low expression – Page 3 – Communicable Diseases Research

Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

네트워크 의학은 SARS-COV-2/COVID-19 감염을 뇌 미세 혈관 손상 및 치매 유사인지 장애에서 신경 염증에 연결합니다.

Research

Published on 2021-06-092022-09-10
Journal: Alzheimer's Research & Therapy [Category] MERS, SARS, 유전자 메커니즘, 치료기술,

Purification and characterization of the receptor‐binding domain of SARS‐CoV‐2 spike protein from Escherichia coli

Research Article

Published on 2021-05-072022-10-31
Journal: Engineering in Life Sciences [Category] COVID-19,

Susceptibility to SARS-CoV-2 of Cell Lines and Substrates Commonly Used to Diagnose and Isolate Influenza and Other Viruses

Research

Published on 2021-05-012022-10-31
Journal: Emerging Infectious Diseases [Category] COVID-19, SARS,

[키워드] ACE2 acute respiratory syndrome Affect analyzed angiotensin-converting enzyme 2 canine cell line cell lines cell type cellular coronavirus coronavirus disease COVID-19 D614G mutation diagnose diagnostic disease enzyme evaluated help humans Infection Influenza influenza viruses isolate kidney LINE low expression MDCK MDCK cells mice Other overcome overexpression receptor reported respiratory infections SARS-CoV-2 SARS-CoV-2 cell SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus spike protein substitution substrate Surveillance susceptibility susceptible the spike protein virus viruses zoonoses
[DOI] 10.3201/eid2705.210023 PMC 바로가기 [Article Type] Research

Blood neutrophils from children with COVID-19 exhibit both inflammatory and anti-inflammatory markers

COVID-19에 걸린 어린이의 혈액 호중구는 염증 및 항염증 마커를 모두 나타냅니다

Observational Study

Published on 2021-05-012022-08-31
Journal: EBioMedicine [Category] SARS, 바이오마커, 임상, 진단,

[키워드] Activation acute lung injury Adhesion Molecule adhesion molecules Adults analyzed Anti-inflammatory Asymptomatic Blood Blood samples Buenos Aire Buenos Aires CD11b CD64 CD66b Cell-adhesion molecules cell-free DNA children children with COVID-19 circulating neutrophil circulating neutrophils Concentration COVID-19 cytokine cytokine production Cytokines DNA ELISA expression Fcγ receptor flow cytometry fluorometry healthy children healthy controls HLA-DR IgG IgG antibodies IgG antibody immune response infiltration Inflammatory inhibitory receptor Inhibitory Receptors L-selectin low expression lower expression Lung function Lung injury marker Mild MIS-C Moderate COVID-19 NET NETs neutrophil Neutrophils no differences observational study PD-L1 pediatric pediatric COVID-19 phenotype plasma Plasma levels Prevent promotion quantified receptor respiratory respiratory symptoms SARS-CoV-2 Science serum severe COVID-19 severe respiratory symptom severe respiratory symptoms Spike protein supported syndrome technology the spike protein tissue university was performed were measured
[DOI] 10.1016/j.ebiom.2021.103357 PMC 바로가기 [Article Type] Observational Study

Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells

Research

Published on 2021-04-142022-10-30
Journal: Journal of Translational Medicine [Category] COVID-19, MERS, SARS,

Repurposing of approved drugs with potential to interact with SARS-CoV-2 receptor

Research Article

Published on 2021-03-292022-10-04
Journal: Biochemistry and Biophysics Reports [Category] 신약개발,

[키워드] Abstract ACE ACE1 ACE2 addition Amino acid Analysis angiotensin approved drug binding Cell comparable coronavirus 2 COVID-19 distribution domain Drug repurposing entry of SARS-CoV-2 enzyme epithelial expression homolog host cells host-virus interaction human cells human lung Image Infection Interaction interfere low expression organized peptidase predict primary sequence Proteins RBD receptor Receptor binding domain Region reported repurposing respiratory S protein same order SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 spike protein similarities similarity spike glycoprotein Spike protein the SARS-CoV-2 tissue Transmission variety viral spike protein X-ray crystallographic structure
[DOI] 10.1016/j.bbrep.2021.100982 PMC 바로가기 [Article Type] Research Article

T Cell Activation, Highly Armed Cytotoxic Cells and a Shift in Monocytes CD300 Receptors Expression Is Characteristic of Patients With Severe COVID-19

T 세포 활성화, 고도로 무장된 세포독성 세포 및 단핵구 CD300 수용체 발현의 변화는 중증 COVID-19 환자의 특징입니다

Comparative Study

Published on 2021-03-112022-09-12
Journal: Frontiers in Immunology [Category] SARS, 진단,

[키워드] activated Activation adaptive alteration Analysis analyzed association CD300a CD300c CD300e CD4 CD8 cells characterized Clinical characteristics clinical phenotype Clinical sign cohort of patient correlated Correlation analysis COVID-19 cytotoxic described double negative expression expression pattern flow cytometric study follicular granzyme B help HLA-DR host immune responses immature Immune cell immune system Immunopathogenesis infected with SARS-CoV-2 Laboratory low expression Mild moderate monocyte Monocytes NK cell NK cells Patient patients performed receptors severe COVID-19 severe disease severity shift T cell subset T cells
[DOI] 10.3389/fimmu.2021.655934 PMC 바로가기 [Article Type] Comparative Study

SARS-CoV-2 infection induces mixed M1/M2 phenotype in circulating monocytes and alterations in both dendritic cell and monocyte subsets

SARS-CoV-2 감염은 순환 단핵구에서 혼합 M1/M2 표현형을 유도하고 수지상 세포 및 단핵구 하위 집합 모두에서 변경을 유도합니다

Clinical Trial

Published on 2020-12-312022-08-13
Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, 임상, 진단,

[키워드] activated Activation adoptive immunity alteration Analysis B lymphocytes Cell center circulating monocyte clinical Clinical Center clinical manifestation clinical manifestations COVID-19 patient cytometric dendritic cell dendritic cells event expressed Flow Flow cytometric analysis functional highlight Immunity immunological indicated induce Innate immunity less low expression lymphocyte Lymphocytes M1 and M2 monocytes M2 marker M2 monocyte M2 monocytes marker Mild mild case mild cases Mild symptom mild symptoms monocyte Monocytes myeloid NK cell NK cells Patient Peripheral blood peripheral blood cell peripheral blood cells phenotype phenotypic preserved proportion recruited SARS-COV-2 infection severe cases severe disease severe symptom severity subset Symptom T and B lymphocytes the disease was performed
[DOI] 10.1371/journal.pone.0241097 PMC 바로가기 [Article Type] Clinical Trial

Dynamic SARS-CoV-2-Specific Immunity in Critically Ill Patients With Hypertension

고혈압이 있는 중환자의 동적 SARS-CoV-2-특이적 면역

Immunology

Published on 2020-12-102022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

[키워드] absence Activation acute respiratory syndrome Antibody Response caused CD38 CD4 CD8 Cellular responses Chronic illness clinical coronavirus coronavirus disease correlated COVID-19 COVID-19 patient Critical critical cases dynamic dysregulation exhibited expression finding Health HLA-DR hypertension hypertensive patient IFNγ IgA IgG IgM Ill immunological characteristics infected with SARS-CoV-2 Infection low expression lymphopenia onset of symptoms outbreak outcome Patient Prolonged SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 viral load severe COVID-19 severe disease severe SARS-CoV-2 significantly surviving patients T cell T cells the patient titers of IgG Viral load were measured
[DOI] 10.3389/fimmu.2020.596684 PMC 바로가기 [Article Type] Immunology

Genetic mechanisms of critical illness in COVID-19

Research

Published on 2020-12-012022-10-05
Journal: Nature [Category] 신약개발, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] Antiviral association caused CCR2 chemotactic chromosome Clinical practice coronavirus disease COVID-19 Critical Critically ill patient dipeptidyl peptidase drugs ENCODE enzyme activator Evidence expression gene cluster Genetic Genetic variant Genome-wide association study genome-wide significant GenOMICC Host identify IFNAR2 Inflammatory intensive care units life-threatening low expression Lung inflammation lung tissue mechanism mendelian randomization OAS1 OAS2 organ damage randomized clinical trial receptor replicated robust severe COVID-19 target the interferon therapeutic transcriptome-wide Treatment TYK2 tyrosine with COVID-19
[DOI] 10.1038/s41586-020-03065-y [Article Type] Research