Severe COVID-19: NLRP3 Inflammasome DysregulatedImmunology Published on 2020-06-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] activate Activation Adaptive immune response COVID-19 COVID-19 patient Cytokine storm downregulate dysregulated endogenous adjuvant activity FIVE HMGB1 immune immune system NLRP3 NLRP3 inflammasome potential treatment option reduced resulting SARS-CoV-2 severe COVID-19 severe COVID-19 patients therapy tissue damage virus [DOI] 10.3389/fimmu.2020.01580 PMC 바로가기 [Article Type] Immunology
Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-Term Population-Scale ImmunityReport Published on 2020-06-082022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, [키워드] ACE2 receptor activate Adaptive immune response B cell epitopes binding can be used CD4 CD8 conserved coronavirus Coronaviruses COVID-19 DNA DNA vaccine domain Efficacy engage epitope expected furin cleavage site generate genomic region histocompatibility complex HLA identification Immunity immunogenicity implementation include majority membrane fusion MHC mRNA peptide predicted proteome Region reported RNA RNA vaccine robust SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 vaccine SARS2 subset tested the spike protein thought Vaccine Vaccines validation viral genome [DOI] 10.1016/j.xcrm.2020.100036 PMC 바로가기 [Article Type] Report
Protective Adaptive Immunity Against Severe Acute Respiratory Syndrome Coronaviruses 2 (SARS-CoV-2) and Implications for VaccinesPathology Published on 2020-06-012022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Adaptive immune response Against Asymptomatic characterized coronavirus coronavirus disease COVID-19 died disease dry cough elicited Fever global pandemic immune response imperative infected with SARS-CoV-2 Intervention Mild Neutralizing antibodies Novel coronavirus pandemic Pathogenesis Prevent Protective public health respiratory Respiratory disease responsible SARS-CoV-2 SARS-CoV-2 virus Spread T-cell immunity Therapeutic strategies Vaccine Vaccines [DOI] 10.7759/cureus.8399 PMC 바로가기 [Article Type] Pathology
Impact of sex and gender on COVID-19 outcomes in EuropeReview Published on 2020-05-252022-10-28 Journal: Biology of Sex Differences [Category] COVID-19, MERS, SARS, [키워드] ACE acute respiratory syndrome Adaptive immune response analyses antiviral therapies cardiovascular conditions China Chinese condition content coronavirus coronavirus disease Course COVID-19 develop disease entry receptor enzyme epidemiological Europe European country Evidence expression of gene fatality Fatality rate Gender Health highest immune system Impact incidence include mechanism men modulating offer outcome Prophylactic Psychological receptor reduced Renin angiotensin aldosterone system reported risk stratification SARS-CoV2 Sex Sex difference Stress the disease therapeutic option Therapeutic treatment TMPRSS2 Treatment women [DOI] 10.1186/s13293-020-00304-9 PMC 바로가기 [Article Type] Review
COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males?Hypothesis Published on 2020-05-142022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE1 ABO ACE1/ACE2 ACE2 ACE2 expression ACE2 gene activate acute respiratory syndrome ADAM17 Adaptive immune response addition Affect Anti-inflammatory approved both sexes cell entry China Chinese contract the virus coronavirus COVID-19 COVID-19 patient death died drugs Epidemic epidemiological data events female females Genes heterozygous Hong Kong hospital human ACE2 receptor immune-related gene IMPROVE individual Infection Inflammation intensive care Interaction involved locus lung shut-down male men mortality rate New coronavirus Other outcome pandemic Prognosis prognostic molecular/genetic markers progression proportions RAS-pathway reducing required responsible resulting role SARS-CoV-2 SARS-CoV-2 disease several gene Sex sex/gender-gap SOX3 Spread SRY subsequent susceptible the SARS-CoV-2 Thromboembolism thrombosis transmembrane serine protease Vaccines WHO women World Health Organization Wuhan, China [DOI] 10.3390/ijms21103474 PMC 바로가기 [Article Type] Hypothesis
Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesisResearch Article Published on 2020-05-132022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 치료제, [키워드] adaptive Adaptive immune response Adaptive immunity Analysis antiviral drugs applied cause caused complications coronavirus COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Disease progression early phase epithelial cell Host immune response Immunity implication Infection Influenza Influenza virus innate immune response Innate immunity Interaction lung mathematical Mortality opposite pandemic Pathogenesis patients potential treatment option SARS‐CoV‐2 virus SARS‐CoV‐2 severity Suppressing target cell‐limited model the timing viral clearance Viral load viral pathogenesis virus viruses [DOI] 10.1002/jmv.25866 PMC 바로가기 [Article Type] Research Article
Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19Opinion Article Published on 2020-05-112022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress syndrome Adaptive immune response Alzheimer’s disease Alzheimer’s disease approach Bacterial Brain Chemotherapy cognitive coronavirus disease COVID-19 develop disorder Down syndrome drug Effect effective Encephalitis GM-CSF granulocyte-macrophage colony-stimulating factor humans Immunity imperative Inflammation innate immune system Intervention investigated mouse model Neuroinflammation Nile Other other diseases pandemic pathology Patient recruitment regenerative respiratory SARS-CoV-2 shown stimulate treated Treatment Viral diseases viral infections viral pneumonias virus West West Nile Virus [DOI] 10.12688/f1000research.23729.1 PMC 바로가기 [Article Type] Opinion Article
Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent IndividualsShort communication Published on 2020-05-032022-10-05 Journal: Immunity [Category] SARS, 치료기술, [키워드] activity Adaptive immune response Adaptive immunity Analysis antibodies Antibody titer Blood cellular immunity Cohort collected correlation COVID-19 COVID-19 patient COVID-19 patients detection discharge discharged discharged patients effective eight Follow-up analysis humoral IgG immune responses Immunoglobulin implication individual neutralization outbreak pathogenesis of COVID-19 Patient protective immunity provide pseudotype SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2-specific antibody SARS-CoV-2-specific T cells severe cases T cells tested Vaccine World Health Organization worldwide pandemic [DOI] 10.1016/j.immuni.2020.04.023 [Article Type] Short communication
A Nonfunctional Opsonic Antibody Response Frequently Occurs after Pneumococcal Pneumonia and Is Associated with Invasive Disease비기능성 옵소닌 항체 반응은 폐렴구균 폐렴 후에 자주 발생하며 침습성 질환과 관련이 있다.Article Published on 2020-02-052024-07-31 Journal: mSphere [Category] 폐렴구균 감염증, [키워드] Adaptive immune response Bacteremia immunoglobulins opsonization phagocytosis Pneumonia Streptococcus pneumoniae [DOI] 10.1128/mSphere.00925-19 PMC 바로가기
Nasal priming with immunobiotic lactobacilli improves the adaptive immune response against influenza virusArticle Published on 2020-01-012023-06-24 Journal: International immunopharmacology [Category] 신종인플루엔자, [키워드] Adaptive immune response immunobiotics Influenza virus Lactobacillus rhamnosus CRL1505 respiratory immunity vaccination [DOI] 10.1016/j.intimp.2019.106115