Persistence of Immune Response in Health Care Workers After Two Doses BNT162b2 in a Longitudinal Observational Study종단 관찰 연구에서 BNT162b2 2회 투여 후 의료 종사자의 면역 반응 지속Observational Study Published on 2022-03-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] age All participants Analysis antibody average binding binding antibody BNT162b2 BNT162b2 vaccine booster dose booster doses booster vaccinations Care cellular Cellular immune response Course COVID-19 disease declining described detectable dose Efficacy evaluated Follow-up groups Health Health care Health care worker hospital humoral humoral and cellular immunity humoral immune response immune response immunological Immunological memory individual interferon Interferon-gamma longitudinal mRNA mRNA-based vaccine Neutralizing antibodies obesity observational study of BNT162b2 Older age participant Participants peptide peptides persistence Pfizer Quantitative response response rate resulting SARS-CoV-2 SARS-COV-2 infection second dose semi-quantitative Serological testing shown vaccination Vaccine worker [DOI] 10.3389/fimmu.2022.839922 PMC 바로가기 [Article Type] Observational Study
Escape and Over-Activation of Innate Immune Responses by SARS-CoV-2: Two Faces of a CoinSARS-CoV-2에 의한 타고난 면역 반응의 탈출 및 과잉 활성화: 동전의 두 얼굴Review Published on 2022-03-042022-09-11 Journal: Viruses [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] addition cellular receptor coin coronavirus CoV COVID-19 pathogenesis CoVs Cytokines Defense disease dysregulated escape evade face Host human population IFN IFN signaling pathways IL-1 IL-1 family cytokine IL-1 family cytokines IL-18 IL-1β immune responses Inflammasome inflammasome activation inflammasomes Innate innate immune innate immune response innate immune responses innate immune system Innate immunity interferon invading pathogens MERS MERS-CoV Multiple Pathogenesis Pathogens potential mechanism potential mechanisms Prognosis pyroptosis Recognition response SARS-CoV-1 SARS-CoV-2 with COVID-19 [DOI] 10.3390/v14030530 PMC 바로가기 [Article Type] Review
Marked increase of interferon-β after BNT162b2 mRNA vaccination: a case of polyarthritis with pleurisyBNT162b2 mRNA 예방접종 후 인터페론-β의 현저한 증가: 흉막염을 동반한 다발성관절염 1예Case Reports Published on 2022-03-022022-09-12 Journal: BMJ case reports [Category] MERS, SARS, 진단, [키워드] association BNT162b2 mRNA comparable COVID-19 cytokine disease elevated Exacerbation had no healthy subjects IFN-β immunological immunological products and vaccines immunology increase in innate immune system interferon mRNA vaccine mRNA vaccines Musculoskeletal musculoskeletal syndromes. one patient Other Patient polyarthritis Prednisolone receiving reported Rheumatic diseases SARS-CoV-2 serum Treatment vaccination [DOI] 10.1136/bcr-2021-246533 PMC 바로가기 [Article Type] Case Reports
Trajectories of humoral and cellular immunity and responses to a third dose of mRNA vaccines against SARS-CoV-2 in patients with a history of anti-CD20 therapy항-CD20 치료 이력이 있는 환자에서 체액성 및 세포성 면역의 궤적과 SARS-CoV-2에 대한 3차 mRNA 백신에 대한 반응Article Published on 2022-03-012022-09-11 Journal: RMD Open [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] Analysis anti-CD20 anti-CD20 therapy anti-CD20 treatment anti-SARS-CoV-2 immune response anti-SARS-CoV-2 immune responses antibody concentration Antibody concentrations cell-mediated immune Cell-mediated immunity cellular immunity CMI comparable Concentration Control covariance COVID-19 decay dose elicited healthy volunteer healthy volunteers humoral humoral and cell-mediated immunity Humoral response humoral responses IgG immune responses Immunity immunogenicity inefficient interferon interferon-γ investigated Linear regression majority mRNA vaccine non-responder non-responders outcome Participants Patient patients registration number Responder responders response reveal rituximab RNA SARS-CoV-2 SARS-CoV-2 vaccine second vaccination systemic vasculitis Therapies therapy Trajectories trajectory Trial Registration Number vaccination Vaccination strategy Vaccine vaccine dose Vasculitis [DOI] 10.1136/rmdopen-2021-002166 PMC 바로가기 [Article Type] Article
The cGAS-STING pathway drives type I IFN immunopathology in COVID-19cGAS-STING 경로는 COVID-19에서 I형 IFN 면역병리를 유발합니다Article Published on 2022-03-012022-09-11 Journal: Nature [Category] SARS, 진단, 치료기술, 치료법, [키워드] activate addition caused cell death cGAS characterized ChIP Clinical outcome Complication Control COVID-19 Critical cyclic GMP cytosolic disease DNA Endothelial cell endothelial cell damage endothelial cells IFNs Immunity immunopathology IMPROVE increase in Infection infection with SARS-CoV-2 Inflammation interferon interferons interferons (IFNs late phase limit lung Lung inflammation Lung pathology Macrophage macrophages Manifestations mice mitochondrial mitochondrial DNA outcome Pathogenesis pathogenesis of COVID-19 pathway patients with COVID-19 pharmacological principle Profiling Rapid induction reduce response responses reveal SARS-CoV-2 severe lung inflammation STING sustained tissue Type Type I IFN type I IFN responses type I IFNs type I interferons virus propagation [DOI] 10.1038/s41586-022-04421-w PMC 바로가기 [Article Type] Article
Role of toll-like receptors in modulation of cytokine storm signaling in SARS-CoV-2-induced COVID-19SARS-CoV-2로 유발된 COVID-19에서 사이토카인 폭풍 신호전달의 조절에서 톨 유사 수용체의 역할Review Published on 2022-03-012022-09-11 Journal: Journal of medical virology [Category] SARS, 치료법, [키워드] Balanced Blood circulation COVID-19 cytokine Cytokine storm Cytokine storms Cytokines death driving dsRNA Elimination endosomal Factor help IL-1β IL-4 IL-6 IL-8 Imbalance immune regulation individual Inflammatory inflammatory signaling innate immune system interferon interleukin killing MAPK membrane-bound modulation multiple organ failure multiple organ failures multiple-organ multiple-organ failure Necrosis NF-κB nonself other organs pathogen Pro-inflammatory genes pro-inflammatory mediator pro-inflammatory mediators recognize recognizing replicate role SARS-CoV-2 Signaling ssRNA ssRNA. systemic circulation the cytokine storm TLR TLR3 TLR4 TLR7 TLR7/8 TLR8 TLRs Toll-like receptor Toll-like receptors Transcription translation TRIF Tumor tumor necrosis tumor necrosis factor [DOI] 10.1002/jmv.27405 PMC 바로가기 [Article Type] Review
SARS-CoV-2-mediated evasion strategies for antiviral interferon pathways항바이러스 인터페론 경로에 대한 SARS-CoV-2 매개 회피 전략Review Published on 2022-03-012022-09-11 Journal: Journal of microbiology (Seoul, Korea) [Category] COVID19(2023년), SARS, 변종, [키워드] Antiviral antiviral drug antiviral drugs coronavirus COVID-19 COVID-19 pandemic Defense determine develop effective effort evade Host host cell host defense IFN immune evasion Immune receptor Immunity Innate innate immune Interaction interferon interferon pathway mechanism Pathogenesis SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins Signaling signaling pathways Therapeutic strategies understanding Vaccine variants viral replication [DOI] 10.1007/s12275-022-1525-1 PMC 바로가기 [Article Type] Review
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening고처리량 스크리닝 적용을 위한 안정적인 SARS-CoV-2 레플리콘 시스템 구축Article Published on 2022-03-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral Antiviral effect antiviral effects Bacterial bacterial artificial chromosome biosafety level Biosafety Level 3 BSL2 BSL3 camostat Cell cell line cell lines cells chromosome compounds condition conditions coronavirus COVID-19 examined exhibited Favipiravir gene encoding In vitro infection inhibited interferon level 3 luciferase luciferase activity molnupiravir Neomycin Novel coronavirus Particles powerful tool produced RdRP RdRp inhibitor Remdesivir Renilla Renilla luciferase replicon reported RNA SARS-coronavirus SARS-coronavirus-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgRNA sgRNAs stable cell stable cell line suppressed the SARS-CoV-2 transient transfection transiently transfected Treatment VeroE6 cells Viral proteins viral replication [DOI] 10.1016/j.antiviral.2022.105268 PMC 바로가기 [Article Type] Article
Inhaled interferons beta and SARS-COV2 infection: a preliminary therapeutic perspective흡입 인터페론 베타 및 SARS-COV2 감염: 예비 치료 관점Article Published on 2022-03-012022-09-11 Journal: Expert review of respiratory medicine [Category] SARS, 임상, 치료제, [키워드] accelerate Antiviral Area Asthma available data clinical study Compound COPD COVID-19 disease Duration of therapy effective therapy Efficacy ENhance Exogenous expert form host response Infection Inflammation Inhaled interferon investigated medication nebulization pathway Perspective potential therapy Predictive promise regimen SARS-CoV2 SARS-CoV2 infection therapeutic therapy [DOI] 10.1080/17476348.2022.2008910 PMC 바로가기 [Article Type] Article
Poly(Lactide- co-Glycolide) Nanoparticle-Mediated Vaccine Delivery of Encapsulated Surface Antigen Protein of Hepatitis B Virus Elicits Effective Immune ResponseArticle Published on 2022-03-012023-06-12 Journal: Viral immunology [Category] B형 간염, [키워드] HBV surface antigen IL-2 interferon Lymphocytes nanovaccine PLGA [DOI] 10.1089/vim.2021.0058