Antibody Profiling in COVID-19 Patients with Different Severities by Using Spike Variant Protein Microarrays스파이크 변이 단백질 마이크로어레이를 사용한 다양한 중증도의 COVID-19 환자에서 항체 프로파일링Article Published on 2022-05-032022-09-11 Journal: Analytical Chemistry [Category] MERS, 변종, 진단, [키워드] ACE2 ACE2 binding antibody antibody isotypes collected competition COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical critical cases death demonstrated Disease progression dose-dependent inhibition Drug screening elevated evaluated except for healthy subject healthy subjects humoral Humoral immunity immune inhibitors Microarray Mild Neutralizing activity Neutralizing antibodies nonstructural protein 3 patients Perindopril Profiling Protein protein 3 ramipril serum serum IgG severity Specificities specificity spike spike variant spike variants variant [DOI] 10.1021/acs.analchem.1c05567 PMC 바로가기 [Article Type] Article
Immunogenicity of Inactivated SARS-CoV-2 Vaccines in Patients With Rheumatoid Arthritis: A Case Series류마티스 관절염 환자에서 비활성화된 SARS-CoV-2 백신의 면역원성: 사례 시리즈Article Published on 2022-04-252022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] (C-reactive protein age analyzed antibody Antibody Response Antibody responses Arthritis Autoimmune disease C-reactive protein C-RP calculated CCP chemiluminescence Chinese Community COVID-19 disease dose ELISA ELISA kit erythrocyte sedimentation erythrocyte sedimentation rate ESR FIVE healthy control healthy subjects humoral IgG immune response immune responses immunofluorescence immunogenicity immunoturbidimetry in some inactivated inactivated SARS-CoV-2 vaccines Inactivated vaccine indirect immunofluorescence lowest lymph Medicine mRNA Neutralizing Neutralizing antibodies neutralizing antibody Neutrophils no correlation not differ Patient patients peptide Protein receiving recruited reported Rheumatoid rheumatoid arthritis rheumatoid factor SARS-CoV-2 SARS-CoV-2 vaccine sedimentation rate Sery significantly lower Spearman correlation analysis Test Traditional Traditional Chinese medicine vaccination Vaccines was used were measured [DOI] 10.3389/fpubh.2022.875558 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection in dialysis and kidney transplant patients: immunological and serological response투석 및 신장 이식 환자의 SARS-CoV-2 감염: 면역학적 및 혈청학적 반응Article Published on 2022-04-012022-09-11 Journal: Journal of Nephrology [Category] COVID19(2023년), SARS, 치료법, [키워드] alteration anti-spike antibodies anti-spike antibody anti-spike antibody response B cells B-cell baseline baseline characteristics CD4 CD8 chemokine chemokines controls COVID-19 cytokine Cytokines DCs dendritic cell dialysis expression groups healthy subject healthy subjects Hemodialysis high mortality rate Hospitalization IFN-α IL10 IL6 immunological immunology innate immune system involved kidney transplant kidney transplant recipient kidney transplant recipients lymphocyte Lymphocyte subsets Lymphocytes moderate-severe monocyte Monocyte activation monocyte HLA-DR neutrophil neutrophil recruitment Patient patients patients with COVID-19 populations proportion SARS-CoV-2 SARS-COV-2 infection serological response severe disease symptom onset T cells terminally differentiated the disease two groups uninfected was increased were measured [DOI] 10.1007/s40620-021-01214-8 PMC 바로가기 [Article Type] Article
Low serum levels of zinc and 25-hydroxyvitmain D as potential risk factors for COVID-19 susceptibility: a pilot case-control study Research Published on 2022-03-232022-10-05 Journal: European journal of clinical nutrition [Category] SARS, 치료법, 치료제, [키워드] case-control study Comorbidities Comorbidity Control control group coronavirus disease COVID-19 COVID-19 PCR test deficiency diagnosed with COVID-19 educational status evaluate Factor healthy subjects individual interquartile range Iran median Nasopharyngeal swab no significant difference Patient PCR performed polymerase chain positive potential risk predicted Result risk factor SARS-COV-2 infection selected serum Serum level Sex significantly lower single-center specificity subject Tehran Treatment were recorded [DOI] 10.1038/s41430-022-01095-5 [Article Type] Research
SARS-COV-2 Infection, Vaccination, and Immune-Mediated Diseases: Results of a Single-Center Retrospective StudyObservational Study Published on 2022-03-212022-10-04 Journal: Frontiers in Immunology [Category] SARS, 임상, [키워드] Adaptive immune response affected alteration anti-SARS-CoV-2 antibody anti-spike antibodies antibody Arthritis Autoimmunity clinical manifestation Cohort complex conducted correlated correlation COVID-19 COVID-19 pandemic deregulated described diagnosed evaluated group healthy healthy subject healthy subjects Hospitalized Host Hypothesis immune immune response Immune-mediated immune-mediated disease Immuno-Mediated Reactions induce Infection Inpatient Laboratory manifestation myocarditis Occurrence Outpatient Patient Reactions responsible Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV2 serological Support Symptom vaccination Vaccine vaccine antigen [DOI] 10.3389/fimmu.2022.859550 PMC 바로가기 [Article Type] Observational Study
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects Research Published on 2022-03-162022-10-05 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 치료제, [키워드] Administered adverse events AUC blood sample calculated Chinese collected dose drug candidate enrolled evaluate exhibited food-effect had no healthy subject healthy subjects indicated JT001 MAD metabolite occurred patients with COVID-19 per protocol pharmacokinetic analysis Phase I PK parameters Placebo plasma repeated Safety SARS-CoV-2 Serious Adverse Event subject Support Tablet Tolerability VV116 [DOI] 10.1038/s41401-022-00895-6 [Article Type] Research
Marked increase of interferon-β after BNT162b2 mRNA vaccination: a case of polyarthritis with pleurisyBNT162b2 mRNA 예방접종 후 인터페론-β의 현저한 증가: 흉막염을 동반한 다발성관절염 1예Case Reports Published on 2022-03-022022-09-12 Journal: BMJ case reports [Category] MERS, SARS, 진단, [키워드] association BNT162b2 mRNA comparable COVID-19 cytokine disease elevated Exacerbation had no healthy subjects IFN-β immunological immunological products and vaccines immunology increase in innate immune system interferon mRNA vaccine mRNA vaccines Musculoskeletal musculoskeletal syndromes. one patient Other Patient polyarthritis Prednisolone receiving reported Rheumatic diseases SARS-CoV-2 serum Treatment vaccination [DOI] 10.1136/bcr-2021-246533 PMC 바로가기 [Article Type] Case Reports
High serum nitrates levels in non-survivor COVID-19 patientsObservational Study Published on 2022-03-012022-10-05 Journal: Medicina intensiva [Category] SARS, 바이오마커, 임상, [키워드] 30-Day mortality ABC APACHE II association AUC Blood Canary Island carried Coronavirus 2019 coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Determination English healthy subjects hospital ICU ICU admission ICUs intensive care unit Kaplan-Meier Kaplan-Meier analysis Logistic regression analysis Mortalidad Mortality mortality rate Nitrate nitrite Niveles séricos de nitratos no difference non-survivor observation Patient patients Prognosis Pronóstico prospectivo serum Serum nitrate levels Serum nitrate levels. SOFA SOFA score Spain Spanish surviving patient variable [DOI] 10.1016/j.medine.2020.10.007 PMC 바로가기 [Article Type] Observational Study
Evaluation of circulating leucocyte populations both in subjects with previous SARS-COV-2 infection and in healthy subjects after vaccinationObservational Study Published on 2022-03-012022-10-05 Journal: Journal of Immunological Methods [Category] SARS, 임상, [키워드] addition binding CD4 CD8 Cell circulating COVID-19 COVID-19 infection COVID-19 mRNA BNT162b2 COVID-19 mRNA BNT162b2 (Pfizer-BioNTech) vaccine Cytometry decrease develop effector effector cell Flow Flow cytometry characterization groups healthy healthy subject healthy subjects immune mechanism immune response immune system increased expression Infection initial Innate innate immune response leucocyte leukocyte pathogen Pfizer-BioNTech Population promote receptor reduction subject subjects T cell T cell immune response T cell response T cells TEMRA terminal vaccination Vaccine viral clearance viral replication [DOI] 10.1016/j.jim.2022.113230 PMC 바로가기 [Article Type] Observational Study
Can FeNO be a biomarker in the post-COVID-19 patients monitoring?FeNO는 코로나19 이후 환자 모니터링에서 바이오마커가 될 수 있습니까?Article Published on 2022-03-012022-09-11 Journal: Respiratory medicine [Category] MERS, SARS, 바이오마커, [키워드] 95% CI Asthma Biomarker bronchial asthma Can clinical manifestation clinical manifestations Consistency control group Corticosteroid Corticosteroids COVID-19 disease onset enrolled FeNO healthy subject healthy subjects healthy volunteer Hospitalized Hypothesis Inflammatory mean difference men nitric oxide Patient post-COVID-19 post-COVID-19 patient Post-COVID-19 patients reported statistically significant syndrome systemic corticosteroid systemic corticosteroids the mean treated women [DOI] 10.1016/j.rmed.2022.106745 PMC 바로가기 [Article Type] Article