Intranasal immunization with recombinant Vaccinia virus encoding trimeric SARS-CoV-2 spike receptor-binding domain induces neutralizing antibodyArticle Published on 2022-09-222022-11-15 Journal: Vaccine [Category] SARS, 진단, 치료기술, [키워드] BALB/c mice Bronchoalveolar lavage fluid cellular immune responses COVID-19 detectable dissemination domain Effects elicited evaluated exhibited expressing humoral IgA IgG immune response immunization immunized induce Infection intranasal Lymphocytes mice mucosal mucosal immune nasal washe neutralization neutralization activities Neutralizing Neutralizing antibodies neutralizing antibody RBD respiratory response robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein secretory IgA sera systemic immune response transmission of SARS-CoV-2 trimeric trimeric RBD Vaccine vaccinia vaccinia virus virus [DOI] 10.1016/j.vaccine.2022.08.054 PMC 바로가기
SARS-CoV-2-specific immunoglobulin Y antibodies are protective in infected miceArticle Published on 2022-09-192022-11-15 Journal: PLoS Pathogens [Category] SARS, 변종, 진단, 치료제, [키워드] acute respiratory syndrome Ad5-hACE2 administration antibody Antigen applied characterized control group Coronavirus-2 disease edema Efficacy evaluated Evidence examined experiments hemorrhage Human immunization Immunoglobulin increased survival induce inflammatory cell infiltration injected intranasal lung mice Mild morbidity non-specific plaque reduction neutralization Prophylactic Protective Recombinant SARS-CoV-2 RBD reduced required safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SDS-PAGE severe disease variants virus [DOI] 10.1371/journal.ppat.1010782 PMC 바로가기
Chemically Modified Bovine β-Lactoglobulin as a Broad-Spectrum Influenza Virus Entry Inhibitor with the Potential to Combat Influenza OutbreaksArticle Published on 2022-09-162022-11-15 Journal: Viruses [Category] SARS, 신종인플루엔자, 진단, 치료제, [키워드] acute respiratory syndrome administration binds bovine bovine β-lactoglobulin broad-spectrum charged residues chemical modification combat coronavirus effective Efficacy highly pathogenic HIV host cells HPV Human immunodeficiency virus human papillomavirus in vitro in vivo Infection infections Influenza influenza A influenza A virus influenza vaccines Influenza virus inhibiting inhibitor intranasal lack mice outbreak Outbreaks Potential Prevent prevention Prophylactic SARS-CoV-2 sialic acid subunit the receptor-binding domain viral entry viral entry inhibitor. viruses [DOI] 10.3390/v14092055 PMC 바로가기
Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variantsArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] administration antibodies Antibody therapeutics Antiviral antiviral prophylaxis and therapeutics Biological sciences comparable conserved effective epitope fusion protein IgA IgG Fc Immunity infected with SARS-CoV-2 Infection intranasal invasive K18-ACE2 less Lineage mammalian Microbiology mucosal nanobody neutralization neutralize omicron Pichia pastoris produced Prophylactic Prophylaxis provide RBD recognize SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant severe respiratory disease Therapeutic treatment transgenic mice variant variants VoC [DOI] 10.3389/fimmu.2022.995412 PMC 바로가기
Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from a lethal SARS-CoV-2 infectionArticle Published on 2022-09-122022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, 치료기술, [키워드] absence acute respiratory syndrome Administered administration animal model blocked bronchoalveolar C57BL/6 caused CD4 CD8 coronavirus Coronavirus disease-19 COVID-19 COVID-19 progression current demonstrated effective Efficacy elicited evaluated expressing full-length histopathological IgA antibody IgG immune responses Immunity immunogenic immunogenicity induce intramuscular intranasal intranasal delivery K18-hACE2 transgenic mice Local lung lung lesion lymph nodes mice modified vaccinia virus morbidity and mortality mucosal mucosal immune MVA nasal washe Nasal washes neutralizing antibody parental Prevent pro-inflammatory cytokine PROTECT Protective protective efficacy Protein responses Result S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission SARS-CoV-2 variant SARS-CoV-2 virus SARS-CoV-2-specific immune response serum single dose spleen susceptible systemic immune response systemically T-cell immune response the SARS-CoV-2 Transmission undetectable upper respiratory tract vaccination Vaccine vaccine administration vaccine candidate vaccine candidates vaccine dose virus infection [DOI] 10.3389/fimmu.2022.995235 PMC 바로가기
Engineering the common cold to be a live-attenuated SARS-CoV-2 vaccineArticle Published on 2022-09-082022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료기술, [키워드] all age group animal models Antigen approach Asymptomatic Attenuated benefit catch caused center Characteristics common cold Control did not reduce drug effective effort Engineering Express healthy Hospitalization hosts Human Human rhinovirus immune response Immunity induce Infection intranasal intranasal vaccination live vaccine Mortality mucosal nasal swab pandemic coronavirus pathogen pathogenic prevention Protective Proteins reducing Replication replication competent respiratory virus rhinovirus rhinoviruses robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV2 serotype serum Social distancing measure Spread strain tested Vaccine vaccine candidate vector virus [DOI] 10.3389/fimmu.2022.871463 PMC 바로가기
An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosaArticle Published on 2022-09-072022-11-15 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome adaptive addition anti-Spike IgG B cells Beta boost booster cellular immunity Central nervous system Complete coronavirus coronavirus disease COVID-19 COVID-19 vaccine cross-protective delta variant effective effector memory Host humoral Humoral immunity IgA Immunity immunization induce Infection inflammatory properties intranasal intranasal vaccination intranasally lentiviral lentiviral vaccine lung mice mRNA mucosa mucosal mucosal booster vaccine mucosal immunity nasal non-replicative omicron organism pandemic Protective reducing SARS-CoV-2 SARS-CoV-2 emerging variants of concern SARS-CoV-2 immunity shown specificity susceptible T cell target the SARS-CoV-2 transgenic mice vaccination vaccine candidate variant variants of concern Viral transmission waning anti-COVID-19 immunity. [DOI] 10.1016/j.ymthe.2022.04.016 PMC 바로가기
Effect of intra-nasal nitrilotriacetic acid trisodium salt in lowering elevated calcium cations and improving olfactory dysfunction in COVID-19 patientsRandomized Controlled Trial Published on 2022-09-012022-10-05 Journal: European archives of oto-rhino-laryngology : offic [Category] 임상, [키워드] Analysis Anosmia association Concentration COVID-19 COVID-19 adult patient COVID-19 patient Effect elevated enrolled functional healthy increase in intracellular calcium intranasal nasal olfactory olfactory disorders olfactory dysfunction patients worldwide Randomized controlled trial Research SARS-CoV-2 secretion selective significant decrease Smell Sodium chloride Symptom Treatment was performed [DOI] 10.1007/s00405-022-07424-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
A Bacteriophage-Based, Highly Efficacious, Needle- and Adjuvant-Free, Mucosal COVID-19 VaccineArticle Published on 2022-08-302022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition adenovirus-based Administered administration ambient Antibody titer bacteriophage CRISPR engineering bacteriophage T4 mucosal platform BALB/c broad immunity to SARS-CoV-2 variants bronchoalveolar lavage specimen bronchoalveolar lavage specimens caused CD4 CD8 Cell-mediated immune responses cellular immune responses Complete COVID COVID-19 CRISPR cytokine death delta variant dose drug effective elicited enzyme Epidemic exhibited exterior food generate globe gut microbiota hACE2 humoral Immunity induce Infection injected interior intramuscularly intranasal intranasally lung lesion mice mouse-adapted SARS-CoV-2 mRNA mucosal nasal needle needle-free intranasal vaccine not affect nucleocapsid protein omicron other respiratory infection pandemic Pathogens phage T4 platform predicted Prevent provide provided response responses robust SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants secretory IgA sera spike sterilizing immunity. T cell temperature the United State the vaccine Transgenic mouse Transmission trimer Vaccine variants Viral transmission Virus neutralization virus-neutralizing antibody World Health Organization [DOI] 10.1128/mbio.01822-22 PMC 바로가기
Airway-resident T cells from unexposed individuals cross-recognize SARS-CoV-2Article Published on 2022-08-292022-10-05 Journal: Nature Immunology [Category] SARS, 임상, 진단, 치료기술, [키워드] clearance contribute coronavirus immunity correlated COVID-19 pandemic Critical cross-reactive disease functional healthcare worker healthy donor helping household contact individual Infection intranasal Lower respiratory tract memory T cell mucosal murine model recent respiratory virus response SARS-CoV-2 shown suggested T cell T cells vaccination Vaccines viral control [DOI] 10.1038/s41590-022-01292-1 [Article Type] Article