Alanine – Page 3 – Communicable Diseases Research

Efficacy of Tocilizumab in COVID-19: Single-Center Experience

COVID-19에서 Tocilizumab의 효능: 단일 센터 경험

Research Article

Published on 2021-12-302022-09-12
Journal: BioMed Research International [Category] 진단,

Rapid characterization of spike variants via mammalian cell surface display

Technology

Published on 2021-12-162022-10-31
Journal: Molecular Cell [Category] COVID-19, SARS,

[키워드] Abstract accelerate ACE2 ACE2 binding Alanine Alpha antibody Antigen antigenicity B.1.1.28 B.1.1.7 B.1.351 B.1.617.2 cell display circulating variant convalescent plasma COVID-19 Critical display ectodomain epitope epitope mapping expression FIVE glycosylated highlight immune system immunogenic mammalian cell Mutagenesis Mutation N-terminal domain neutralizing antibody neutralizing monoclonal antibody NTD peptide platform Proteins Rapid Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein spike spike variant spike variants Threats Vaccine variant variants variants of concern viral glycoproteins
[DOI] 10.1016/j.molcel.2021.11.024 PMC 바로가기 [Article Type] Technology

Impact of Latent Tuberculosis on Severity and Outcomes in Admitted COVID-19 Patients

Internal Medicine

Published on 2021-11-252022-10-31
Journal: Cureus [Category] COVID-19,

Prognostic Potential of Liver Enzymes in Patients With COVID-19 at the Leishenshan Hospital in Wuhan

Cellular and Infection Microbiology

Published on 2021-11-162022-10-31
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,

[키워드] 95% confidence interval Alanine ALT ALT - alanine transaminase analyses Analysis aspartate aminotransferase/alanine aminotransferase Aspartate transaminase AST AST - aspartate transaminase AST/ALT biochemical clinician Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 patients COVID-19 progression Cox regression Curve demonstrated determine elevated hazard ratio help higher risk hospital Kaplan-Meier curves Kaplan-Meier survival curve Liver function Liver function test Mortality Odds ratio pandemic Patient patient information Pneumonia Potential Prognosis prognosis of patient Result severe COVID-19 severity severity of COVID-19 treatment for COVID-19 was collected were used Wuhan
[DOI] 10.3389/fcimb.2021.636999 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Effect of mutation on structure, function and dynamics of receptor binding domain of human SARS-CoV-2 with host cell receptor ACE2: a molecular dynamics simulations study

돌연변이가 숙주 세포 수용체 ACE2와 인간 SARS-CoV-2의 수용체 결합 도메인의 구조, 기능 및 역학에 미치는 영향: 분자 역학 시뮬레이션 연구

Article

Published on 2021-11-012022-09-11
Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종,

[키워드] 6M0J ACE2 ACE2-RBD Affect Alanine alanine mutant alanine mutants Analysis angiotensin angiotensin-converting enzyme-II binding binding affinity cellular protease cellular proteases complex complexes conserved coronavirus Critical Directed mutagenesis disease severity drug Effect entry of SARS-CoV-2 enzyme exhibit FIVE flexible host cell host cell receptor human ACE2 human SARS-CoV-2 hydrogen Infection information inhibitor initiate Interface residues intermolecular hydrogen bond MD simulation MD simulations molecular molecular dynamics Molecular dynamics simulation molecular interaction motif Mutagenesis mutant Mutation priming Principal component provide RBD RBM recent Receptor binding Receptor binding domain receptor binding motif receptor binding motif. Receptor-binding domain Replication rate residue residues SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD Spike protein supported the binding affinity the receptor-binding domain viral spike protein ward wild-type
[DOI] 10.1080/07391102.2020.1802348 PMC 바로가기 [Article Type] Article

Liver and kidney function in patients with Covid-19 treated with remdesivir

렘데시비르 치료를 받은 코로나19 환자의 간 및 신장 기능

Randomized Controlled Trial

Published on 2021-11-012022-09-11
Journal: British Journal of Clinical Pharmacology [Category] SARS, 임상, 치료제,

Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

면역 탈출 변이체 추적을 위한 SARS-CoV-2 RBD 특이적 중화 항체의 결합 핫스팟에 대한 포괄적인 매핑

Research

Published on 2021-10-142022-09-10
Journal: Genome Medicine [Category] MERS, SARS, 변종, 진단,

[키워드] accumulation ACE2 binding additive effect Alanine Amino acid antibody antibody escape mutant Antibody-mediated neutralization antigenic antigenic site antigenic sites B.1.351 B.1.617.1 binding binding affinity changes in characterized circulating Comprehensive convalescent individual convalescent individuals convalescent plasma COVID-19 described determinant determinants domain E484K early stage escape mutation Escape variants Evidence Evolution F486L facilitate Host host immunity immune Immune escape impair independent K417N L452R memory B cell memory B cells Mutation N501Y NAb NAbs natural mutation neutralization Neutralizing antibodies neutralizing antibody not affect pandemic provide pseudoviruses RBD RBD antigenic sits RBD mutation RBD-specific antibody reactive Receptor-binding domain Recombinant protein recombinant proteins Result SARS-CoV-2 selected single B cell specific antibodies strain supplementary material Surveillance the RBD Treatment treatment of COVID-19 variant variants variants of SARS-CoV-2 virus was performed
[DOI] 10.1186/s13073-021-00985-w PMC 바로가기 [Article Type] Research

Effect of Vitamin D Supplementation on Muscle Status in Old Patients Recovering from COVID-19 Infection

COVID-19 감염에서 회복 중인 노인 환자의 근육 상태에 대한 비타민 D 보충제의 효과

Randomized Controlled Trial

Published on 2021-10-092022-09-12
Journal: Medicina [Category] MERS, SARS, 임상, 진단,

[키워드] 6MWT addition Alanine alanine aminotransferase Aldolase aspartate Aspartate aminotransferase biochemical parameter Biochemical parameters Biochemistry blood count carried center cholecalciferol conducted contribute cortisol COVID-19 creatine creatine kinase damage decrease decreases double-blind trial Effect Elderly patient elderly patients exercise Glucose health center Health status hematological homeostasis hormone Improvements Infection involved Lactate lactate dehydrogenase life material men metabolism muscle Myoglobin objective pathology Patient physical physical fitness pilot study Placebo protective role Protein Quality of life reported Respiratory function Respiratory function tests Result returned SARS-CoV-2 serum spirometry status suffered Testosterone total protein transaminase two group two groups urea uric acid Vitamin Vitamin D Vitamin D supplementation was used
[DOI] 10.3390/medicina57101079 PMC 바로가기 [Article Type] Randomized Controlled Trial

Liver function test abnormalities at hospital admission are associated with severe course of SARS-CoV-2 infection: a prospective cohort study

병원 입원시 간 기능 테스트 이상 SARS-COV-2 감염의 심각한 과정과 관련이 있습니다 : 전향 적 코호트 연구

Article

Published on 2021-10-012022-08-31
Journal: Gut [Category] MERS, SARS, 바이오마커,

[키워드] abnormality Admission age Alanine alanine aminotransferase albumin ALT analysed aspartate Aspartate aminotransferase association AST baseline Comorbidities composite endpoint Course COVID-19 COVID-19 patients COVID-19-related death defined Elevation gamma-glutamyltransferase Gender Hospital admission ICU ICU admission ICU treatment independent risk factor Injury intensive care intensive care unit Liver disease Liver function Liver function test Liver injury mechanical ventilation Patient patients predominant proportion prospective cohort study Prospective Study reported SARS-CoV-2 SARS-COV-2 infection the disease university hospital
[DOI] 10.1136/gutjnl-2020-323800 PMC 바로가기 [Article Type] Article

Improved Synthesis of a Cyclic Glutamine Analogue Used in Antiviral Agents Targeting 3C and 3CL Proteases Including SARS-CoV-2 M pro

SARS-CoV-2 M pro를 포함한 3C 및 3CL 프로테아제를 표적으로 하는 항바이러스제에 사용되는 고리형 글루타민 유사체의 향상된 합성

Article

Published on 2021-09-172022-09-11
Journal: The Journal of organic chemistry [Category] SARS, 치료제,

[키워드] 3CL agent Alanine Amino acid analogue Antiviral Compound conditions cyclic form Glutamine Improved Including lack M pro methodology oxime preparation Protease inhibitor purification reagent SARS-CoV-2 synthesis targeting yielding
[DOI] 10.1021/acs.joc.1c01299 PMC 바로가기 [Article Type] Article