Postoperative Onset and Detection of SARS-CoV-2 in Surgically Resected Specimens From Gastrointestinal Cancer Patients With Pre/Asymptomatic COVID-19전/무증상 COVID-19가 있는 위장암 환자의 수술로 절제된 표본에서 SARS-CoV-2의 수술 후 발병 및 검출Article Published on 2020-12-012022-09-11 Journal: Annals of surgery [Category] SARS, 치료기술, [키워드] Abnormalities abnormality ACE2 All the patient all the patients analyzed cancer patient Case fatality rate Chest computed tomography clinical Clinical course clinical courses Clinical data collected Computed tomography COVID-19 cytoplasm death detect detection Diagnosis elective surgeries Elective surgery enrolled Enterocyte enterocytes epidemiologic feature Evidence evidence of expression Fatality rate feasibility Gastrointestinal high risk highlight implication Infection Limited Macrophage macrophages male median age much higher natural history Onset pandemic Patient patients with COVID-19 postoperative presenting respiratory respiratory symptom respiratory symptoms SARS-CoV-2 specimen specimens surgery Surgical Procedure symptom onset tissue Treatment treatment of COVID-19 tropism of SARS-CoV-2 [DOI] 10.1097/SLA.0000000000004362 PMC 바로가기 [Article Type] Article
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19COVID-19에 대한 질병 징후 및 약물 용도 변경에 대한 조사 및 인구 기반 검증에 대한 네트워크 의학 접근 방식Observational Study Published on 2020-11-062022-08-13 Journal: PLoS Biology [Category] Medicine and Health Sciences, 신약개발, 유전자 메커니즘, 임상, [키워드] 95% CI ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADRB2 African American African Americans age Analysis angiotensin Angiotensin II angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors approach approved Asthma asthma patient asthma patients blocker candidate caused Chain Reaction co-expression Comorbidity Consequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Crohn disease database disease disease manifestation elevated Enterocyte host protein identify ileal increase individual Inflammatory Inflammatory bowel disease IRAK3 Laboratory Laboratory test likelihood Manifestations mechanism Medical conditions melatonin metabolomics methodology molecular morbidity morbidity and mortality network observation observational study Odds ratio pandemic Pathogenesis Patient platform positive positive test result potential treatments Propensity score protein interactions protein–protein interactions proteome proteomics receptor Receptor Blockers reduced respiratory risk SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Sex significantly single-cell Single-cell RNA sequencing smoking test result therapy tissue tissues TMPRSS2 Transcriptome transcriptomics Treatment treatment of COVID-19 widespread with COVID-19 [DOI] 10.1371/journal.pbio.3000970 PMC 바로가기 [Article Type] Observational Study
Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19Articles Published on 2020-10-312022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, SARS, [키워드] Acute inflammation addition angiotensin-converting enzyme 2 bowel Colon colonic Conservative management Course COVID-19 COVID-19 pandemic Diagnosis elevated Enterocyte Extrapulmonary feature hemorrhage hospital Hospitalized host receptor increasingly Inflammation intensive care Liver transaminases management manifestation Necrosis Paralytic Patient Pneumonia Potential potential mechanism presenting receptors renal reported Respiratory disease SARS-COV-2 infection Severe COVID-19 Infection Severe COVID-19 pneumonia specimen Spread Support ventilator viral entry virus [DOI] 10.4269/ajtmh.20-0894 PMC 바로가기 [Article Type] Articles
SARS-CoV-2 Targets by the pscRNA Profiling of ACE2, TMPRSS2 and Furin ProteasesArticle Published on 2020-10-282022-10-30 Journal: iScience [Category] COVID-19, [키워드] ACE2 Acidic Analysis Cell cells cellular comprehensive view COVID-19 pandemic Enterocyte expression information intestinal enterocyte kidney less lung AT2 cell macrophages Microbiology Novel coronavirus physical barrier Profiling Protein proximal tubule cells receptor RNA SARS-CoV-2 single-cell single-cell level stromal cell systemic target target cell targets the SARS-CoV-2 Thyroid tissue TMPRSS2 transcriptomics Virology [DOI] 10.1016/j.isci.2020.101744 PMC 바로가기 [Article Type] Article
An Asymptomatic SARS-CoV-2-Infected Infant With Persistent Fecal Viral RNA Shedding in a Family Cluster: A Rare Case ReportMedicine Published on 2020-09-252022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome antiviral immunity Asymptomatic asymptomatic infection caused Clinical characteristics clinical symptom Cluster coronavirus coronavirus disease COVID-19 Enterocyte Epidemic epidemiological exhibited family Family cluster fecal Fecal sample fecal viral RNA shedding female highlight immune system individual Infant male Nasopharyngeal swab nasopharyngeal swab sample outbreak pandemic persistent positive Prevent report RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 testing shedding tested [DOI] 10.3389/fmed.2020.562875 PMC 바로가기 [Article Type] Medicine
Gut microbiota and Covid-19- possible link and implicationsReview article Published on 2020-08-012022-10-05 Journal: Virus research [Category] SARS, 유전자 메커니즘, [키워드] ACE2 receptor ACE2 receptors age alveolar epithelial cells binding cause caused COVID-19 diet disease Diseases Dysbiosis Elderly patient Enterocyte environmental factor Express faece functional genetics gut microbiome gut microbiota Immunity implication IMPROVE Improving infected patients Infection initiated intestinal epithelial cell Lung disease Lung infection Lung microbiota microbiota pandemic patients Perturbation Prophylactic reported respiratory virus role SARS-CoV-2 SARS-CoV-2 RNA small intestine Therapies Trial [DOI] 10.1016/j.virusres.2020.198018 [Article Type] Review article
Immunological co-ordination between gut and lungs in SARS-CoV-2 infectionArticle Published on 2020-07-242022-11-01 Journal: Virus research [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome Affect alveolar Amino acid Cell ciliated cell coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients detected in stool Diagnosis Enterocyte enzyme epithelial expressed facilitate Fecal sample gastrointestinal tract GI Tract Gut gut microbial ecology gut–lung axis Health human-to-human transmission hygiene IBD immunological infect Inflammatory bowel disease lung Lungs microbiota organ pandemic patients receptor RNA SARS-CoV-2 SARS-COV-2 infection subsequent Symptom transmission of SARS-CoV-2 Transport Viral RNA [DOI] 10.1016/j.virusres.2020.198103 PMC 바로가기 [Article Type] Article
Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal TractBrief Report Published on 2020-06-112022-10-31 Journal: Genes [Category] COVID-19, SARS, [키워드] abundance ACE2 acute respiratory syndrome Cell co-expression coronavirus COVID-19 dataset Enterocyte Evidence Gastrointestinal gastrointestinal tract GI Tract highest Infection Lower proportion relative SARS-CoV-2 SARS-CoV-2 entry scRNA-seq Single-cell RNA-sequencing small intestine TMPRSS2 tract [DOI] 10.3390/genes11060645 PMC 바로가기 [Article Type] Brief Report
Host Gene Expression of Macrophages in Response to Feline Coronavirus InfectionArticle Published on 2020-06-092022-10-31 Journal: Cells [Category] Coronavirus, [키워드] affected aligned arise cells contagious coronavirus develop downregulated gene Enterocyte event Ex vivo Feline coronavirus Gene Expression genetics healthy highlight host gene expression Host immune response host response immune immune activation Immune status in viral infections inhibiting Innate immunity intestine involved Macrophage macrophages male Monocytes Mutation overlap Pathogenesis pathogenic predominant replicate response resulting RNA sequencing Signaling systemically the disease Transcriptome upregulated gene viral read viral transcript virus virus uptake [DOI] 10.3390/cells9061431 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across TissuesArticle Published on 2020-05-282022-10-31 Journal: Cell [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 expression acute respiratory syndrome airway epithelial cell angiotensin-converting enzyme 2 Anti-viral bind cause Cell cells cellular cellular entry clade coronavirus COVID-19 dataset disease ENhance Enterocyte epithelia epithelial Factor goblet secretory cells Health Host host proteases host response host tissue Human identify ileal absorptive enterocytes implication Infection Influenza interferon interferon-stimulated gene ISG lung Lung injury lung tissue mechanism mouse mouse single-cell RNA-sequencing nasal non-human primate Pathogenesis Pneumocytes promote Protein raising regulate SARS-CoV-2 SARS-CoV-2 spike scRNA-seq single-cell RNA-seq dataset Specific subset target the disease tissue tissues TMPRSS2 TMPRSS2 expression transmembrane serine protease Type type II pneumocytes upregulated upregulation urgency viral infections [DOI] 10.1016/j.cell.2020.04.035 PMC 바로가기 [Article Type] Article