapeutic TNF-α Tocilizumab Treatment wild-type
[DOI] 10.3389/fimmu.2020.621441 PMC 바로가기 [Article Type] Immunology

Risk factors for mortality of coronavirus disease-2019 (COVID-19) patients in two centers of Hubei province, China: A retrospective analysis

중국 후베이성 두 곳의 코로나19(COVID-19) 환자 사망 위험 요인: 후향적 분석

Research Article

Published on 2021-01-282022-09-10
Journal: PLoS ONE [Category] 치료기술,

[키워드] 95% confidence interval Acute cardiac injury acute respiratory distress acute respiratory distress syndrome Admission age analyzed approach ARDS assist cardiac injury Characteristics China CK-MB clinical clinician collected Comorbidities Comorbidity Complication Computed tomography conducted consolidation coronavirus coronavirus disease COVID-19 COVID-19 patients Cox regression analysis creatine creatine kinase death Dyspnea enrolled Factor Frequency global pandemic hazard ratio hemoglobin identify independent risk factor independent risk factors indicated Laboratory Lactate lactate dehydrogenase LDH Mortality multivariate multivariate Cox regression analysis non-survivor Older on admission outbreak overall mortality Patient patient age PCT poor prognosis predictor procalcitonin radiological radiological features renal respiratory distress Respiratory distress syndrome Result Retrospective analysis risk factor Risk factors survivor syndrome the median Treatment variable variables Wuhan Wuhan, China
[DOI] 10.1371/journal.pone.0246030 PMC 바로가기 [Article Type] Research Article

The use of electrical impedance tomography for individualized ventilation strategy in COVID-19: a case report

COVID-19에서 개별 환기 전략을 위한 전기 임피던스 단층 촬영의 사용: 사례 보고

Case Reports

Published on 2021-01-222022-09-01
Journal: BMC Pulmonary Medicine [Category] Fulltext, MERS, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome body position Care Case report clinical close monitoring Computed tomography COVID-19 COVID-19 patient electrical impedance Electrical impedance tomography End-Expiratory Pressure extubation help identify information Invasive mechanical ventilation Lung function management MONITOR offer pandemic of COVID-19 Patient Personalizing ventilation strategies Phenotypes Positive end-expiratory pressure provide required respiratory distress Respiratory distress syndrome Support syndrome the patient therapeutic intervention therapeutic interventions Titrate of positive end-expiratory pressure unique Ventilation was used weaning while
[DOI] 10.1186/s12890-021-01411-y PMC 바로가기 [Article Type] Case Reports