The SARS-CoV-2/Receptor Axis in Heart and Blood Vessels: A Crisp Update on COVID-19 Disease with Cardiovascular Complications심장 및 혈관의 SARS-COV-2/수용체 축 : 심혈관 합병증을 가진 COVID-19 질병에 대한 선명한 업데이트Review Published on 2021-07-122022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 receptor ACE2 receptors Activation association attribute attributes axis binding Blood blood vessel blood vessels bradykinin cardiovascular cardiovascular complication cardiovascular complications cardiovascular disease chronic condition chronic conditions complement Complication components COVID-19 COVID-19 disease Defense described detrimental disease dysfunction Effect Effects endothelial Endothelial dysfunction expression pattern function glycocalyx Health Organization heart Host host defense immune cell response immune cell responses mechanism organ pandemic Patient patient with COVID-19 Platelets potential molecular provide receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus the patient thrombosis vascular leakage vessel vessels WHO World Health Organization [DOI] 10.3390/v13071346 PMC 바로가기 [Article Type] Review
A comprehensive review on clinical and mechanistic pathophysiological aspects of COVID-19 Malady: How far have we come?Covid-19 Malady의 임상 및 기계적 병리 생리 학적 측면에 대한 포괄적 인 검토 : 우리는 얼마나 멀리 왔습니까?Review Published on 2021-06-072022-09-10 Journal: Virology Journal [Category] MERS, 치료제, [키워드] ACE2 receptors affecting analyzed approved articles Case report case reports Case series clinical presentation comorbid disease comorbid diseases Comorbidities Comorbidity contributed coronavirus coronavirus disease COVID-19 current cytokine cytokine production damage determine disease manifestation disease severity Effect Entry mechanism host cell host cells immune response include Inflammation irreversible damage lead long term Manifestations mechanism Mortality observational studies organ damage organ system organ systems outbreak pandemic pathology pathophysiologic pathophysiological Pathways patients penetration Prevalence recorded Research retrieved reveal short term Signs and symptoms SPSS Symptoms systemic inflammation Treatment underlying disease Vaccine Viral Viral proteins [DOI] 10.1186/s12985-021-01578-0 PMC 바로가기 [Article Type] Review
Biosensors as a future diagnostic approach for COVID-19Review Published on 2021-05-152023-06-19 Journal: Life sciences [Category] MERS, SARS, [키워드] ACE2 receptors Bioreceptors COVID-19 electrochemical rapid detection SARS-CoV-2 Spike proteins SPR Viral biosensor. [DOI] 10.1016/j.lfs.2021.119117 PMC 바로가기 [Article Type] Review
Vaping, SARS-CoV-2, and Multisystem Inflammatory Syndrome: A Perfect StormPediatrics Published on 2021-05-122022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] ACE ACE2 ACE2 receptors acute respiratory distress alteration ARDS association characterized children clearance consequence COVID-19 Defense develop disease Electronic cigarette EVALI fibrosis Health highlight immune system Impact Inflammation Inflammatory MIS-C morbidities Multisystem inflammatory syndrome oxidative stress pandemic peribronchial plethora Protective receptor respiratory symptom resulting risk SARS-CoV-2 shown storm syndrome target unique upregulation vaping vaping-associated lung injury virus [DOI] 10.3389/fped.2021.647925 PMC 바로가기 [Article Type] Pediatrics
Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection중화 압타머는 S/RBD-ACE2 상호작용을 차단하고 숙주 세포 감염을 방지합니다Article Published on 2021-04-262022-09-11 Journal: Angewandte Chemie (International ed. in English) [Category] SARS, 치료제, [키워드] ACE2 ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach aptamer Aptamers binding binding affinity block blocked blocking conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 domain host cell human host cells Infection Interaction motif neutralization neutralize Prevent Protein RBD receptor Receptor-binding domain Receptor-binding domain (RBD) S protein SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus synthetic target therapy treat viral particle virus virus infection Virus neutralization [DOI] 10.1002/anie.202100345 PMC 바로가기 [Article Type] Article
Insights into disparities observed with COVID-19COVID-19로 관찰된 격차에 대한 통찰력Review Published on 2021-04-012022-09-11 Journal: Journal of internal medicine [Category] SARS, 변종, 유전자 메커니즘, [키워드] ABO accumulation ACE ACE2 ACE2 receptor ACE2 receptors affected African African American African Americans age Americans Amino acid amino acid substitution amino acid substitutions androgen Angiotensin-converting enzyme Blood cardiac death cardiovascular disease caused Chronic kidney disease co-morbidities co-morbidity components contribute COVID-19 creating diabetes disease severity disparity element Ethnicity evaluated Evidence expression Factor Gender groups Health help high risk higher risk Hispanic Hispanic/Latinx human disease hypertension Infection infection with SARS-CoV-2 inhibitor insight kidney Kidney disease Latinx mechanism mechanisms men morbidities morbidity Mortality Native obesity Older Population race Racial risk risk factor Risk factors SARS-CoV-2 SARS-CoV-2 spike protein Serine serine protease serine protease TMPRSS2 severe COVID-19 severity sodium sodium channel Spike protein Structure sudden cardiac death the SARS-CoV-2 the United State The United States TMPRSS2 triggered understanding United States variant with COVID-19 [DOI] 10.1111/joim.13199 PMC 바로가기 [Article Type] Review
Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2스파이크 단백질의 돌연변이와 ACE2의 대립유전자 변이는 SARS-CoV-2에 대한 표적 치료 전략에 영향을 미칩니다Article Published on 2021-03-182022-09-11 Journal: Zoological research [Category] SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 allele Amino acid analyzed angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 antiviral agent Antiviral agents binding caused Chinese clinical Clinical data Comorbidities Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 progression docking domain drug drug therapy effective English enzyme enzyme-linked immunosorbent assays exhibited genetic data interact Mortality mutant Mutation pandemic Patient peptide Point mutation populations Protein Receptor binding Receptor-ligand docking Renin renin-angiotensin system Research SARS-CoV-2 SARS-CoV-2 pandemic Sequence analysis severe acute respiratory syndrome Coronavirus spike Spike protein Spread Symptom target targeted therapy targets the SARS-CoV-2 the spike protein Transmission treat Treatment treatment of COVID-19 Vaccine variant Variation [DOI] 10.24272/j.issn.2095-8137.2020.301 PMC 바로가기 [Article Type] Article
Applications of Protein Secondary Structure Algorithms in SARS-CoV-2 ResearchSARS-CoV-2 연구에서 단백질 2차 구조 알고리즘의 적용Review Published on 2021-03-052022-09-11 Journal: Journal of Proteome Research [Category] SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 protein ACE2 proteins ACE2 receptor ACE2 receptors Algorithm Algorithms Amino acid amino acid sequence Analysis application binding affinity can be used can not compare protein Complete computational tool computational tools Contact Course COVID-19 evaluate example experiments explained faster Genome global effort help highlight homology information nucleotide pandemic Pandemics Protein protein similarity protein structure question reflected required Research SARS-CoV-2 SARS-CoV-2 spike protein secondary secondary structure sequence sequence similarities similarity Spike protein Structure the binding affinity Vaccine design viruses while zoonotic origin zoonotic origins [DOI] 10.1021/acs.jproteome.0c00734 PMC 바로가기 [Article Type] Review
Soluble ACE2 as a potential therapy for COVID-19COVID-19에 대한 잠재적 치료제로서의 가용성 ACE2Article Published on 2021-03-012022-09-11 Journal: American journal of physiology. Cell physiology [Category] SARS, 변종, [키워드] ACE2 ACE2 receptor ACE2 receptors acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin II angiotensin-converting enzyme 2 ARDS binding Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection exaggerated inflammatory response Infection lung Lung injury Mutagenesis Neutralizing potential therapy Protein receptors respiratory sACE2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 soluble ACE2 therapeutic option therapy treat variant with COVID-19 [DOI] 10.1152/ajpcell.00478.2020 PMC 바로가기 [Article Type] Article
Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2Article Published on 2021-02-052022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, [키워드] ACE2 receptors bat bat ACE2 bind binding coronavirus cryo-EM structure Cryoelectron microscopy Evolution Evolution of SARS-CoV-2 exhibit Guangdong implicated pandemic pangolin RaTG13 SARS-CoV-2 SARS-CoV-2 spike spike spike glycoprotein Spike protein Structure suggested [DOI] 10.1038/s41467-021-21006-9 PMC 바로가기 [Article Type] Article