Assessing efficacy of antiviral therapy for COVID-19 patients: A case study on remdesivir with bayesian synthesis design and multistate analysisCOVID-19 환자에 대한 항바이러스 요법의 효능 평가: 베이지안 합성 설계 및 다중 상태 분석을 사용한 렘데시비르에 대한 사례 연구Article Published on 2021-06-012022-09-11 Journal: Journal of the Formosan Medical Association = Taiw [Category] SARS, 치료제, [키워드] 95% CI Analysis antiviral therapy applied Assessing Bayesian Bayesian synthesis sequential design case study clinical Clinical efficacy COVID-19 COVID-19 patient death discharge Disease progression Efficacy empirical evidence Evidence High-risk patients Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients medium Mortality outcome outcome measure outcome measures Patient patients with COVID-19 progression reducing reducing mortality reduction Remdesivir required risk of death sequential design significantly shorter standard care group statistically significant subsequent therapy treated treated patient Trial Two-arm [DOI] 10.1016/j.jfma.2021.04.026 PMC 바로가기 [Article Type] Article
Determinants of in-hospital mortality in COVID-19; a prospective cohort study from PakistanResearch Article Published on 2021-05-272022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] 95% CI adjusted Admission age all-cause mortality conducted Critical disease death decrease determinant determinants died distribution enrolled Gender higher odd Hospital stay hospitalized COVID-19 patient ICU in both group in-hospital mortality increase in invasive IQR Karachi Lactate less Logistic regression lymphocyte median Mortality MOST Most patient Multisystem organ failure Multivariable regression non-invasive ventilation non-survivor oxygen saturation Patient patients peripheral oxygen saturation pro-calcitonin procalcitonin prospective cohort study Prospective Study required Respiratory failure serum serum albumin SOFA score Support survivor Survivors ventilator [DOI] 10.1371/journal.pone.0251754 PMC 바로가기 [Article Type] Research Article
Shedding of infectious SARS-CoV-2 by hospitalized COVID-19 patients in relation to serum antibody responses혈청 항체 반응과 관련하여 입원한 COVID-19 환자에 의한 감염성 SARS-CoV-2의 배출Research Published on 2021-05-272022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway airways antibodies Antibody Response Antibody titers caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-sectional cross-sectional study Culture detectable global pandemic Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients IgG immunofluorescence assay immunofluorescence assay (IFA Immunoglobulin Immunoglobulin G in vitro Karolinska University Hospital lower risk median microneutralization Microneutralization assay Neutralizing antibodies neutralizing antibodies titer neutralizing antibodies titers Neutralizing antibody titer neutralizing antibody titers objective Patient patients PCR analysis performed positively correlated potential risk replicating virus respiratory Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 RNA SARS-CoV-2 specific antibodies SARS-CoV-2 transmission SARS-CoV-2-specific IgG serum serum antibody response severe acute respiratory syndrome Coronavirus shedding specific antibody symptom duration symptom onset Total Transmission two patients Viral viral shedding virus were assessed [DOI] 10.1186/s12879-021-06202-8 PMC 바로가기 [Article Type] Research
Effects of potent neutralizing antibodies from convalescent plasma in patients hospitalized for severe SARS-CoV-2 infection중증 SARS-CoV-2 감염으로 입원한 환자에서 회복기 혈장의 강력한 중화항체 효과Randomized Controlled Trial Published on 2021-05-272022-08-13 Journal: Nature Communications [Category] SARS, 바이오마커, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] approach autologous humoral response benefit clinical benefit comparable convalescent plasma Course COVID-19 COVID-19 patient COVID-19 patients Cytokines decision disease course donors drug Effect ENhance focus Hospital admission hospitalized COVID-19 patient Immunological response IMPROVE Infection majority neutralizing antibody neutralizing SARS-CoV-2 antibodies neutralizing SARS-CoV-2 antibody no effect Patient patients hospitalized plasma proinflammatory cytokines randomized clinical trial respiratory respiratory tract Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-COV-2 infection selected serum proinflammatory cytokine serum proinflammatory cytokines severe SARS-CoV-2 standard care survival the disease translational Translational research treat treated Treatment treatment for COVID-19 Trial Viral viral clearance viral infection Virological virological and immunological responses [DOI] 10.1038/s41467-021-23469-2 PMC 바로가기 [Article Type] Randomized Controlled Trial
Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a clinical pilot studyMiscellaneous Published on 2021-05-222022-10-31 Journal: European archives of oto-rhino-laryngology : offic [Category] COVID-19, SARS, [키워드] Anti-inflammatory antiviral response applicability Care Cell culture cells COVID-19 COVID-19 patient COVID-19 patients demonstrated Dexpanthenol expression Health hospitalized COVID-19 patient immune modulation in vitro model Inflammatory ingredient investigated modulation Mouth wash mouthwashe nasopharyngeal offer patients pharyngeal pilot study positive professionals Proinflammatory cytokine reduce reducing reduction reduction in Research Result RT-qPCR Saliva significantly supplementary material swabs Viral load virus was determined Zinc [DOI] 10.1007/s00405-021-06873-8 PMC 바로가기 [Article Type] Miscellaneous
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes환기된 COVID-19 환자의 심각한 T 세포 과민반응은 장기간의 바이러스 지속성 및 나쁜 결과와 상관관계가 있습니다Article Published on 2021-05-212022-09-12 Journal: Nature Communications [Category] SARS, 바이오마커, 진단, 치료기술, 치료법, [키워드] basophils benefit blood sample caused Cell clinical recovery components coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine secretion dendritic cells downstream Effect extrinsic Factor female hospitalized COVID-19 patient hospitalized COVID-19 patients hyperinflammation identify IL-2 Immunosuppressive medication independent independent of male marker monocyte Monocytes neutrophil Neutrophils outcome overcome Patient patients plasma plasmacytoid dendritic cells Pneumonia polyclonal poor prognosis predict prolonged virus persistence reduced Respiratory distress syndrome respond SARS-CoV-2 SARS-CoV2 infection shown T cell T cell activation T cell response Ventilated ventilated patients viral infection viral persistence Whole blood [DOI] 10.1038/s41467-021-23334-2 PMC 바로가기 [Article Type] Article
Corticosteroids for hospitalized patients with mild to critically-ill COVID-19: a multicenter, retrospective, propensity score-matched studyClinical Trial Published on 2021-05-212022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] 95% CI 95% confidence interval administration analyzed assigned baseline clinical clinical microbiology clinical status coronavirus disease Corticosteroid Corticosteroids COVID-19 COVID-19 patient Day diagnosed disease disease severity Efficacy enrolled evaluate Factor hazard ratio hospital hospitalized COVID-19 patient hospitalized patient IMPROVE intubation Invasive mechanical ventilation Japan Methylprednisolone Mild multicenter network Odds ratio outcome Patient primary endpoint propensity score matching radiological finding receive reduced Registered registry required retrospective Retrospective study Severe patient severity significantly lower significantly shorter Standard dose systemic corticosteroid university use of corticosteroid Ventilation Virology with COVID-19 [DOI] 10.1038/s41598-021-90246-y PMC 바로가기 [Article Type] Clinical Trial
The Efficacy of Antioxidant Oral Supplements on the Progression of COVID-19 in Non-Critically Ill Patients: A Randomized Controlled TrialArticle Published on 2021-05-192022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] alkaline phosphatase antioxidant antioxidants biochemical C-reactive protein clinical evidence clinical parameter clinical trial Controlled COVID-19 cytokine production Cytokine storm Disease progression double-blinded ferritin Final functional groups help hospitalized COVID-19 patient IL-6 Ill IMPROVE improvement Infection Inflammatory cytokine interleukin-6 investigated leukocyte Lymphocyte count MCP-1 monocyte Neutrophil-to-lymphocyte ratio non-critically ill non-critically ill patients oral outcome parameter parameters Patient patients with SARS-CoV-2 Protein Randomized reduced risk significantly significantly lower the cytokine storm the placebo group TNF-α tumor necrosis factor-α were measured [DOI] 10.3390/antiox10050804 PMC 바로가기 [Article Type] Article
COVID-19 and the liver: an adverse outcome pathway perspectiveCOVID-19와 간: 불리한 결과 경로 관점Review Published on 2021-05-152022-09-11 Journal: Toxicology [Category] SARS, 치료제, [키워드] adverse outcome anticipated AOP binding caused COVID-19 COVID-19 patients hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia knowledge liver Liver damage Liver injury Local mechanism pathway Pathways Perspective pharmacological treatment Research SARS-CoV-2 systemic inflammation Therapies Vaccine virus [DOI] 10.1016/j.tox.2021.152765 PMC 바로가기 [Article Type] Review
Randomized controlled trial of convalescent plasma therapy against standard therapy in patients with severe COVID-19 disease중증 COVID-19 질환 환자의 표준 요법에 대한 회복기 혈장 요법의 무작위 대조 시험Randomized Controlled Trial Published on 2021-05-112022-08-13 Journal: Scientific Reports [Category] SARS, 임상, 치료기술, 치료법, [키워드] 95% CI appear biochemical parameter Biochemical parameters clinical Clinical outcome confirmation Control Controlled trial convalescent patient Convalescent plasma therapy COVID-19 disease COVID-19 patient CP group died feasibility ferritin ferritin level higher risk hospitalized COVID-19 patient hospitalized COVID-19 patients hypoxia IMPROVE measure mechanical ventilation Mortality NIV no difference no differences no significant difference no significant differences Non-invasive not differ one patient open open label Patient pilot study plasma Primary outcome primary outcome measure Randomized Randomized controlled trials required respiratory indice respiratory indices risk risk ratio Safe secondary outcome secondary outcome measure Secondary outcomes severe COVID-19 severe COVID-19 disease severe disease Standard of care Standard therapy therapy Trial Two patient two patients Ventilation Virology [DOI] 10.1038/s41598-021-89444-5 PMC 바로가기 [Article Type] Randomized Controlled Trial