IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in SwedenResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] SARS, 바이오마커, [키워드] addition analysed baseline Biomarker Biomarkers C-reactive protein (CRP Care classical correlated correlation COVID-19 COVID-19 disease severity COVID-19 pandemic CRP Cytokine/IL-6 defined demonstrated Epidemiology First wave glycoprotein group groups hospital Hospital admission hospitalised patient IL-6 IL-6 pathway IL-6 receptor immune immune response Infection Inflammation intensive care involved Level longitudinal cohort study marker moderate moderate-severe Mortality not differ pathogen pathway Pathways Patient patients with moderate plasma Potential difference Respiratory Support Result severe COVID-19 severe SARS-CoV-2 sgp130 significantly sIL-6R with COVID-19 [DOI] 10.1016/j.cyto.2022.156020 [Article Type] Research article
Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19Article Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Affect antibodies Asymptomatic autoantibody B-cell function children children with COVID-19 complement Complication complications coronavirus coronavirus disease COVID-19 COVID-19 complications COVID-19 disease Critical detectable develop diagnosed Diagnostic Criteria died disease evaluated Genetic genetic cause genetic diagnosis help hypoxemic IFN signaling IFN-I immune immune response Immunity immunodeficiency Inborn error inborn errors of immunity individual infected with SARS-CoV-2 Infection Inflammasome Inflammatory Inflammatory factor Mild Molecular diagnosis Mortality mortality rate MOST multisystem inflammatory syndrome in children (MIS-C) Mutation Neutralizing Patient patients patients with asymptomatic Pediatric patients plasma Pneumonia Primary Immunodeficiency reported SARS-CoV-2 SARS-CoV-2-specific antibodies severe COVID-19 disease syndrome tested Treatment Type I IFN was performed were measured whole-exome sequencing [DOI] 10.1016/j.jaci.2022.09.005 PMC 바로가기
Oral and dermatologic lesions observed in mild COVID-19 patients infected after 3rd vaccine dosearticle Published on 2022-11-012024-09-02 Journal: Oral diseases [Category] 대상포진, [키워드] COVID-19 immune response oral cavity SARS-CoV-2 Vaccine [DOI] 10.1111/odi.14232 PMC 바로가기 [Article Type] article
Longitudinal survey of humoral and cellular response to SARS-CoV-2 infection in childrenArticle Published on 2022-11-012022-11-15 Journal: Microbiological research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Abbott acute infection age analysed anti-RBD IgG antibody antibody blood sample cellular response children COVID-19 decrease diagnosed humoral Humoral response IgG IgG antibodies IgG antibody IgG response immune response Infection longitudinal longitudinal study molecular nasopharyngeal swabs Oxford paediatric patient participant Patient persistence positive SARS-CoV-2 SARS-CoV-2 IgG SARS-COV-2 infection seroconversion rate seroconverted seropositive significant decrease suffered T-cell Response [DOI] 10.1016/j.micres.2022.127145 PMC 바로가기
Elevated IL-18 predicts poor prognosis in critically ill COVID-19 patients at a Brazilian hospital in 2020-21Article Published on 2022-11-012022-11-15 Journal: Future Microbiology [Category] SARS, 바이오마커, [키워드] analyzed association Biomarker Brazil clinical outcomes contribute COVID-19 COVID-19 patient Critically ill Critically ill patient cross-sectional cytokine Deceased dysregulated evaluated exhibited hospital IL-18 immune immune response Inflammation Inflammatory response Innate immunity intensive care laboratory data marker Older Patient patients with COVID-19 Platelet poor prognosis predict quantified significantly higher sociodemographic data with COVID-19 [DOI] 10.2217/fmb-2022-0057 PMC 바로가기
Evaluation of the efficacy of four anti-SARS-CoV-2 antibodies after vaccination using kits from two manufacturers: A prospective, longitudinal, cohort study at 11 serial time points within 160 daysArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome Affect anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies antibody Antibody detection cohort study Consistency CoronaVac coronavirus COVID-19 Efficacy evaluated half-live IgG antibody IgM antibody immune response less moderate Neutralizing antibodies neutralizing antibody SARS-CoV-2 SARS-CoV-2 vaccines subject the vaccine total antibodies total antibody vaccination Vaccine [DOI] 10.1016/j.intimp.2022.109285 PMC 바로가기
Humoral and Cellular Immune Response After Third and Fourth SARS-CoV-2 mRNA Vaccination in Liver Transplant RecipientsArticle Published on 2022-11-012022-11-15 Journal: Clinical gastroenterology and hepatology : the off [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome anti-S anti-SARS-CoV-2 antibody Antibody Response Antibody titer cellular Cellular immune response coronavirus COVID-19 defined domain dose filtration first vaccination HCs healthy control humoral immune response Immunosuppression increase increase in investigated liver liver transplant liver transplant recipients LTR LTRs Lymphocyte count mRNA mRNA-based non-responders Odds ratio Patient Prospective Study RBD recipient responders response risk factor SARS-CoV-2 SARS-CoV-2 vaccination second vaccination Seroconversion seronegative seropositive spike-specific T-cell response T cells the median Third and Fourth SARS-CoV-2 Vaccination. Transplant vaccination Vaccinations [DOI] 10.1016/j.cgh.2022.06.028 PMC 바로가기
The immune response as a double-edged sword: The lesson learnt during the COVID-19 pandemicArticle Published on 2022-11-012022-11-16 Journal: Immunology [Category] SARS, 변종, [키워드] Asymptomatic breadth cellular Clinical severity COVID-19 COVID-19 pandemic Critical Cross-immunity cytokine Cytokine storm detrimental disease disease severity effort events Evidence feature highlighting immune response Immunopathogenesis Infection Innate immunity pathogen pathogenic processes Protective protective immunity protective role provided public health reducing resulting T-cell immunity the SARS-CoV-2 therapeutic approaches tissue injury Vaccine Viral variants [DOI] 10.1111/imm.13564 PMC 바로가기
Potential mechanisms of vaccine-induced thrombosisArticle Published on 2022-11-012022-11-15 Journal: European journal of internal medicine [Category] 유전자 메커니즘, 진단, [키워드] activate Ad26.COV2.S Adenovirus administration AdV vector antibodies antibody Autoimmune heparin-induced thrombocytopenia B cell Bacteria BNT162b cerebral venous sinuse ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine characterized clinical conformational change Contact COVID-19 COVID-19 vaccine COVID-19 vaccines described develop Effectiveness elicited events expression Factors Gene therapy heparin-induced thrombocytopenia hexone immune complex immune response Immune thrombocytopenia immunothrombosis IMPROVE induce intrinsic knowledge laboratory feature mechanism monocyte occur PF4 Platelet Platelets Potential proinflammatory Protein receiving resulting Spike protein splice subject syndrome T-cell thrombosis Vaccine Vaccine- induced immune thrombocytopenia and thrombosis. vectors Venous thrombosis viruses [DOI] 10.1016/j.ejim.2022.08.002 PMC 바로가기
Performance and validation of an adaptable multiplex assay for detection of serologic response to SARS-CoV-2 infection or vaccinationArticle Published on 2022-11-012022-11-15 Journal: Journal of Immunological Methods [Category] SARS, 진단, 치료기술, 치료제, [키워드] Antibody Response Antigen antigenic target assays correlated COVID-19 IgG immune response increasingly Infection infection with SARS-CoV-2 measure measurement multiplex Multiplex assay nucleocapsid antigen performance platform Quantitative ranged RBD Receptor binding domain S1 and S2 SARS-CoV-2 SARS-COV-2 infection sensitivity serologic assay Serologic response serology specificity subunit vaccination Variation [DOI] 10.1016/j.jim.2022.113345 PMC 바로가기