Iota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitroIota-carrageenan은 SARS-CoV-2를 중화하고 시험관 내에서 바이러스 복제를 억제합니다Research Article Published on 2021-02-172022-08-13 Journal: PLoS ONE [Category] Biochemistry, MERS, 진단, 치료제, [키워드] absence acute respiratory syndrome administration attachment caused cell entry clinical effectiveness common cold competent coronavirus demonstrated dose duration of symptom effective Endemic in vitro in vitro data inhibit iota-carrageenan lentivirus nasal Nasal spray neutralize neutralized Particle Patient Prophylactic Prophylaxis pseudotyped public health threat reduction Replication respiratory respiratory viruses Safe SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2 spike pseudotyped lentivirus SARS-CoV-2 virus Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus severity spike glycoprotein the cell the SARS-CoV-2 therapeutic translated Treatment Vaccine viral replication wild type [DOI] 10.1371/journal.pone.0237480 PMC 바로가기 [Article Type] Research Article
Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae흡입 가능한 복합 니클로사미드-리소자임 입자의 개발 및 평가: 코로나바이러스 감염 및 후유증에 대한 광범위한 스펙트럼, 환자 적응형 치료제Research Article Published on 2021-02-112022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, MERS, [키워드] acquisition administration alternative antiviral efficacy approach causative agent clinical development coronavirus Coronavirus infection coronavirus strains COVID-19 pandemic demonstrated development drug drug level Dry powder inhaler endogenous protein Formulation hLYS human lysozyme Hypothesis in vitro in vivo inflammatory lung damage lower airway lung damage MERS MERS-CoV methicillin methicillin-resistance staphylococcus aureus pneumonia nasal Nasal spray nebulizer NIC niclosamide offer Particle Pneumonia primary site Protein respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 infections secondary to Spread Stage Staphylococcus aureus the disease treating COVID-19 Treatment upper and lower airways [DOI] 10.1371/journal.pone.0246803 PMC 바로가기 [Article Type] Research Article
Review of the use of nasal and oral antiseptics during a global pandemicReview Published on 2021-01-192022-10-31 Journal: Future Microbiology [Category] COVID-19, [키워드] Abstract addition antiviral property Cell chlorhexidine clinical trial COVID-19 demonstrated early stage global pandemic hydrogen peroxide hypertonic hypertonic saline in vitro Infection Intervention iota-carrageenan Listerine log mitigate nasal Nasal spray oral rinse povidone-iodine progression Prophylaxis reduction respiratory infections review SARS-CoV-2 target Transmission transmission of SARS-CoV-2 Viral load viral replication [DOI] 10.2217/fmb-2020-0286 PMC 바로가기 [Article Type] Review
Virucidal effect of povidone iodine on COVID-19 in the nasopharynx: A structured summary of a study protocol for an open-label randomized clinical trial비인두에서 COVID-19에 대한 포비돈 요오드의 바이러스 살균 효과: 공개 라벨 무작위 임상 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-01-042022-09-10 Journal: Trials [Category] 임상, [키워드] 6 hour 6 hours acute renal failure adverse effect adverse effects adverse event adverse events anticipated Arm-1 ARMS assigned baseline being randomized Blinding both groups chronic renal failure clinical trial college comparator Concentration conducted confirmed case COVID-19 COVID-19 case COVID-19 virus creatinine criteria Data analysis diagnosed diet disease dissemination distilled water DMC Efficacy element eligibility assessment estimated glomerular filtration rate evaluate exclusion filtration rate Final glomerular filtration rate groups Identifier in both groups include Inclusion inclusion criteria independent Informed consent Intervention intervention arm intervention arms intervention group invasive involved Iodine KDIGO lactating masking Microsoft Excel Modification nasal Nasal Irrigation Nasal spray nasopharynx Noninvasive ventilation number objective Occurrence Open-label Other outcome parallel-group participant Patient performed Placebo positive Povidone Iodine pregnant women Primary outcome proportion protocol random number generation randomization Randomized randomized clinical trial RCT receive recruited Registered renal renal disease renal failure required routine care Sample size screened sealed secondary outcome sensitivity Seven single-center Stage statistician status Study protocol supplementary material Symptom Thyroid thyroid disease Trial trial protocol Trial registration Version virucidal virus website [DOI] 10.1186/s13063-020-04963-2 PMC 바로가기 [Article Type] Letter
In Vitro Virucidal Effect of Intranasally Delivered Chlorpheniramine Maleate Compound Against Severe Acute Respiratory Syndrome Coronavirus 2Allergy/Immunology Published on 2020-09-172022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Against analysis of variance ANOVA Antiviral antiviral activity Antiviral effect average calculated CCID Cell culture Chlorpheniramine chlorpheniramine maleate clinical trials Compound Contact Control coronavirus coronavirus 2 COVID-19 COVID-2019 CPM determine dose Effect effective endpoint titer genome sequence GraphPad Prism hospitalized patient Hydroxychloroquine in vitro independent infected cells Infection Influenza initial intranasal intranasally Log reduction medication MERS-CoV Middle East Mild-to-moderate nasal Nasal spray novel coronavirus disease outbreak pandemic Patient placebo-controlled study Randomized reduced reduction in replicate respiratory respiratory syndrome coronavirus responsible Result Safe SARS-CoV SARS-CoV-2 similarity Standard deviation statistically significant strain tested Treatment USA-WA1/2020 Vero Viral load virucidal virus was tested [DOI] 10.7759/cureus.10501 PMC 바로가기 [Article Type] Allergy/Immunology