Depressive, anxiety, and post-traumatic stress symptoms affecting hospitalized and home-isolated COVID-19 patients: a comparative cross-sectional studyResearch Published on 2021-05-042022-10-29 Journal: Middle East Current Psychiatry [Category] COVID-19, [키워드] Affect affected affecting Anxiety both group chronic disease contrary COVID-19 COVID-19 patient COVID-19 patients COVID-19 virus cross-sectional Davidson Trauma Scale depressive develop diagnosed DTS Factors HADS Home isolation hospital Hospitalized hospitalized COVID-19 patients increase in independent involved Isolation Logistic regression analysis majority male MOST Patient positive post-traumatic stress symptom Post-traumatic stress symptoms presenting symptoms Protective protective factor Psychiatric psychiatric disorder Psychiatric symptoms Result risk factor scored significantly statistically significant statistically significant difference subject Symptom Symptoms symptoms of depression the patient thought [DOI] 10.1186/s43045-021-00105-9 PMC 바로가기 [Article Type] Research
Effectiveness of hydrogen peroxide as auxiliary treatment for hospitalized COVID-19 patients in Brazil: preliminary results of a randomized double-blind clinical trialRandomized Controlled Trial Published on 2021-05-012022-10-04 Journal: Epidemiology and Health [Category] 임상, [키워드] acute respiratory syndrome adverse effect asked auxiliary clinical trial control group coronavirus coronavirus disease coughing COVID-19 double-blind Dyspnea effective Effectiveness evaluate evaluated Evidence experimental group Fisher exact test group Hospital stay hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient hydrogen peroxide Mild moderate MOST mouthwashes nasal Nasal Sprays no significant difference Patient polymerase chain positive Randomized randomly divided reduction in reported Safe SARS-CoV-2 severity Student test Symptom Symptoms tested the patient Treatment were recorded were used [DOI] 10.4178/epih.e2021032 PMC 바로가기 [Article Type] Randomized Controlled Trial
VitaminD supplementation for the prevention and treatment of COVID-19: a position statement from the Spanish Society of Geriatrics and GerontologyResearch article Published on 2021-05-012022-10-05 Journal: Revista española de geriatría y gerontología [Category] 치료법, [키워드] acute phase Administered Adults advanced age anti-inflammatory effect bilateral pneumonia chronic condition Clinical practice coronavirus disease COVID-19 dendritic cell dose dysregulation Evidence expressed frailty Gerontology hospitalized COVID-19 patients hyperinflammatory cytokine storm immune immune cells immune function immune system IMPROVE Inflammation lack macrophages modulate Monocytes morbidity and mortality Older Older adults over Patient patients with COVID-19 Prevent receptor recommendation reported SARS-CoV-2 severe respiratory symptom shown Society Spanish T lymphocytes treat Treatment VDR Vitamin D vitamin D deficiency Vitamin D supplementation [DOI] 10.1016/j.regg.2021.02.001 [Article Type] Research article
IL-6-based mortality prediction model for COVID-19: Validation and update in multicenter and second wave cohortsCOVID-19에 대한 IL-6 기반 사망률 예측 모델: 다기관 및 2차 유행 코호트의 검증 및 업데이트Clinical Trial Published on 2021-05-012022-09-11 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] age all subject all subjects assist calculated calculator calibration calibration slope characteristic Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 mortality death discrimination distress Early detection Effect Europe evaluated external validation facilitate First wave help high risk hospitalized COVID-19 patients IL-6 implementation include Lactate lactate dehydrogenase lymphocyte Mortality mortality risk multicenter neutrophil Neutrophil-to-lymphocyte ratio outcome oxygen pandemic Patient Peripheral blood predict predicted Predictive Predictive model Probability respiratory distress risk factor second wave validation validation cohort validation cohorts [DOI] 10.1016/j.jaci.2021.02.021 PMC 바로가기 [Article Type] Clinical Trial
Generation of WAe001-A-58 human embryonic stem cell line with inducible expression of the SARS-CoV-2 nucleocapsid proteinSARS-CoV-2 뉴클레오캡시드 단백질의 유도성 발현을 갖는 WAe001-A-58 인간 배아 줄기 세포주의 생성Article Published on 2021-05-012022-09-11 Journal: Stem cell research [Category] SARS, 치료법, [키워드] activate celebrex cell line cell types Comorbidities Comorbidity COVID-19 death discharged embryonic embryonic stem cell expression Generation hospitalized COVID-19 patient hospitalized COVID-19 patients Host karyotype morphology multiple organ multiple organs nucleocapsid nucleocapsid protein PGE prostaglandin prostaglandin E Protein SARS-CoV SARS-CoV-2 SARS-CoV-2 N protein stem cell suggested the SARS-CoV-2 Transcription transcriptionally transposon Treatment [DOI] 10.1016/j.scr.2021.102197 PMC 바로가기 [Article Type] Article
Metabolic Signatures Associated with Severity in Hospitalized COVID-19 Patients입원한 COVID-19 환자의 중증도와 관련된 대사 신호Observational Study Published on 2021-04-302022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 바이오마커, 임상, [키워드] adenine adenine nucleotide Admission assist association Barcelona Biomarker Biomarkers blood pressure ceramide Ceramides change clinical evolution collected correlated COVID-19 COVID-19 patient COVID-19 pneumonia Critical Degradation demographic disease severity enrolled evaluate Evolution Hospitalization hospitalized COVID-19 patients hospitalized patient identifying Inclusion Inflammation Kynurenine metabolic metabolic pathway metabolic pathways metabolism metabolomic metabolomics moderate nicotinamide obesity oxygen oxygen saturation parameter pathophysiology plasma samples Pneumonia radiological reaction reductions reductions in Registered respiratory respiratory rate respiratory severity severity signature significantly single-center study Spain Stratification stratified subsequent Tryptophan Viral viral infection was measured with COVID-19 [DOI] 10.3390/ijms22094794 PMC 바로가기 [Article Type] Observational Study
D-Dimer Level and Neutrophils Count as Predictive and Prognostic Factors of Pulmonary Embolism in Severe Non-ICU COVID-19 PatientsObservational Study Published on 2021-04-262022-10-04 Journal: Viruses [Category] MERS, SARS, 임상, [키워드] age anticoagulation baseline data Biomarker Cohort collected count COVID-19 Cox regression models D-dimer death Embolism enrolled Factor higher risk Hospitalized hospitalized COVID-19 patients ICU ICU transfer identify incidence laboratory biomarkers lack Level Logistic marker median Mortality multicenter neutrophil non-ICU Occurrence outcome Patient Predictive predictive factor Prognosis prognostic Prognostic factor pulmonary pulmonary angiography Pulmonary embolism retrospective RT-PCR severe COVID-19 patient Thromboprophylaxis transfer [DOI] 10.3390/v13050758 PMC 바로가기 [Article Type] Observational Study
HLA-A*11:01:01:01, HLA-C*12:02:02:01-HLA-B*52:01:02:02, Age and Sex Are Associated With Severity of Japanese COVID-19 With Respiratory FailureImmunology Published on 2021-04-222022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome age allele Analysis association Asymptomatic case can be used case-control analysis center clinical marker clinician Comorbidities confounding factor coronavirus coronavirus disease COVID-19 decrease develop Diagnosis disease eight failure global health Haplotype help highest HLA HLA allele HLA gene hospitalized COVID-19 patients identify infected individual Japan Japanese knowledge majority Medicine Mild mild symptoms Mortality Next-generation sequencing outbreak pandemic Patient recruited remained respiratory risk SARS-CoV-2 sensitivity severe COVID-19 severe respiratory symptoms severity of COVID-19 Sex significantly specificity susceptibility genes susceptible Tokyo utility virus was performed WHO with COVID-19 World Health Organization [DOI] 10.3389/fimmu.2021.658570 PMC 바로가기 [Article Type] Immunology
Development of a severity of disease score and classification model by machine learning for hospitalized COVID-19 patients입원 중인 코로나19 환자를 위한 머신러닝을 통한 질병 점수 및 분류 모델의 중증도 개발Research Article Published on 2021-04-212022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] 95% CI 95% confidence interval Admission age applied AUC C-reactive protein calculator Charlson Comorbidity Index clinical and laboratory features Cohort Comorbidity COVID-19 patients detect development died Disease progression efficient estimated glomerular filtration rate evaluated filtration rate FiO2 glomerular filtration rate higher risk hospital Hospital admission Hospitalization Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients identify laboratory feature Lymphocytes machine-learning management mechanical ventilation open oxygen oxygen saturation Patient patients performance performed Peripheral blood predict procalcitonin progression required Result risk Sensitivity and specificity severe disease severe disease progression Severity of disease SpO2 stratified tested variable was used were used [DOI] 10.1371/journal.pone.0240200 PMC 바로가기 [Article Type] Research Article
Humoral immune responses in hospitalized COVID-19 patientsOriginal Article Published on 2021-04-202022-10-04 Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome Analysis anti-S IgG Anti-SARS-CoV-2 S antibodies antibody antibody isotype association caused coronavirus Coronavirus 2019 COVID-19 COVID-19 patient detect Diagnosis diagnosis of COVID-19 disease disease severity ELISA enzyme-linked immunosorbent female females Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient humoral immune response Humoral immunity IgA IgA antibodies IgA antibody IgA response IgG IgG and IgM IgM IgM antibody immune response Immunity Infection investigated isotype male material Non-severe non-severe patients participated Patient patients positive Protein public health crisis Qualitative response Result RT-PCR SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 RNA Saudi Arabia sera severe significantly significantly higher Specific the S protein the SARS-CoV-2 Variation Viral proteins virus was used were measured [DOI] 10.1016/j.sjbs.2021.04.032 PMC 바로가기 [Article Type] Original Article