Bioinformatic prediction of immunodominant regions in spike protein for early diagnosis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Bioinformatics Published on 2021-04-082022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory syndrome Amino acid antibody Antibody detection Antigen antigen detection Antigen-capture antigenicity approach Bioinformatic bioinformatics Bioinformatics analysis caused coronavirus COVID-19 Critical detection system early diagnosis epitope expected generate glycosylation site high accuracy hydrophilicity immunodominant immunodominant epitopes Immunodominant fragments mice Mutation nucleic acid Pandemics peptide Region Result S1 subunit SARS-CoV-2 SARS-CoV-2 detection selected sequence specificity spike Spike protein stimulate strong immune response the S1 subunit virus particle [DOI] 10.7717/peerj.11232 PMC 바로가기 [Article Type] Bioinformatics
Bioinformatic Analysis of Genome-Predicted Bat CathelicidinsArticle Published on 2021-03-232022-10-30 Journal: Molecules [Category] COVID-19, [키워드] Analysis antimicrobial peptide Antiviral antiviral activity bat binding domain Bioinformatic bioinformatics Cathelicidin coding complex component conserved COVID-19 cysteine Defense docking domain Evolution examined form Genome help Host in silico Innate immunity learning microbial NCBI database Pathogens peptide Phylogenetic relationship Protein protein sequence public health RBD retrieved SARS-CoV-2 sequence sequenced spike Structural analysis the SARS-CoV-2 unique virus viruses [DOI] 10.3390/molecules26061811 PMC 바로가기 [Article Type] Article
Bioinformatic analyses hinted at augmented T helper 17 cell differentiation and cytokine response as the central mechanism of COVID‐19–associated Guillain‐Barré syndrome생물정보학 분석은 COVID-19 관련 길랑-바레 증후군의 중심 기전으로서 증강된 T 헬퍼 17 세포 분화 및 사이토카인 반응을 암시Original Article Published on 2021-03-102022-09-10 Journal: Cell Proliferation [Category] SARS, 유전자 메커니즘, [키워드] Abnormalities Activation Algorithm Analysis analyzed association autoimmune attack autonomic Bioinformatic CD86 cell differentiation Cluster Clustering conditions COVID‐19 COVID‐19 CSF2 cytokine cytokine response databases demonstrated disease disease entity DisGeNET Evidence Genes Genetic Guillain‐Barré syndrome IL10 IL1B IL23A IL27 IL2RA IL4 IL6 Interaction ISG20 ITGAM knowledge Macrophage Markov material mechanism mononuclear cell mononuclear cells network analysis objective parameter pathophysiological mechanism pathway Patient PBMC performed Peripheral blood Peripheral blood mononuclear cells peripheral nerves platform PTGS2 Regulatory regulatory genes required Result retrieved risk SARS‐CoV‐2 shown STRING subset suggested syndrome T helper Th17 TNF Transcriptome transcriptome analysis Version was used [DOI] 10.1111/cpr.13024 PMC 바로가기 [Article Type] Original Article
COMPARE Analysis, a Bioinformatic Approach to Accelerate Drug Repurposing against Covid-19 and Other Emerging EpidemicsResearch article Published on 2021-03-012022-10-05 Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 신약개발, 치료제, [키워드] Algorithm Analysis Anti-SARS-CoV-2 Activity Antibiotics Antiviral antiviral activity approach Bioinformatic bioinformatics cancer cell lines COMPARE analysis Compound COVID-19 described Dexamethasone drug Drug discovery Drug repurposing drugs growth Hydroxychloroquine in silico In silico methods include inhibitory methotrexate National Cancer Institute nicotinamide nucleosides Other Outbreaks pharmacological profile Repository repurposing resource Ritonavir SARS-CoV-2 structures tested uridine viral epidemics vitamin A vitamins were used [DOI] 10.1177/2472555220975672 [Article Type] Research article
Analysis of Three Mutations in Italian Strains of SARS-CoV-2: Implications for Pathogenesis이탈리아 SARS-CoV-2 균주의 3가지 돌연변이 분석: 발병에 대한 의미Article Published on 2021-01-012022-09-11 Journal: Chemotherapy [Category] 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affecting analyzed approved Bioinformatic characterization coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 deaths disease Efficacy enveloped virus evaluate Evolution of SARS-CoV-2 Evolutionary analysis GISAID identify Italian Italian patients Mutation mutations Protein modeling Registered respiratory responsible SARS-CoV-2 SARS-CoV-2 isolate sequenced severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein strain Surveillance syndrome Syndrome coronavirus 2. the spike protein used to evaluate Vaccine vaccine efficacy virus whole genome whole genomes Wuhan [DOI] 10.1159/000515342 PMC 바로가기 [Article Type] Article
Identification of Lysine Acetylation Sites on MERS-CoV Replicase pp1abResearch Published on 2020-11-232022-10-30 Journal: Molecular & Cellular Proteomics : MCP [Category] Coronavirus, [키워드] acetylated acetylation Affect Analysis Bioinformatic bioinformatics conserved coronavirus disease enzyme activity event events expressing facilitate Factor Factors HDAC HEK293 cells Host host response identification immunoaffinity immunoprecipitation infected cell life-threatening mechanism MERS MERS-CoV NCBI database occur pandemic peptide peptides polyprotein post-translational modifications pp1ab predict predicted Protein regulate Regulatory replicase Replication reported responsible RNA virus sequence SIRT1 Site subject upstream viral infection Viral protein viral replication viruses was performed western blotting [DOI] 10.1074/mcp.RA119.001897 PMC 바로가기 [Article Type] Research
Epidemiology, evolutionary origin, and malaria‐induced positive selection effects of G6PD ‐deficient alleles in Chinese populations중국 인구에서 G6PD 결핍 대립유전자의 역학, 진화 기원 및 말라리아 유발 양성 선택 효과Original Article Published on 2020-10-312022-10-30 Journal: Molecular Genetics & Genomic Medicine [Category] COVID-19, 말라리아, [키워드] affected allele Analysis Bioinformatic China Chinese Chinese population correlated deficiency disorder Effect Epidemiology Evidence evolutionary origin Features FIVE Frequency G6PD Genome glucose‐6‐phosphate dehydrogenase (G6PD) information malaria natural selection nucleotide pathogenic performed Population populations Positive selection Prevalence ranged reported Result Strong variant [DOI] 10.1002/mgg3.1540 PMC 바로가기 [Article Type] Original Article
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2SARS-CoV-2의 진입 수용체인 지오텐신 전환 효소 2의 생물정보학적 특성화Research Article Published on 2020-10-282022-08-13 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 gene ACE2 mRNA age and gender Analysis angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 angiotensin-converting enzyme 2 binding site Bioinformatic bioinformatics caused Cell cell type cell types ciliary classical club COVID-19 COVID-19 epidemic duodenum endothelial entry receptor enzyme epithelial epithelial cells expressed expression functions Gene ontology analysis goblet goblet cells Health Organization highest immunohistochemistry include indicated interferon-stimulated response element International IRF8 IRF9 kidney lung Novel coronavirus novel coronavirus SARS-CoV-2 Ontology organ pandemic positive predict promoter promoters Protective public health emergency Regulation Renin renin-angiotensin system respiratory respiratory tract SARS-CoV-2 signal small intestine Stat1 suggested target cell target cells Testis Trachea transcription factor transcriptional regulation Vascular vessel World Health Organization [DOI] 10.1371/journal.pone.0240647 PMC 바로가기 [Article Type] Research Article
Bioinformatic study to discover natural molecules with activity against COVID-19Research Article Published on 2020-10-062022-10-31 Journal: F1000Research [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affecting Bioinformatic bioinformatics China coronavirus coronavirus disease COVID-19 COVID-19 disease database disease drug drug candidate effective globe high throughput virtual screening Human inhibitory molecular docking Molecular docking study ramipril reported SARS-CoV-2 screened Spread the disease Treatment World Health Organization Zinc [DOI] 10.12688/f1000research.26731.1 PMC 바로가기 [Article Type] Research Article
In Silico Prediction of Molecular Targets of Astragaloside IV for Alleviation of COVID-19 Hyperinflammation by Systems Network Pharmacology and Bioinformatic Gene Expression AnalysisPharmacology Published on 2020-09-162022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ADORA2A ADRB2 alleviation Analysis Anti-inflammatory antioxidant approach Astragaloside IV Bioinformatic Bioinformatics analysis caused chemokine contribute COVID-19 COVID-19 patients cytokine cytokine storms dataset DEGs differentially expressed gene down-regulated genes drug candidate GBP1 Gene Expression Omnibus Genes GEO GO term GSE147507 hyper-inflammation hyperinflammation IL1B IL6 Inflammation KEGG KEGG pathway Kyoto MLNR MMP13 network network pharmacological network pharmacology NFKBIA NLRP3 Ontology overlap overlapping pathway pathway enrichment performed pharmacological mechanism Pharmacology Potential prediction PTAFR Result SARS-CoV-2 screened System target TNF Treatment TRIM21 up-regulated [DOI] 10.3389/fphar.2020.556984 PMC 바로가기 [Article Type] Pharmacology