The U-shaped association of serum iron level with disease severity in adult hospitalized patients with COVID-19Observational Study Published on 2021-06-282022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 임상, 치료법, [키워드] adjusted age and sex analyzed association Coronavirus disease 2019 COVID-19 COVID-19 severity demonstrated disease severity Diseases exacerbating groups hospitalized COVID-19 patient hospitalized patient Host Infectious disease Infectious diseases initial Mild mitigate Multivariate analysis no significant difference pathogenic Patient patients serum severe respiratory failure significantly significantly higher significantly lower tissue damage Transferrin Trigger viral infection with COVID-19 [DOI] 10.1038/s41598-021-92921-6 PMC 바로가기 [Article Type] Observational Study
Detection of SARS-CoV-2 RNA in serum is associated with increased mortality risk in hospitalized COVID-19 patients혈청에서 SARS-COV-2 RNA의 검출은 입원 COVID-19 환자의 사망률 증가와 관련이 있습니다.Observational Study Published on 2021-06-232022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] Accuracy adjusted Admission age baseline best Biomarker Biomarkers C-reactive protein Charlson index collected correlation COVID-19 COVID-19 patients Cox regression models Critical death defined detection Diseases Health Service Hospitalization hospitalized COVID-19 patient ICU admission IL-6 increased mortality LDH lymphopenia marker Microbiology Mortality National National Health Services observational study Older outcome Oxygenation PaO Patient predict predicted Predictive procalcitonin risk Risk factors Roche SARS-CoV-2 RNA SARS-CoV-2 RNA detection sensitivity serum Serum level serum levels severity Sex specificity technique Thermo Fischer Scientific threshold variable Viremia was performed [DOI] 10.1038/s41598-021-92497-1 PMC 바로가기 [Article Type] Observational Study
Vitamin D Metabolites and Clinical Outcome in Hospitalized COVID-19 Patients입원한 COVID-19 환자의 비타민 D 대사 산물 및 임상 결과Article Published on 2021-06-222022-09-10 Journal: Nutrients [Category] MERS, SARS, 바이오마커, [키워드] Admission calcium clinical Clinical course clinical courses Clinical data Clinical outcome Cohort Concentration Course COVID-19 COVID-19 patient COVID19 CRP cytokine Cytokine storm Degradation degradation products determined by died females Frequency functions Graz hospital hospital information systems hospitalized COVID-19 patient IL-6 immune response information Information Systems Laboratory male marker mechanical ventilation metabolism metabolite Non-survivors not differ Older outcome patients peak concentration peak concentrations phosphate required Retrospective study serum serum concentrations serum sample significantly Support survivor Survivors university university hospital Vitamin D vitamin D metabolites Vitamin D status [DOI] 10.3390/nu13072129 PMC 바로가기 [Article Type] Article
Blood coagulation parameter abnormalities in hospitalized patients with confirmed COVID-19 in Ethiopia에티오피아에서 확인 된 COVID-19를 가진 입원 환자의 혈액 응고 파라미터 이상Observational Study Published on 2021-06-212022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 임상, 치료기술, [키워드] abnormal coagulation abnormality activated partial thromboplastin time aPTT Care Coagulation coagulation parameter Coagulopathy Complication conducted Corona Covid patients COVID-19 COVID-19 patient COVID-19 patients critical COVID-19 patients cross-sectional cross-sectional study defined disease disease severity dominant elevated Germany Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient INR international normalized ratio normalized Older parameter Partial partial thromboplastin time Patient Platelet Platelet count profile Prognostic factor prothrombin Prothrombin time Result statistical analysis statistically significant study participant Study participants subject thrombocytopenia thromboembolic Thromboembolic event Thromboembolic events THROMBOPLASTIN time Treatment Virus Disease Wiesbaden with COVID-19 [DOI] 10.1371/journal.pone.0252939 PMC 바로가기 [Article Type] Observational Study
COVID-19 in persons aged 70+ in an early affected German district: Risk factors, mortality and post-COVID care needs—A retrospective observational study of hospitalized and non-hospitalized patientsObservational Study Published on 2021-06-182022-10-04 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] affected all-cause mortality analysed Care Clinical data Complete country COVID-19 discharge Effect evaluate examined Factors First wave functional Germany group Healthcare system hospital Hospitalized hospitalized COVID-19 patient hospitalized patient include Inclusion infected patients Infection Intervention Mortality Observational cohort study Odds ratio Older older patient older population outcome outpatients and inpatients pandemic Patient patients who survived patients with COVID-19 positive predictor public health reported Result retrospective risk Risk factors SARS-CoV-2 Screening Symptom tested the disease Treatment Tübingen with COVID-19 [DOI] 10.1371/journal.pone.0253154 PMC 바로가기 [Article Type] Observational Study
Clinical outcome, risk assessment, and seasonal variation in hospitalized COVID-19 patients—Results from the CORONA Germany studyObservational Study Published on 2021-06-172022-10-04 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] age analyses Analysis baseline C-reactive protein (CRP clinical Cohort cohort study conducted Course COVID 19 COVID-19 COVID-19 patient creatinine CRP death disease disease severity Effect epidemiological finding Germany heterogeneous hospital Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient hospitalized patients hospitals in-hospital mortality lactate dehydrogenase LDH Mild Mortality mortality rate multicenter Odds ratio outcome pandemic Pneumonia positive patient prognostic Prognostic factor Rate respiratory rate risk risk stratification SARS CoV-2 Seven Support Temporal analysis Treatment Variation variations Ventilation was collected [DOI] 10.1371/journal.pone.0252867 PMC 바로가기 [Article Type] Observational Study
Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses초기 환자 반응의 심층 마이닝에서 교차 반응성 SARS-CoV-2 중화 항체Immunology Published on 2021-06-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] affected antibodies antibody antibody repertoire Antibody Response approach B cell B.1.1.28 B.1.1.7 B.1.351 BCR binding binding epitope blocking antibody Brazil conserved convergence COVID-19 cross-reactivity deep described epitope Epitopes highlight hospitalized COVID-19 patient hospitalized COVID-19 patients independent monoclonal antibodies monoclonal antibody Mutation Neutralizing antibodies neutralizing antibody occur passive immunization Patient phage display RBD binding receptor reduced reported response reveal SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variants sensitivity sequence sequences Sequencing South Africa study group the RBD unlikely Vaccine Viral viral variant Viral variants [DOI] 10.3389/fimmu.2021.678570 PMC 바로가기 [Article Type] Immunology
Incidence, diagnosis, treatment methods, and outcomes of clinically suspected venous thromboembolic disease in patients with COVID-19 in a quaternary hospital in BrazilOriginal Article Published on 2021-06-112022-10-30 Journal: Jornal Vascular Brasileiro [Category] COVID-19, [키워드] óbito Admission Analysis analyzed anticoagulation baseline Brazil Characteristics clinically suspected Comorbidities concomitance confirmed case Coronavirus disease-19 COVID-19 D-dimer D-dimer level D-dimer levels D-dimer value death demographic diagnosed Diagnosis discharged disease drug therapy elevated Embolia pulmonar epidemiological had no hospital hospital discharge Hospitalized hospitalized COVID-19 patient indicated Infection intensive care intensive care units management medical record MOST nine objective occurred Occurrence outcome Patient patients patients hospitalized patients with COVID-19 pharmacological Prevalence Prophylaxis Pulmonary embolism remained Result significant decrease significant increase study period Study protocol Symptom symptomatic symptomatic cases Thromboembolism Thromboprophylaxis thrombosis tratamento farmacológico treat Treatment Tromboembolismo venoso Trombose Variation venous thromboembolic viral infection VTE worsening [DOI] 10.1590/1677-5449.200203 PMC 바로가기 [Article Type] Original Article
Exercise Ventilatory Inefficiency in Post-COVID-19 Syndrome: Insights from a Prospective EvaluationArticle Published on 2021-06-112022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] abnormality acute phase age Analysis asymptomatic patient Biomarker Cardiopulmonary cardiopulmonary exercise testing cardiovascular risk factors characterized CO2 comparable conducted Coronavirus disease 2019 COVID-19 disease Dyspnea Echocardiogram Efficiency evaluated exercise female Follow-up functional Hospitalization hospitalized COVID-19 patient identify impairment inefficiency Inflammatory response insight lung no significant difference pet Post-COVID-19 syndrome potential mechanism predicted Prevalence proportion Prospective Pulmonary function test Quality of life serum single-center study six-minute walking test survivor symptomatic syndrome ventilation/perfusion ventilatory ventilatory inefficiency [DOI] 10.3390/jcm10122591 PMC 바로가기 [Article Type] Article
Alterations in T and B cell function persist in convalescent COVID-19 patients회복 중인 COVID-19 환자에서 T 및 B 세포 기능의 변화가 지속됨Clinical and Translational Report Published on 2021-06-112022-09-14 Journal: Med (New York, N.Y.) [Category] MERS, SARS, 임상, 진단, [키워드] Abstract Activation acute COVID-19 Affect alteration B cell B cell subset B cells breathlessness caused CD8 change changes in Characteristics Clinical outcome clinical outcomes conducted Context contribute convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus disease COVID-19 COVID-19 patient cytokine defined disease Effect elevated Evidence examined fatigue finding Frequency functional funding Giving groups Health hospital discharge Hospitalization hospitalized COVID-19 patient identify IL-10 IL-17 IL-6 immune response Infection Long COVID longer-term immunity Lung disease Lung pathology lymphocyte Medicine Novel coronavirus outcome pandemic parameter Patient persistence phenotype Phenotypes phenotypic Population pro-inflammatory receptor restored skewed subgroup subgroups subsequent Symptom Symptoms T cell T cells Trust viral infection Wellcome Trust with COVID-19 [DOI] 10.1016/j.medj.2021.03.013 PMC 바로가기 [Article Type] Clinical and Translational Report