Intermediate-dose anticoagulation, aspirin, and in-hospital mortality in COVID-19: A propensity score-matched analysisClinical Trial Published on 2021-04-012022-10-05 Journal: American journal of hematology [Category] SARS, 임상, [키워드] adjust adult COVID-19 patients Analysis anticoagulation antiplatelet antithrombotic therapy Aspirin Cohort cohorts of patient Complication confounding factors covariate covariates COVID-19 cumulative examined hazard ratio Hospitalized hospitalized patient Illness severity In-hospital In-hospital death in-hospital mortality incidence Intensive marker Mortality multivariable occur Patient Primary outcome propensity score matching Regression model Retrospective study significantly lower therapy treatment group with COVID-19 yielding [DOI] 10.1002/ajh.26102 PMC 바로가기 [Article Type] Clinical Trial
The Experiences of Family Members of Ventilated COVID-19 Patients in the Intensive Care Unit: A Qualitative Study중환자실 코로나19 환기환자 가족의 경험: 정성적 연구Covid-19 Published on 2021-04-012022-09-01 Journal: The American Journal of Hospice & Palliative Care [Category] MERS, 진단, [키워드] adult COVID-19 patient adult COVID-19 patients analyzed Anxiety Care caused communication coronavirus coronavirus disease COVID-19 COVID-19 diagnosis COVID-19 patient Critically ill Critically ill patient critically ill patients Diagnosis difficulty Effect end-of-life exacerbated experience exploratory expressed family family member family members Healthcare provider healthcare providers ICU include information intensive care intensive care unit intensive care units Limited member outcomes Palliative care pandemic Patient care preferences Qualitative question reaction reported seeking Stress Support the patient thematic analysis Ventilated virus Visitor while with COVID-19 [DOI] 10.1177/10499091211006914 PMC 바로가기 [Article Type] Covid-19
Demystifying Excess Immune Response in COVID-19 to Reposition an Orphan Drug for Down-Regulation of NF-κB: A Systematic ReviewNF-κB의 하향 조절을 위한 희귀 약물의 재배치를 위한 COVID-19의 과도한 면역 반응 이해: 체계적인 검토Review Published on 2021-02-272022-09-10 Journal: Viruses [Category] MERS, 신약개발, [키워드] adult COVID-19 patients article Autopsies biopsies clinical trial clinical trials country COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines demonstrated downstream drug effector eligibility English excess excess immune response Final Histamine histamine-conjugated-normal human immunoglobulin human immunoglobulin hyper-inflammation IL-10 IL-6 immune response Immunoglobulin immunological inhibit interleukin Joanna lack mechanism molecule molecules morbidity morbidity and mortality neutralization NF-κB nuclear translocation Orphan pathway pro-inflammatory cytokine pro-inflammatory cytokines reposition repositioning response resulting review Risk of bias SARS-CoV-2 screened searched Side effects Signaling specificity Therapeutics TNF-α TNFα tumour necrosis factor Tumour Necrosis Factor α upstream were used [DOI] 10.3390/v13030378 PMC 바로가기 [Article Type] Review
Temporal association between human upper respiratory and gut bacterial microbiomes during the course of COVID-19 in adultsArticle Published on 2021-02-182022-10-04 Journal: Communications Biology [Category] MERS, 바이오마커, [키워드] adult COVID-19 patients anal swab association Bacterial bacterial microbiome category change Community complex controls Course COVID-19 COVID-19 adult patients COVID-19 patient COVID-19 patients Disease progression dynamic form Gut healthy healthy control infect Interaction longitudinal analysis microbial community Microbiome Mild multiple organ non-COVID-19 patient other diseases Patient performed Prognostic markers respiratory tract rRNA SARS-CoV-2 Sequencing synchronous Temporal the disease the patient type I upper respiratory viral infection [DOI] 10.1038/s42003-021-01796-w PMC 바로가기 [Article Type] Article
Clinical characteristics of asymptomatic and symptomatic COVID-19 patients in the Eastern Province of Saudi ArabiaObservational Study Published on 2021-01-012022-10-05 Journal: Journal of infection and public health [Category] SARS, 임상, [키워드] Admission adult COVID-19 patients Asymptomatic asymptomatic patient Characteristics Chest radiograph clinical Clinical characteristics clinical presentation Contact COVID-19 COVID-19 cases COVID-19 infection COVID-19 patient deficiency Diabetes Mellitus epicenter female G6PD Hospitalization hypertension initial intensive care Iraq laboratory data majority median age negative RT-PCR negativity no significant difference p value Patient patients Qatif Radiographic reported required SARS-CoV-2 Saudi Arabia symptomatic the patient [DOI] 10.1016/j.jiph.2020.11.002 PMC 바로가기 [Article Type] Observational Study
Impact of comorbid asthma on severity of coronavirus disease (COVID-19)코로나바이러스 질환(COVID-19)의 중증도에 대한 동반이환 천식의 영향Clinical Trial Published on 2020-12-112022-08-13 Journal: Scientific Reports [Category] MERS, SARS, 임상, [키워드] acute exacerbation adult COVID-19 patient adult COVID-19 patients age assessment Asthma asthma patient asthma patients Clinical outcome Comorbidities Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 patient database death demonstrated evaluated Health Insurance Impact insurance Korean Male sex Medical research Mortality Odds ratio old age Patient poor prognosis potential risk Respiratory failure retrospective cohort study review risk factor Risk factors selected severity Sex were assessed [DOI] 10.1038/s41598-020-77791-8 PMC 바로가기 [Article Type] Clinical Trial
Prevalence of Headache in Patients With Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-Analysis of 14,275 PatientsNeurology Published on 2020-11-272022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] 95% confidence interval adult COVID-19 patients CIs clinical clinical manifestation coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical critical appraisal database discharged eligible female Google Scholar headache ICU identify Joanna Briggs Institute Meta-analysis moderate no significant difference non-ICU outbreak Prevalence Quality random-effects model Registered review searched Spread survived systematic review was done Wuhan, China [DOI] 10.3389/fneur.2020.562634 PMC 바로가기 [Article Type] Neurology
Adapting hospital capacity to meet changing demands during the COVID-19 pandemicResearch Article Published on 2020-10-162022-10-28 Journal: BMC Medicine [Category] COVID-19, MERS, SARS, [키워드] Admission adult COVID-19 patients analysed baseline calculate Care condition conducted coronavirus disease COVID-19 COVID-19 hospitalisation COVID-19 pandemic COVID-19 patient COVID-19 patients Critical care dataset Elective surgery England ENhance evaluate General & acute greater hospital Hospital capacity hospitals Intervention interventions literature review National National Health Service NHS Nurses pandemic Patient provided Result sustained treat Treatment [DOI] 10.1186/s12916-020-01781-w PMC 바로가기 [Article Type] Research Article
Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation530 Published on 2020-10-132022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory syndrome Adaptive immune response adaptive immune system adult COVID-19 patient adult COVID-19 patients Bacterial binding binding epitope caused children complex coronavirus Coronaviruses COVID-19 COVID-19 patient Cytokine storm disease Escalation European Excessive activation exhibit explain glycoprotein histocompatibility complex hyperinflammation Hyperinflammatory Hyperinflammatory syndrome implication include Infection Interaction intercellular MHCII MIS-C motif Mutation Pandemics pathogenic Patient residue SARS virus SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike SARS-related coronaviruses selected sequence severe COVID-19 patients Shock Significance skewed staphylococcal superantigen Support supported Symptom syndrome T cell T cell receptor T cell receptors TCR TCR binding TCRs the cytokine storm the receptor-binding domain the SARS-CoV-2 therapeutic approaches Toxic shock syndrome triggered TSS unique virus with COVID-19 [DOI] 10.1073/pnas.2010722117 PMC 바로가기 [Article Type] 530
Analysis of the Risk Factors for Mortality in Adult COVID-19 Patients in Wuhan: A Multicenter StudyMedicine Published on 2020-08-252022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] adult COVID-19 patients age analyzed association Chi-square Clinical characteristics clinician coronavirus disease COVID-19 D-dimer level died early stage Factor Fisher high-risk patient hospital identify In-hospital death laboratory-confirmed Mann-Whitney U Mortality multicenter study multivariable Non-survivors outbreak Patient Platelet regression analysis risk factor Risk factors SARS-CoV-2 serum creatinine Spread survivor univariable were used with COVID-19 Wuhan Wuhan, China [DOI] 10.3389/fmed.2020.00545 PMC 바로가기 [Article Type] Medicine