Performance and validation of an adaptable multiplex assay for detection of serologic response to SARS-CoV-2 infection or vaccinationArticle Published on 2022-11-012022-11-15 Journal: Journal of Immunological Methods [Category] SARS, 진단, 치료기술, 치료제, [키워드] Antibody Response Antigen antigenic target assays correlated COVID-19 IgG immune response increasingly Infection infection with SARS-CoV-2 measure measurement multiplex Multiplex assay nucleocapsid antigen performance platform Quantitative ranged RBD Receptor binding domain S1 and S2 SARS-CoV-2 SARS-COV-2 infection sensitivity serologic assay Serologic response serology specificity subunit vaccination Variation [DOI] 10.1016/j.jim.2022.113345 PMC 바로가기
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccineArticle Published on 2022-11-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activated airway epithelial cells Antigen B cell Beta Cell cross-reactive delta variant dendritic cell development domain effective elicited facilitated humoral IgA response immune response Immunity induce Inflammation intranasal long-lasting lung mice Microparticle mucosal nasal Parenteral porous prime and boost Protective RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 vaccine subunit type 1 helper vaccination Vaccinations Vaccine variant Viral load [DOI] 10.1016/j.trsl.2022.06.004 PMC 바로가기
Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19Article Published on 2022-11-012022-11-16 Journal: Chest [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed association Bacteria bronchiolar CD8+ T-cell chemokine correlated COVID-19 CXCL8 Cytokines cytotoxic death Defense Diseases eight exploratory expression Extracellular fatal COVID-19 function heterogeneity IL-8 immune response immunohistochemistry infiltration Inflammation Inflammatory inherent leukocyte liver tissues Local lung Lungs mechanism Messenger RNA mRNA mRNA levels multiplexed immunofluorescence NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils no correlation pathogenic Patient polymerase chain pulmonary thrombi quantified Respiratory failure response SARS-CoV-2 severe COVID-19 shown T-lymphocyte the SARS-CoV-2 tissue tissue damage tissue viral load validation cohorts viral loads [DOI] 10.1016/j.chest.2022.06.007 PMC 바로가기
Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohortArticle Published on 2022-11-012022-11-15 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome Biomarker Biomarkers CCL5 Cell cellular response characterized chemokine children Chilean clinical clinical feature Cohort Complication convalescent coronavirus COVID-19 CXCL10 CXCL8 Cytokine storm deep degranulation disease dysregulation elevated enzyme-linked immunosorbent enzyme-linked immunospot flow cytometry gastrointestinal involvement humoral identify IL-10 IL-18 IL-6 immune dysregulation immune response Immunity Inflammation Inflammatory intestinal inflammation laboratory biomarker Latin life-threatening Ligand MIS-C mononuclear cell MOST motif multisystemic multisystemic inflammatory syndrome in children. natural killer neutralizing antibody neutralizing antibody assays NK cell NK cell deficiency occur organ Patient patients predict representing reveal robust severe multisystemic severity Shock significantly stools susceptibility sustained syndrome T-cell activation underlie was increased was performed [DOI] 10.1016/j.jaci.2022.09.006 PMC 바로가기
Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and ThailandArticle Published on 2022-11-012022-11-15 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Affect Africa Antibody Response Antigen collected coronavirus coronavirus disease Coronaviruses country COVID-19 COVID-19 pandemic distribution Endemic HIV-1 human SARS-CoV-2 IgG response immune response Kenya less Middle East monoclonal antibody much higher Nigeria nucleocapsid protein participant Participants populations Profiling Protein respiratory infections respiratory syndrome coronavirus response SARS SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike screened Serosurvey serum and plasma severe acute respiratory syndrome coronavirus 2 significantly more subunit tested Thailand the receptor-binding domain Uganda Vaccine viruses zoonoses [DOI] 10.3201/eid2811.221041 PMC 바로가기
Antibody and T-cellular response to COVID-19 booster vaccine in SARS-CoV-1 survivorsSARS-CoV-1 생존자의 COVID-19 추가 백신에 대한 항체 및 T세포 반응Article Published on 2022-11-012022-11-15 Journal: Clinical immunology (Orlando, Fla.) [Category] SARS, 백일해, 진단, 파상풍, [키워드] acute respiratory syndrome Antibody titer Beta booster booster vaccination Booster vaccine CD4 CD8 comparable coronavirus COVID-19 Delta dose effective elicit elicited generate healthy individual humoral immune response less MOST naïve neutralization neutralizing antibody omicron robust SARS-CoV-1 SARS-CoV-1 survivors SARS-CoV-2 survivor Survivors T cell response T cell responses T-cell Response WA1 while Wuhan-Hu-1 [DOI] 10.1016/j.clim.2022.109103 PMC 바로가기
Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infectionArticle Published on 2022-11-012023-06-12 Journal: Gut [Category] B형 간염, Fulltext, [키워드] cellular immunology chronic hepatitis hepatitis B immune response T lymphocytes [DOI] 10.1136/gutjnl-2021-324646 PMC 바로가기
Immunoassay and mass cytometry revealed immunological profiles induced by inactivated BBIBP COVID-19 vaccineArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] analyzed antibody Antibody titer B cell booster booster dose caused Cell Cluster Concentration conducted COVID-19 COVID-19 vaccine CyTOF Cytometry declined decrease distribution Efficacy ENhance healthy highlight humoral Immune cell immune response Immunity immunization immunoassay immunological profile inactivated individual injection Injections lack maintain marker multicenter neutralizing antibody not significantly different participant prevalence of COVID-19 proportion protective effect recall receiving recruited reduced SARS-CoV-2 second dose serum antibody shown significantly significantly increased Still subject surface marker sVNT the antibody response the vaccine vaccination Vaccine vaccine doses vaccine injection Viral variants virus neutralization test [DOI] 10.1002/jmv.27983 PMC 바로가기
Early identification of high-risk individuals for monoclonal antibody therapy and prophylaxis is feasible by SARS-CoV-2 anti-spike antibody specific lateral flow assayArticle Published on 2022-11-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] SARS, 진단, 치료기술, [키워드] Abbott anti-spike antibodies anti-spike antibody antibody Antibody test Antibody titer appear approved Architect assist benefit CMIA correlated strongly COVID-19 detect effective feasible female IgM/IgG immune response Immune status immunoassay individual IQR Lateral lateral flow lateral flow assay log-linear regression median age Microparticle monoclonal antibody monoclonal antibody therapy monoclonal antibody treatment natural infection participant Patient Prophylaxis SARS-CoV-2 SARS-CoV-2 IgG sera seronegative patient Severe COVID-19 Infection tested therapy Treatment undergo vaccination [DOI] 10.1016/j.diagmicrobio.2022.115788 PMC 바로가기
Safety and immunogenicity of MVC-COV1901 vaccine in older adults: Phase 2 randomized dose-comparison trialArticle Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] 진단, [키워드] Administered adverse event age binding antibody clinical trial Comorbidities Comorbidity COVID-19 infection demonstrated dose double-blind elicited General population High dose High-dose immune response immunization immunogenicity immunosenescence Mild mortality rates MVC-COV1901 vaccine negative correlation Neutralizing Older older adult Older adults participant Phase 2 protein subunit vaccine Randomized regimen Registered robust Safety SARS-CoV-2 stratified subject Trial Vaccine [DOI] 10.1016/j.ijid.2022.08.021 PMC 바로가기