Respiratory distress syndrome – Page 25 – Communicable Diseases Research

Outcomes of an intermediate respiratory care unit in the COVID-19 pandemic

COVID-19 전염병에서 중간 호흡기 치료 단위의 결과

Research Article

Published on 2020-12-162022-09-12
Journal: PLoS ONE [Category] MERS, SARS, 진단,

Compassionate Use of Tocilizumab for Treatment of SARS-CoV-2 Pneumonia

SARS-CoV-2 폐렴 치료를 위한 토실리주맙의 자비로운 사용

Article

Published on 2020-12-152022-09-11
Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 신약개발, 진단, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adverse adverse events anti-IL-6R antigen receptor appear approved benefit C-reactive protein C-reactive protein (CRP chimeric antigen receptor clinical and laboratory parameters clinical trials compassionate use coronavirus COVID-19 CRP cytokine Cytokine storm death Decline declines dose drug Drug administration Efficacy event examined Follow-up food Food and Drug Administration hospitalized patient hospitalized patients IL-6 IL-6R Inflammation interleukin interleukin 6 Intubated laboratory parameter Laboratory parameters mechanical ventilation morbidity morbidity and mortality Mortality occurred offer outcomes oxygen Oxygen requirements oxygen saturation oxygen saturations oxygen support pathogenic Patient patients patients with SARS-CoV-2 Placebo placebo-controlled Pneumonia predominant Preliminary data profiles proof Randomized rationale reducing required respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 pneumonia SARS-CoV2 Serious Adverse Event Serious Adverse Events severe acute respiratory syndrome Coronavirus Significant reduction significant reductions single-center study supported T-cell temperature therapy Tocilizumab Treatment vasopressor requirement vasopressor requirements vasopressor support
[DOI] 10.1093/cid/ciaa812 PMC 바로가기 [Article Type] Article

What Open-Lung Biopsy Teaches Us about ARDS in COVID-19 Patients: Mechanisms, Pathology, and Therapeutic Implications

개폐 생검이 COVID-19 환자의 ARDS에 대해 가르치는 것: 기전, 병리학 및 치료적 의미

Research Article

Published on 2020-12-092022-09-10
Journal: BioMed Research International [Category] 치료기술,

[키워드] acute respiratory distress syndrome alveolar damage Analysis Anticoagulant ARDS assist Atypical Berlin biopsy cause caused chain Chain Reaction Coagulopathy Compliance COVID-19 Culture dead Dead space difficulty dual FIBRIN Glucocorticoids High dose hyaline membrane hyaline membranes Hypoxemia Injury intensive care intensive care unit lung lung tissue mechanical ventilation meet microthrombi pathophysiology Patient patients physician pleural fluid polymerase chain reaction Protective pulmonary parenchyma reaction researcher respiratory respiratory distress Respiratory distress syndrome RT-PCR SARS-CoV-2 severe hypoxemia Shunt shunt effect specimens Therapeutic approach thrombotic tissue biopsy two patients understanding vascular congestion Ventilation-perfusion ratio was performed
[DOI] 10.1155/2020/2909673 PMC 바로가기 [Article Type] Research Article

Update on COVID-19 Myocarditis

COVID-19 심근염에 대한 업데이트

Review

Published on 2020-12-092022-09-10
Journal: Medicina [Category] MERS, SARS, 치료제,

[키워드] Acute coronary syndrome acute respiratory syndrome addition Affect arrhythmia Arrhythmias cardiac Cardiac complications Cardiogenic shock Complication convalescent plasma coronary syndrome coronavirus coronavirus 2 COVID-19 COVID-19 disease current Diagnosis Endomyocardial biopsy etiologies Evidence expected heart failure Host immune response human body imaging modality include increasingly Injury Intervention key factor Laboratory laboratory findings life life threatening life-threatening management manifestation morbidity morbidity and mortality MRI myocarditis Non-invasive organ system organ systems performed reducing refractory remains uncertain Remdesivir respiratory respiratory distress Respiratory distress syndrome Respiratory system SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 disease Severe respiratory distress Shock Steroids Support syndrome therapy Viral while
[DOI] 10.3390/medicina56120678 PMC 바로가기 [Article Type] Review

SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells

SARS-CoV-2 스파이크 단백질은 상피 세포에서 지오텐신 II 수용체 신호 전달의 활성화에 의해 IL-6 트랜스 신호 전달을 촉진합니다

Research Article

Published on 2020-12-072022-08-13
Journal: PLoS Pathogens [Category] Biology and Life Sciences, MERS, SARS, 진단,

[키워드] ACE2 ACE2 expression Activation acute respiratory distress acute respiratory distress syndrome ADAM Aggressive angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Angiotensin II AP-1 AT1 Author c-Fos candesartan Candesartan cilexetil cascade Cell cell interactions cells Characteristics chemokines classical combating coordination Coronavirus infection COVID-19 COVID-19 disease COVID-19 disease severity culture supernatant cytokine cytokine response Cytokine storm Cytokines disease severity down-regulation ectopic expression elevated endothelial Endothelial cell epithelial epithelial cell epithelial cells excessive inflammatory response expressed expressing expression Extracellular generate Host human epithelial cell human epithelial cells human liver hyper-inflammatory response IL-6 IL-6R indicated induce inducer Infection Inflammatory cytokine inhibit inhibited Interaction leads Lung epithelial cells Lung injury Macrophage macrophage activation macrophages MAPK MCP-1 mechanism mediators Monocytes monocytes/macrophage monocytes/macrophages Multi-organ damage NF-κB observation pathology pathway patient sera Phosphorylation primary host pro-inflammatory promote promoted promotion protease protein expression pulmonary epithelial cell receptor receptor antagonist receptor protein receptor signaling referred to Regulatory residue respiratory distress Respiratory distress syndrome SARS Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secretion Signaling SOCS3 soluble IL-6R Spike protein STAT3 suggested syndrome therapeutic therapeutic intervention tissue damage trans trans-signaling transcriptional transmembrane vascular endothelial cell Viral viral infection viral spike protein with COVID-19
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article

Safety and Efficacy of Ixekizumab and Antiviral Treatment for Patients with COVID-19: A structured summary of a study protocol for a Pilot Randomized Controlled Trial

COVID-19 환자를 위한 익세키주맙 및 항바이러스 치료의 안전성 및 효능: 파일럿 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약

Randomized Controlled Trial

Published on 2020-12-042022-08-13
Journal: Trials [Category] MERS, SARS, 임상, 진단, 치료제,

[키워드] 1:1 acute respiratory distress syndrome administer anticipated antiviral therapy Arbidol ARDS Autoimmune diseases bind blinded Blinding by mouth carried caused change chemokines China Chinese Chinese Clinical Trial Registry Chloroquine clinical Controlled Course COVID-19 Cytokines Data collection discharge dissemination Efficacy element enrolled epidemic of COVID-19 evaluated excluded experiment first stage first stage) focus global public health group Human monoclonal antibody hypodermic injection IL-17A immune response independent inhibit initiated injection intensive care interferon interleukin interleukin-17A Intravenous injection involved Ixekizumab Lopinavir Lopinavir/ritonavir mouth name Nanjing number objective open open trial Open-label organ injury outcome overactivation parallel group participant Patient patients with COVID-19 Prevent Primary outcome pro-inflammatory cytokine pro-inflammatory cytokines protocol pulmonary pulmonary CT random randomisation randomised randomization Randomized randomized patient randomly divided receive recruitment registration number registry reported Research respiratory respiratory distress Respiratory distress syndrome ribavirin Ritonavir Safety Sample size Severe infection severe infections severity South stages Standard status Study protocol subject Taltz Th17 cell Th17 cells therapy treated Treatment Trial Trial registration Trial Registration Number two group two groups university Version website with COVID-19
[DOI] 10.1186/s13063-020-04925-8 PMC 바로가기 [Article Type] Randomized Controlled Trial

Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol

SARS-CoV-2(COVID-19) 양성 중환자에서 보조 요법으로 고용량 아연 정맥 주사에 대한 무작위 대조 시험: 시험 프로토콜

Article

Published on 2020-12-022022-09-11
Journal: BMJ Open [Category] SARS, 임상,

[키워드] Analysis caused Controlled trial coronavirus COVID-19 Critically ill demonstrated discharge distress double-blind duration of follow-up Effect Elemental end-organ Ethical approval Ethics ethics committee evaluate healthcare High-dose hospitalised patient Human hypoxic independent Infectious diseases Injury International intravenous lowest oxygen saturation mechanism non-ventilated patient non-ventilated patients oxygen oxygen saturation oxygen saturations oxygen supplementation Oxygenation pandemic PaO participant peer-reviewed Placebo positive primary outcome measure Primary outcome measures protective effect public health randomised controlled trial recruited recruitment reduction registration number Research Ethics respiratory respiratory distress Respiratory distress syndrome Respiratory illness respiratory infections Result resulting RNA polymerase robust SARS-CoV-2 SARS-COV-2 infection syndrome therapy Treatment trial protocol Vaccine ventilated patient ventilated patients Viral viral respiratory infection viral respiratory infections Virology was obtained Zinc
[DOI] 10.1136/bmjopen-2020-040580 PMC 바로가기 [Article Type] Article

SARS coronavirus 2: from genome to infectome

SARS 코로나바이러스 2: 게놈에서 감염체로

Review

Published on 2020-12-012022-09-10
Journal: Respiratory Research [Category] Fulltext, MERS, SARS, 조류인플루엔자, 치료제,

[키워드] ACE2 receptors acute respiratory distress acute respiratory distress syndrome acute respiratory distress syndrome (ARDS) acute respiratory syndrome acute respiratory syndrome coronavirus animal ARDS bat bats betacoronaviruses China comorbid condition comorbid conditions Coronavirus-2 Coronaviruses coughing COVID-19 COVID-19 infection cytokine Cytokine storm deaths disorders disseminate droplet droplets etiological agent generate Genome human-to-human transmission immune signaling pathway immune signaling pathways immunocompromised individuals individual leads Lower respiratory tract Mild multi-organ failure multisystemic occur other organs pangolins Pathways Registered reported respiratory Respiratory disease respiratory distress Respiratory distress syndrome SARS Coronavirus SARS-CoV-1 SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 severe respiratory disease sneezing spike glycoprotein susceptible syndrome target transmitted virus
[DOI] 10.1186/s12931-020-01581-z PMC 바로가기 [Article Type] Review

Laboratory biomarkers associated with COVID-19 severity and management

COVID-19 중증도 및 관리와 관련된 실험실 바이오마커

Article

Published on 2020-12-012022-09-11
Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 바이오마커,

[키워드] acute respiratory distress acute respiratory distress syndrome Analysis ARDS Biomarker Biomarkers Care correlated COVID-19 CRP cytokine Cytokine storms Cytokines death disease course disease severity Escalation evidence of fraction heterogeneous identification IL-10 IL-6 IL-6 level IL-6 levels Illness severity implicated implication intensive care Intervention Laboratory test Laboratory tests LDH LDH. management Mild multi-organ failure Ordinal Scale oxygen patient triage radiological evidence resource respiratory respiratory distress Respiratory distress syndrome Respiratory failure Respiratory Support sensitivity severe patients severity specificity Stratification Symptom syndrome the WHO therapy Ventilation WHO ordinal scale with COVID-19
[DOI] 10.1016/j.clim.2020.108614 PMC 바로가기 [Article Type] Article

May omega-3 fatty acid dietary supplementation help reduce severe complications in Covid-19 patients?

오메가-3 지방산 식이 보충제가 코로나19 환자의 심각한 합병증을 줄이는 데 도움이 될까요?

Review

Published on 2020-12-012022-09-11
Journal: Biochimie [Category] 임상,

[키워드] absence acute phase acute respiratory distress syndrome appear ARDS balance clinical outcomes clinical study coronavirus coronavirus disease country Critical Critically ill Critically ill patient critically ill patients Cytokine storm syndrome Cytokines demonstrated derivative dietary intake Diseases docosahexaenoic acid Docosopentaenoic acid Eicosapentaenoic acid EPA fatty Fatty acid fatty acids help Immune cell immune cells Immunity IMPROVE improve clinical outcome Infectious diseases Inflammatory Lipid lipid mediator lung damage mediators multiple organ failure Omega omega-3 omega-3 PUFA Omega-3 PUFAs omega-3 supplementation onset of symptoms Polyunsaturated precursor Prevent PUFAs recommendations reduce Replication respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 infected patients severe complication Stage Symptom systemic inflammation Treatment Vaccine Viral viral infection virus virus entry α-linolenic acid.
[DOI] 10.1016/j.biochi.2020.09.003 PMC 바로가기 [Article Type] Review