Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic interventionCOVID-19 질병의 발병기전에서 ACE-2 수용체의 역할 이해: 치료적 개입을 위한 잠재적 접근Review Published on 2021-12-012022-09-11 Journal: Pharmacological Reports [Category] SARS, 변종, [키워드] ACE ACE gene ACE-2 receptor ACE2 ACE2 receptor ACE2 receptors acute lung injury acute respiratory distress syndrome aldosterone angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 approach cardiovascular system Cell correlation COVID-19 COVID-19 pathogenesis disorders distress enzyme genomic variant homologue human cells hypertension intake lung Lung injury manifestation medications molecular pandemic of COVID-19 pathogenesis of COVID-19 pathophysiology pathway persistence Proteins question raised raising receptor Renin renin-angiotensin-aldosterone system researcher respiratory distress Respiratory distress syndrome rhACE2 SARS-CoV-2 SARS-CoV-2-infected patients therapeutic intervention these viruses understanding viral particle virus [DOI] 10.1007/s43440-021-00303-6 PMC 바로가기 [Article Type] Review
Roles of host mitochondria in the development of COVID-19 pathology: Could mitochondria be a potential therapeutic target?Review Published on 2021-11-232022-10-30 Journal: Molecular Biomedicine [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor activities angiotensin-converting enzyme-2 caused cells consequence coronavirus disease 19 COVID-19 COVID-19 disease Cytokine storm healthcare Host Infection Inflammation innate immune response Interaction mechanism Mitochondria mitochondrial outbreak pandemic Pathologies pathology potential therapeutic target progression receptor role SARS-CoV-2 SARS-CoV-2 entry scrutiny shown significant changes in Spread therapeutic treatment for COVID-19 understanding unique virus [DOI] 10.1186/s43556-021-00060-1 PMC 바로가기 [Article Type] Review
Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native, B.1.351, B.1.617.2, and P.1 SARS-CoV-2 spike proteins근원이없는 COVID-19 긍정적 인 개체로부터의 항체의 교차 반응성, B.1.351, B.1.617.2 및 p.1 SARS-COV-2 스파이크 단백질Article Published on 2021-11-082022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE-2 ACE-2 receptor Adults affinity analyzed antibodies antibody antibody level antibody levels B.1.351 B.1.617.1 B.1.617.2 Beta BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 collected COVID-19 cross-reactivity Delta ectodomain Effectiveness elicited enrolled Evidence evidence of except for Gamma humoral Humoral response implication individual individuals infected with SARS-CoV-2 inhibited Interaction interactions nCoV neutralization Optical sensors P.1 P.1 variant pandemic PCR-confirmed positive individual Proteins relative SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein Spike proteins SPR Spread sustained the spike protein vaccinated individual vaccinated individuals vaccination variant spike VoC VOCs [DOI] 10.1038/s41598-021-00844-z PMC 바로가기 [Article Type] Article
Serum IgG anti-SARS-CoV-2 Binding Antibody Level Is Strongly Associated With IgA and Functional Antibody Levels in Adults Infected With SARS-CoV-2혈청 IgG 항-SARS-CoV-2 결합 항체 수준은 SARS-CoV-2에 감염된 성인의 IgA 및 기능적 항체 수준과 밀접한 관련이 있습니다Immunology Published on 2021-10-082022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] ACE-2 receptor acute respiratory syndrome Adults age anti-S anti-S antibody anti-S ELISA anti-SARS-CoV-2 antibody binding antibody concentrations coronavirus coronavirus disease correlation COVID-19 cumulative cutoff value demographic groups demonstrated diagnostic disease severity ELISA ELISAs Endemic enzyme Epidemiology evaluate evaluated female full length full-length functional functional antibody human serum IgA IgG immunosorbent Level male Negative predictive value neutralizing antibody NPV pandemic positive Positive predictive value PPV Protein Quantitative reported Result robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 PCR SARS-CoV-2 seroprevalence sensitivity sera Serological assay serology serum dilution Significant significantly higher specificity Spread Surveillance Symptom Test statistics to define vaccine candidate were measured Wuhan, China yielding [DOI] 10.3389/fimmu.2021.693462 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 inhibition using a mucoadhesive, amphiphilic chitosan that may serve as an anti-viral nasal spray항 바이러스 비강 스프레이로서 작용할 수있는 점막 흡착성, 양친 매성 키토산을 사용한 SARS-COV-2 억제Article Published on 2021-10-082022-08-31 Journal: Scientific Reports [Category] SARS, 치료기술, 치료제, [키워드] A549 ACE-2 receptor adverse effect Anti-viral binding Biomedical materials Brain Cell clinical testing Concentration controls Coronavirus infections Course COVID-19 COVID-19 pandemic detect dose dosed effective electrostatic epithelial cells expressing Good host cells human airway human airway epithelial human airway epithelial cells hypothesise Infection inhibit injected limit log mammalian mechanism mice nares nasal nasal epithelial cell open Polymer Practice Prevent preventive intervention Prophylactic RATs reduce respiratory respiratory droplet Respiratory droplets respiratory tract Safe SARS-CoV-2 Spread spread of COVID-19 statistical significance TCID transgenic mice Vero E6 Vero E6 cell VERO E6 cells Viral viral entry viral infection Viral load virus [DOI] 10.1038/s41598-021-99404-8 PMC 바로가기 [Article Type] Article
IgG Antibodies Develop to Spike but Not to the Nucleocapsid Viral Protein in Many Asymptomatic and Light COVID-19 CasesIgG 항체는 스파이크에 발달하지만 많은 무증상 및 가벼운 Covid-9 사례에서 Nucleocapsid 바이러스 단백질이 아닙니다.Article Published on 2021-09-282022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] ACE-2 receptor anti-RBD Anti-RBD IgG antibody Antibody detection Asymptomatic Asymptomatic case Cohort cohort of patient conducted correlated COVID-19 detectable disease severity domain help IgG IgG antibodies IgG antibody immune response Indicator individual Infection inhibit Interaction LIGHT lung lesion lung lesions majority moderate nucleocapsid nucleocapsid protein Protein raise RBD Receptor-binding domain remained SARS-CoV-2 serum Serum Neutralization severe symptoms severity spike Spike protein Symptom the antibody the disease the RBD the spike protein Viral [DOI] 10.3390/v13101945 PMC 바로가기 [Article Type] Article
COVID-19 Pandemic and Vaccines Update on Challenges and ResolutionsCOVID-19 팬데믹 및 백신 관련 과제 및 해결 방법 업데이트Review Published on 2021-09-102022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 변종, [키워드] ACE-2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 all age group all age groups Alpha Antibody-dependent enhancement approach approval approved attenuated vaccine Attenuated Virus B.1.1.7 B.1.351 B.1.429 B.1.525 B.1.617 B.1.617.2 BCG being Beta booster dose candidate vaccine caused CD8 challenge China city clinical development clinical trial combating Compliance contrary Coronaviridae family coronavirus coronavirus disease Coronavirus-2 COVID-19 CTL Delta disease severity Effectiveness Efficacy elicit Emergency use Epsilon Eta Gamma herd immunity host cells immune activation immune response immune responses Immunity inactivated Inactivated Vaccines inhibit intracellular pathogen Live attenuated vaccine MOST Multiple multiple antigens multivariant vaccines Mutation mutations Neutralizing antibodies neutralizing antibody nucleic acids pandemic pathogen Phase III clinical trials platform potential limitations Prophylactic Replication Resolution RNA virus SARS CoV-2 variant SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein subunit vaccines T cell the Coronaviridae Vaccine vaccine candidate Vaccine hesitancy Vaccines variant variants Viral Viral antigen viral antigens viral entry viral spike protein viral vectors virus viruses WHO Wuhan [DOI] 10.3389/fcimb.2021.690621 PMC 바로가기 [Article Type] Review
What GI Physicians Need to Know During COVID-19 PandemicCOVID-19 팬데믹 동안 소화기 의사가 알아야 할 사항Review Published on 2021-09-012022-09-11 Journal: Digestive diseases and sciences [Category] SARS, 치료기술, [키워드] abnormality ACE-2 receptor anorexia appear caused cell line clearance confounding factor COVID-19 detected in stool diarrhea elevated enzyme Evidence General population GI symptom GI symptoms GI Tract host cells hypoxia infection rate infection rates involved liver Liver disease liver enzyme liver enzymes Liver manifestations: GI symptoms Loss of Smell management medications Mild morbidity and mortality Mortality nausea Patient patients patients with COVID-19 pharyngeal physician proportion recommendation Respiratory illness RNA SARS-CoV-2 Sepsis severe disease Severity of disease Stool Transmission Viral RNA virus vomiting worldwide pandemic [DOI] 10.1007/s10620-020-06625-4 PMC 바로가기 [Article Type] Review
Current Perspectives in the Discovery of Newer Medications Against the Outbreak of COVID-19Molecular Biosciences Published on 2021-07-122022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE-2 ACE-2 receptor Against age approaches Asymptomatic bind candidate cardiovascular disease clinical trials coronavirus COVID-19 COVID-19 disease current death diagnostic Effect effort Health Host human lung identify in-silico manuscript medication Mild new strain outbreak pandemic disease patients patients of COVID-19 peptides Perspective PROTECT researcher Respiratory disease SARS-CoV-2 severe respiratory illness small molecule Spike protein Spread spread of COVID-19 suggested target the spike protein the vaccine therapeutic targets treat Treatment viral entry virus [DOI] 10.3389/fmolb.2021.648232 PMC 바로가기 [Article Type] Molecular Biosciences
Modulation of Host Immune Response Is an Alternative Strategy to Combat SARS-CoV-2 PathogenesisImmunology Published on 2021-07-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] ACE-2 receptor acting activated alveolar alveolar macrophage caused CD8+ T cell chemokines chemotactic combat complex COVID-19 cytokine Cytokines fusion help high mortality Host host cell Host immune response host immune system infected cells inflammatory mediator kill Local macrophages membrane Modifying Monocytes Neutrophils NK cells pandemic phagocytosis pneumocyte Pneumocytes Protein receptor reduce replicate response RTC SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2virus secreting Spike protein Strategy the disease therapeutic targets TMPRSS2 translated type-2 pneumocyte viral life cycle viral membrane Viral RNA virus [DOI] 10.3389/fimmu.2021.660632 PMC 바로가기 [Article Type] Immunology