Levels of Soluble CD14 and Tumor Necrosis Factor Receptors 1 and 2 May Be Predictive of Death in Severe Coronavirus Disease 2019가용성 CD14 및 종양 괴사 인자 수용체 1 및 2의 수준은 심각한 코로나바이러스 질병 2019에서 사망을 예측할 수 있음Article Published on 2021-03-032022-08-31 Journal: The Journal of Infectious Diseases [Category] 바이오마커, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus asymptomatic infection CD14 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical Critical disease death died disease disease severity Factor fatty Fatty acid Hospital admission individual individuals Inflammation Level Mild moderate monocyte Monocyte activation Monocytes Necrosis Patient Protein receptor respiratory respiratory distress resulting SARS-CoV-2 serum biomarker serum biomarkers severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Severe respiratory distress TNFR1 TNFR2 Tumor tumor necrosis tumor necrosis factor uninfected [DOI] 10.1093/infdis/jiaa744 PMC 바로가기 [Article Type] Article
SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytesArticle Published on 2021-03-012022-10-04 Journal: Cell Death Discovery [Category] 치료제, [키워드] 2019 coronavirus disease Activation acute respiratory syndrome caspase-1 cellular component cleavage coronavirus COVID-19 critically ill patients death engage gasdermin D human monocytes hyper-inflammation IL-1ß Inflammasome Inflammatory response intensive care leukopenia mechanism monocyte Monocytes Patient Peripheral blood pro-inflammatory cytokine pyroptosis recruited reduce viral replication respiratory tract SARS-CoV-2 severe COVID-19 therapy Trigger viral infection [DOI] 10.1038/s41420-021-00428-w PMC 바로가기 [Article Type] Article
A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patientsObservational Study Published on 2021-03-012022-10-04 Journal: International journal of obesity (2005) [Category] 임상, 치료기술, 치료법, [키워드] Alpha appear BMI circulating Clinical outcome clinical parameter collected Concentration COVID-19 COVID-19 patient COVID-19 patients Critically ill cytokine cytokine response declined disease course groups ICU ICU admission ICU patient IFN-γ IL-1 receptor antagonist IL-10 IL-6 IL-8 immune response Immunological response in both groups independent risk factor Inflammatory inflammatory parameter Inflammatory response interferon interferon gamma investigated IP-10 Laboratory mechanical ventilation mechanisms monocyte Mortality Necrosis no difference obese obese patient obesity outcome parameter Patient Protein Respiratory function Respiratory mechanics severe disease course significantly lower suggested temperature TNF-α ventilator [DOI] 10.1038/s41366-021-00747-z PMC 바로가기 [Article Type] Observational Study
Do initial hematologic indices predict the severity of COVID-19 patients?Article Published on 2021-02-262022-10-29 Journal: Turkish Journal of Medical Sciences [Category] COVID-19, MERS, [키워드] 95% confidence interval Admission age analyzed AUC comparison COVID-19 COVID-19 case COVID-19 patient COVID-19 patients disease distribution early stage evaluate groups hematologic hematological ICU initial intensive care intensive care unit interquartile range investigated laboratory-confirmed leukocytes lymphocyte material median age Mild MLR moderate monocyte neutrophil Neutrophils NLR parameter parameters Patient patients Platelet Platelets predict Prognosis proportion Red cell Result ROC Curve severity of COVID-19 significantly higher transferred Volume [DOI] 10.3906/sag-2007-97 PMC 바로가기 [Article Type] Article
COVID-19 Impairs Immune Response to Candida albicansCOVID-19는 Candida albicans에 대한 면역 반응을 손상시킵니다Immunology Published on 2021-02-262022-09-11 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] abrogated Activation acute respiratory distress acute respiratory distress syndrome Antigen ARDS Aspergillus fumigatus Blood Candida Candida albican Candida albicans CD244 CD38 CD4 CD8 CD80 changes in characterization characterized clinical parameter Clinical parameters coronavirus coronavirus disease coronavirus disease-2019 COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients cytokine cytokine release Cytokines cytokines IL-6 detrimental elevated fungal healthy controls HLA-DR ICU ICU admission IL-10 IL-1α IL-1β IL-6 IL-8 Immune phenotype immune response Infection lipopolysaccharide Listeria monocytogene Listeria monocytogenes LPS Lymphocytes marker monocyte Monocyte activation not differ Pathogenesis PD-1 plasma Prognosis recent respiratory distress response SARS-CoV-2 second hit Secondary infection secondary infections severe acute respiratory distress syndrome susceptibility syndrome T cells therapy TNF upregulation were assessed were used yeast [DOI] 10.3389/fimmu.2021.640644 PMC 바로가기 [Article Type] Immunology
Increased sCD163 and sCD14 Plasmatic Levels and Depletion of Peripheral Blood Pro-Inflammatory Monocytes, Myeloid and Plasmacytoid Dendritic Cells in Patients With Severe COVID-19 Pneumonia중증 COVID-19 폐렴 환자에서 sCD163 및 sCD14 혈장 수준 증가 및 말초 혈액 염증 유발 단핵구, 골수성 및 형질세포양 수지상 세포 고갈Comparative Study Published on 2021-02-262022-08-31 Journal: Frontiers in Immunology [Category] MERS, 바이오마커, [키워드] Activation Admission ARDS CD163 circulating Clinical outcome clinical utility correlation correlations COVID-19 COVID-19 pneumonia cut-off D-dimer DCs dendritic cell dendritic cells Depletion disease severity early stage ELISA Evidence ferritin flow cytometry greater groups healthy donor healthy donors Hospital admission IL-6 immune cells increase in Increased Inflammatory marker Innate immune cells intermediate monocytes LDH Level marker mDC mDCs monocyte Monocytes myeloid non-classical monocyte Non-classical monocytes on admission patients with COVID-19 pDC pDCs percentage peripheral Peripheral blood peripheral blood monocytes plasmacytoid DC plasmacytoid DCs Pneumonia positive correlation Predictive progression Result risk SARS-CoV-2 sensitivity severity of COVID-19 specificity subject subjects subset the disease [DOI] 10.3389/fimmu.2021.627548 PMC 바로가기 [Article Type] Comparative Study
Clinical Characteristics and Risk Factors for Mortality in Very Old Patients Hospitalized With COVID-19 in SpainObservational Study Published on 2021-02-252022-10-05 Journal: The Journals of Gerontology Series A: Biological S [Category] 임상, [키워드] Admission age Age ≥ 80 Analysis analyzed atherosclerotic Barthel Index C-reactive protein cardiovascular disease Chest clinical Clinical characteristics Cohort Comorbidity conducted consecutive patient COVID-19 death Dementia Diabetes Mellitus Factor functional glomerular filtration rate hospital Hospitalized identify In-hospital in-hospital mortality independent risk factor Inpatient lactate dehydrogenase lymphocyte Male sex median age men monocyte Mortality multicenter multivariate logistic regression neutrophil Organ failure overall case-fatality rate oxygen saturation Patient poor prognosis Predictive predictor Primary outcome Prognostic factors qSOFA Rate registry retrospective risk factor SARS-CoV-2 Spain Spanish temperature was performed with COVID-19 [DOI] 10.1093/gerona/glaa243 PMC 바로가기 [Article Type] Observational Study
Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection난소암과 관련된 동반 질환 및 염증 및 SARS-CoV-2 감염에 대한 영향Review Published on 2021-02-252022-09-12 Journal: Journal of Ovarian Research [Category] MERS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age aldosterone among others androgen angiotensin Cancer patients caused cellular Characteristics chemokine chemokines chronic inflammation colony-stimulating factor comorbid condition comorbid conditions Comorbidities Comorbidity condition contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 symptoms Cytokines death develop disease dysregulated early stage G-CSF gonadotropin granulocyte granulocyte colony-stimulating factor greater Hormones Hospitalization hospitalizations IL-10 IL-2 IL-6 Immunocompromised Increased Infection Inflammation Inflammatory cytokine Inflammatory cytokines interferon involved IP-10 M-CSF Macrophage macrophage colony-stimulating factor MCP-1 mechanism microenvironment molecular monocyte monocyte chemoattractant protein-1 Necrosis organs outcome ovarian cancer Pathogenesis Patient pro-inflammatory Protein public health RAAS Renin renin-angiotensin-aldosterone system risk risk factor SARS-CoV-2 SARS-COV-2 infection sera Severe case severe cases significantly subject TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor α upregulation vulnerable population women [DOI] 10.1186/s13048-021-00787-z PMC 바로가기 [Article Type] Review
Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019코로나바이러스 질병 2019의 조기 진단에서 바이오마커로서의 단핵구 CD169 발현Article Published on 2021-02-242022-09-11 Journal: The Journal of Infectious Diseases [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome CD169 coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 patient diagnosis of COVID-19 expression hospital Infection interferon-alpha monocyte Monocytes outbreak overexpressed Patient plasma receptor respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus suspicion thrombocytopenia type I Viral viral infections [DOI] 10.1093/infdis/jiaa724 PMC 바로가기 [Article Type] Article
Establishing Classifiers With Clinical Laboratory Indicators to Distinguish COVID-19 From Community-Acquired Pneumonia: Retrospective Cohort StudyOriginal Paper Published on 2021-02-222022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, [키워드] AGR albumin Algorithm Algorithms analyzed AUROC Blood Cell characteristic classification algorithm Classifier classifiers clinical clinical laboratory indicators clinical symptom clinician Combination combinations community-acquired pneumonia Concentration corpuscular hemoglobin COVID-19 COVID-19 patient COVID-19 patients effective Establishing help imaging examination Indicator initial symptom Isolation Laboratory Logistic regression Machine learning algorithms management monocyte neutrophil count nine objective Patient patients with COVID-19 PCT procalcitonin random RBC recall reduction in Result uric acid WBC White blood cell [DOI] 10.2196/23390 PMC 바로가기 [Article Type] Original Paper