pro-inflammatory cytokine – Page 25 – Communicable Diseases Research

E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation

Research

Published on 2020-06-182022-10-28
Journal: Respiratory Research [Category] COVID-19,

Bradycardia in Patients With COVID-19: A Calm Before the Storm?

Cardiology

Published on 2020-06-132022-10-31
Journal: Cureus [Category] COVID-19,

[키워드] acute respiratory syndrome Admission arrhythmia association bradycardia cardiac cardiovascular case sery Comorbidity contributing to Corona Virus Disease coronavirus coronavirus disease correlation COVID-19 Cytokine release syndrome (CRS) Cytokine storm demographic described dexmedetomidine ECG Effects electrocardiogram EpiC Fahrenheit females FIVE Health heart rate ICU Infection Inflammatory knowledge Laboratory laboratory-confirmed lowest maintain male manifestation maximum body temperature mean arterial pressure medication multifactorial network nine pacemaker cells Patient pro-inflammatory cytokine Prolonged propofol QTc interval ranged receiving reported required retrospective SARS-CoV-2 sars-cov-2 (severe acute respiratory syndrome coronavirus -2) severe hypoxia Surveillance Transient Treatment triggers Two patient university Vasopressor
[DOI] 10.7759/cureus.8599 PMC 바로가기 [Article Type] Cardiology

Cytokine Release Syndrome (CRS) and Nicotine in COVID-19 Patients: Trying to Calm the Storm

Immunology

Published on 2020-06-112022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS,

[키워드] “cytokine storm” activate acute respiratory syndrome affected Anti-inflammatory approach approved cause caused characterized China Cholinergic anti-inflammatory pathway clinically COVID- 19 COVID-19 CRS Cytokine Release Syndrom (CRS) Cytokine release syndrome effort epidemiological Evidence Hospitalized hyperinflammation Hypothesis Inflammation inhibit less lung many cases New coronavirus Nicotine pathway patients pro-inflammatory cytokine Proinflammatory cytokine receptor reduce Release rising mortality Safe SARS-CoV-2 SARS-CoV-2 (virus) severe SARS-CoV-2 Signal transduction smoker statistically storm Therapies therapy Treatment ulcerative colitis worldwide pandemic
[DOI] 10.3389/fimmu.2020.01359 PMC 바로가기 [Article Type] Immunology

Lessons Learned to Date on COVID-19 Hyperinflammatory Syndrome: Considerations for Interventions to Mitigate SARS-CoV-2 Viral Infection and Detrimental Hyperinflammation

Immunology

Published on 2020-05-292022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS,

[키워드] 2019-nCoV Antiviral antiviral immune response Asymptomatic boost caused cellular protease China complications coronavirus COVID-19 COVID-19 progression COVID-19 severity Cytokine release syndrome Date determine develop disease Disease progression drug drugs targeting event Factor help host cell hyperinflammation Hyperinflammatory immune include individual Inflammatory responses inhibit SARS-CoV-2 Intervention key factor lesson Lungs mechanism of action monoclonal antibody multifactorial occur pandemic pro-inflammatory cytokine randomized clinical trials reported Repurposed drug SARS-CoV-2 SARS-CoV-2 replication serine protease inhibitor severe COVID-19 Spread the timing transmission of SARS-CoV-2 Treatment strategies viral infection
[DOI] 10.3389/fimmu.2020.01131 PMC 바로가기 [Article Type] Immunology

Immunity, parasites, genetics and sex hormones: contributors to mild inflammatory responses in COVID-19?

Essay

Published on 2020-05-152022-10-28
Journal: The Pan African Medical Journal [Category] COVID-19, MERS,

The novel immunomodulatory biologic LMWF5A for pharmacological attenuation of the “cytokine storm” in COVID-19 patients: a hypothesis

Hypothesis

Published on 2020-05-132022-10-28
Journal: Patient Safety in Surgery [Category] COVID-19,

[키워드] “cytokine storm” acute lung injury acute respiratory distress syndrome ARDS attenuate Barrier function biologic Clinical outcome COVID-19 COVID-19 infection COVID-19 pandemic cultures Cytokine storm defined described Diffuse alveolar damage drug Efficacy endothelial ENhance evaluate Evidence food fraction homeostasis Human serum albumin hyperinflammation Hyperinflammatory Hypothesis immune immune response immunomodulatory immunomodulatory effect implicated IMPROVE in vitro Inflammation intensive care LMWF5A low molecular weight nebulized Osteoarthritis Oxygenation parameter Patient pharmacological presentation pro-inflammatory cytokine promote pulmonary infections Randomized controlled trial reduce reduce mortality required respiratory SARS-CoV-2 Testing the cytokine storm therapy variety Ventilation while with COVID-19
[DOI] 10.1186/s13037-020-00248-4 PMC 바로가기 [Article Type] Hypothesis

Towards treatment planning of COVID-19: Rationale and hypothesis for the use of multiple immunosuppressive agents: Anti-antibodies, immunoglobulins, and corticosteroids

Article

Published on 2020-05-082022-10-04
Journal: International immunopharmacology [Category] MERS, SARS, 임상, 치료법,

[키워드] accelerate anti-IL6 antibody benefit cell entry Characteristics clinical benefit Controlled clinical trial correlated Corticosteroid Corticosteroids COVID-19 COVID-19-related death cytokine essential element fatal disease humans Hypothesis IL6 immune system Immunoglobulin immunoglobulins immunosuppressive IMPROVE Inflammation interleukin 6 monoclonal antibody Novel coronavirus outcomes Patient patients with COVID-19 pro-inflammatory cytokine Prognosis prognosis of patient rationale reduce SARS-CoV2 severe COVID-19 severity shown target targeted therapy therapeutic option therapy Treatment use of corticosteroid Viral load with COVID-19
[DOI] 10.1016/j.intimp.2020.106560 PMC 바로가기 [Article Type] Article

Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?

세포외 HMGB1: 코로나19를 포함한 중증 폐염증 치료 표적?

Review

Published on 2020-05-072022-08-13
Journal: Molecular Medicine [Category] MERS, SARS, 유전자 메커니즘,

[키워드] 2019 novel coronavirus 2019 novel coronavirus disease activated activated innate immunity cells acute respiratory distress acute respiratory distress syndrome Apoptosis ARDS Blood cause cells from males cellular cytosol complexes concentrations coronavirus disease COVID-19 COVID-19-associated inflammation cytokine cytosolic DAMP DAMPs danger molecule Danger molecules detrimental disease Disulfide Disulfide-HMGB1 dying cell dying cells endocytosed endocytosis endogenous damage-associated molecular pattern endolysosomal system endothelial cells expressed expression Extracellular extracellular DNA Extracellular HMGB1 extracellular SARS-CoV-2 RNA female form HMGB1 identify in vivo individuals induce inflammasome activation Inflammation Influenza initiate innate immunity cells lung Lungs lysosome Lysosomes lytic cell death molecular molecule HMGB1 Necrosis Novel coronavirus novel coronavirus disease observation other molecules PAMP PAMPs pathogen pathogen-associated molecular Pathogenesis pathogenic molecule Pathways physiological plasma Pneumonia pro-inflammatory cytokine pro-inflammatory cytokine release proinflammatory receptor pulmonary endothelial cell pulmonary endothelial cells pulmonary inflammation RAGE reduction released respiratory distress Respiratory distress syndrome RNA SARS-CoV-2 secreted syndrome Therapeutic compounds therapeutic target therapy TLR4 TLR4 receptor TLR4 receptors transfer transported Trigger triggers venous venous blood
[DOI] 10.1186/s10020-020-00172-4 PMC 바로가기 [Article Type] Review

Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths

Review

Published on 2020-04-022022-10-30
Journal: Nutrients [Category] COVID-19, SARS,

[키워드] 25-hydroxyvitamin D acute respiratory distress acute respiratory distress syndrome (ARDS) addition age anti-inflammatory cytokines ascorbic acid Cathelicidin chronic disease clinical trial Comorbidity Concentration concentrations conducted contribute Controlled trial coronavirus COVID-19 COVID-19 pandemic Cytokine storm death deficiency dose Epidemiology evaluate Health include infected with COVID-19 Inflammation Influenza knowledge Lungs measure mechanism mechanisms Observational observational study occurred outbreak Pneumonia prevention pro-inflammatory cytokine Public quarantine raise recommendations reduce reduced reducing reported respiratory tract infection Respiratory tract infections risk risk of COVID-19 risk of infection risk of infections solar radiation southern hemisphere Treatment UVB viral replication Vitamin C Vitamin D Vitamin D supplementation
[DOI] 10.3390/nu12040988 PMC 바로가기 [Article Type] Review

Associations between immune-suppressive and stimulating drugs and novel COVID-19—a systematic review of current evidence

Review

Published on 2020-03-272022-10-31
Journal: ecancermedicalscience [Category] COVID-19,

[키워드] acute respiratory syndrome adverse events anti-CD20 auto-immune disease blockade blockers Cancer Chemotherapy coronavirus COVID-19 COVID-19 pandemic COVID-19 patient Cytokines Cytotoxic chemotherapy drug drugs Effect elevated Evidence higher risk host immunity IL-1 IL-6 IL-6 inhibitor immune modulation Immune suppression Impact In vitro studies induce inhibitor inhibitors Jak JAK-STAT pathway Janus kinase Kinase inhibitor less low-dose methotrexate modulation Necrosis non-steroidal anti-inflammatory drug NSAIDS OVID Patient patients patients with COVID-19 Prednisolone pro-inflammatory cytokine pulmonary complications respiratory diseases Result secretion severity shown Steroids systematic review target TNFα treated Treatment
[DOI] 10.3332/ecancer.2020.1022 PMC 바로가기 [Article Type] Review